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Survivorship
Genomics/Genetics

Study Identifies Genetic Variants That May Contribute to Accelerated Aging in Childhood Cancer Survivors

Scientists from St. Jude Children’s Research Hospital have identified variants in two genes that may be associated with accelerated aging in childhood cancer survivors. Their research looked at the difference between the survivors’ biologic age and chronologic age. The study, published by Dong et...

Breast Cancer
Survivorship
Cardio-oncology

How Do Lifestyle and Cardiovascular Risk Factors Relate to Heart Failure Subtypes in Postmenopausal Breast Cancer Survivors?

In an analysis from the Women’s Health Initiative reported in JACC: CardioOncology, Kerryn W. Reding, PhD, MPH, RN, and colleagues identified the incidence of hospitalization for heart failure among postmenopausal breast cancer survivors, finding that both incidence of hospitalization and risk of...

Survivorship

Cardiovascular Mortality and Cancer Mortality Over Time Among Cancer Survivors

In an English retrospective cohort study reported in JACC: CardioOncology, Strongman et al found that cardiovascular mortality in older cancer survivors ultimately exceeded mortality from common primary cancers in the time since their primary cancer diagnosis. However, the eventual predominance of...

Issues in Oncology
Survivorship

Study Finds Cancer Treatment May Create Employment Difficulties for Some Rural Women

Rural women are likely to face significant challenges finding secure and reliable employment following cancer treatment if they did not already have a secure job at the time of their diagnosis, according to a new study led by University of Arkansas for Medical Sciences (UAMS) researchers. The...

Hematologic Malignancies
Survivorship

Late Mortality and Life Expectancy After Autologous Blood or Marrow Transplant: Analysis From 1981 to 2014

In an analysis from the BMT Survivor Study reported in the Journal of Clinical Oncology, Smita Bhatia, MD, MPH, and colleagues assessed late mortality over a 30-year period among patients who underwent autologous blood or marrow transplantation (BMT) for hematologic malignancies. They found an...

Survivorship
Palliative Care

Managing Long-Term Toxicity From Pelvic Radiation Therapy

Advances over the past 3 decades in improvements in cancer prevention and screening strategies and more effective diagnostics and therapies in cancer care have led to unprecedented declines in death rates from all cancers, including prostate, gynecologic, and colorectal/anal cancers. The fastest...

Survivorship

Research Outlines Obstetric and Perinatal Outcomes for Female Survivors of Childhood Cancer

Survivors of childhood cancer who become pregnant in adulthood are as likely to have healthy babies as those without a history of cancer, according to a new study published by Zgardau et al in the Journal of the National Cancer Institute. Their children also don’t have higher risks of birth defects ...

COVID-19
Survivorship

Risk of COVID-19 Infection and Complications Among Survivors of Childhood, Adolescent, and Young Adult Cancers

In a Canadian population-based study reported in the Journal of Clinical Oncology, Gupta et al found that survivors of childhood, adolescent, and young adult cancers were not at a greater risk of COVID-19 infection or severe complications of infection compared with matched controls without cancer....

Survivorship

Understanding How LGBTQI+ Cancer Survivors Experience Cancer Care

Members of the lesbian, gay, bisexual, transgender, and queer/questioning, intersexed (LGBTQI+) community face numerous challenges and barriers when accessing the health-care system in the United States, including cancer care; as a result, they may be at greater risk for developing cancer and...

Issues in Oncology
Survivorship

Centralizing Care for Adolescents and Young Adults With Cancer to Improve Long-Term Survivorship

This past fall, Memorial Sloan Kettering (MSK) Cancer Center in New York expanded its adolescent and young adult (AYA) program with the establishment of the Lisa and Scott Stuart Center for Adolescent and Young Adult Cancers. The Stuart Center is now part of the increasing list of about 50 academic ...

Thyroid Cancer
Survivorship

Risk of Second Primary Malignancies After Radioactive Iodine Treatment for Pediatric and Young Adult Patients With Differentiated Thyroid Cancer

In a study reported in the Journal of Clinical Oncology, Pasqual et al found that patients younger than 45 years who received radioactive iodine treatment for nonmetastatic differentiated thyroid cancer had an increased risk for the subsequent development of primary solid tumors. As stated by the...

Breast Cancer
Survivorship

Cardiometabolic Risk Factors in Breast Cancer Survivors

In the case-control Pathways Heart Study reported in the Journal of Clinical Oncology, Kwan et al found that breast cancer survivors had an elevated risk for incident diabetes overall and according to treatment as well as an elevated risk of incident hypertension according to treatment vs controls...

Survivorship

Effect of Daily Sitting Time and Weekly Physical Activity on Cancer Survivorship

In a study reported in JAMA Oncology, Cao et al found that the combination of increased daily sitting time and low weekly leisure-time physical activity was associated with poorer overall and cancer-specific survival among U.S. cancer survivors. Study Details The study involved data from a...

Issues in Oncology
Survivorship

Developing a Comprehensive System for Personalized Survivorship-Centered Care Plans

By 2040, the number of cancer survivors in the United States is expected to climb from 17 million today to 26.1 million, with most living 5 years or more after their diagnosis. However, many of these survivors will need ongoing monitoring for treatment-related side effects and cancer recurrence...

Survivorship

Study Examines Role of Psychological Distress in AYA Cancer Survivors

New research indicates that psychological distress from cancer and its treatment can cause many adolescent and young adult (AYA) cancer survivors to seek additional care and burden them with considerable medical expenses. The findings were published by Abdelhadi et al in the journal Cancer....

Prostate Cancer
Survivorship

Disconnect Between Expectations and Outcomes: Major Factor in Treatment-Related Regret Among Patients With Localized Prostate Cancer

“A disconnect between patient expectations and outcomes” is a major contributor to treatment-related regret among patients with localized prostate cancer, according to a study published in JAMA Oncology.1 The disconnect, “both as it relates to treatment efficacy and adverse effects, appears to...

Breast Cancer
Gynecologic Cancers
Survivorship

Effect of Bupropion vs Placebo on Sexual Desire in Postmenopausal Female Cancer Survivors

In a phase II trial (NRG-CC004) reported in the Journal of Clinical Oncology, Barton et al found that bupropion, a dopaminergic agent, did not improve sexual desire vs placebo as measured by the Female Sexual Function Index (FSFI) desire subscale among postmenopausal women with low desire scores...

Survivorship

Achieving Equity in Cancer Care for Adolescents and Young Adults With Cancer

Although cancer in adolescents and young adults (AYAs), defined by the National Cancer Institute as those between the ages of 15 and 39, is relatively rare—in 2020 nearly 90,000 AYAs were diagnosed with cancer and about 9,300 died of the disease1—and 5-year relative survival rates are high, between ...

Lymphoma
Survivorship

Study Finds Younger B-Cell Non-Hodgkin Lymphoma Survivors May Have a Higher Risk of Age-Related Diseases Than Older Survivors

Non-Hodgkin lymphoma is one of the most common cancers diagnosed in the United States, accounting for nearly 4% of all cancers. This year, about 81,600 individuals will be diagnosed with non-Hodgkin lymphoma, and nearly 21,000 will die from the cancer. A study by Ocier et al published in Cancer...

Survivorship

Effect of Social Determinants of Health on Receipt of Survivorship Care Plans

Survivorship care plans are an important tool to help cancer survivors transition from active treatment to follow-up care, but a study published by Timsina et al in Supportive Care in Cancer has found that a number of vulnerable groups have a lower likelihood of receiving such plans. Cancer...

Survivorship

Study Assesses Benefit of Digital Health Tools for Cancer Survivors

New study results suggest that to maximize effects of digital support tools for cancer survivors, it is essential to personalize information and increase engagement efforts. The report, published by Leach et al in the journal Cancer, demonstrated significant improvement in the ability to manage...

Solid Tumors
Survivorship
Supportive Care

Goal-Focused Emotion-Regulation Therapy for Young Adult Testicular Cancer Survivors

Psychological therapy may reduce adverse biobehavioral effects of testicular cancer in young adult survivors, according to a pilot study published by Hoyt et al in the American Journal of Men’s Health. Biobehavior is the interaction of biologic processes and behavior. The recently published...

issues in oncology
survivorship

Courtney Williams, DrPH, on Cancer Survivors: Working Together to Improve Patient Adherence

Courtney Williams, DrPH, of the National Cancer Institute, discusses the costs associated with cancer survivors who don’t take their medications and cites the need for research to better understand whether residing in an urban or rural area may affect prescription adherence, and what interventions might help increase drug adherence and improve health outcomes.

Breast Cancer
Survivorship

Active Living After Cancer Program May Improve Physical Functioning for Breast Cancer Survivors

Breast cancer survivors who participated in Active Living After Cancer, an evidence-based 12-week group program, markedly increased their physical activity and ability to accomplish the basic pursuits of daily life, reported Tami-Maury et al in the journal Cancer. The results show the program could ...

Breast Cancer
Survivorship

Effect of Mindfulness Meditation and Survivorship Education on Depressive Symptoms in Younger Breast Cancer Survivors

In a phase III trial (Pathways to Wellness) reported in the Journal of Clinical Oncology, Julienne E. Bower, PhD, and colleagues found that both mindfulness meditation and survivorship education interventions significantly reduced depressive symptoms in younger breast cancer survivors. Study...

Issues in Oncology
Survivorship

Two Studies Explore the Role of Primary Care Providers in Effective Cancer Care

Communication between patients and their primary care providers is key to ensuring effective cancer care, both before diagnosis and after treatment, according to two recent papers authored by University of Michigan Rogel Cancer Center researchers. Although each study analyzed different stages of...

Survivorship
Cost of Care
Issues in Oncology

Study Examines Link Between Obesity in Long-Term Cancer Survivors and Increased Health-Care Utilization and Spending

A new study from the American Cancer Society published by Xuesong Han, PhD, and colleagues in the journal Cancer has found a link between obesity and the substantial economic burden of nearly $20 billion in 2016 among long-term cancer survivors in the United States, with one-third attributable to...

Survivorship

Disparities Observed in Follow-up Care Among Young Adult Childhood Cancer Survivors

A research team examined gaps and disparities in lifelong follow-up among childhood cancer survivors, including taking a closer look at long-term follow-up care plans, specifically for underserved populations. Their study showed that age and ethnic background are associated with inadequate...

Survivorship
Pain Management

Does Pain Affect the Employment and Financial Outcomes of Cancer Survivors?

In a study reported in the Journal of Clinical Oncology, Halpern et al found that cancer survivors with pain had worse employment and financial outcomes than did those reporting no pain. Study Details The study used data from 1,213 adult survivors identified from the 2016–2017 Medical Expenditure...

Survivorship
Issues in Oncology

Frailty and Neurocognitive Decline Among Young Adult Childhood Cancer Survivors

In a prospective study from the St. Jude Lifetime Cohort reported in the Journal of Clinical Oncology, Williams et al found that prefrailty and frailty among young adult childhood cancer survivors were associated with neurocognitive decline vs nonfrail counterparts, mirroring the association...

Breast Cancer
Survivorship

Pregnancy Outcomes and Maternal Complications Among Survivors of Breast Cancer

In a systematic review and meta-analysis reported in the Journal of Clinical Oncology, Matteo Lambertini, MD, PhD, and colleagues found that breast cancer survivors were less likely to have subsequent pregnancy vs the general population and more likely to have preterm birth. However, no reduction...

Colorectal Cancer
Survivorship

Quality of Life With General Practitioner– vs Surgeon-Led Colon Cancer Survivorship Care

In a 1-year interim analysis of a Dutch study (I CARE) reported in The Lancet Oncology, Vos et al found no clinically meaningful difference in changes in quality of life from baseline among patients with colon cancer with general practitioner– vs surgeon-led survivorship care. In addition,...

Lymphoma
Survivorship

Parenthood Status and Use of Assisted Reproductive Techniques in Younger Hodgkin Lymphoma Survivors

In a Danish population-based study reported in the Journal of Clinical Oncology, Øvlisen et al found that parenthood rates in younger Hodgkin lymphoma survivors who did not experience early relapse were similar to those in the general population, but that use of assisted reproductive techniques...

Issues in Oncology
Survivorship

Addressing Sexuality Challenges Throughout the Cancer Care Continuum

Multiple studies have shown that sexuality and intimacy problems are common among patients with cancer, often beginning at the time of diagnosis and persisting through the continuum of care into the survivorship setting. Although these problems have been well documented, many patients and survivors ...

Head and Neck Cancer
Survivorship

Study Explores Taste and Smell Dysfunction in Head and Neck Cancer Survivors

Most survivors of head and neck squamous cell cancers report that their sense of taste is dulled, changed, or lost during radiation treatment. In a study of taste and smell dysfunction in 40 cancer survivors, scientists found that the tips of these individuals' tongues were significantly less...

Breast Cancer
Survivorship

Breast Cancer Risk Prediction Model for Childhood Cancer Survivors Who Received Chest Radiation

In an analysis from the Childhood Cancer Survivor Study (CCSS) and the Dutch Hodgkin Late Effects and LATER cohorts reported in the Journal of Clinical Oncology, Moskowitz et al developed a model for predicting the risk of breast cancer among childhood cancer survivors treated with chest...

Survivorship

Study Examines Barriers to Survivorship Care

Even among a large group of cancer survivors who were mostly insured, college-educated, and had annual incomes above the national average, up to 10% delayed care in the previous 12 months because they simply could not afford out-of-pocket expenses like copays and deductibles. These findings were...

Survivorship

Refining Cardiovascular Risk Assessment in Childhood Cancer Survivors

There are an estimated 500,000 childhood cancer survivors in the United States, a number that will increase exponentially in the coming years. Over half of all childhood cancer survivors will have received cardiotoxic therapies during primary cancer treatment or relapse. For these survivors, there...

Survivorship

Improving Prediction of Risk for 10-Year Left-Ventricular Systolic Dysfunction in Survivors of Childhood Cancer

In a Dutch study reported in JACC: CardioOncology, Jan M. Leerink, PhD candidate, of Amsterdam UMC, University of Amsterdam Department of Clinical and Experimental Cardiology, and colleagues found that the addition of ejection fraction measurement at the time of first surveillance echocardiogram...

Global Cancer Care
COVID-19
Survivorship
Issues in Oncology

Celebrating 50 Years of Cancer Progress: The International View

Although the National Cancer Act of 1971 has resulted in tremendous advances in cancer research, which have led to sharp declines in cancer mortality in the United States—from 1991 to 2018, there has been a 31% decrease in overall cancer death rates—and more than 17 million cancer survivors,1 much...

Breast Cancer
Survivorship

Risk of Second Cancer by Hormone Receptor Status Among Breast Cancer Survivors

A new study has found breast cancer survivors in general have higher risk of new cancer diagnosis compared to healthy individuals. The article, published by Hyuna Sung, PhD, and colleagues in the journal Cancer, stated that compared to the general population in the United States, the risk of new...

Breast Cancer
Survivorship

Low-Risk Breast Cancer Survivors May Experience Long-Term Physical and Psychological Effects

Survivors of low-risk breast cancer may experience wide-ranging and significant physical and psychological symptoms after cancer treatment, according to a new study presented by Jessica Schumacher, PhD, and colleagues at the American Society of Breast Surgeons (ASBrS) Annual Meeting. Researchers...

Breast Cancer
Survivorship

Overweight Breast Cancer Survivors May Be at Increased Risk of Developing a Secondary Malignancy

Breast cancer survivors who are overweight have a statistically significant increased risk of developing second primary cancers, according to results from a study conducted by Feigelson et al and published in the Journal of the National Cancer Institute. “These findings have important public health ...

Cost of Care
Survivorship

Adult Survivors of AYA Cancers May Be More Likely to Experience Medical Financial Hardship

A new study has found higher rates of medical financial hardship among adult survivors of adolescent and young adult (AYA) cancers than in adults without a history of cancer in the United States. The research was published by Lu et al in JNCI: The Journal of the National Cancer Institute....

Integrative Oncology
Pain Management
Survivorship

Electroacupuncture and Auricular Acupuncture vs Usual Care for Chronic Musculoskeletal Pain in Cancer Survivors

In the PEACE study, reported in JAMA Oncology, Jun J. Mao, MD, MSCE, and colleagues found that both electroacupuncture and auricular acupuncture significantly reduced pain severity vs usual care in cancer survivors with chronic musculoskeletal pain. Noninferiority of auricular acupuncture to...

Survivorship
Supportive Care

Inclusion of Surveillance Ejection Fraction in Predicting Risk of 10-Year Left-Ventricular Systolic Dysfunction in Survivors of Childhood Cancer

In a Dutch study reported in JACC: CardioOncology, Leerink et al found that the addition of ejection fraction measurement at the time of first surveillance echocardiogram improved prediction of 10-year risk of left-ventricular systolic dysfunction vs prediction based on cumulative anthracycline and ...

gynecologic cancers
survivorship
symptom management

Lauren Thomaier, MD, on Predicting Chemotherapy-Induced Peripheral Neuropathy in Gynecologic Cancer Survivors

Lauren Thomaier, MD, of the University of Minnesota, discusses the genetic variants found to be associated with an increase in chemotherapy-induced neuropathy symptoms in a cohort of gynecologic cancer survivors. Combining these variants with clinical characteristics may provide an important treatment tool (ID# 10253).

Colorectal Cancer
Survivorship

Use of Chemotherapy and Risk of Alzheimer’s Disease in Colorectal Cancer Survivors

In a retrospective cohort study reported in JCO Oncology Practice, Akushevich et al found that receipt of chemotherapy was associated with a reduced risk of Alzheimer’s disease in colorectal cancer survivors. As stated by the investigators, “Evidence on the nature of the relationship between...

CNS Cancers
Survivorship

Weight Gain in Childhood Brain Tumor Survivors and Potential Association With Hypothalamic-Pituitary Dysfunction

In a Dutch study reported in the Journal of Clinical Oncology, van Schaik et al found that significant weight gain and being overweight and/or obese are common in childhood brain tumor survivors and may be associated with hypothalamic-pituitary dysfunction. Study Details The study involved data...

Lymphoma
Survivorship

Effect of Risk-Adapted Therapy on Long-Term Morbidity in Pediatric Patients With Hodgkin Lymphoma

In an analysis from the Childhood Cancer Survivor Study reported in the Journal of Clinical Oncology, Kevin C. Oeffinger, MD, and colleagues found that adoption of risk-adapted therapy in the 1990s was associated with reduced risk of serious chronic health conditions in pediatric Hodgkin lymphoma...

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