Five-Year Outcomes With Tisagenlecleucel in Patients With Relapsed or Refractory B-Cell Lymphomas
Long-term follow-up of a single-center trial of tisagenlecleucel showed maintained responses in a high proportion of patients with relapsed or refractory DLBCL and follicular lymphoma...
Study Finds Missing Annual Mammogram Increases Risk of Death From Breast Cancer
Regular mammography screening substantially reduces the risk of dying from breast cancer, according to a large study of over half a million women...
Study Examines Extrapleural Pneumonectomy After IMRT for Malignant Pleural Mesothelioma
A phase II study found that hemithoracic IMRT and extrapleural pneumonectomy produced good short- and long-term outcomes but was associated with high rates of perioperative morbidity...
Bipolar Androgen Therapy vs Enzalutamide in Asymptomatic Patients With Metastatic Castration-Resistant Prostate Cancer
The phase II TRANSFORMER trial found no difference in PFS with bipolar androgen therapy vs enzalutamide in men with metastatic castration-resistant prostate cancer...
ASCO Coronavirus Resources
As the coronavirus (COVID-19) continues to spread, ASCO is committed to providing the most current information and resources to its members and the larger oncology...
Mark Ratain on Empowering the FDA to Require Dose Optimization of All New Oncology Drugs
Chung-Han Lee on the Evolving Landscape of First-Line Therapy for Metastatic Renal Cell Carcinoma
Govind Persad on Informed Consent and Information-Sharing for Minors With Cancer
David Irwin: Life and Death Under COVID-19
Lori J. Goldstein: Should BMI Guide the Choice of Chemotherapy in Patients With Breast Cancer?
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Recent Advances in the Treatment of FGFR-Altered Advanced Cholangiocarcinoma
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Adjuvant Therapy in HER2-Positive, Hormone Receptor–Positive Breast Cancer
Addition of Lenalidomide to R-CHOP in Newly Diagnosed Patients With DLBCL
In a phase II signal-seeking trial (ECOG-ACRIN E1412) reported in the Journal of Clinical Oncology, Grzegorz S. Nowakowski, MD, and colleagues found that the addition of lenalidomide (R) to R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone; R2CHOP) improved outcomes...
Impact of Genes on Total Number and Type of Nevi
A study by Duffy et al in the Journal of Investigative Dermatology reported on specific gene variations affecting the number and types of moles on the body and their role in causing skin cancer. “The goal was to investigate the genetic underpinnings of different mole classes, or...
Endoscopic Nasopharyngectomy vs IMRT for Previously Treated, Resectable, Locally Recurrent Nasopharyngeal Carcinoma
In a Chinese phase III trial reported in The Lancet Oncology, Liu et al found that endoscopic nasopharyngectomy was associated with improved overall survival vs intensity-modulated radiotherapy (IMRT) in patients with resectable locally recurrent nasopharyngeal carcinoma who had received prior...
Machine Learning Algorithm Is Successful in Predicting Malignancy in Patients With Multiple Pulmonary Nodules
Although guidelines exist for the use of several clinical prediction models based on logistic regression to help estimate the risk of lung cancer before treatment decision-making, they almost all focus on solitary pulmonary nodules, and have not shown accuracy in predicting malignancy in multiple...
Gemcitabine/Eribulin in Cisplatin-Ineligible Metastatic Urothelial Carcinoma
In the final analysis from a phase II California Cancer Consortium trial (NCI-9653) reported in the Journal of Clinical Oncology, Sadeghi et al found the combination of gemcitabine and eribulin showed activity in cisplatin-ineligible patients with metastatic urothelial carcinoma. Study Details...
Chemotherapy-Induced ‘Dormancy’ in AML Allows Cancer Cell Survival, May Contribute to Relapse
Researchers have identified a cellular resilience mechanism through which acute myeloid leukemia (AML) cells survive cancer treatment and repopulate, leading to disease relapse. The research, published by Cihangir Duy, PhD, MS, and colleagues in Cancer Discovery, also suggests that certain drugs...
Deintensified Chemoradiotherapy for HPV-Associated Oropharyngeal Squamous Cell Carcinoma
In a phase II trial reported in the Journal of Clinical Oncology, Chera et al found that deintensified chemoradiotherapy produced favorable outcomes in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma. Study Details In the multicenter trial, 114 patients were recruited...
