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Colorectal Cancer

Colorectal Cancer May Be Linked to Heightened Risk of Cardiovascular Mortality

The risk of death from cardiovascular causes may be higher among patients diagnosed with colorectal cancer compared with the general population, according to new findings presented by Ayaz et al at the American College of Cardiology (ACC) Annual Scientific Session 2025.

Skin Cancer

Advanced Refractory Melanoma: Addition of Tilsotolimod to Ipilimumab

As reported in the Journal of Clinical Oncology by Adi Diab, MD, and colleagues, the phase III ILLUMINATE trial showed adding the Toll-like receptor-9 agonist tilsotolimod to ipilimumab in patients with advanced refractory melanoma produced no benefit.

Lung Cancer

Advanced PD-L1–Positive NSCLC: Ivonescimab vs Pembrolizumab

In an interim analysis of a Chinese phase III trial (HARMONi) reported in The Lancet, Xiong et al found that ivonescimab—a bispecific antibody against PD-1 and VEGF—significantly improved progression-free survival vs pembrolizumab in the first-line setting for patients with advanced PD-L1–positive non–small cell lung cancer (NSCLC).


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Gastroesophageal Cancer
Gastrointestinal Cancer

FDA Approves Pembrolizumab for HER2-Positive Gastric or GEJ Cancer Expressing PD-L1

The U.S. Food and Drug Administration (FDA) has granted traditional approval to the PD-L1 inhibitor pembrolizumab (Keytruda) with trastuzumab, fluoropyrimidine-, and platinum-containing chemotherapy for the first-line treatment of adults with locally advanced unresectable or metastatic HER2-positive gastric or gastroesophageal junction (GEJ) adenocarcinoma whose tumors express PD-L1 (Combined Positive Score [CPS] ≥ 1).

Supportive Care
Issues in Oncology
Prostate Cancer

Exercise Intervention May Improve Sexual Dysfunction in Men With Prostate Cancer

Erectile dysfunction could be improved through regular exercise in men with prostate cancer, according to a recent study published by Galvão et al in JAMA Network Open.

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Hematologic Malignancies

Rami S. Komrokji, MD, on Myelodysplastic Neoplasms: Classifying Risks Among Subsets of Disease

Issues in Oncology

New Reports Assess Oncology Workforce Well-Being, Propose Solutions to Address Burnout

Physician burnout has increased significantly in the past decade, and organizational strategies are vital to improve physician well-being, according to new research from ASCO. This compilation includes reports on the state of professional well-being among oncologists in 2023, burnout trends among...

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Microultrasound- vs MRI-Guided Biopsy for Prostate Cancer Diagnosis

Biopsies guided by high-resolution ultrasound may be as effective as those using magnetic resonance imaging (MRI) in diagnosing prostate cancer, an international clinical trial has shown. The technology, called micro-ultrasound, is cheaper and easier to use than MRI. It could significantly speed up ...

Paolo Corradini, MD, on PMBCL and DLBCL: Comparing Outcomes With Axicabtagene Ciloleucel

Issues in Oncology

CMS Expects Between 750,000 to 2 Million to Lose Coverage If ACA Proposal Is Implemented

On March 10, 2025, the Centers for Medicare & Medicaid Services (CMS) released the Marketplace Integrity and Affordability Proposed Rule aimed at addressing improper enrollments in the Affordable Care Act (ACA) Health Insurance Marketplace. This is the first proposed rule released under the new ...

Breast Cancer

Results Announced From Phase II VERITAC-2 Clinical Trial in Breast Cancer

Arvinas, Inc. and Pfizer Inc. recently announced results from the randomized phase III VERITAC-2 clinical trial (ClinicalTrials.gov identifier NCT05654623) evaluating vepdegestrant monotherapy vs fulvestrant in adults with estrogen receptor–positive, HER2-negative advanced or metastatic breast...

TB Vaccination Could Enhance BCG Response in Patients With Non–Muscle-Invasive Bladder Cancer, Study Finds

Two doses of a simple tuberculosis (TB) vaccination after surgery helps the immune system fight cancer cells and may improve patient outcomes among those with non–muscle-invasive bladder cancer, according to a pilot study of 40 patients. Initial results from the RUTIVAC-1 Trial were presented by...

Hematologic Malignancies
Leukemia

Nigel Russell, MD, on Acute Myeloid Leukemia: New Findings on FLAG-Ida and Gemtuzumab Ozogamicin

Prostate Cancer

Screening Was Key to the Early Detection of My Prostate Cancer

As a Native American and former president of the Seneca Nation of Indians, I am keenly aware of the disparities in cancer care we face in accessing screening and treatment, which results in worse survival rates compared with those of racial and ethnic populations.1 Native American and Alaska Native ...

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Can a Urine Test Minimize Postoperative Scans for RCC Recurrence?

A simple urine test could accurately detect clear cell renal cell carcinoma (RCC) recurrence at an early stage, potentially sparing patients from undergoing invasive scans and enabling quicker access to treatment, according to new findings presented by Dabestani et al at the European Association of ...

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