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issues in oncology

Is Cancer Mortality Higher in Counties That Experience Persistent Poverty?

Residents of counties that experience persistent poverty face a disproportionately high risk of cancer mortality, according to a study published by Jennifer L. Moss, PhD, and colleagues in Cancer Epidemiology, Biomarkers & Prevention. Persistent Poverty Areas of persistent poverty are defined...

issues in oncology

Ending Systemic Racism in Oncology Is Everyone’s Responsibility

Five years ago, as Rachel B. Issaka, MD, MAS, was beginning her second year as a gastroenterology fellow and feeling proud of the progress she was making in her training, she was suddenly confronted with an all-too-familiar slight that underrepresented minority providers may often experience. As...

gastrointestinal cancer
genomics/genetics

Genetic Testing May Be Cost-Effective for Newly Diagnosed Patients With GIST

In a paper published by Banerjee et al in JAMA Network Open, researchers reported that genetic testing is cost-effective and beneficial for newly diagnosed patients with metastatic gastrointestinal stromal tumors (GIST), a type of soft-tissue sarcoma that develops in specialized nerve cells in the...

breast cancer
symptom management

Monika K. Krzyzanowska, MD, MPH, on Early-Stage Breast Cancer: Ambulatory Toxicity Management in the AToM Study

Monika K. Krzyzanowska, MD, MPH, of the Princess Margaret University Health Network, discusses study findings on remote proactive telephone-based toxicity management for patients with breast cancer receiving chemotherapy. Although the telehealth program was associated with fewer grade 3 toxicities ...

breast cancer
immunotherapy

Lisa A. Carey, MD, on Triple-Negative Breast Cancer: Paclitaxel, Nab-paclitaxel, and Atezolizumab in IMpassion Trials

Lisa A. Carey, MD, of the University of North Carolina, discusses phase III results from two IMpassion trials, 130 and 131, which explored, respectively, atezolizumab plus nab-paclitaxel vs placebo plus nab-paclitaxel in previously untreated locally advanced or metastatic triple-negative breast...

solid tumors
immunotherapy

First-in-Class Human IgG4 Monoclonal Antibody Shows Activity Alone and Combined With Pembrolizumab in Advanced Solid Tumors

MK-4830—a novel, first-in-class human IgG4 monoclonal antibody targeting the myeloid-specific anti–immunoglobulin-like transcript 4 (ILT4) receptor—administered either as a single agent or in combination with pembrolizumab was well tolerated and showed activity in heavily pretreated patients with...

kidney cancer
genomics/genetics

Is ctDNA Effective in Detecting Genomic Alterations in Patients With Metastatic Kidney Cancer?

Circulating tumor DNA (ctDNA) analysis is a minimally invasive genomic assessment tool utilizing targeted next-generation sequencing of peripheral blood. At the ESMO Virtual Congress 2020, Zengin et al reported genomic results from a large cohort of patients with metastatic renal cell carcinoma...

skin cancer
immunotherapy

Alexander M. Eggermont, MD, PhD, on Melanoma: Pembrolizumab vs Placebo After Complete Resection

Alexander M. Eggermont, MD, PhD, of the Princess Maxima Center for Pediatric Oncology, discusses final results of the phase III EORTC 1325-MG/Keynote 054 trial, which confirmed a sustained recurrence-free survival benefit of pembrolizumab vs placebo in patients with resected high-risk stage III...

breast cancer
immunotherapy

Aditya Bardia, MD, MPH, on Triple-Negative Breast Cancer: Sacituzumab Govitecan vs Treatment of Physician’s Choice

Aditya Bardia, MD, MPH, of Massachusetts General Hospital Cancer Institute, discusses results from the phase III ASCENT trial, which showed the antibody-drug conjugate sacituzumab govitecan-hziy improved progression-free and overall survival more than standard single-agent chemotherapy in patients...

issues in oncology
supportive care

Malnutrition Among Patients With Cancer Admitted to the Hospital May Increase the Risk for Infection

Upon hospital admission for cancer, many patients already demonstrated a high prevalence of malnutrition per Global Leadership Initiative on Malnutrition (GLIM) criteria, which was associated with the risk of developing a nosocomial infection, according to findings presented by Nuñez Abad et al at...

thyroid cancer

Pralsetinib in RET-Mutated Medullary Thyroid Cancer

Pralsetinib (also known as BLU-667) showed activity in patients with advanced RET mutation–positive medullary thyroid cancer, including high rates of durable response, disease control, and 18-month progression-free survival. These findings were presented by Hu et al at the ESMO Virtual Congress...

covid-19

Leukemia & Lymphoma Society Launches First Clinical Trial in Patients With Hematologic Malignancy and COVID-19

In response to studies showing that between 30% and 60% of patients with blood cancer are at risk of death if infected with COVID-19 compared with patients who are cancer-free, the Leukemia & Lymphoma Society (LLS) has announced its launch of the first clinical trial dedicated solely to this...

Sylvester Comprehensive Cancer Center Receives $126 Million Gift

A gift of $126 million to the Sylvester Comprehensive Cancer Center at the University of Miami Leonard M. Miller School of Medicine will accelerate advances in finding cures for cancer and expand innovative treatment options. The donation is the single largest in the University of Miami’s 95-year...

lymphoma
immunotherapy

NCCN Adds Tafasitamab-cxix to Its Clinical Practice Guidelines in Oncology for B-Cell Lymphomas

MorphoSys and Incyte have announced that tafasita­mab-cxix, a humanized Fc-modified cytolytic CD19-targeting monoclonal antibody, has been included in the latest National Comprehensive Cancer Network Clinical Practice Guidelines®  (NCCN Guidelines®) in Oncology for B-Cell Lymphomas. Specifically,...

Leading Cancer Treatment Recommendations From NCCN Available in Several Languages

The National Comprehensive Cancer Network® (NCCN®) has announced the availability of multiple non–English-language versions of the NCCN Clinical Practice Guidelines in Oncology® (NCCN Guidelines®) for numerous high-incidence cancer types. These treatment recommendations can be accessed for free at...

Cleveland Clinic Appoints New Chair of Head and Neck Institute

Cleveland Clinic has appointed Patrick J. Byrne, MD, MBA, as Chair of the Head & Neck Institute. Dr. Byrne joins Cleveland Clinic from The Johns Hopkins Hospital, where he served as Director of the Division of Facial Plastic and Reconstructive Surgery in the Department of Otolaryngology/Head...

Cancer Center at Brown University Established

The Corporation of Brown University has approved the establishment of the Cancer Center at Brown. The center takes a broad-spectrum approach to research, from working to understand how cancer develops, grows, and metastasizes, to developing new therapeutics for patients in a personalized way that...

covid-19

COVID-19 Pandemic Delays Cancer Care and Strains Resources

Delays and cancellation of cancer treatments and other safety measures undertaken to minimize the risk of exposure to COVID-19 have generated a huge backlog in oncology care and research. The threat of delayed diagnoses looms while oncology professionals face burnout, according to new studies...

National Survey Shows Decline in Overall Youth E-Cigarette Use, Uptick in Use of Disposable Products

In september, 2020, the U.S. Food and Drug Administration (FDA), in partnership with the Centers for Disease Control and Prevention, released new data from the 2020 National Youth Tobacco Survey (NYTS). The results, published by Wang et al in Morbidity and Mortality Weekly Report (MMWR), showed 1.8 ...

Eric P. Winer, MD, Recipient of Lifetime Achievement in Mentoring Award

In September 2020, Eric P. Winer, MD, was honored with the William Silen Lifetime Achievement in Mentoring Award, presented by the Office for Diversity, Inclusion & Community Partnership at Harvard Medical School. Dr. Winer is Professor of Medicine, Harvard Medical School, and Director of the...

Karmanos Receives $630,000 CATCH-UP Grant to Recruit Minority, Rural Patients to Clinical Trials

Researchers at the Barbara Ann Karmanos Cancer Institute have secured a 1-year, $630,000 grant from the National Cancer Institute (NCI) to help support the Institute’s clinical trials, which target underserved populations in Detroit and in the rural areas that Karmanos serves. The NCI P30 Cancer...

IU Cancer Center Researcher Awarded $5.7 Million to Study Chemotherapy-Induced Hearing Loss, Toxicities

A researcher at the Indiana University (IU) Melvin and Bren Simon Comprehensive Cancer Center has been awarded a 5-year, $5.7 million National Cancer Institute (NCI) grant to evaluate long-term health outcomes for patients with cancer who receive platinum-based chemotherapies. An internationally...

Irish Boy With His Scapula

The text and photograph here are excerpted from a four-volume series of books titled Oncology: Tumors & Treatment, A Photographic History, The Antiseptic Era 1876–1900 by Stanley B. Burns, MD, FACS, and Elizabeth A. Burns. The photograph appears courtesy of Stanley B. Burns, MD, and The Burns...

NYGC Launches Collaborative Cancer Genomics Research Projects Focused on Underserved Populations

Leading cancer scientists working with the New York Genome Center (NYGC) announced that grants are being awarded to fund six projects that address the role of ethnicity in several major cancer types, taking advantage of the diversity of patients being treated at health-care institutions throughout...

covid-19

City of Hope Leads Novel Clinical Trial to Treat Patients With Cancer and COVID-19

City of Hope is investigating an innovative treatment for patients with cancer and COVID-19 by repurposing leflunomide, an anti-inflammatory drug for rheumatoid arthritis that is inexpensive and has few serious side effects, in a new clinical trial. Patients treated for cancer in the past 2 years...

covid-19

Corticosteroids Improve Survival in Critically Ill Patients With COVID-19, According to International Trial

In a demonstration of global collaboration, clinician-scientists have pooled data from 121 hospitals in 8 countries to find that inexpensive, widely available steroids may improve the odds that very sick patients with COVID-19 will survive the illness. The findings were made through the Randomized...

World Gynecologic Oncology Awareness Day: Turning the World Purple

Advocates for patients with cancer and medical professionals in more than 20 countries planned activities for World Gynecologic Oncology Day (World GO Day). A project of the European Society of Gynaecological Oncology (ESGO) and the European Network of Gynaecological Cancer Advocacy Groups...

breast cancer

Erica L. Mayer, MD, MPH, on Early Breast Cancer: Palbociclib With Endocrine Therapy vs Endocrine Therapy Alone

Erica L. Mayer, MD, MPH, of Dana-Farber Cancer Institute, discusses an initial analysis of phase III findings from the PALLAS trial, which suggested the benefits observed in the metastatic setting with palbociclib plus endocrine therapy did not translate into the earlier adjuvant setting for...

immunotherapy

Meta-analyses of Quality of Life in Patients Treated With Checkpoint Inhibitors

Findings from two meta-analyses designed to summarize quality-of-life data on patients receiving immune checkpoint inhibitor therapy for cancer were presented at the ESMO Virtual Congress 2020 (Abstract 1568O). These meta-analyses found that patients receiving immune checkpoint inhibitors had...

issues in oncology

Efforts to Broaden Eligibility Criteria for Clinical Trials Seek to Include More Racial and Ethnic Minority Patients

A review of the 2019 Drug Trials Snapshots Report1 from the U.S. Food and Drug Administration (FDA) showed that although female participation in clinical trials grew to 72% from 56% in the FDA’s 2018 Drug Trials Snapshots Report,2 ethnic minority participation in clinical trials actually declined...

colorectal cancer
geriatric oncology

Elderly Patients With Advanced Colorectal Cancer Treated With Adjuvant Oxaliplatin Plus Fluoropyrimidines: Tolerability and Benefit

Among patients with stage III colon cancer, patients aged 70 or older were less tolerant of adjuvant oxaliplatin/flouropyrimidine therapy, in addition to having poorer relapse-free interval rates on the regimen, according to findings from a large subgroup analysis of the phase III TOSCA trial...

genomics/genetics
immunotherapy

Nivolumab Shows Activity in edPOLE-Mutated, MMR-Proficient Advanced Cancers

Nivolumab monotherapy showed high response and disease control rates in patients with pathogenic exonuclease domain POLE (edPOLE)-mutated, mismatch repair (MMR)-proficient advanced tumors containing confirmed pathogenic mutations, according to findings presented by Benoit J.C. Rousseau, MD, PhD, of ...

issues in oncology
legislation
health-care policy
covid-19

AACR Releases 10th Edition of Annual Cancer Progress Report

The American Association for Cancer Research (AACR) has released the 10th edition of its annual Cancer Progress Report. The report highlights how cancer research, largely supported by federal investments in the National Institutes of Health (NIH) and the National Cancer Institute (NCI), is...

skin cancer
immunotherapy

Adjuvant Nivolumab vs Ipilimumab in Resected Advanced Melanoma: Long-Term Follow-up of CheckMate 238

Long-term findings from the phase III CheckMate 238 study showed that nivolumab improved 4-year recurrence-free survival compared with ipilimumab in patients with resected stage IIIB to C or IV melanoma in the overall population as well as across subgroups of patients stratified by disease stage...

gynecologic cancers

Does Radical Hysterectomy Improve Survival in Patients With Cervical Cancer and Intraoperative Detection of Positive Lymph Nodes?

No significant difference was observed in the risk of recurrence, local recurrence, or death between patients with cervical cancer in whom a radical uterine procedure (mostly radical hysterectomy) was completed or abandoned upon intraoperative detection of positive pelvic lymph nodes. These...

lung cancer

Cécile Le Pechoux, MD, on NSCLC: Comparing Postoperative Radiotherapy With No Radiotherapy

Cécile Le Pechoux, MD, of the Institut Gustave Roussy, discusses new findings from an international trial on an old controversy: What is the role of postoperative radiotherapy in locally advanced (stage III) non–small cell lung cancer? The researchers enrolled patients with completely resected...

lung cancer
immunotherapy

Benjamin Besse, MD, PhD, on NSCLC: Neoadjuvant Atezolizumab for Resectable Disease

Benjamin Besse, MD, PhD, of the Gustave Roussy Cancer Centre, discusses results of the phase II PRINCEPS trial, which assessed, for the first time, the effect of just one injection of the immunotherapy atezolizumab before surgery in patients with resectable non–small cell lung cancer (Abstract...

skin cancer
immunotherapy

Paolo A. Ascierto, MD, on Melanoma: Sequencing Targeted Treatments and Immunotherapy

Paolo A. Ascierto, MD, of the Istituto Nazionale Tumori, discusses phase II results on progression-free survival for patients with advanced melanoma in the SECOMBIT study, whose aim is to evaluate the different sequencing of a BRAF inhibitor (encorafenib) plus a MEK inhibitor (binimetinib) with...

colorectal cancer
immunotherapy

Thierry Andre, MD, on Colorectal Cancer: Health-Related Quality of Life With Pembrolizumab vs Chemotherapy

Thierry Andre, MD, of Hôpital Saint-Antoine, discusses phase III KEYNOTE-177 findings on the reduced risk of disease progression or death in patients receiving pembrolizumab monotherapy as a first-line treatment of microsatellite instability–high and/or mismatch repair–deficient metastatic...

covid-19

Joint Statement From the AMA, AHA, and ANA on U.S. Coronavirus Death Toll

Today, the American Medical Association (AMA), American Hospital Association (AHA), and American Nurses Association (ANA) released a joint statement on the amount of deaths caused by the coronavirus in the United States. Today we mark a somber milestone as more than 200,000 people in the United...

gynecologic cancers

SOLO1 5-Year Follow-up: Maintenance Olaparib for BRCA-Mutated Advanced Ovarian Cancer

Almost half of patients who received the PARP inhibitor olaparib for newly diagnosed BRCA-mutated advanced ovarian cancer remained disease-free after 5 years, according to data presented by Susana Banerjee, MBBS, PhD, and colleagues during the ESMO Virtual Congress 2020 (Abstract 811MO). Patients...

colorectal cancer

Is Drinking Coffee Daily Linked to Improved Survival in Patients With Advanced Colorectal Cancer?

In a large group of patients with metastatic colorectal cancer, consumption of a few cups of coffee a day was associated with longer survival and reduced risk of disease progression, according to findings reported by Mackintosh et al in JAMA Oncology. The findings, based on data from a large...

breast cancer

Stephen R.D. Johnston, MD, PhD, on Early Breast Cancer: Abemaciclib in High-Risk Disease

Stephen R.D. Johnston, MD, PhD, of The Royal Marsden NHS Foundation Trust, discusses phase III study findings from the global monarchE trial, which showed that when added to standard adjuvant endocrine therapy, abemaciclib is the first CDK4/6 inhibitor to improve invasive disease–free survival in...

prostate cancer

Nicholas D. James, PhD, MBBS, on Prostate Cancer: Abiraterone Acetate Plus Prednisolone for Hormone-Naive Disease

Nicholas D. James, PhD, MBBS, of The Institute of Cancer Research, London, discusses long-term STAMPEDE trial results that showed patients with metastatic, hormone-naive prostate cancer benefited from abiraterone acetate plus prednisolone in terms of overall and failure-free survival, as well as...

kidney cancer
immunotherapy

Sumanta K. Pal, MD, on Renal Cell Carcinoma: Cabozantinib Plus Atezolizumab as First-Line Therapy

Sumanta K. Pal, MD, of the City of Hope National Medical Center, discusses results from the COSMIC-021 study, which tested two different doses of cabozantinib, each with a standard dose of atezolizumab, administered to patients with metastatic advanced clear cell renal cell carcinoma. Dr. Pal...

issues in oncology

New Report Focuses on Cancer Statistics in Adolescents and Young Adults

A new report examining cancer in adolescents and young adults (AYAs, defined as diagnoses occurring between the ages of 15 and 39) provides updated estimates of the contemporary cancer burden in this age group, with predictions that 89,500 cases and 9,270 deaths will occur in this group in 2020 in...

lung cancer

David S. Hong, MD, on NSCLC: Durability of Clinical Benefit and Biomarkers in Patients Treated With Sotorasib

David S. Hong, MD, of The University of Texas MD Anderson Cancer Center, discusses study findings on sotorasib, a novel, first-in-class, oral KRASG12C inhibitor. The agent demonstrated durable disease control in heavily pretreated patients with non–small cell lung cancer (Abstract 1257O).

head and neck cancer
immunotherapy

Ezra E.W. Cohen, MD, on Head and Neck Cancer: Avelumab and Chemoradiotherapy in Locally Advanced Disease

Ezra E.W. Cohen, MD, of the University of California, San Diego, discusses primary results of the phase III JAVELIN trial of locally advanced squamous cell carcinoma of the head and neck, in which the immune checkpoint inhibitor avelumab was combined with chemoradiotherapy followed by avelumab...

breast cancer

Erika P. Hamilton, MD, on Breast Cancer: Abemaciclib With or Without Tamoxifen in HR-Positive, HER2-Negative Metastatic Disease

Erika P. Hamilton, MD, of Sarah Cannon Research Institute, discusses results of the nextMONARCH study, which indicated that combining abemaciclib with tamoxifen improved overall survival. Dr. Hamilton also details adverse events in different arms of the study (Abstract 273O).

breast cancer

Andreas Schneeweiss, MD, on Breast Cancer: Comparing Neoadjuvant Chemotherapy With Paclitaxel, Doxorubicin, and Carboplatin

Andreas Schneeweiss, MD, of the Heidelberg University Hospital and German Cancer Research Center, discusses phase III survival data from the GeparOcto trial, which compared the neoadjuvant chemotherapy intense dose-dense EPC (epirubicin, paclitaxel, and cyclophosphamide) with weekly paclitaxel and...

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