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Showing 5551 - 5600Dana-Farber Cancer Institute to Establish Chen-Huang Center for EGFR-Mutant Lung Cancers
Dana-Farber Cancer Institute will create the Chen-Huang Center for EGFR-Mutant Lung Cancers to stimulate research, promote clinical trials, and strengthen the Institute’s capabilities for studying and treating lung cancer. The Chen-Huang Center is being established with a $5 million gift from...
Largest Single-Year Drop in Cancer Mortality Ever Reported: 2016–2017
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017—the largest single-year drop in cancer mortality ever reported. These findings were reported in “Cancer Statistics, 2020,” the latest edition of the American Cancer Society’s annual report on cancer...
Yale Cancer Center Study Suggests New Approaches Needed to Manage Ibrutinib-Related Toxicities in Patients With CLL
New findings by Yale Cancer Center and Smilow Cancer Hospital researchers show that, as the use of ibrutinib increases in patients with chronic lymphocytic leukemia (CLL), so do the rates of patients who stop taking the drug. The study was presented at the 2019 American Society of Hematology (ASH)...
Cleveland Clinic Taussig Cancer Institute Recognizes New Staff, New Appointments
In a news release issued by Cleveland Clinic Taussig Cancer Institute, the following announcements were made. Center Adds Clinical Psychologist to Staff Melissa Walt, PsyD, a clinical psychologist, recently joined the Cleveland Clinic Taussig Cancer Institute. She will focus on the psychological...
ACCC Project Focuses on Improving Care of Older Adults With Cancer
To prepare the multidisciplinary cancer care team for the growing prevalence of cancer and comorbidities among our nation’s graying population, the Association of Community Cancer Centers (ACCC)—in collaboration with The Gerontological Society of America and the International Society of Geriatric...
AACI Marks Milestone With New Member: Cold Spring Harbor Laboratory
The Association of American Cancer Institutes (AACI) welcomes its newest and 100th member—Cold Spring Harbor Laboratory (CSHL) Cancer Center—one of seven National Cancer Institute–designated basic laboratory cancer centers. The CSHL Cancer Center has nine shared resources that facilitate cancer...
Community Oncology Alliance Elects Officers and New Board Members for 2020
The Community Oncology Alliance (COA) has announced the election of new and re-appointed members to the Board of Directors and Executive Committee. The Board and Committee are comprised of volunteer representatives from community oncology, who direct the management of COA by its Executive ...
Fred Hutch Names Thomas J. Lynch, Jr, MD, as New President and Director
Fred Hutchinson Cancer Research Center recently announced that Thomas J. Lynch, Jr, MD, will become the center’s new President and Director. Dr. Lynch, a cancer expert in solid tumor research, precision medicine, and immuno-oncology, will join Fred Hutch on February 1. Dr. Lynch will become the...
ASH Honors Member of Congress and Leaders of NIDDK and NCI
The American Society of Hematology (ASH) recognized representative Tom Cole (R–OK); the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Hematology and Training Program Director Terry Bishop, PhD; and National Cancer Institute (NCI) Program Director William Merritt, PhD,...
Forbes Magazine Names 2020 Class of 30 Under 30, Including Honorees in Science and Health Care
Forbes magazine released the ninth annual “30 Under 30” list Class of 2020 in December 2019, featuring the newest group of 600 young entrepreneurs, scientists, and innovative individuals who were recognized for their extraordinary accomplishments at early ages. A total of 30 honorees were selected...
FDA Grants Breakthrough Therapy Designation to Tucatinib in Combination Therapy for HER2-Positive Breast Cancer
Seattle Genetics recently announced that the U.S. Food and Drug Administration (FDA) has granted Breakthrough Therapy designation to tucatinib, in combination with trastuzumab and capecitabine, for the treatment of patients with locally advanced unresectable or metastatic HER2-positive breast...
Study Finds African Americans With Cancer Are at Higher Risk for Blood Clots
African Americans appear to be at higher risk for cancer-associated venous thromboembolism than patients with cancer of other races, according to a recent study by Vipul Chitalia, MD, PhD, of Boston University Medical Center, published in the American Journal of Clinical Oncology.1 Several studies...
New NCCN Pediatric Cancer Guidelines for B-Cell Lymphomas
The National Comprehensive Cancer Network® (NCCN®) has published new guidelines for treating children, adolescents, and young adults with pediatric aggressive mature B-cell lymphomas, including Burkitt lymphoma and diffuse large B-cell lymphoma. NCCN published the first pediatric NCCN Clinical...
2020 GI Cancers Symposium: Higher Concentration of Fusobacterium nucleatum Found in Colorectal Tumors in Patients Younger Than 45
A bacterium typically linked to periodontal disease, Fusobacterium nucleatum, could play an important role in the rising incidence of colorectal cancer in people younger than age 45. Another type of bacteria, Moraxella osloensis, has been found in colorectal cancer tumors at a nearly fourfold...
CancerCare to Provide Support for Patients With Cancer Impacted by the California Wildfires
As many California residents continue to deal with the aftermath of past wildfires and the advent of new ones, CancerCare is now offering a patient assistance program for both emotional and financial support to patients with cancer affected by the California fires. As a leading national nonprofit...
Steven N. Kalkanis, MD, Selected to Lead Henry Ford Medical Group
Following a national search, Henry Ford Health System has selected its own Steven N. Kalkanis, MD, as Chief Executive Officer of the Henry Ford Medical Group. He succeeds William A. Conway, MD, who is stepping down after more than 4 decades with the health system. Dr. Kalkanis will provide...
Two New Grants to Support Transformative Cancer Research
Two grants for research that could transform cancer therapies have been funded through an innovative partnership between the American Association for Cancer Research (AACR) and MPM Capital through its management of the UBS Oncology Impact Fund. This unique grant program allows investigators to...
Stephanie Lee, MD, MPH, Begins Term as ASH President
Stephanie Lee, MD, MPH, an expert in graft-vs-host disease as well as blood and bone marrow diseases, will serve as President of the American Society of Hematology (ASH) for a 1-long term through December 2020. Dr. Lee is a member and Associate Director of the Clinical Research Division at Fred...
American Cancer Society Welcomes Three New Members to the Board of Directors
The American Cancer Society (ACS) has announced three new members to the Board of Directors, effective January 1, 2020. Joining the ACS board are Katie Eccles, Patrick Geraghty, and Oyebode Taiwo, MD, MPH. The ACS Board of Directors consists of 21 members, which include 5 officers (elected for a ...
2020 GI Cancers Symposium: Young Adults With Colorectal Cancer Living in Areas of Low Income, Education Likely to Have Worse Survival Outcomes
A retrospective analysis of 26,768 young adults with colorectal cancer aged 40 and under found that those who live in areas with lower income (a median income of less than $38,000) and less education (under 79% high school graduation rate), as well as those who live in urban areas, had worse...
2020 GI Cancers Symposium: Patient-Reported Outcomes From IMbrave150, BEACON CRC
Patient-reported outcomes from two large studies show that quality of life is maintained longer with newer drug combinations compared with standard-of-care treatments in patients with unresectable hepatocellular carcinoma and BRAF V600E–mutant metastatic colorectal cancer. The results, from...
2020 GI Cancers Symposium: Detecting GI Tumors Using a Cell-Free DNA Test
A blood-based screening test using cell-free DNA to identify methylation signals of hard-to-detect gastrointestinal (GI) cancers could potentially help detect disease at earlier stages. This research will be presented by Brian M. Wolpin, MD, MPH, and colleagues at the 2020 Gastrointestinal Cancers...
Does Proton Pump Inhibitor Use Affect Cognition in Breast Cancer Survivors?
Proton pump inhibitors, which are sometimes recommended to ease stomach problems during cancer treatment, may have an unintended side effect: impairment of breast cancer survivors' memory and concentration. These findings were published by Madison et al in the Journal of Cancer Survivorship....
Using T-Cell Fraction to Predict Melanoma Recurrence
In a paper published by Pruessmann et al in Nature Cancer, investigators presented a new, quantitative technique that leverages DNA sequencing to make more sophisticated and accurate predictions about which primary melanomas are likely to recur and spread. "As recently as 10 years ago, the outlook...
Three Studies Examine Relationship Between B-Cell Enrichment and Response to Immunotherapy
The likelihood of a patient responding to immune checkpoint blockade may depend on B cells in the tumor, located within specialized immune-cell clusters known as tertiary lymphoid structures, according to three studies all recently published in Nature. The studies showed that enrichment of B cells...
FDA Pipeline: Priority Reviews in Ovarian Cancer, Prostate Cancer, and NSCLC
This week, the U.S. Food and Drug Administration (FDA) granted Priority Review to treatments for ovarian, prostate, and lung cancer; granted Orphan Drug designation to therapies for chemotherapy-induced thrombocytopenia and multiple myeloma; and granted Breakthrough Device designation to platforms...
Treatment Resistance and Novel Therapies in FGFR-Mutated Cholangiocarcinoma
A new study has shown how resistance to fibroblast growth factor receptor (FGFR) inhibitor treatment develops in patients with cholangiocarcinoma and suggests that adding another therapy at the time of disease progression might resensitize tumor cells to initial therapy. These findings were...
Genomic Aberrations and Pancreatic Cancer Subtypes
Researchers have discovered detailed new genetic information about the subtypes of pancreatic cancer. A better understanding of the disease groups may lead to new treatment options and improved clinical outcomes for this lethal disease, Chan-Seng-Yue et al reported in Nature Genetics. The study...
Are Women in Europe or Asia More Likely to Have Breast-Conserving Therapy Than Those in the United States?
Neoadjuvant systemic therapy can shrink tumors in patients with breast cancer and, in some cases, allow patients to receive breast-conserving therapy who would otherwise require mastectomy. However, in the United States, about 55% of patients who become eligible for breast-conserving therapy after...
Use of Artificial Intelligence for Diagnosing and Grading Prostate Cancer
Researchers have developed a method based on artificial intelligence (AI) for the histopathologic diagnosis and grading of prostate cancer. The study, published by Ström et al in The Lancet Oncology, showed that the AI system can be trained to detect and grade prostate cancer from needle biopsy...
Higher 21-Gene Recurrence Score May Be Associated With Increased Risk of Locoregional Recurrence in Patients With Breast Cancer
A new study shows that a test physicians commonly use to guide chemotherapy for patients with breast cancer after surgery may also help them decide whether radiation therapy may be of benefit. Results published by Wendy A. Woodward, MD, PhD, and colleagues in JAMA Oncology suggest patients with an...
Patients With HPV-Positive and HPV-Negative Oropharyngeal Cancer May Have Different Rates of Mortality
New research indicates that there is a higher risk of early death among patients with oropharyngeal cancer not associated with human papillomavirus (HPV) vs those whose tumors are HPV-positive. The findings are published by Fullerton et al in Cancer. The incidence of oropharyngeal cancer is...
Molecular Characteristics of Leptomeningeal Melanoma Metastases
Patients with advanced melanoma who develop metastases in the leptomeninges usually have a poor prognosis—most patients only survive for 8 to 10 weeks after diagnosis. One reason for this poor prognosis is that very little is known about the molecular development of leptomeningeal melanoma...
Association Between Colorectal Cancer and Ulcerative Colitis
Patients with the inflammatory bowel disease ulcerative colitis have a higher risk of dying from colorectal cancer, despite modern therapy, even though the risk has declined in recent years. Olén et al published these findings in The Lancet. Previous research has shown that patients with ulcerative ...
FDA Pipeline: Fast Track/Orphan Drug Designation for Cholangiocarcinoma Treatment, Breakthrough Device Designation for Bladder Cancer Test
This week, the U.S. Food and Drug Administration (FDA) granted Fast Track designation to infigratinib for patients with advanced or metastatic cholangiocarcinoma with a certain genetic mutation, and Orphan Drug designation to the treatment for patients with cholangiocarcinoma. The FDA also granted...
Does Statin Use Increase Overall Survival in Patients With Colorectal Cancer?
About 40 million adults in the United States take a statin to lower their cholesterol and reduce the risk for heart disease—but they may also be getting an added anticancer benefit, a growing body of evidence suggests. According to research presented at the American Heart Association’s Scientific...
FDA Approves Avapritinib for the Treatment of PDGFRA-Mutated Gastrointestinal Stromal Tumor
On January 9, the U.S. Food and Drug Administration (FDA) approved avapritinib (Ayvakit) for the treatment of adults with unresectable or metastatic gastrointestinal stromal tumor (GIST) that harbors platelet-derived growth factor receptor alpha (PDGFRA) exon 18 mutation. This approval includes...
Step Counts May Help Predict Treatment Outcomes for Patients With NSCLC
A new study suggests step counters could play a role in predicting outcomes for people undergoing chemoradiation therapy for lung cancer. These findings were published by Ohri et al in the International Journal of Radiation Oncology • Biology • Physics. “I consider step counts to be a new vital...
Prevalence of Alcohol Use Among Patients With Cancer and Survivors
New research published by Nina N. Sanford, MD, and colleagues in JNCCN—Journal of the National Comprehensive Cancer Network has found most cancer survivors reported that they are current alcohol drinkers, with a subset of those survivors self-reporting excessive drinking behaviors. “We recommend...
FDA Approves PD-1 Inhibitor for BCG-Unresponsive, High-Risk Non–Muscle Invasive Bladder Cancer
Today, the U.S. Food and Drug Administration (FDA) approved pembrolizumab (Keytruda) for the treatment of patients with bacillus Calmette-Guérin (BCG)-unresponsive, high-risk, non–muscle invasive bladder cancer with carcinoma in situ with or without papillary tumors who are ineligible for or have...
Many Pelvic Examinations and Papanicolaou Tests Performed on Young Women May Be Unnecessary
Pelvic examinations and cervical cancer screenings are no longer recommended for most females under age 21 during routine health visits, but a new study has found that millions of young women are undergoing the tests, which can lead to false-positive testing, overtreatment, anxiety, and needless...
Does Weight-Loss Surgery Lower the Risk of Malignant Melanoma?
Bariatric surgery is associated with a distinct reduction in skin cancer risk, according to findings published by Taube et al in JAMA Dermatology. This finding further substantiates the connection between weight loss and malignant skin cancer. “This [study] provides further evidence for a...
Largest Single-Year Drop in Cancer Mortality Reported in ‘Cancer Statistics, 2020’
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017—the largest single-year drop in cancer mortality ever reported. These findings were reported in “Cancer Statistics, 2020,” the latest edition of the American Cancer Society’s annual report on cancer...
T-DM1 Shows Activity in HER2-Amplified Salivary Gland Cancer in Small Patient Sample of NCI-MATCH
The antibody-drug conjugate ado-trastuzumab emtansine (T-DM1) showed activity in HER2-amplified salivary gland tumors, according to data published by Jhaveri et al in Annals of Oncology. The publication is for ‘Arm Q,’ which is one of nearly 40 single-arm phase II treatments in the NCI-Molecular...
Physical Activity at Recommended Levels May Lower Risk of Multiple Cancers
A pooled analysis of nine prospective studies involving more than 750,000 adults has found that recommended amounts of leisure-time physical activity were linked to a lower risk for seven cancers, with several cancer types having a dose/response relationship. These findings were published by...
One Cycle of Bleomycin/Etoposide/Cisplatin May Be as Effective as Two for Patients With Testicular Cancer
Testicular cancer recurrence may be prevented by giving men one cycle of chemotherapy instead of the two cycles used as standard. Lowering the overall exposure to chemotherapy also reduced side effects. These findings were published by Cullen et al in European Urology. Testicular cancer is the most ...
JAVELIN Bladder 100 Study of Avelumab for Urothelial Cancer Meets Primary Endpoint
The phase III JAVELIN Bladder 100 trial met its primary endpoint of overall survival at the planned interim analysis. In this study, patients with previously untreated locally advanced or metastatic urothelial carcinoma whose disease did not progress on induction chemotherapy and who were randomly...
Saliva Test May Play A Role in the Early Detection of HPV-Related Oropharyngeal Cancer
A report by Wang et al in The Journal of Molecular Diagnostics described the use of acoustofluidics, a noninvasive method that analyzes saliva for the presence of human papillomavirus type 16 (HPV-16), the pathogenic strain of the disease associated with oropharyngeal cancers. This novel technique...
FDA Finalizes Enforcement Policy on Unauthorized Flavored Cartridge-Based E-Cigarettes
Amid the epidemic levels of youth use of e-cigarettes and the popularity of certain products among children, the U.S. Food and Drug Administration (FDA) has issued a policy prioritizing enforcement against certain unauthorized flavored e-cigarette products that appeal to children, including fruit...
Screening Rates Rose Among People Aged 45–49 After Release of Updated Colorectal Cancer Guidelines
Colorectal cancer screening rates more than doubled among people aged 45 to 49 in the months after the release of updated American Cancer Society guidelines in 2018 recommending screening in that age group, according to a new study. According to the findings from Fedewa et al—published in...
