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breast cancer
survivorship

Breast Cancer Survival Is Significantly Decreased Among Premenopausal Women Previously Treated With Radiation for Childhood or AYA Cancer

Although radiotherapy is integral to the multidisciplinary therapy used in the treatment of common childhood and adolescent and young adult (AYA) cancers, including Hodgkin lymphomas, sarcomas, and breast cancer, the treatment is a strong risk factor for a secondary breast malignancy, especially...

lung cancer

Leora Horn, MD, on NSCLC: Ensartinib vs Crizotinib in ALK–Positive Disease

Leora Horn, MD, of Vanderbilt University, discusses phase III results from the eXalt3 trial, which suggest that ensartinib, a novel, next-generation ALK inhibitor, is superior to crizotinib in terms of progression-free survival as well as efficacy in central nervous system metastases for patients...

lung cancer

Misako Nagasaka, MD, on NSCLC: Sintilimab, Pemetrexed, and Platinum as First-Line Therapy

Misako Nagasaka, MD, of the Barbara Ann Karmanos Cancer Institute, discusses results of the ORIENT-11 trial, which showed that, although sintilimab plus pemetrexed and platinum significantly improved progression-free survival, the combination only nominally improved overall survival in patients...

issues in oncology

Developing Policies to Address Patient Racial Bias and Race-Based Provider Requests

Public momentum for efforts to address structural and systemic racism has led many health-care institutions to consider how they can work to bring about positive change. In this column, drawing on important recent work by Kimani Paul-Emile, JD, PhD, Professor of Law at Fordham University School of ...

From Behind the Iron Curtain to a Career in Gynecologic Cancer Research for Daniela Matei, MD

Daniela Matei, MD, Diana, Princess of Wales Professor of Cancer Research at Northwestern Feinberg School of Medicine, Chicago, grew up Sibiu, a picturesque Romanian city situated at the foothills of the Cindrel Mountains in historic Transylvania. “Both of my parents were physicians, and some of my ...

leukemia

Obinutuzumab, Ibrutinib, and Venetoclax in Treatment-Naive and Relapsed or Refractory Chronic Lymphocytic Leukemia

In a single-institution phase II trial reported in the Journal of Clinical Oncology, Rogers et al found that the combination of obinutuzumab, ibrutinib, and venetoclax produced high response rates in both treatment-naive and relapsed or refractory chronic lymphocytic leukemia. Study Details A total ...

head and neck cancer

Transoral Robotic Surgery May Improve Outcomes in Early-Stage Oropharyngeal Cancer

Robotic surgery for patients with early-stage oropharyngeal squamous cell cancer may be associated with improved health outcomes, including better long-term survival, according to a study published by Nguyen et al in JAMA Oncology. Transoral robotic surgery is a minimally invasive procedure in...

pancreatic cancer

Sortilin May Be a Potential Therapeutic Target in Pancreatic Cancer

In a study published by Gao et al in The American Journal of Pathology, scientists reported the discovery of an increased level of the neuroprotein sortilin in pancreatic cancer cells. The investigators speculated that this finding may lead to the development of more effective treatment for...

covid-19

Chemotherapy and COVID-19 Outcomes in Patients With Cancer at Memorial Sloan Kettering Cancer Center

In a single-institution study reported in the  Journal of Clinical Oncology, Jee et al found that the receipt of cytotoxic chemotherapy within 35 days of COVID-19 diagnosis in patients with cancer was not associated with increased risk of severe or critical COVID-19. The investigators also...

Roswell Park Care Network and Oneida Health Name New Radiation Oncology Medical Director

Roswell Park Comprehensive Cancer Center and Oneida Health announced the appointment of Maya Mathew, MD, as Medical Director of the Dorothy G. Griffin Radiation Oncology Center in Oneida, New York, part of the Roswell Park Care Network. In her new position, Dr. Mathew will lead a team that includes ...

lung cancer

Two Organizations Collaborate to Evaluate the Utility of Liquid Biopsy in Treating Lung Cancer

The Cancer Research Institute and The Mark Foundation for Cancer Research have launched an innovative clinical trial that aims to demonstrate the utility of liquid biopsy in assessing responses of patients with lung cancer to immunotherapy (ClinicalTrials.gov identifier NCT04093167). If the trial...

Sanjiv Sam Gambhir, MD, PhD, Pioneer in Molecular Imaging, Dies at 57

Sanjiv Sam Gambhir, MD, PhD, Professor and Chair of Radiology at the Stanford School of Medicine and an internationally recognized pioneer in molecular imaging, died on July 18, 2020, of cancer. He was 57. The Virginia and D.K. Ludwig Professor of Cancer Research, Dr. Gambhir dedicated his career...

Gynecologic Cancer Advocate, Wendy Noelle Ericsson, Dies at Age 60

The Society of Gynecologic Oncology announced with sadness the death of Wendy Noelle Ericsson, an advocate and champion of the Foundation for Women’s Cancer, an advocacy group supporting research, education, and public awareness of gynecologic cancers. Ms. Ericsson’s death was due to complications...

Cornelius O. ‘Skip’ Granai, MD, Champion of Cancer Care for Women, Dies at 71

Cornelius O. “Skip” Granai, MD, Founder of the Program in Women’s Oncology at Women & Infants Hospital of Rhode Island, died on June 28, 2020, after a long bout with cancer. Dr. Granai strongly believed that cancer care for women should encompass both breast and gynecologic cancers, according...

Anticipate Difficulties by Patients in Adhering to Tamoxifen Therapy

Patients prescribed tamoxifen may not report when they interrupt or discontinue therapy, according to the results of a study published in the Journal of Clinical Oncology.1 Using blood draws to determine serum levels of tamoxifen among 1,177 premenopausal women with invasive breast cancer, the...

breast cancer

One in Six Premenopausal Women With Invasive Breast Cancer Is Nonadherent to Tamoxifen Therapy

Measuring serum levels of tamoxifen among premenopausal women being treated for invasive breast cancer identified a “worryingly high proportion of patients, one in six, who were nonadherent to therapy at only 1 year after treatment prescription,” researchers reported in the Journal of Clinical...

solid tumors

Tumeur Fibro-Plastique

The text and photograph here are excerpted from a four-volume series of books titled Oncology: Tumors & Treatment, A Photographic History, The Anesthesia Era 1845–1875 by Stanley B. Burns, MD, FACS, and Elizabeth A. Burns. The photograph appears courtesy of Stanley B. Burns, MD, and The Burns...

Dana-Farber Launches New Center for Prevention and Treatment of BRCA-Related Cancers

Of the tens of thousands of genes in cellular DNA, one group of genes is tasked with ensuring that every cell reproduces itself exactly when it divides to make new cells. Perhaps the best known of these genes are the BRCA genes, which if inherited with a significant alteration, confer a markedly...

After Immigrating From India, Neha Vapiwala, MD, FACR, Followed Her Dream of a Career in Medicine

Neha Vapiwala, MD, FACR, Professor and Vice Chair of Education in the Department of Radiation Oncology and newly appointed Dean of Admissions at the Perelman School of Medicine at the University of Pennsylvania (UPenn), Philadelphia, was born in India to parents who aspired to emigrate to the...

integrative oncology

Ashwagandha

The ASCO Post’s Integrative Oncology series is intended to facilitate the availability of evidence-based information on integrative and complementary therapies sometimes used by patients with cancer. In this installment, Gary Deng, MD, PhD, and Jyothirmai Gubili, MS, present updated information on ...

global cancer care

Cancer on the Global Stage: Incidence and Cancer-Related Mortality in Cambodia

The ASCO Post is pleased to continue this occasional special focus on the worldwide cancer burden. In this issue, we feature a close look at the cancer incidence and mortality rates in Cambodia. The aim of this special feature is to highlight the global cancer burden for various countries of the...

Penn Medicine Receives $4.9 Million Grant to Improve Uptake of Cancer Care Best Practices

Although extensive research has suggested ways to ensure that patients receive evidence-based cancer care, putting these solutions into widespread practice can be a complex, challenging, and inefficient process. Now, a new grant awarded to the Perelman School of Medicine at the University of...

covid-19

Managing Cancer in Older Adults During the COVID-19 Pandemic

The COVID-19 pandemic is an additional competing risk to factor in when making decisions about anticancer treatment for older adults. It poses a potential barrier to equal and evidence-based management of cancer in this group of patients. Implementing geriatric assessments in routine clinical...

GO2 Foundation for Lung Cancer to Honor Charles Swanton, MD, With the 2020 Bonnie J. Addario Lectureship Award

The GO2 Foundation for Lung Cancer presented Charles Swanton, MD, PhD, FRCP, FMedSci, FRS, Senior Group Leader at the Francis Crick Institute, with the 2020 Bonnie J. Addario Lectureship Award at the Physicians’ Education Resource 21st Annual International Lung Cancer Congress. GO2 is recognizing...

Mary-Claire King, PhD, Honored With 2020 William L. McGuire Memorial Lecture Award

Mary-Claire King, PhD, will receive the William L. McGuire Memorial Lecture Award at the 2020 San Antonio Breast Cancer Symposium (SABCS), to be held virtually from December 8 to 12, 2020. The William L. McGuire Memorial Lectureship was established in 1992 to commemorate Dr. McGuire’s significant...

Association of Community Cancer Centers Announces 2020 Innovator Award Recipients

The Association of Community Cancer Centers (ACCC) announced the winning programs for its 10th annual ACCC Innovator Awards, highlighting the year’s leading-edge strategies to challenges faced by oncology programs and practices across the country. The eight ACCC Innovator Award winners feature...

David A. Karnofsky’s Early Contributions to Cancer Research Helped Establish Oncology as a Medical Discipline

For nearly 30 years, from the time he was a young resident at the Collis P. Huntington Memorial Hospital for Cancer Research of Harvard University, until his death from lung cancer on August 31, 1969, David A. Karnofsky, MD, dedicated himself to the pursuit of scientific excellence and the...

multiple myeloma

How to Treat Patients With Multiple Myeloma Cost-Effectively Without Compromising Outcome

The dramatic advances in the diagnosis and treatment of multiple myeloma over the past 20 years have resulted in significant improvements in overall survival, with 5-year relative survival rates now around 50% and more than 60% for patients younger than age 70.1 The proteasome inhibitors...

cost of care

How the First International Summit on Interventional Pharmacoeconomics Is Sparking Discussion on Reducing Cancer Costs

Three years ago, former Chief Executive Officer of ASCO, Allen S. Lichter, MD; Laurence H. Baker, DO, Professor in the Departments of Internal Medicine and Pharmacology at the University of Michigan Medical School in Ann Arbor; Leonard Saltz, MD, a gastrointestinal oncologist at Memorial Sloan...

ASCO Answers Guide to Cancer Survivorship

The ASCO Answers Guide to Survivorship has the tools and resources your patients need to prepare for their lives after treatment. This vital resource will inform your patients and their caregivers about topics like the importance of follow-up care, concerns about recurrence, and managing long-term...

Rural Cancer Care: Models of Success and Barriers Highlighted in New State of Cancer Care in America Package

JCO Oncology Practice has published an article on rural cancer care as part of the State of Cancer Care in America series. “Closing the Rural Cancer Care Gap: Three Institutional Approaches” draws from data presented during the second State of Cancer Care in America live event as well as supporting ...

Into the Ring With Tap Cancer Out

Brazilian jiu-jitsu (BJJ) athletes use combat techniques designed to dominate one’s opponent with control and force. The goal: make your opponent be the first to tap out. In 2010, BJJ practitioner Jon Thomas was surprised to discover there was no philanthropic presence within his sport. That’s when ...

Health Groups Oppose Suspending Immigration for Health-Care Providers and Family Members

The Association for Clinical Oncology signed on to a letter from the American Medical Association (AMA) and statements from the Council of Medical Specialty Societies and the American College of Physicians’ Council of Subspecialty Societies expressing concerns about the Trump Administration’s...

prostate cancer

BRCA Study: Clinic Is Saving Men’s Lives in Israel

Uriya, age 49, visits Israel’s Rabin Medical Center for a cancer screening. On the surface, he shows no signs of disease. However, results from a study by David Margel, MD, PhD, revealed Uriya is living with prostate cancer at an early yet curable stage. Uriya carries the BRCA gene. Rabin Medical...

issues in oncology

For Your Patients: An Expert Q&A on Cancer Disparities and Health Equity

Cancer does not affect all people equally. The phrase “cancer disparities” refers to the differences in the number of new cancer cases as well as differences in cancer outcomes that exist among different populations. Disparities more often negatively affect racial and ethnic minorities, poor...

leukemia
lymphoma

Final ASCEND Results Confirm Acalabrutinib as a Standard for Relapsed CLL

The Bruton’s tyrosine kinase (BTK) inhibitors have been one of the most exciting advances in the tre atment of chronic lymphocytic leukemia (CLL) and have led to the development of chemotherapy-free treatments for both treatment-naive as well as relapsed or refractory CLL based on studies where...

leukemia
lymphoma

Acalabrutinib Improves Progression-Free Survival vs Idelalisib Plus Rituximab or Bendamustine Plus Rituximab in Relapsed or Refractory CLL

As reported in the Journal of Clinical Oncology by Paolo Ghia, MD, PhD, of the Università Vita-Salute San Raffaele, Milan, Italy, and colleagues, the phase III ASCEND trial showed significantly prolonged progression-free survival with acalabrutinib monotherapy vs the investigator’s choice of...

Jae Jung, PhD, Appointed Chair of Cleveland Clinic Lerner Research Institute’s Cancer Biology Department

Cleveland Clinic has appointed Jae Jung, PhD, as Chair of Lerner Research Institute’s Department of Cancer Biology. Dr. Jung will also serve as Director of the new Center for Global and Emerging Pathogens Research, which will focus on public health threats ranging from the Zika virus to...

skin cancer

Adding Immunotherapy to BRAF/MEK Inhibition in BRAF V600–Mutant Melanoma: First Step on the Journey

As investigators, we were always determined to find the drug to work with BRAF/MEK inhibitor combination therapy. It had come on like a storm and showed us that we could help even those with the most advanced metastatic melanoma, as long as it harbored the magical BRAF V600E mutation.1...

skin cancer

Addition of Atezolizumab to Vemurafenib/Cobimetinib in Unresectable Advanced BRAF V600–Mutant Melanoma

As reported inThe Lancet by Ralf Gutzmer, MD, of Medizinische Hochschule Hannover, Germany, and colleagues, the phase III IMspire150 trial has shown that the addition of atezolizumab to BRAF and MEK inhibitor therapy with vemurafenib and cobimetinib improved progression-free survival in the...

immunotherapy

The Parker Institute for Cancer Immunotherapy Appoints John Connolly, PhD, as Chief Scientific Officer

The Parker Institute for Cancer Immunotherapy (PICI) announced that John Connolly, PhD, has been named Chief Scientific Officer. In this role, Dr. Connolly will design and execute PICI’s overall research strategy in close collaboration with the institute’s leadership team, center directors, and...

skin cancer
immunotherapy

Researchers Outline Need for Evaluation of Gene-Expression Profiling in Melanoma

A consensus statement published in JAMA Dermatology by an international group of melanoma researchers evaluated the use of prognostic gene-expression profile testing to guide clinical management of melanoma.1 The group cautioned against the routine use of currently available gene-expression...

hematologic malignancies

The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues

The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that occasionally quizzes readers on issues in hematology. In this installment, Drs. Abutalib, Pemmaraju, and Medeiros highlight the clinically aggressive blastic plasmacytoid dendritic cell neoplasm. For each quiz...

Steven Grossman, MD, PhD, Named Cancer Physician in Chief of USC Norris Comprehensive Cancer Center

The University of Southern California (USC) Norris Comprehensive Cancer Center and Keck Medicine of USC have announced the appointment of oncologist and cancer researcher Steven Grossman, MD, PhD, as the center’s Cancer Physician in Chief. In this inaugural position, Dr. Grossman will provide...

Raymond N. DuBois, MD, PhD, Named Director, MUSC Hollings Cancer Center

The Medical University of South Carolina (MUSC) President David J. Cole, MD, FACS, has announced the appointment of MUSC College of Medicine Dean Raymond N. DuBois, MD, PhD, to the additional role as Director of the MUSC Hollings Cancer Center. Dr. DuBois has headed the College of Medicine for more ...

Heather Brandt, PhD, to Lead Cancer Prevention Community Outreach Projects for St. Jude

St. Jude Children’s Research Hospital has appointed Heather Brandt, PhD, a behavioral scientist with expertise in cancer prevention and control, to lead community outreach and research programs focused on the prevention of human papillomavirus (HPV)-associated cancers through vaccination. In...

Association of American Cancer Institutes to Honor Nobel Laureate William G. Kaelin, Jr, MD

William G. Kaelin, Jr, MD, will receive a Distinguished Scientist Award from the Association of American Cancer Institutes (AACI) on October 12, during the 2020 AACI/Cancer Center Administrators Forum Annual Meeting. Due to COVID-19–related restrictions on travel and gatherings, the meeting will...

Bert W. O’Malley, Jr, MD, Named President and Chief Executive Officer of the University of Maryland Medical Center

Following an extensive national search, Bert W. O’Malley, Jr, MD, has been appointed as the new President and Chief Executive Officer of the University of Maryland Medical Center (UMMC), the flagship academic hospital for the University of Maryland Medical System and an anchor institution in...

lymphoma
immunotherapy

Tafasitamab-cxix in the Treatment of Diffuse Large B-Cell Lymphoma

In the Clinic provides overviews of novel oncology agents, addressing indications, mechanisms of action, administration recommendations, safety profiles, and other essential information needed for the appropriate clinical use of these drugs. On July 31, 2020, tafasitamab-cxix, a CD19-directed...

covid-19

Repurposing Drugs for the Treatment of COVID-19

A vaccine for COVID-19 is currently the Holy Grail, but even if an effective vaccine were developed on a fast-track timetable, it may be effective in only a percentage of people, judging by existing flu vaccines, which show efficacy rates of approximately 45% and vary year by year. Until we have a...

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