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Hepatobiliary Cancer

HIMALAYA: 5-Year Analysis Confirms Survival Benefit of STRIDE Regimen in Hepatocellular Carcinoma

An updated overall survival analysis of the phase III HIMALAYA study, now at 5 years, confirms the benefit for the STRIDE regimen of the monoclonal antibodies durvalumab plus tremelimumab in unresectable hepatocellular carcinoma. At the European Society for Medical Oncology (ESMO) Congress 2024, investigators reported an unprecedented doubling of 5-year survival, which was 19.6% with STRIDE vs 9.4% with sorafenib alone, a 24% reduction in the risk of death. This benefit was accentuated in patients achieving disease control, and no additional safety concerns were observed with extended follow-up


Legislation

Navigating Uncharted Waters in the Post-Chevron Sea Change

It is not often that the oncology community looks to the Supreme Court to forecast its future. In 2024, two decisions seemingly unrelated to health care were issued that are likely to have a monumental impact on oncology care delivery. The Court’s rulings—on June 28, Loper Bright Enterprises et al v Raimondo, Secretary of Commerce et al and on July 1, Corner Post, Inc. v Board of Governors of the Federal Reserve System—changed the way federal laws and regulations that govern cancer care, cancer research, and health care as a whole are made. ASCO has voiced serious concerns about these rulings, which destabilize the administrative state and the regulatory framework on which the U.S. health-care system is built.

 

Lung Cancer

Amivantamab-vmjw Plus Lazertinib Improves Long-Term Outcomes in First-Line Setting of EGFR-Mutant Advanced NSCLC

The combination of the EGFR-MET bispecific antibody amivantamab-vmjw and the EGFR tyrosine kinase inhibitor lazertinib continues to demonstrate superior efficacy compared with the kinase inhibitor osimertinib alone in the first-line treatment of EGFR-mutant advanced non–small cell lung cancer (NSCLC). These findings were presented at the International Association for the Study of Lung Cancer (IASLC) 2024 World Conference on Lung Cancer. Extended follow-up data from the phase III MARIPOSA study showed 3-year intracranial progression-free survival with the combination was more than double that of osimertinib monotherapy (38% vs 18%).


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Issues in Oncology

Creating a Culture of Diversity, Equity, and Inclusion: Why It Matters Clinically and Ethically

The National Comprehensive Cancer Network (NCCN) has always prided itself on its commitment to evidence-based, expert consensus–driven recommendations for cancer care, with a special focus on breaking down the barriers that contribute to disparities in outcomes across all patients with cancer. With that mission in mind, on September 10, 2024, experts assembled in Washington, DC, to participate in the NCCN Oncology Policy Summit: Advancing Diversity, Equity, and Inclusion in the Cancer Workforce. During the first panel discussion, experts with varied perspectives and experience thoughtfully discussed the many facets of diversity, equity, and inclusion (DEI), why it is integral to the oncology workforce as well as vital for patients with cancer, and how to know when an institution has taken the necessary steps to integrate practice strategies to improve the inequities in cancer care.

 

Gynecologic Cancers

KEYNOTE-A18: Overall Survival in Cervical Cancer Improved by Pembrolizumab Plus Chemoradiotherapy

In the phase III ENGOT-cx11/GOG-3047/KEYNOTE-A18 trial presented at the European Society for Medical Oncology (ESMO) Congress 2024, the PD-1 inhibitor pembrolizumab plus chemoradiotherapy, with pembrolizumab continued as monotherapy, improved overall survival in previously untreated, high-risk locally advanced cervical cancer, validating the regimen as the new standard of care in high-risk patients. Domenica Lorusso, MD, PhD, of the Gynaecology/Oncology Unit of Fondazione Policinico Universitario A. Gemelli IRCCS, Rome and Humanitas San Pio X, Milan, Italy, presented the findings during the Presidential Symposium on Practice-Changing Trials, garnering robust applause from the audience. The updated analysis was simultaneously published in The Lancet.

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Hematologic Malignancies

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Global Cancer Care

Shared Reflections on the 2024 ASCO Annual Meeting: From Networking to Mentorship and More

The ASCO Annual Meeting brings together oncologists, researchers, and health-care professionals to share the latest advancements in cancer care. The 2024 ASCO Annual Meeting (ASCO24) was particularly momentous for those of who received the international development and education award (IDEA). As...

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Sintilimab/Bevacizumab in Relapsed or Persistent Ovarian Clear Cell Carcinoma

In a Chinese phase II trial (INOVA) reported in The Lancet Oncology, Peng et al found that the combination of sintilimab and bevacizumab showed activity in patients with relapsed or persistent ovarian clear cell carcinoma. Study Details In the multicenter trial, 37 evaluable patients with exposure...

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Legislation

Cancer Provider Groups Across the Country Urge Congress to Pass Prior Authorization Reform

The Association for Clinical Oncology (ASCO), along with 46 state oncology societies, sent a letter to U.S. House and Senate leadership urging Congress to pass the Improving Seniors’ Timely Access to Care Act (H.R. 8702/S. 4532), which would streamline prior authorization practices within Medicare...

Genomics/Genetics

Coping With the Risk of Hereditary Cancer

All these preventive strategies to avoid cancer or to catch it early have made me feel both in control and out of control of my health. — Frances Merrill Tweet this quote Three years ago, it had become clear that I needed to be tested for the BRCA1/2 mutation. I knew my ...

FDA Approves Inavolisib Combination in PIK3CA-Mutated, HR-Positive, HER2-Negative Advanced Breast Cancer

The U.S. Food and Drug Administration (FDA) approved the PI3K inhibitor inavolisib (Itovebi) with the CDK4/6 inhibitor palbociclib and fulvestrant for adults with endocrine-resistant, PIK3CA-mutated, hormone receptor (HR)-positive, HER2-negative, locally advanced or metastatic breast cancer, as...

Hematologic Malignancies
Leukemia

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Ann Partridge, MD, MPH, Receives ESMO Award for Significant Contributions to Breast Cancer Research and Patient Care

Ann Partridge, MD, MPH Ann Partridge, MD, MPH, of Dana-Farber Cancer Institute, was named the recipient of the 2024 ESMO Award during the opening session of the European Society for Medical Oncology (ESMO) Congress 2024 in Barcelona. The international award recognizes her work and commitment...

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Global Disparities May Exist in Availability, Timeliness of New Cancer Drugs

Despite considerable progress in the discovery and development of new cancer drugs between 1990 and 2022, there may be disparities in both the availability and timeliness of these treatment options globally, particularly among lower-income countries, according to a recent study published by Li et...

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