Alicia K. Morgans, MD, MPH, FASCO, on How Does Androgen Receptor Inhibition Affect Quality of Life?
2025 ASCO Annual Meeting
Alicia K. Morgans, MD, MPH, FASCO, of Dana-Farber Cancer Institute, discusses health-related quality-of-life data from the phase III ARANOTE trial, which evaluated the androgen receptor inhibitor darolutamide in combination with androgen-deprivation therapy (ADT) vs ADT plus placebo for patients with metastatic hormone-sensitive prostate cancer (Abstract 5004).
Transcript
Disclaimer: This video transcript has not been proofread or edited and may contain errors.
On behalf of the ARASENS investigators, I was very pleased to present the ARASENS quality of life data. ARASENS is a phase three study in patients with metastatic hormone-sensitive prostate cancer. Patients were enrolled and were randomized to ADT plus darolutamide versus ADT and placebo to assess a primary endpoint of radiographic progression-free survival of darolutamide in this setting. Importantly, patients who were enrolled were predominantly high-volume metastatic disease and most had de novo metastatic hormone-sensitive disease. In terms of the quality of life analysis, patients were assessed by the Brief Pain. In the patients treated with ADT plus darolutamide versus ADT alone. I think also importantly the subscales of the FACT-P that were analyzed did suggest that certain subscales were improved more than others including urinary symptoms and prostate cancer-specific symptoms as well as functional well-being and social well-being, suggesting that patients were reporting that they had better time with their families and performing their daily activities. Ultimately, these suggest that darolutamide in the addition to ADT were improving metastatic hormone-sensitive prostate cancer patients' quality of life in addition to being associated with the radiographic progression-free survival advantage for this combination.
The ASCO Post Staff
William G. Wierda, MD, PhD, of The University of Texas MD Anderson Cancer Center, discusses two abstracts on lisocabtagene maraleucel (liso-cel) in relapsed/refractory (R/R) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). In Abstract 7037, liso-cel with ibrutinib demonstrated better efficacy and safety compared with liso-cel monotherapy, with statistically significant differences for complete response rate and overall response rate. In Abstract 7039, patients with R/R CLL/SLL who had received two or more prior lines of therapy had improved response, delayed progression, and prolonged survival with liso-cel compared with a real-world cohort treated with standard-of-care therapy.
The ASCO Post Staff
South Florida has a unique demographic, characterized by a large Hispanic population with ancestries from the Caribbean and Central and South America. Arelis Esther Martir-Negron, MD, of Miami Cancer Institute, presents data from a retrospective analysis that sought to determine the frequency and spectrum of BRCA pathogenic/likely pathogenic variants in this population (Abstract 10579).
The ASCO Post Staff
Raffaele Califano, MD, of the Christie NHS Foundation Trust and the University of Manchester, discusses outcomes by osimertinib resistance mechanisms in MARIPOSA-2, a study that evaluated the efficacy of the bispecific antibody amivantamab-vmjw plus chemotherapy vs chemotherapy in patients with EGFR-mutant advanced NSCLC after disease progression on osimertinib (Abstract 8639).
The ASCO Post Staff
Bjorn Henning Gronberg, MD, PhD, of Norwegian University of Science and Technology (NTNU) and St. Olavs Hospital, presents phase II findings on the efficacy of atezolizumab after chemoradiotherapy (CRT) in limited-stage small cell lung cancer (SCLC) (LBA8005).
The ASCO Post Staff
Gerhardt Attard, MD, PhD, of the Cancer Institute, University College London, presents findings from the phase III AMPLITUDE trial, which looked at the combination of niraparib and abiraterone acetate plus prednisone for patients with metastatic castration-sensitive prostate cancer with alterations in homologous recombination repair (HRR) genes (Abstract LBA5006).
