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issues in oncology

Cardinale B. Smith, MD, PhD, on Redesigning Care Coordination From the Patient’s Perspective

Cardinale B. Smith, MD, PhD, of the Icahn School of Medicine at Mount Sinai, discusses results of a pilot study suggesting dedicated lay staff members, who facilitated admissions and discharges for patients with cancer across care settings, could improve health-care utilization, quality, and the...

issues in oncology
covid-19

Cardinale B. Smith, MD, PhD, on Telehealth Disparities During the COVID-19 Pandemic

Cardinale B. Smith, MD, PhD, of the Icahn School of Medicine at Mount Sinai, discusses findings showing Black, Hispanic, and Asian patients with cancer used telehealth less often during the COVID-19 pandemic than White patients with cancer, a negative trend that will become more problematic as this ...

genomics/genetics
cns cancers

Radiation-Induced Genetic Deletions May Be Associated With Poorer Patient Outcomes

Treatment of diffuse gliomas with radiotherapy resulted in an increased number of genomic small deletions that make up a unique signature, according to findings presented at the Molecular Analysis for Precision Oncology (MAP) Congress 2020 (Abstract 2MO). Furthermore, an increased burden of...

lung cancer
genomics/genetics

Do Patients With Early-Stage NSCLC Have a Higher Tumor Mutational Burden Than Those With More Advanced Disease?

The tumors of patients with stage I and II non–small cell lung cancer (NSCLC) demonstrated a generally higher tumor mutational burden and more often displayed the mutational signature associated with tobacco smoking than those of patients with more advanced disease, according to findings presented...

colorectal cancer

ASTRO Issues Clinical Guideline on Radiation Therapy for Rectal Cancer

A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides guidance for physicians who use radiation therapy to treat patients with locally advanced rectal cancer. Recommendations outline indications and best practices for pelvic radiation treatments, as well as the...

Dr. Christina Cone Honored With The Mary Pazdur Award for Excellence in Advanced Practice in Oncology by APSHO

The Advanced Practitioner Society for Hematology and Oncology (APSHO) presented the third annual Mary Pazdur Award for Excellence in Advanced Practice in Oncology to Christina Cone, DNP, APRN, ANP-BC, AOCNP®, of Duke Cancer Institute, at the JADPRO Live Virtual conference, an annual educational...

palliative care

Behavioral Nudges Combined With Machine Learning Mortality Estimates May Improve Rate of Advanced Cancer Care Conversations

An electronic nudge to clinicians—triggered by an algorithm that used machine-learning methods to flag patients with cancer who would most benefit from a conversation around end-of-life goals—tripled the rate of those discussions, according to a new prospective, randomized study of nearly 15,000...

bladder cancer
immunotherapy

Neoadjuvant Dual Checkpoint Blockade in Certain Patients With Localized Bladder Cancer

Neoadjuvant combination therapy with the anti–CTLA-4 therapy tremelimumab and the anti–PD-1 therapy durvalumab was well tolerated and showed early signs of activity in patients ineligible to receive cisplatin-based chemotherapy, all of whom had tumors with high-risk features that are associated...

lung cancer
genomics/genetics

Fragment Analysis as a MET Exon 14 Screening Strategy in NSCLC Tumors

Comparison of two techniques used in screening non–small cell lung cancer (NSCLC) tumor samples demonstrated that fragment analysis could detect large MET exon 14 skipping deletions that were missed by next-generation sequencing, according to findings presented at the Molecular Analysis for...

symptom management

Anne M. Barry-Weers, RN, on Decreasing Hospitalizations for Patients Receiving IV Chemotherapy

Anne M. Barry-Weers, RN, of Aurora Health Care/Aurora Cancer Care in Milwaukee, discusses strategies that helped patients with cancer to better manage their chemotherapy-related symptoms at home, thus reducing visits to the emergency department and inpatient admissions, and improving treatment...

geriatric oncology
symptom management

Marie A. Flannery, PhD, and Eva Culakova, PhD, on Managing Symptoms in Older Adults With Advanced Cancer

Marie A. Flannery, PhD, and Eva Culakova, PhD, both of the University of Rochester, discuss a geriatric assessment tool that helped reduce symptomatic toxicities, as measured by Patient-Reported Outcomes Common Terminology Criteria for Adverse Events (Abstract 138).

issues in oncology

Katherine Enright, MD, MPH, on Improving the Quality of Oral Cancer Drug Delivery

Katherine Enright, MD, MPH, of Trillium Health Partners in Ontario, discusses a model of quality improvement, which potentially could be adapted across health systems to improve oral systemic cancer care (Abstract 184).

issues in oncology

Joseph M. Unger, PhD, on Patient Interest in Clinical Trial Enrollment: A New Analysis

Joseph M. Unger, PhD, of Fred Hutchinson Cancer Research Center, discusses study results showing that more than half of all patients with cancer, regardless of race or ethnicity, agree to take part in clinical trials, a finding that upends conventional beliefs. He talks about removing the barriers...

skin cancer

Long-Term Benefit of Adjuvant Immunotherapy Sustained in Stage III or IV Melanoma

The benefit of anti–PD-1 antibodies in the adjuvant treatment of patients with stage III or stage IV melanoma continues to be observed at around 4 years for both pembrolizumab and nivolumab, according to updates of pivotal trials presented at the European Society for Medical Oncology (ESMO) Virtual ...

breast cancer
issues in oncology

Limited English-Language Proficiency May Affect Frequency of Screening Mammograms

Limited English-language proficiency may be a risk factor for receiving screening mammograms less often, according to new study results using national data. These findings, concerning women age 40 and older living in the United States, were presented at the American College of Surgeons Clinical...

leukemia
geriatric oncology

FDA Approves Venetoclax Combination Regimen for Certain Adult Patients With AML

On October 16, the U.S. Food and Drug Administration (FDA) granted regular approval to venetoclax (Venclexta) in combination with azacitidine, decitabine, or low-dose cytarabine for newly diagnosed acute myeloid leukemia (AML) in adults age 75 or older or who have comorbidities precluding intensive ...

bladder cancer

Urine-Based Liquid Biopsy May Perform Similarly to Urine Cytology in Detecting Urothelial Carcinoma

Analysis of DNA copy number variants in the cells exfoliated in urine showed improved sensitivity and similar specificity in detecting urothelial carcinoma compared to urine cytology, according to results published by Zeng et al in Clinical Cancer Research. “Urine cytology, which is widely used to...

colorectal cancer
cost of care

Veena Shankaran, MD, on Colorectal Cancer: Cumulative Financial Hardship of Treatment

Veena Shankaran, MD, of the Seattle Cancer Care Alliance, discusses study findings from a national sample of patients with metastatic colorectal cancer who are on systemic therapy. A year into their treatment, nearly three out of four patients had major financial hardships despite access to health...

lymphoma
immunotherapy

FDA Extends the Approval of Pembrolizumab for Patients With Classical Hodgkin Lymphoma

On October 14, the U.S. Food and Drug Administration (FDA) extended the approval of pembrolizumab (Keytruda) for the following indications:   Adult patients with relapsed or refractory classical Hodgkin lymphoma Pediatric patients with refractory classical Hodgkin lymphoma or classical Hodgkin...

skin cancer

ASCO’s Policy Statement on Skin Cancer Prevention Focuses on Four Key Areas to Reduce Incidence and Save Lives

The increasing incidence rates of skin cancer in the United States are staggering. It is the most common cancer diagnosed in the country, and current estimates show that about 9,500 Americans are diagnosed with skin cancer every day. Over the course of a year, more than 3 million people are...

breast cancer
covid-19

Melissa K. Accordino, MD, on Breast Cancer Care Delivery: Impact of the COVID-19 Pandemic

Melissa K. Accordino, MD, of Columbia University Medical Center, discusses findings showing nearly half of the patients with breast cancer treated at an academic center in New York City experienced a change or delay in their workup or treatment during the COVID-19 pandemic. Race and socioeconomic...

issues in oncology
breast cancer

Do Hospitals That Primarily Serve Minority Patients Offer Standard Surgical Care for Patients With Breast Cancer?

Among accredited cancer centers in the United States, hospitals serving primarily minority patients are as likely as other hospitals to offer the standard of surgical care for early-stage breast cancer, according to results presented at the virtual American College of Surgeons Clinical Congress...

covid-19

New Study Offers a Global Review of the Impact of COVID-19 on Cancer Treatment and Research

A recent review of scientific literature showed that the COVID-19 pandemic has impacted virtually every aspect of cancer care and research—from introducing new risks for patients to disrupting the delivery of treatment and the continuity of research. The report, published by Ziad Bakouny, MD, and...

breast cancer
symptom management

Can Routine Scans Help Predict Which Patients With Breast Cancer May Be at Risk for Heart Disease?

Automated analysis of the routine scans of patients with breast cancer may help to predict which women have a greater risk of developing cardiovascular disease, according to research presented by Gal et al at the 12th European Breast Cancer Conference (Abstract 7). Women who have been treated for...

lymphoma
immunotherapy

Identifying Characteristics of Infused CAR T Cells Associated With Efficacy and Toxicity in Patients With Large B-Cell Lymphoma

Researchers have identified molecular and cellular characteristics of anti-CD19 chimeric antigen receptor (CAR) T-cell infusion products associated with how patients with large B-cell lymphoma respond to treatment and develop side effects. The research team also found that early changes in...

head and neck cancer
pain management

Oral Cancer Pain May Predict Likelihood of Metastasis

Oral cancer may be more likely to spread in patients experiencing high levels of pain, according to a team of researchers who found genetic and cellular clues as to why metastatic oral cancers are so painful. These findings were published by Bhattacharya et al in Scientific Reports. Researchers...

sarcoma

Matti S. Aapro, MD, on Curing Sarcomas: An Expert Review

Matti S. Aapro, MD, of the Genolier Cancer Center, reviews the state of the science in sarcoma treatment: specialized surgery, disease diversity, emerging therapies, and the diagnostic approach to soft-tissue disease.

pancreatic cancer

Making Strides in the Management of Pancreatic Cancer

The Special Conference on Pancreatic Cancer, sponsored by the American Association for Cancer Research (AACR) and held virtually this year, showcased cutting-edge discoveries and promising advances in the understanding and treatment of pancreatic cancer, reported by some of the world’s foremost...

hematologic malignancies
immunotherapy
gastroesophageal cancer
gastrointestinal cancer

FDA Pipeline: Designations for Treatments of Rare Blood Cancer, B-Cell Malignancies, and Gastric Cancers

Recently, the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy designation to an antibody-drug conjugate for the treatment of patients with relapsed or refractory blastic plasmacytoid dendritic cell neoplasm (BPDCN); gave Fast Track designation to a novel chimeric antigen...

prostate cancer
supportive care

New Study Finds Low Rates of Bone Mineral Density Testing in Men Treated With ADT for Prostate Cancer

A report published by Hu et al in JNCCN—Journal of the National Comprehensive Cancer Network found the rate of bone mineral density testing in people with prostate cancer undergoing androgen-deprivation therapy (ADT) has improved in recent years, but remains low. ADT is considered a cornerstone of...

breast cancer
immunotherapy

NeoALTTO Trial: Final Analysis Examines Neoadjuvant Lapatinib/Trastuzumab in HER2-Positive Breast Cancer

Final analysis of results from a randomized clinical trial of lapatinib and trastuzumab given before surgery in patients with early HER2-positive breast cancer has found that women who had a pathologic complete response survived longer without cancer recurrence than patients who did not. This was...

Dana-Farber Opens Clinical Trial to Evaluate Simple Blood Test for Many Types of Cancer

Recent advances such as immune, cellular, and targeted therapies have provided new and effective means to treat a variety of cancers. Despite this considerable progress, cancer caught in its earliest stages remains the most curable. That is why Dana-Farber Cancer Institute is opening a new clinical ...

Dana-Farber Cancer Institute to Establish Benderson Family Program for Triple-Negative Breast Cancer

Dana-Farber Cancer Institute has received a $5 million gift from the Benderson Family of Sarasota, Florida, that will accelerate research in triple-negative breast cancer (TNBC) and strengthen Dana-Farber’s capabilities for treating this disease. The gift establishes the Benderson Family Program...

pain management
palliative care
issues in oncology

How Anxiety, Depression, and Low Social Support Impact the Intensity of Cancer Pain

Pain is one of the most common byproducts of cancer and its treatment. Tumors, surgery, intravenous chemotherapy, radiation therapy, targeted therapy, supportive care therapies (such as bisphosphonates), and diagnostic procedures can all cause pain in patients and may contribute to symptoms of...

Debbie’s Dream Foundation Launches New COVID-19 Resources and Support Program

Debbie’s Dream Foundation: Curing Stomach Cancer (DDF) recently announced its new COVID-19 Resources and Support Program. The program’s primary goal is to support, educate, and protect the already vulnerable stomach cancer community during the pandemic. The new initiative will help patients with...

Immunologist Thirumala-Devi Kanneganti, PhD, Receives NCI Outstanding Investigator Award

Thirumala-Devi Kanneganti, PhD, Vice Chair of the St. Jude Children’s Research Hospital Department of Immunology, has received a National Cancer Institute (NCI) Outstanding Investigator Award to build on her discoveries related to the innate immune system, inflammation, and cell death in health and ...

issues in oncology
gynecologic cancers
colorectal cancer
covid-19

A Primary Care Physician Explores Barriers to Cancer Prevention and Clinical Trial Accrual

To accelerate progress in the survival rates of people with cancer in the United States and to reduce cancer disparities across the entire spectrum of cancer from diagnosis to survivorship, there needs to be increased access to cancer screening and prevention programs. To shed light on this...

covid-19
issues in oncology

Mobilizing for Greater Equity in Health Care Despite the Challenges of COVID-19

The lockdown phase of the coronavirus (COVID-19) pandemic and continued measures, such as social distancing, while necessary, are disrupting cancer care in ways that will have consequences for months, if not years, to come. Studies are showing that delayed or suspended cancer treatments,...

$111 Million NIH Grant Awarded to Prevent and Treat HIV-Associated Cancers

The widespread use of antiretroviral therapy to suppress the human immunodeficiency virus (HIV) has helped tens of millions of people with HIV live healthier, longer lives—but an unfortunate consequence of people living longer with HIV is an increased risk of cancer. For 25 years, the AIDS...

LUNGevity Foundation Recognizes Recipients of 2020 Career Development Awards

LUNGevity Foundation, a nonprofit organization, recently announced three recipients of its 2020 Career Development Awards for lung cancer research. These awards were presented to Kathyrn Arbour, MD, Assistant Attending at Memorial Sloan Kettering Cancer Center; Carl Gay, MD, PhD, of The University...

solid tumors
pancreatic cancer

My Inherited Condition Has Led to a Life and Career I Love

My father died of thymic cancer when I was 14, and that’s when I decided to become an oncologist. Ironically, the first patient I diagnosed with cancer was me. In 2009, during my first week of training in hematology/oncology at the Mayo Clinic, I began having severe abdominal pain, which had...

City of Hope Hires Stephen Gruber, MD, PhD, MPH, to Head Its Center for Precision Medicine

Cancer geneticist Stephen Gruber, MD, PhD, MPH, has joined City of Hope as Director of its newly founded Center for Precision Medicine. He will lead a team of more than 14 researchers who will work across the institution to pioneer personalized cancer prevention and treatment plans. As a medical...

2020 Class of Giants of Cancer Care Announced

The Eighth Annual Giants of Cancer Care class of inductees was recently announced by OncLive, a multimedia resource focused on providing oncology professionals with relevant information on patient care. The virtual awards ceremony will be held on November 5 at 7.30 PM EST and will be available...

issues in oncology
colorectal cancer

Study Finds Racial Disparities in Management of Colorectal Cancer Spreading to the Liver

Colorectal cancer is more prevalent among Black people, a group with the highest rates of death for an illness that is curable if caught early. “The unfortunate reality is that minorities, especially Black people, have a much lower chance of getting life-saving cancer treatment. Health care works...

solid tumors
head and neck cancer

Neck Tumor

The text and photographs here are excerpted from a four-volume series of books titled Oncology: Tumors & Treatment, A Photographic History, The Anesthesia Era 1845–1875 by Stanley B. Burns, MD, FACS, and Elizabeth A. Burns. The photograph appears courtesy of Stanley B. Burns, MD, and The Burns...

University of Rochester School of Medicine and Dentistry Names Ruth O’Regan, MD, Chair, Department of Medicine

Ruth O’Regan, MD, Chief of Hematology, Medical Oncology and Palliative Care at the University of Wisconsin, has been named the next Charles A. Dewey Professor and Chair of Medicine at the University of Rochester Medical Center’s (URMC) School of Medicine and Dentistry, pending approval by the...

Cedars-Sinai Announces Addition of New Researchers, Physicians to Faculty

In a news release issued earlier this month, Dan Theodorescu, MD, PhD, Director of Cedars-Sinai Cancer Center in Los Angeles, welcomed several new researchers and physicians to the faculty of the institution. “I am very grateful to the institutional leadership that our efforts to expand the breadth ...

covid-19

A Young Oncologist Cares for Patients With Cancer Amid COVID-19 Pandemic

The COVID-19 pandemic changed the face of U.S. health-care services in such rapid fashion that many providers were caught off guard, learning and preparing on the fly. Patients with cancer, given their multiple physical and emotional challenges, were especially vulnerable. To get a sense of the...

breast cancer

Phase III NALA Trial Meets Primary Endpoint in Previously Treated HER2-Positive Breast Cancer

As reported in the Journal of Clinical Oncology by Cristina Saura, MD, of Vall d’Hebron University Hospital, Barcelona, and colleagues, the phase III NALA trial has shown significantly prolonged progression-free survival with the irreversible pan-HER tyrosine kinase inhibitor neratinib plus...

immunotherapy

City of Hope Scientists Explore Combination Immunotherapy for Solid Tumors

City of Hope scientists have combined two immunotherapies—an oncolytic virus and chimeric antigen receptor (CAR) T-cell therapy—to target solid tumors that are otherwise difficult to treat with CAR T-cell therapy alone, according to a recent study in Science Translational Medicine.1 In preclinical...

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