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issues in oncology

ASCO’s Approach to Health Information Technology and the Rapid-learning System

The slow, but inevitable evolution of electronic oncology health-care systems has already, at least conceptually, moved to the next generation of machines that not only store and process data, but also have the ability to provide real-time clinical decision support. At ASCO’s first Quality Care...

Expert Point of View: Antonio Palumbo, MD

Antonio Palumbo, MD, Chief of the Myeloma Unit at the University of Torino in Italy, told The ASCO Post that the results with MLN9708 “look quite interesting,” and the drug could change the treatment of the disease. “This combination, with lenalidomide, accelerates response, and the ability to...

leukemia

FDA Approves Ponatinib to Treat CML and Philadelphia Chromosome–positive ALL

In December, the FDA granted accelerated approval to ponatinib (Iclusig) for the treatment of adult patients with chronic-, accelerated-, or blast-phase chronic myeloid leukemia (CML) that is resistant or intolerant to prior tyrosine kinase inhibitor therapy or Philadelphia chromosome–positive...

issues in oncology

National Comprehensive Cancer Network Appoints New CEO

The National Comprehensive Cancer Network (NCCN) recently appointed nationally regarded breast cancer expert Robert W. Carlson, MD, as its new CEO. Previously, Dr. Carlson was Professor of Medicine in the Division of Oncology and Medical Informatics, Stanford University Medical Center; he first...

health-care policy
legislation

Last-minute ‘Fiscal Cliff’ Deal by Congress Again Averts Medicare Cuts to Physicians

A last-minute patch to the sustainable growth rate formula included in the “fiscal cliff” deal averted massive cuts to oncologists who care for and treat Medicare patients. “This end-of-year crisis management once again demonstrates the critical need for fundamental reform of the Medicare...

Expert Point of View: Peter Ravdin, MD and Sandra M. Swain, MD, FACP

Putting these results in perspective, Peter Ravdin, MD, moderator of a San Antonio Breast Cancer Symposium press conference where ATLAS findings were discussed, said that in the United States, there is currently a different strategy for pre- and postmenopausal women. Tamoxifen is used as primary...

cost of care
health-care policy

More Thoughts on Rationing Cancer Care

I read the article about “The Ethics of Rationing Cancer Care” with interest (The ASCO Post, Dec 15, 2012). The issue of rationing (or rational) care has likely been debated since Hippocrates. Yet the topic has become a focus of acute interest with the current fiscal crises facing countries around...

SIDEBAR: Expect Questions from Patients

Results from the Adjuvant Tamoxifen: Longer Against Shorter (ATLAS) study “will have a follow-on effect of being able to guide physicians about the advantages of longer than 5 years of therapy for the premenopausal woman,” said V. Craig Jordan, OBE, PhD, DSc, Scientific Director at the Lombardi...

breast cancer

'Practice-changing' ATLAS Study Supports 10 vs 5 Years of Tamoxifen Therapy in Women with Breast Cancer

"Practice-changing" is the term several physicians and researchers used when asked by the media to describe the results of a study showing that extending tamoxifen therapy from 5 to 10 years for women with estrogen receptor (ER)-positive breast cancer further reduced recurrence and mortality....

Leon and Norma Hess Center for Science and Medicine Opens at Mount Sinai

The Leon and Norma Hess Center for Science and Medicine at Mount Sinai in New York officially opened in December, housing significant areas of six of Mount Sinai’s most influential institutes focusing on brain, cancer, heart, children’s health, genomics, and imaging. With a half-million square feet ...

gynecologic cancers

Internationally Renowned Gynecologic Cancer Researcher Joins Ohio State

Internationally renowned uterine cancer researcher and geneticist Paul Goodfellow, MD, PhD, will lead a new team of three researchers devoted to gynecologic oncology research at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and Richard J. Solove Research...

leukemia
breast cancer

Oncology Trailblazer James F. Holland, MD, Recalls a Time of Unbridled Scientific Excitement 

James F. Holland, MD, began his journey into oncology when it was still a nascent discipline, working alongside groundbreaking pioneers in the field such as Drs. Emil “Tom” Frei and C. Gordon Zubrod. Dr. Holland recently shared a glimpse of his role in oncology’s formative years with The ASCO Post. ...

Oncology Meetings

February Highlights of ASH® Miami, FL and San Francisco, CAFebruary 1-2 • Miami, Florida, and San Francisco, CaliforniaFor more information: www.hematology.org/meetings Optimizing Outcomes in Colorectal CancerFebruary 7 • Boston, MassachusettsFor more information: www.omedlive.com Interventional...

issues in oncology

Helping Patients Prepare for Cancer Treatment Decisions

Under the stress of a cancer diagnosis and overwhelmed with the influx of information, patients often report that they feel unprepared to engage fully in the discussion with their health-care provider around a critical treatment decision. Consequently, the Cancer Support Community—an international...

The Conquer Cancer Foundation Announces Its Sustaining Donor Program

You can help the Conquer Cancer Foundation fulfill its mission of creating a world free from the fear of cancer when you make a monthly gift today. When you become a sustaining donor to the Foundation, your monthly gift will provide a reliable stream of support that is so vital to ensuring that the ...

ASCO's CancerProgress.Net: Where We've Come From, Where We Are, and Where We're Going 

The British science historian James Burke once wrote, “If you don’t know where you’ve come from, you don’t know where you are.” To tell the story of where we are in the treatment of people with cancer and how we got there, ASCO launched an ambitious history project in 2011 with a new website,...

health-care policy

Health Insurance Issues for Young Cancer Survivors

The latest addition to Cancer.Net’s video series for young adults, Moving Forward: Perspectives from Survivors and Doctors, deals with the health insurance issues young adult cancer survivors may face. This video series is a collaboration between Cancer.Net and LIVESTRONG. Each set of videos in the ...

breast cancer
lung cancer

ASCO Decision Aids Intersect Evidence-based Guidelines, Productive Patient Communication

Imagine this common clinical scenario: A 64-year-old woman presents with a new abnormality on a mammogram. A core needle biopsy and subsequent partial mastectomy reveal a 1.8-cm invasive ductal carcinoma. Sentinel lymph nodes are negative for cancer. The tumor is moderately differentiated and is...

issues in oncology

New England Journal of Medicine Article Reports Inferior Outcome in Using Alternative Treatments to Counter Mechlorethamine Shortage

ASCO Immediate Past President Michael P. Link, MD, recently coauthored a perspectives piece in The New England Journal of Medicine on the impact of drug shortages on children with cancer. The paper, “The Impact of Drug Shortages on Children with Cancer — The Example of Mechlorethamine,” describes...

Coalition of Cancer Cooperative Groups Celebrates 10 Years of Clinical Trial Participation Awards

For any community practice, participation in a clinical trial can be a time-consuming, intense commitment. But this commitment is integral to the advancement of new methods and therapies, which is why the Coalition of Cancer Cooperative Groups has exactly one mission: increasing clinical trial...

Samuel M. Silver, Elected as a Master of ACP

Samuel M. Silver, MD, PhD, has been elected as a Master of the American College of Physicians (ACP). Mastership is conferred upon a select number of candidates following election by ACP’s Awards Committee and Board of Regents. Dr. Silver is Assistant Dean for Research and Professor of Internal...

Pediatric Cancer Foundation Names Four Recipients of 2012 Award, Each to Receive Grant for Research 

Alex’s Lemonade Stand Foundation, a nonprofit group dedicated to finding cures for all children with cancer, has named four researchers 2012 recipients of the “A” Award. Christopher Vakoc, MD, PhD, of Cold Spring Harbor Laboratory; Roland Walter, MD, PhD, of the Fred Hutchinson Cancer Research...

myelodysplastic syndromes

Ezatiostat Gets Orphan Designation for Treatment of Myelodysplastic Syndrome

Telik, Inc, announced that its product candidate, ezatiostat hydrochloride (Telintra), has been granted orphan drug designation by the FDA for the treatment of myelodysplastic syndromes (MDS). Ezatiostat is an investigational agent in development for the treatment of MDS and idiopathic chronic...

breast cancer

Dune Medical Devices Receives FDA Approval for the MarginProbe System

Dune Medical Devices, Inc, announced that the FDA has granted Premarket Approval to the MarginProbe System, the company’s breakthrough intraoperative tissue assessment tool for early-stage breast cancer surgery. The technology significantly improves surgeons’ ability to intraoperatively identify...

Expert Point of View: Martin Dreyling, MD

Martin Dreyling, MD, Professor of Medicine at Ludwig Maximilians University in Munich and Coordinator of the European Mantle Cell Lymphoma Network, commented on the data emerging for ibrutinib in lymphoma. “Ibrutinib is the molecule of the year at ASH,” he told The ASCO Post. “With other molecular ...

lung cancer

ACS Releases Lung Cancer Screening Guidelines

As reported online in CA: A Cancer Journal for Clinicians,1 based on results from the National Lung Screening Trial (NLST) sponsored by the National Cancer Institute (NCI), the American Cancer Society (ACS) has released lung cancer screening guidelines recommending that select clinicians should...

SIDEBAR: Shout-out to Policymakers on Diabetes Education

“If we could just give a shout-out to policymakers to understand that in the long term,” when patients who have diabetes and cancer receive adequate diabetes education, “we are cutting our length of stay, we are decreasing hospital costs, we are decreasing readmission rates,” June McKoy, MD, MPH,...

issues in oncology

Keeping Diabetes under Control Is Critical to Good Outcomes for Patients Who Also Have Cancer 

In the News focuses on media reports that your patients may have questions about at their next visit. This continuing column will provide summaries of articles in the popular press that may prompt such questions, as well as comments from colleagues in the field. Cancer and diabetes can be comorbid...

Oncology Meetings

February Scripps Cancer Center’s 33rd Annual Clinical Hematology and Oncology ConferenceFebruary 16-19 • San Diego, CaliforniaFor more information:www.scripps.org/events/clinical-hematology-and-oncology-february-16-2013 2013 Translational Research Cancer Centers Consortium: The Power of Negative...

University of Michigan Cancer Center Names Kathleen Cooney, MD, to Head Clinical Operations

The University of Michigan (U-M) Comprehensive Cancer Center in Ann Arbor has named Kathleen Cooney, MD, as Deputy Director for Clinical Services.  Dr. Cooney is Frances and Victor Ginsberg Professor of Hematology/Oncology and Chief of the Division of Hematology/Oncology at the U-M Medical School...

breast cancer

Researchers Develop Automated Breast Density Test Linked to Cancer Risk

Researchers at Moffitt Cancer Center in Tampa, Florida, and colleagues at the Mayo Clinic in Rochester, Minnesota, have developed a novel computer algorithm to quantify breast density based on analysis of a screening mammogram. Increased levels of mammographic breast density have been shown in...

palliative care

Important Messages about Palliative Care and Hospice at the Heart of New End-of-life Memoir 

The illness memoir’s appeal proves enduring in a very crowded genre, perhaps because illness is a tie that binds us all. As Susan Sontag wrote in her classic work, Illness as a Metaphor, “Illness is the night-side of life, a more onerous citizenship. Everyone who is born holds dual citizenship, in...

leukemia

Genetic Basis of High-risk Childhood Cancer Points to Possible New Drug Treatment Strategy

Research led by scientists at St. Jude Children’s Research Hospital, Memphis, Tennessee, has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes. The findings also provide the first evidence of the...

David A. Karnofsky's Early Contributions to Cancer Research Helped Establish Oncology as a Medical Discipline 

For nearly 30 years, from the time he was a young resident at the Collis P. Huntington Memorial Hospital for Cancer Research of Harvard University, until his death from lung cancer on August 31, 1969, David A. Karnofsky, MD, dedicated himself to the pursuit of scientific excellence and the...

integrative oncology

Turmeric 

The use of dietary supplements by cancer patients has risen significantly over the past 2 decades despite insufficient evidence of safety and effectiveness. Finding reliable sources of information about dietary supplements can be daunting. Patients typically rely on family, friends, and the...

Hematology/Oncology Team Joins NewYork-Presbyterian Hospital/Columbia University Medical Center

The Herbert Irving Comprehensive Cancer Center (HICCC) at NewYork-Presbyterian Hospital/Columbia University Medical Center has welcomed five new clinician-scientists specializing in leukemia. These practitioners joined the HICCC faculty in early January 2013. The new staff members are Mark G....

cost of care
health-care policy

The Doctor Who Championed Patient Navigation in Harlem 

After completing his residency at Memorial Sloan-Kettering Cancer Center, Harold P. Freeman, MD, arrived at Harlem Hospital Center in 1967, where the overwhelming majority of his patients presented with late-stage disease. That early experience with underserved patients would shape his career as...

solid tumors

Gene in Eye Melanomas Linked to Good Prognosis

Melanomas that develop in the eye often are fatal. Now, researchers at Washington University School of Medicine and the Siteman Cancer Center, St. Louis, Missouri, report they have identified a mutated gene in melanoma tumors of the eye that appears to predict a good outcome. The research was...

issues in oncology

As Computers Learn to 'Talk' to Each Other, Patient Care Will Improve 

Last fall, Edward P. Ambinder, MD, Clinical Professor of Medicine, Hematology, and Medical Oncology at the Icahn School of Medicine at Mount Sinai in New York, and a member of ASCO’s Health Information Technology Work Group, spoke about “The Information Age: Cyberspace and Cancer,” at the...

Young Investigator Award's Humble Beginnings Mark the Start of Something Big

Judith Kaur, MD, was presented with the very first Young Investigator Award (YIA) at the 1984 ASCO Annual Meeting in Toronto in what she felt was a “very prestigious event”—having breakfast with the ASCO president. The purpose of the new YIA program was to provide grant funding to help a young...

solid tumors

Help Your Patients Find the Latest Research on GU Cancers

The 2013 Genitourinary Cancers Symposium is taking place now, from February 14–16 in Orlando, Florida. Direct your patients to www.cancer.net/GUsymposium to find written summaries for patients and a podcast that highlights the research presented at the meeting. Also on Cancer.Net, your patients can ...

global cancer care

International Members Cite Networking, Enhanced Patient Care Among Benefits of ASCO Membership 

Thanks to the membership category ASCO designed for physicians in developing countries, Brazilian oncologist Milena Mak, MD, can greatly enhance the care she delivers in the very busy 580-bed Instituto do Cancer do Estado de Sao Paulo. And radiation oncologist Pooja Nandwani Patel, MD, can use the...

breast cancer

Research Roundup from San Antonio: New Data on Triple-negative, HER2-positive, Local, and Advanced Breast Cancer 

The 2012 San Antonio Breast Cancer Symposium featured more than 2,500 abstracts and lectures, including timely research in the field and discussions for scientists and clinicians alike. In addition to nearly two dozen in-depth reports from the meeting, The ASCO Post brings readers the following...

leukemia

ASH International Clinical Collaboration Replicates High Cure Rate of APL in Developing Countries

The work of an American Society of Hematology (ASH) international clinical network collaborative focused on modernizing treatment protocols for patients in the developing world with acute promyeloctyic leukemia (APL) has drastically improved cure rates in patients in Central and South America. In...

colorectal cancer

Bevacizumab Approved as Combination Therapy for Metastatic Colorectal Cancer after Progression on First-line Bevacizumab Therapy

On January 23, 2013, the FDA approved bevacizumab (Avastin) for use in combination with fluoropyrimidine-irinotecan or fluoropyrimidine-oxaliplatin based chemotherapy for the treatment of patients with metastatic colorectal cancer whose disease has progressed on a first-line bevacizumab-containing...

Expert Point of View: C. Kent Osborne, MD

C. Kent Osborne, MD, Professor of Medicine and Molecular and Cellular Biology at Baylor College of Medicine and Director of the Lester and Sue Smith Breast Center at Baylor told The ASCO Post that this is “brand new” data that “looks very interesting.” He noted that groups for whom letrozole is the ...

Expert Point of View: Sandra M. Swain, MD, FACP and Eric P. Winer, MD

Commenting on the study presented by Dr. Wolff at the 2012 San Antonio Breast Cancer Symposium, ASCO President Sandra M. Swain, MD, FACP, Medical Director, Washington Cancer Institute, MedStar Washington Hospital Center, Washington, DC, said she found it “disturbing” that about half the population...

breast cancer
leukemia

Chemotherapy for Breast Cancer Carries a Small, but Concerning, Risk for Leukemia 

The risk for developing a secondary malignancy after chemotherapy for breast cancer is very small, but it is statistically significantly higher than for the general population, a review of the National Comprehensive Cancer Network (NCCN) database revealed in a study presented at the 2012 San...

Erratum

Two of the articles published in the January 15, 2013, issue of The ASCO Post included comments from a Dr. Peter Ellis. One report, from the 2012 Quality Care Symposium referred to Peter G. Ellis, MD, of UPMC, Pittsburgh, while a second report pertained to a presentation at the 35th ESMO Congress...

issues in oncology
cost of care

Integration across the Spectrum: Community Perspective on the Medical Oncology Home Model 

The term “patient-centered cancer care” has become ingrained in today’s health-care vernacular. However, no matter what modifications occur in clinical oncology practice, the terms value and cost-effectiveness are now a solid part of the equation. At ASCO’s Quality Care Symposium, Linda D....

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