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Breast Cancer
Survivorship

Some Breast Cancer Survivors May Safely De-escalate Mammography 3 Years After Surgery

Women aged 50 or older who had less-frequent mammography 3 years after curative surgery for early-stage breast cancer had similar outcomes as women who had annual mammography, according to results from the Mammo-50 trial presented at the 2023 San Antonio Breast Cancer Symposium (Abstract GS03-02)....

Survivorship

Predicting Primary Ovarian Insufficiency in Childhood Cancer Survivors

As reported in The Lancet Oncology, Im et al have developed risk-prediction models for primary ovarian insufficiency in long-term survivors of childhood cancer. Study Details In the study, models to predict age-specific risk of primary ovarian insufficiency were evaluated among 5-year survivors...

Colorectal Cancer
Survivorship
Supportive Care

Consuming Navy Beans May Improve Gut Health, Regulate Immune and Inflammatory Processes in Colorectal Cancer Survivors

Researchers have uncovered that the regular consumption of navy beans may help modulate markers linked to obesity and disease and improve the gut microbiome in colorectal cancer survivors, according to a novel study published by Zhang et al in eBioMedicine. Background Obesity, poor diet, and...

Colorectal Cancer
Survivorship

Risk of Subsequent Colorectal Cancer After Abdominopelvic Radiotherapy Among Childhood Cancer Survivors

In a European study reported in the Journal of Clinical Oncology, Heymer et al found that the risk of subsequent colorectal cancer was elevated among childhood cancer survivors who had undergone abdominopelvic radiotherapy. Study Details The study used data from the PanCareSurFup Study—a...

Survivorship

Survivors of Childhood Cancer: Study Shows Heart-Related Ailments Linked to Radiotherapy Dose

Research on the advances in radiation modeling presented by Rebecca M. Howell, PhD, at the 2023 American Society for Radiation Oncology (ASTRO) Annual Meeting may provide insights into the late cardiac effects of survivors of childhood cancer in the Childhood Cancer Survivor Study (CCSS).1 Dr....

Cost of Care
Survivorship

Role of Crowdfunding Campaigns in Covering Medical Expenses for Cancer Survivors

Investigators have discovered that cancer survivors in the United States may be increasingly utilizing crowdfunding campaigns like GoFundMe to help cover the costs of medical and other basic household expenses, according to new findings presented by Zheng et al and Yu et al at the 2023 ASCO Quality ...

Breast Cancer
Survivorship

Novel Strategies for Eliminating Dormant Tumor Cells in Breast Cancer Survivors

Researchers have discovered that it may be possible to detect and treat dormant tumor cells in breast cancer survivors, according to new findings presented by DeMichele et al at the European Society for Medical Oncology (ESMO) Congress 2023 (Abstract 244MO). The results may have offered a...

Genomics/Genetics
Survivorship

Germline Cancer-Predisposing Variants and Increased Risk of Late Mortality From Subsequent Malignant Neoplasms in Long-Term Childhood Cancer Survivors

In an analysis from the St. Jude Lifetime Cohort (SJLIFE) and Childhood Cancer Survivor Study (CCSS) reported in The Lancet Oncology, Chen et al found that among long-term survivors of childhood cancers, carriers of germline cancer-predisposing variants were at an increased risk of late mortality...

Issues in Oncology
Survivorship

Many Survivors of Childhood Cancer Experience Lifelong Chronic Health Problems and Shorter Lifespans Than Their Healthier Peers

Each year, nearly 16,000 children between the ages of 0 and 19 years are diagnosed with cancer, and more than 85% survive for at least 5 years. Overall, this is a large increase in survivors since the mid-1970s, when the 5-year survival rate was just 58%. Today, approximately 500,000 people in the...

Issues in Oncology
Survivorship

Postdiagnosis Exercise and Mortality Risk Among Patients With Cancer

In a study reported in the Journal of Clinical Oncology, Lavery et al found that long-term cancer survivors who engaged in postdiagnosis exercise consistent with national guidelines had reduced all-cause mortality, with reductions seen in both cancer and noncancer mortality. Key Findings The study...

Cardio-oncology
Survivorship

Risk Factors for Incident Heart Failure Among Cancer Survivors Aged 18 to 39

In a study reported in a research letter in JACC: CardioOncology, Hibler et al found that survivors of young adult cancers who were exposed to anthracyclines were at an increased risk of subsequent diagnosis of heart failure. Study Details The study involved electronic health record data from the...

Issues in Oncology
Survivorship

Alcohol Consumption Behaviors Among Patients Diagnosed With Cancer

In a study from the National Institutes of Health All of Us Research Program reported in JAMA Network Open, Shi et al found that alcohol consumption and risky drinking behaviors were common among patients with a cancer diagnosis, including patients currently receiving treatment for their cancer....

Survivorship

How the Cancer Moonshot Aims to Improve the Quality of Life for Adolescent and Young Adult Cancer Survivors

Several recent studies have shown an increasingly disturbing trend: the incidence of early-onset cancers—those diagnosed in individuals younger than age 50—is on the rise, and not just in the United States but globally as well. Worldwide, in 2019, there were a reported 1.19 million new cases of...

Breast Cancer
Survivorship

Impact of Interventions to Promote Adjuvant Endocrine Therapy Adherence Among Breast Cancer Survivors

In a systematic review and meta-analysis reported in the Journal of Clinical Oncology, Bright et al found that interventions to promote adjuvant endocrine therapy adherence in breast cancer survivors were successful overall compared with control conditions, although some interventions appeared to...

Survivorship
Cardio-oncology

How Multidisciplinary Specialties Are Coming Together to Improve the Quality of Life of Cancer Survivors

As we detailed in our Special Report “Surviving, but Not Always Thriving, After Cancer,” in the May 25, 2023, issue of The ASCO Post, the combination of advances in more effective therapies to treat cancer, gains in early detection, and sharp declines in tobacco use have led to a staggering 33%...

Survivorship
Issues in Oncology

Study Shows Substantial Racial and Ethnic Disparities Among Survivors of Second Primary Cancers in the United States

In a new study published by Hyuna Sung, PhD, and colleagues in JAMA Network Open, non-Hispanic Black individuals diagnosed with a second primary cancer experienced 21% higher cancer-related death rates and 41% higher cardiovascular-related death rates compared with non-Hispanic White individuals;...

Colorectal Cancer
Survivorship
Geriatric Oncology

Gastrointestinal Symptoms May Be Prevalent in Geriatric Female Colorectal Cancer Survivors

About 80% of geriatric female colorectal cancer survivors may experience a range of gastrointestinal symptoms years after receiving a diagnosis and treatment for their tumors, according to a recent study published by Han et al in PLOS ONE. Background While depression, anxiety, and fatigue are...

Survivorship
Colorectal Cancer
Breast Cancer
Prostate Cancer

Primary Cancer and Noncancer Mortality Among Long-Term Survivors of Solid Tumors

In a study reported in JAMA Network Open, KC et al identified factors involved with primary cancer mortality vs noncancer mortality among long-term survivors of breast, prostate, and colorectal cancers. Study Details The study included data on 627,702 patients in the Surveillance, Epidemiology,...

Survivorship
Issues in Oncology

Study Explores Incidence and Mortality Rates of Cardiovascular Disease Among Black vs White Cancer Survivors

Black cancer survivors in the United States may experience a higher incidence of cardiovascular disease and associated mortality than White cancer survivors, according to a recent study published by Sung et al in the International Journal of Epidemiology. The investigators also found that...

Survivorship

Polygenic Risk Score and Chemotherapy-Related Subsequent Malignant Neoplasms in Childhood Cancer Survivors

In a study reported in the Journal of Clinical Oncology, Im et al found that a polygenic risk score (PRS) may be useful in stratifying risk for subsequent malignant neoplasms among nonirradiated survivors of childhood cancer according to chemotherapy received. Study Details The study involved...

Issues in Oncology
Survivorship

Investigators Identify Requirements to Potentially Optimize Cancer Survivorship Care for Patients in Rural Areas

The vast majority of cancer survivors may rely on primary care physicians for follow-up treatments, especially in rural areas, according to a new study published by Becevic et al in the Journal of Cancer Education. Background Patients often depend on their primary care physicians to help them...

Survivorship

Association of Cardiac Substructure Radiation Dose and Risk of Late Cardiac Disease in Survivors of Childhood Cancer

In an analysis from the Childhood Cancer Survivor Study (CCSS) reported in the Journal of Clinical Oncology, Bates et al identified relationships among radiation therapy doses, cardiac substructures, and risk of late-onset cardiac disease in survivors of childhood cancer. Study Details The analysis ...

Survivorship
Leukemia
Lymphoma
CNS Cancers

Late-Onset Memory Impairment in Adult Survivors of Childhood Cancer

In an analysis reported in JAMA Network Open, Phillips et al found that adult survivors of childhood cancer were at an increased risk of new-onset memory impairment vs their siblings. Modifiable factors associated with increased risk of impairment among survivors were identified. Study Details The...

Breast Cancer
Survivorship

Aromatase Inhibitors May Limit Effectiveness of Weight Loss Medications in Breast Cancer Survivors

Aromatase inhibitors may interfere with the efficacy of weight loss medications in breast cancer survivors, according to a new study presented by Fansa et al at the 2023 Endocrine Society Annual Meeting. Background Aromatase inhibitors are designed to block the activity of the aromatase enzyme,...

Breast Cancer
Survivorship
Geriatric Oncology

Older Breast Cancer Survivors May Experience Accelerated Aging, Worse Functional Outcomes Following Chemotherapy

Investigators have found that older breast cancer survivors—particularly those exposed to chemotherapy—may experience greater epigenetic aging and poorer outcomes than those without a history of cancer, according to a new study published by Rentscher et al in Cancer. Background Epigenetic aging...

Survivorship

Risk Factors for Primary Bone Cancer in Childhood Cancer Survivors: Bone Tissue Radiation Exposure and Alkylating Agent Dose

In a case-control study reported in the Journal of Clinical Oncology, Reulen et al found that an increased risk of primary bone cancer was associated with increasing radiation dose to bone tissue and increasing alkylating agent dose among survivors of childhood cancer. As noted by the...

Survivorship

Accumulation of Chronic Comorbidities Among Survivors of Childhood Cancer

In a study reported in the Journal of Clinical Oncology, Esbenshade et al found that survivors of childhood cancer were more likely to accumulate comorbidities over time than their siblings or the general population. Study Details In the study, Cumulative Illness Rating Scale for Geriatrics...

Survivorship
Issues in Oncology

Cancer Survivors Who Quit Smoking May Have 36% Lower Cardiovascular Risk Than Those Who Continue Smoking

Patients who continue smoking after a cancer diagnosis may have almost a twofold risk of experiencing a heart attack, stroke, or death as a result of cardiovascular disease compared with nonsmokers, according to a new study published by Lee et al in the European Heart Journal. Background According...

Genomics/Genetics
Survivorship

Anthracycline-Related Cardiomyopathy and HP Gene Expression in Childhood Cancer Survivors

In a study reported in JACC: CardioOncology, Singh et al found that haptoglobin (HP) gene expression was associated with risk of anthracycline-related cardiomyopathy in childhood cancer survivors. Study Details In the study, messenger RNA sequencing was performed on total RNA from the peripheral...

Issues in Oncology
Survivorship

Cancer Survivors With Transportation Barriers to Care May Also Experience Financial Hardship, Food Insecurity, and Delays in Timely Care

Investigators have found that many U.S. cancer survivors with transportation barriers to care also reported struggling financially and experiencing additional barriers to timely care, according to new findings presented by Jiang et al at the 2023 ASCO Annual Meeting (Abstract 6534). Study Methods...

Survivorship

A Free-Spirited Childhood on a Dairy Farm, Where Books and Science Experiments Were Encouraged

Susan K. Parsons, MD, MRP, Professor of Medicine and Pediatrics at Tufts University School of Medicine and Founding Director of the Reid R. Sacco Adolescent and Young Adult Program for Cancer and Hereditary Blood Disorders at Tufts Medical Center, grew up on a working dairy farm in Sharon Springs,...

Survivorship

Surviving, but Not Always Thriving, After Cancer

As discussed in Part I of this special feature on cancer survivorship, there are now more than 18 million cancer survivors in the United States, and that number is expected to grow to 26 million by 2040.1 However, most of those survivors—at least two-thirds—either cured or in remission or living...

Survivorship

Surviving, but Not Always Thriving, After Cancer

The improvement in cancer survival rates since President Richard M. Nixon signed the National Cancer Act of 1971 into law is staggering. The legislation further committed the United States to greater investments in cancer-focused research to drive down the rates of cancer diagnoses, boost patient...

Survivorship
Issues in Oncology

Prevalence of Functional Limitations in U.S. Cancer Survivors

In a study reported in a research letter in JAMA Oncology, Patel et al found that the prevalence of self-reported functional limitations in U.S. cancer survivors increased between 1999 and 2018. Study Details The analysis included adults in the 1999 to 2018 National Health Interview Survey (NHIS)...

Survivorship
Issues in Oncology

Study Analyzes Relationship Between Cancer Survivors’ Tobacco Use, Symptom Burden, and Motivation to Quit Smoking

Investigators have found that current smoking and vaping may be associated with a higher burden of symptoms among adult cancer survivors but that these symptoms may not have had an impact on the desire to quit smoking. The new study was published by Price et al in Cancer. Background Continued...

Survivorship

Late Major Surgical Intervention in Survivors of Childhood Cancer

In an analysis from the Childhood Cancer Survivor Study (CCSS) reported in The Lancet Oncology, Dieffenbach et al found that childhood cancer survivors had a heavy cumulative burden of late major surgical interventions. Study Details The study involved data from the CCSS on 5-year survivors of...

Survivorship

Cardiovascular Disease in Survivors of Testicular Cancer

In a Dutch study reported in the Journal of Clinical Oncology, Lubberts et al identified risk factors for cardiovascular disease among survivors of testicular cancer and assessed the impact of cardiovascular disease on quality of life. Study Details The study involved data from a multicenter cohort ...

Survivorship
Issues in Oncology

Cancer Survivors With Transportation Challenges May Face Higher Risk of Emergency Room Use and Mortality

Investigators have found that transportation barriers—delayed care as a result of a lack of transportation—may be associated with increased emergency room use and a higher risk of mortality among patients with and without a history of cancer, according to a new study published by Jiang et al in the ...

Survivorship

Healthy Lifestyles May Be Associated With Reduced Mortality Risk in Pediatric Cancer Survivors

Researchers have provided strong evidence that a healthy lifestyle may significantly reduce mortality in adults who have survived pediatric cancer, according to a new study published by Dixon et al in The Lancet. The findings are among the first to reveal that the specific primary causes of...

Issues in Oncology
Survivorship

Does Discrimination Accelerate Aging in Black Cancer Survivors?

Investigators have found that Black cancer survivors who reported high levels of discrimination showed greater biological aging and frailty than those who reported lower levels of discrimination, according to a new study published by Mandelblatt et al in the journal Cancer. Background...

Breast Cancer
Survivorship

Cancer Stage and Receptor Status May Indicate Risk of Disease Recurrence in Breast Cancer Survivors

Investigators have found that in breast cancer survivors, the cancer’s stage and receptor status may help clinicians predict whether and when cancer might recur after initial treatment, according to a new study published by Neuman et al in Cancer. Study Methods and Results In the new study, the...

Survivorship

Prediction Models for Kidney Failure in Long-Term Survivors of Childhood Cancer

In a study reported in the Journal of Clinical Oncology, Wu et al developed models for predicting kidney failure among 5-year survivors of childhood cancer. Study Details In the study, predictive models were developed using data from 25,483 survivors from the Childhood Cancer Survivor Study (CCSS)...

Survivorship

Lack of Resources May Be Associated With Increased Mortality Rates Among Pediatric Cancer Survivors

Investigators have found that socioeconomic deprivation, the presence of modifiable chronic health conditions, and frailty may all independently be associated with increased rates of late mortality among pediatric cancer survivors, according to a new study published by Ehrhardt et al in JAMA...

Survivorship
Lymphoma

Dietary Intervention May Help Reduce Chronic Fatigue, Improve Quality of Life for Cancer Survivors

Researchers have discovered that dietary interventions may help reduce fatigue, improve diet quality, and lead to an overall better quality of life for cancer survivors, according to a new study published by Weinhold et al in Nutrition and Cancer.  Background For many cancer survivors, the side...

Genomics/Genetics
Survivorship

Higher Rate of Clonal Hematopoiesis in Pediatric Cancer Survivors May Be Linked With Treatment-Induced STAT3 Gene Mutations and Risk of Adverse Long-Term Outcomes

Studies show that although clonal hematopoiesis is an age-related phenomenon in the general population, it can also be induced by exposure to chemotherapy, which can affect both the emergence and evolution of clonal hematopoiesis clones, accelerating aging at both the physiologic and molecular...

Kidney Cancer
Survivorship

Long-Term Outcomes Among Survivors of Wilms Tumor

In an analysis from the Childhood Cancer Survivor Study (CCSS) reported in the Journal of Clinical Oncology, Weil et al found that survivors of unilateral Wilms tumor were at an increased risk for severe chronic health conditions. Study Details The study involved 2,008 5-year survivors diagnosed...

Colorectal Cancer
Lymphoma
Survivorship

Association of Radiation and Procarbazine Dose With Risk of Colorectal Cancer in Survivors of Hodgkin Lymphoma

In a Dutch study reported in JAMA Oncology, Geurts et al found a dose-response relationship between radiotherapy and risk of colorectal cancer among survivors of Hodgkin lymphoma, with the risk being increased with increasing procarbazine dose. Study Details The nested case-control study included...

Survivorship
Leukemia
Lymphoma
Sarcoma

Dexrazoxane and Long-Term Heart Function in Survivors of Childhood Cancer Treated With Doxorubicin

In a study reported in the Journal of Clinical Oncology, Eric J. Chow, MD, MPH, and colleagues found that the use of dexrazoxane was associated with long-term protection of heart function in childhood cancer survivors who received doxorubicin for their cancer. According to the study investigators,...

CNS Cancers
Survivorship

Canadian Trial Highlights Adverse Outcomes in Survivors of Childhood Medulloblastoma

In a population-based study reported in the Journal of Clinical Oncology, Coltin et al found that survivors of childhood medulloblastoma in Ontario were at an increased risk of numerous adverse health outcomes compared with matched noncancer controls.  Study Details In the study, all 5-year...

Hematologic Malignancies
Survivorship
Gastrointestinal Cancer
Lymphoma
Leukemia
Myelodysplastic Syndromes

Risk of Subsequent Gastrointestinal Tract Malignancies After Blood or Marrow Transplantation

In a study reported in JAMA Oncology, McDonald et al found that receipt of blood or marrow transplantation (BMT) was associated with an increased risk of subsequent malignant neoplasms of the gastrointestinal (GI) tract. As stated by the investigators, “Survivors of BMT are at increased risk of...

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