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COVID-19
Survivorship

Adult Survivors of Childhood Cancer May Be at Increased Risk of Severe COVID-19 Infection

People who have survived cancer as children may be at a higher risk of developing severe COVID-19 infection—even decades after their cancer diagnosis, according to results published by Louro et al in The Lancet Regional Health – Europe.

 

Leukemia

Can Planned C-Sections Increase the Risk of Childhood ALL?

Children born by planned cesarean section (C-section) may have an increased risk of developing acute lymphoblastic leukemia (ALL) later in life, according to a recent study published by Kampitsi et al in the International Journal of Cancer. Alhough the researchers did find an association, they emphasized that the overall cancer risk in this population remains low.

 

Breast Cancer

BMI and Cardiovascular Disease Associated With Increased Breast Cancer Risk

Weight-associated risk for developing breast cancer after menopause may be higher among women with cardiovascular disease compared with those without cardiovascular disease and women with or without type 2 diabetes, according to the results of two prospective European cohort studies, which were published in Cancer

 


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Hepatobiliary Cancer

Y-90 Resin Microspheres Receive FDA Approval for the Treatment of Unresectable HCC

The U.S. Food and Drug Administration (FDA) has approved SIR-Spheres Y-90 resin microspheres, manufactured by Sirtex, for the treatment of unresectable hepatocellular carcinoma (HCC). With this approval, these microspheres become the only radioembolization therapy approved for the treatment of both colorectal cancer that has metastasized to the liver and HCC in the United States.

 

Skin Cancer

Intratumoral BO-112 With Pembrolizumab in Anti–PD-1–Resistant Melanoma

In a Spanish-French phase II trial (SPOTLIGHT-203) reported in the Journal of Clinical Oncology, Márquez-Rodas et al investigated the combination of the intratumoral agent BO-112 and pembrolizumab for activity in patients with advanced anti–PD-1–resistant melanoma. BO-112 is a synthetic, double-stranded RNA nanoplexed with polyethylenimine that has shown potential in reversing such resistance in solid tumors.

 

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Women Over the Age of 65 Still at Heightened Risk of HPV-Related Cervical Cancer

Women aged 65 years and older are still at a heightened risk of cervical cancer caused by human papillomavirus (HPV), suggest the findings of a large observational Chinese study published by Ye et al in Gynecology and Obstetrics Clinical Medicine. Most guidelines currently recommend discontinuing...

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The Ohio State Appoints Christian Rolfo, MD, PhD, MBA, to Lead Division of Medical Oncology

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Corticosteroids May Limit Efficacy of Immunotherapy in Patients With NSCLC

Corticosteroids, which are commonly prescribed to alleviate cancer-related symptoms in patients with non–small cell lung cancer (NSCLC) treated with immunotherapy, may be the reason certain immunotherapies fail in treating the disease, according to new research published by Polyakov et al in Cancer ...

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I Was Expecting to Hear I Have Heart Disease, Not Cancer

In 2022, I had a computed tomography (CT) coronary calcium scan to see whether there were any signs of narrowing or blockage in my heart arteries. Heart disease runs in my family. My father died of a heart attack the year before, and I worried that I was at risk for the same fate. It was a complete ...

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The Future of Cell Therapy: Optimizing the CAR to the Disease in B-Cell Malignancies

Over the past 20 years, increased understanding of the biological mechanism of disease has led to improved treatment options for all malignancies. Within each disease subtype, we have molecularly characterized tumors and developed specific treatment algorithms to optimize patient outcomes. Among...

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