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Your search for The ASCO Post Staff,The ASCO Post Staff matches 6721 pages

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gastroesophageal cancer

Trastuzumab Deruxtecan Improves Survival Outcomes in Patients With HER2-Positive Gastric/GEJ Cancer in Second-Line Setting

The international phase III DESTINY-Gastric04 clinical trial found that second-line treatment with fam-trastuzumab deruxtecan-nxki can help people with advanced HER2-positive gastric cancers that have grown during first-line treatment live about 3 months longer. These findings further support the...

lung cancer

Molecular Assay Identifies Patients With Early NSCLC Likely to Benefit From Adjuvant Chemotherapy

Results from an international clinical trial show that a 14-gene molecular assay can help identify patients with early-stage nonsquamous non–small cell lung cancer (NSCLC) who could benefit from adjuvant chemotherapy after surgery. The research will be presented at the 2025 ASCO Annual Meeting...

breast cancer

Vepdegestrant Improves Progression-Free Survival in Select Patients With ESR1-Mutant Advanced Breast Cancer

Results from VERITAC-2 trial showed that the proteolysis-targeting chimera (PROTAC) vepdegestrant could extend progression-free survival for people with previously treated estrogen receptor (ER)-positive, HER2-negative advanced breast cancer with an ESR1 mutation. The research will be presented at...

colorectal cancer

Encorafenib/Cetuximab Plus Chemotherapy Improves Survival in BRAF V600E–Mutant Metastatic Colorectal Cancer

Results from an international phase III study showed that the targeted therapy combination of encorafenib and cetuximab with mFOLFOX6 (leucovorin, fluorouracil, and oxaliplatin) chemotherapy may help patients with BRAF V600E–mutant metastatic colorectal cancer live longer. After early results from...

issues in oncology

ASCO 2025: Alcohol-Related Cancer Deaths Are on the Rise in the United States

A new study led by experts at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, is the first to look at trends over time in alcohol-linked cancer mortality across the United States. The findings were presented at the 2025 ASCO Annual Meeting (Abstract ...

lung cancer
issues in oncology

ASCO 2025: Impact of Wildfire-Related Pollution on Survival in NSCLC

Inhaling wildfire-related air pollution may reduce the likelihood of survival among patients with non–small cell lung cancer (NSCLC), according to new findings presented by Singhal et al at the 2025 ASCO Annual Meeting (Abstract 10520). Background Wildfire-related air pollution contains particulate ...

prostate cancer
immunotherapy

Subset of Men With Rare Prostate Cancer May Benefit From Immunotherapy Added to Chemotherapy and Targeted Maintenance Therapy

Treatment options for aggressive-variant prostate cancer are limited, but a subset of patients have had promising long-term responses with a combination of carboplatin plus cabazitaxel chemotherapy, followed by PARP inhibitor maintenance. This novel combination treatment approach was the focus of a ...

solid tumors
sarcoma

Spatial Transcriptomics Identifies Novel Subtypes Associated With Disease Prognosis in Leiomyosarcoma

Patients with leiomyosarcoma experience a high risk of recurrence and have limited treatment options. No biomarkers or targetable mutations currently improve diagnosis, prognosis, or treatment. Spatial transcriptomics, which are rarely used in sarcomas, may provide insights into leiomyosarcoma...

myelodysplastic syndromes

Study Finds Novel Triplet Regimen Safe and Effective for Patients With Higher-Risk MDS and CMML

Patients with higher-risk myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) often experience temporary responses to current treatments, such as hypomethylating agents, which leads to an increased risk of the disease evolving to acute myeloid leukemia. In a phase II study,...

kidney cancer
immunotherapy

CAR T-Cell Therapy Continues to Demonstrate Activity in Advanced Clear Cell Renal Cell Carcinoma

For patients with metastatic clear cell renal cell carcinoma who did not benefit from checkpoint and tyrosine kinase inhibitors, limited alternative treatment options are available. ALLO-316 is a novel chimeric antigen receptor (CAR) T-cell therapy designed to recognize and kill cells expressing...

colorectal cancer

Online Genetic Testing Platform Demonstrates Notable Engagement Among Patients With Young-Onset Colorectal Cancer

Universal germline testing is essential for identifying hereditary cancer risk, especially for patients with young-onset colorectal cancer who were diagnosed before the age of 50. However, the implementation of universal germline testing has been hampered by increasing demand and limited physician...

multiple myeloma

Genomic Score May Predict Progression From Precursor Condition to Active Multiple Myeloma

Investigators have developed a genomic score, called multiple myeloma-like (MM-like), for predicting progression from multiple myeloma precursor conditions to active cancer, study results published in Nature Genetics showed. The researchers created a map of the genome of multiple myeloma and its...

breast cancer
gynecologic cancers
issues in oncology

Climate Change and Risk for Breast and Gynecologic Cancers

Climate change may be contributing to a small but notable increase in the incidence and mortality rates of breast, ovarian, endometrial, and cervical cancers in the Middle East and North Africa, according to a recent study published by Mataria and Chun in Frontiers in Public Health. Background...

multiple myeloma

Physical Function Acts as Predictor of Survival for Daratumumab-Based Therapy in Multiple Myeloma

Patients with multiple myeloma who had lower physical function scores at the time of treatment initiation demonstrated a greater benefit to daratumumab treatment than those with higher physical function scores, according to the results of a study published in the European Journal of Haematology....

pancreatic cancer
issues in oncology

Alcohol May Be Linked to Higher Risk of Pancreatic Cancer

Investigators may have uncovered a modest but potentially significant association between alcohol consumption and the risk of developing pancreatic cancer, according to a recent study published by Naudin et al in PLOS Medicine. Background Pancreatic cancer is the twelfth most common cancer type...

issues in oncology
supportive care

ESMO Releases Version 2.0 of the Magnitude of Clinical Benefit Scale

The European Society for Medical Oncology (ESMO) has announced the publication of the latest version of its scale that measures the clinical benefit of cancer treatments, the ESMO-MCBS (ESMO-Magnitude of Clinical Benefit Scale). The ESMO-MCBS was first introduced in 2015 and updated to version 1.1...

colorectal cancer

DOJ Finds Federal Bureau of Prisons’ Colorectal Cancer Screening Practices Lacking

An evaluation by the Department of Justice Office of the Inspector General (DOJ OIG) of the Federal Bureau of Prisons’ (BOP) colorectal cancer screening practices for inmates and their clinical follow-up for positive screenings found several serious operational and managerial deficiencies...

skin cancer
genomics/genetics

Use of Niraparib in Patients With Advanced Melanoma

Researchers may have uncovered early indications of the clinical benefit of niraparib in patients with advanced melanoma whose tumors have specific genetic changes impacting DNA repair, according to a recent study published by Kim et al in JCO Precision Oncology. Background The U.S. Food and Drug...

W. Kimryn Rathmell, MD, PhD, FASCO, Named CEO of OSUCCC-James

Following a comprehensive national search, W. Kimryn Rathmell, MD, PhD, FASCO, former Director of the National Cancer Institute (NCI), has accepted the role of Chief Executive Officer (CEO) of The Ohio State University Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J....

Fellows of the AACR Academy Class of 2025

Listed here is the newly elected 2025 class of Fellows of the American Academy for Cancer Research (AACR) Academy, which was recognized at the AACR Annual Meeting, April 25–30, 2025, in Chicago. Rafi Ahmed, PhD, Atlanta, Georgia Sir Shankar Balasubramanian, PhD, Cambridge, UK Bradley Bernstein, MD, ...

issues in oncology

The Power of Translational Science to Transform the Lives of Patients Worldwide

Despite a 30-year history as an ASCO volunteer, for Eric J. Small, MD, FASCO, this past year as President-Elect has opened new perspectives on the organization he will soon lead as ASCO’s 62nd President, effective during the 2025 ASCO Annual Meeting, May 30–June 3, 2025, in Chicago. After serving...

breast cancer

Inavolisib-Based Regimen in PIK3CA-Mutated, HR-Positive, HER2-Negative Advanced Breast Cancer

New findings from the phase III INAVO120 trial showed that adding inavolisib to palbociclib and fulvestrant may help extend survival and delay the time until treatment with chemotherapy in previously treated patients with PIK3CA-mutated, HR-positive, HER2-negative advanced breast cancer. The...

lung cancer

Extensive-Stage SCLC: Lurbinectedin and Atezolizumab

Results from a global phase III clinical trial found that maintenance therapy with a combination of the alkylating agent lurbinectedin and the PD-L1 inhibitor atezolizumab improved survival in some patients with extensive-stage small cell lung cancer (SCLC) compared with maintenance therapy with...

head and neck cancer

WGS Liquid Biopsies for HPV-Associated Head and Neck Squamous Cell Carcinoma

Whole-genome sequencing (WGS)-based circulating tumor DNA (ctDNA) detection of human papillomavirus (HPV)-associated head and neck squamous cell carcinoma (HNSCC), termed HPV-DeepSeek by the study investigators, showed greater sensitivity, specificity, and diagnostic accuracy than any current...

breast cancer

Abbreviated MRI Scans in Detecting Breast Cancer for Women With Dense Breasts

Abbreviated breast MRI scans demonstrated comparable diagnostic accuracy to full multiparametric protocol MRI scans for women with extremely dense breasts, according to findings from the DENSE trial published in Radiology.   MRI scans have greater diagnostic accuracy than mammograms for women with...

prostate cancer
issues in oncology

Revealing Critical Insights for Precision Medicine in Patients With Metastatic Prostate Cancer

Investigators may have uncovered key differences in tumor biology but similarities in survival outcomes in instances of equal access to care between non-Hispanic Black and non-Hispanic White men with metastatic prostate cancer, according to a recent study published by Valle et al in JAMA Network...

breast cancer

Breast Cancer: Genome-Wide Study Identifies Two New Risk Genes in Black South African Women

Investigators have identified two genetic risk loci that may be associated with an increased risk of breast cancer for Black South African women, according to findings from a genome-wide association study published in Nature Communications.   The two risk loci were between UNC13C and RAB27A on...

issues in oncology

A High Proportion of U.S. Adults Are Behind on Cancer Screenings

Investigators have found that a large proportion of U.S. adults are behind on their cancer screenings, according to a new survey from the American Cancer Society Cancer Action Network (ACS CAN). Survey Methods and Findings In the Survivor Views Special Report: National Screening Survey,...

cns cancers
issues in oncology

Gabapentin May Extend Survival in Patients With Glioblastoma

Investigators have found that the antiseizure/pain drug gabapentin may be associated with improved survival in patients with glioblastoma, according to a recent study published by Bernstock et al in Nature Communications. Background With about 12,000 new cases diagnosed annually in the United...

breast cancer

Stromal Disruption Associated With Higher Risk of Developing Aggressive Breast Cancer

Investigators from the National Cancer Institute (NCI) identified changes in stromal breast tissue, called stromal disruption, that may help to identify women with a higher risk of developing breast cancer, according to study findings published in the Journal of the National Cancer Institute. Women ...

prostate cancer

Former President Biden Diagnosed With Metastatic Prostate Cancer

According to his office, Former President Joseph R. Biden Jr has been diagnosed with an “aggressive” type of prostate cancer that has spread to his bones. The New York Times reported that Mr. Biden’s cancer “is characterized by a Gleason score of 9 with metastasis to the bone.” The American Cancer...

gynecologic cancers
issues in oncology

Risk of Gynecologic Cancers After 5 Years of Testosterone Use

Transmasculine and gender-diverse patients receiving testosterone as part of their hormone therapy may not be at an increased risk of developing gynecologic cancers in the first years of treatment, according to a recent study published by Vestering et al in eClinicalMedicine. Background Many...

issues in oncology
symptom management

Novel Prediction Model for Hearing Loss From Chemotherapy in Pediatric Patients With Cancer

In a study reported in the Journal of Clinical Oncology, Millstein et al attempted to develop a predictive model—Pediatric Holistic Evaluation of Auditory Risk (PedsHEAR)—for hearing loss associated with cisplatin chemotherapy in children and adolescents with cancer. Study Details PedsHEAR was...

colorectal cancer

Neoadjuvant Therapy for IBD-Related Rectal Cancer

Total neoadjuvant therapy of intensified chemoradiotherapy was shown to be less effective for treating patients with rectal cancer with inflammatory bowel disease (IBD) than those with sporadic rectal cancer, according to study findings presented during Digestive Disease Week 2025. However, there...

breast cancer

Second-Line Endocrine Therapy With/Without Palbociclib Rechallenge in HR-Positive, HER2-Negative Advanced Breast Cancer

In a phase II trial (PALMIRA) reported in the Journal of Clinical Oncology, Llombart-Cussac et al evaluated whether palbociclib rechallenge with second-line alternative endocrine therapy may improve progression-free survival vs second-line alternative endocrine therapy alone. Study Details In the...

colorectal cancer

Retifanlimab-dlwr Approved for Anal Cancer

On May 15, the U.S. Food and Drug Administration (FDA) approved retifanlimab-dlwr (Zynyz), a PD-1–blocking monoclonal antibody, with carboplatin and paclitaxel for the first-line treatment of adults with inoperable locally recurrent or metastatic squamous cell carcinoma of the anal canal (SCAC)....

breast cancer

Breast Parenchymal Phenotypes and Risk of Breast Cancer

Six parenchymal phenotypes were established that may be associated with a higher risk of developing breast cancer. Studies of these phenotypes identified by radiomics on mammograms demonstrated that these patterns were associated with an increased risk of invasive breast cancer, according to...

lung cancer

FDA Approves Therapy for NSCLC With High c-Met Protein Overexpression

On May 14, the U.S. Food and Drug Administration (FDA) granted accelerated approval to telisotuzumab vedotin-tllv (Emrelis), a c-Met–directed antibody and microtubule inhibitor conjugate, for adults with locally advanced or metastatic, nonsquamous, non–small cell lung cancer (NSCLC) with high c-Met ...

neuroendocrine tumors

FDA Approves First Oral Therapy for Pheochromocytoma and Paraganglioma

On May 14, the U.S. Food and Drug Administration approved the oral hypoxia-inducible factor-2 alpha (HIF-2α) inhibitor belzutifan (Welireg) for patients aged 12 years and older with locally advanced, unresectable, or metastatic pheochromocytoma or paraganglioma (PPGL). This represents the first FDA ...

legislation
health-care policy

Patient Advocacy Groups: Health-Care Programs Are Lifelines—Not Line Items

Forty nonprofit, nonpartisan organizations issued a statement this week to the House Energy & Commerce and Ways & Means Committees in regard to budget cuts and policy changes affecting Medicaid and health-care marketplaces. “As organizations representing millions of patients with serious...

prostate cancer

Elective Nodal Radiotherapy for Oligorecurrent Nodal Prostate Cancer Metastases

In a phase II trial (PEACE V–STORM) reported in The Lancet Oncology, Ost et al found that elective nodal radiotherapy (ENRT) to the pelvis was associated with longer metastasis-free survival vs metastasis-directed therapy (MDT) in patients with pelvic nodal oligorecurrences of prostate cancer....

FDA OCE Announces Project Interface Outreach Initiative

The Oncology Center of Excellence (OCE) at the U.S. Food and Drug Administration (FDA) has launched Project Interface to advance engagement and outreach to patients with cancer, advocacy organizations, and oncology experts.  Its mission is to protect, promote, and advance public health by...

palliative care

AI Model Estimates Biological Age and Predicts Survival in Patients With Cancer

FaceAge, a deep learning system, was developed and validated to estimate biological age from photographs of faces. In a study published in The Lancet Digital Health, FaceAge showed the ability to predict short-term outcomes in patients with cancer.   The study demonstrated that FaceAge could...

breast cancer
gynecologic cancers

Cohort Study Shows Benefits of Bilateral Salpingo-Oophorectomy Without Increased Health Risks

Patients with a history of breast cancer who are carriers of BRCA1 and BRCA2 pathogenic variants benefit from undergoing bilateral salpingo-oophorectomy, the results of a retrospective cohort study published in The Lancet Oncology showed. Women who had their ovaries and fallopian tubes removed...

hematologic malignancies
solid tumors
issues in oncology
supportive care

GLP-1 Receptor Agonists Could Show Anticancer Benefits Beyond Weight Loss

First-generation weight-loss drugs like liraglutide and exenatide could show anticancer benefits beyond weight loss, according to findings from a retrospective, observational study presented by Sagy et al at the European Congress on Obesity (ECO) 2025 and simultaneously published in...

breast cancer
issues in oncology

Combination of Weight Gain, Age at Pregnancy Could Increase Breast Cancer Risk

Investigators have found that the risk of developing breast cancer could be nearly three times higher among women who experience notable weight gain after the age of 20 years and either give birth after age 30 or don’t have children compared with those who give birth before age 30 and whose weight...

solid tumors
hematologic malignancies

Annual or Biennial Multicancer Early Detection Screening Improves Patient Outcomes

The addition of multi-cancer early detection screening using a single blood sample improved patient outcomes whether conducted on an annual or every 2-year basis, according to findings from a modelling study published in BMJ Open.   With earlier detection of disease progression, many cancers could...

gynecologic cancers

FDA Approves At-Home Self-Collection Device for Cervical Cancer Screening

Teal Health announced the U.S. Food and Drug Administration’s (FDA) approval of the Teal Wand™, an at-home vaginal sample self-collection device for cervical cancer screening in the United States. The Teal Wand is a prescription device that will soon be available at getteal.com for individuals aged ...

gynecologic cancers

FDA Approves Doublet for KRAS-Mutated, Recurrent, Low-Grade Serous Ovarian Cancer

Today, the U.S. Food and Drug Administration (FDA) granted accelerated approval to the combination of the dual RAF/MEK inhibitor avutometinib and the FAK inhibitor defactinib (Avmapki Fakzynja Co-pack) for adults with KRAS-mutated, recurrent, low-grade serous ovarian cancer (LGSOC) who have...

issues in oncology

Patterns in Oncology Drug Use After Accelerated Approval Is Withdrawn

The accelerated approval program of the U.S. Food and Drug Administration (FDA) allows certain medications to be marketed if they are indicated for serious disease and there has been preliminary evidence of the drug’s efficacy. Pharmaceutical companies must then conduct postapproval trials to...

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