Advertisement

Search Results

Advertisement



Your search for all items matches 35407 pages

Showing 51 - 100


leukemia

All-Trans Retinoic Acid and Arsenic Trioxide in High-Risk Acute Promyelocytic Leukemia

As reported in the Journal of Clinical Oncology by Platzbecker et al, the European intergroup phase III APOLLO trial showed that an all-trans retinoic acid (ATRA) plus arsenic trioxide (ATO; ATRA-ATO)–based regimen was associated with improved event-free survival vs a standard ATRA plus...

issues in oncology

GLP-1 RAs and Cancer Risk in Adults With Overweight/Obesity

In a retrospective study reported in JAMA Oncology, Dai et al found that use of GLP-1 receptor agonists (GLP-1 RAs) for weight loss in adults with overweight/obesity was associated with an overall reduction in risk of cancer. As stated by the investigators, “…GLP-1 RAs… are widely prescribed for...

global cancer care

A Year of Global Progress Against Cancer—and Persistent Challenges

Despite data from the latest edition of The Cancer Atlas showing that nearly half of cancer mortality worldwide is attributed to modifiable risk factors, cancer incidence and mortality rates continue to soar.1 Globally, approximately 19 million new cases of cancer, excluding nonmelanoma skin...

genomics/genetics

Inherited Variants in 16 Genes May Double the Risk of Multiple Primary Cancers

Individuals carrying a rare pathogenic variant in one of 16 cancer-associated genes were 1.9 times more likely to develop a single cancer and 2.6 times more likely to develop multiple primary cancers, according to the results of a genetic association study published in JAMA Oncology.  These...

hematologic malignancies

Can a Common Anti-inflammatory Drug Help to Control Progression of Clonal Hematopoiesis?

Taking low-dose colchicine daily may slow the progression of a common acquired gene mutation found in the blood of older adults that can lead to certain blood cancers and increased risk of cardiovascular disease, according to a subanalysis of the LoDoCo2 trial published by Mohammadnia et al in JACC ...

leukemia

Farhad Ravandi, MD, on AML: Highlights of Ongoing Research

Farhad Ravandi, MD, provides an overview of acute myeloid leukemia (AML) research highlighted in a session at SOHO, including data on menin inhibitors in NPM1-mutated disease; FLT3 inhibitors in FLT3-mutated disease; IDH inhibitors in IDH1-mutated disease; the role of measurable residual disease;...

leukemia

Elias Jabbour, MD, on CAR T-Cell Therapy for Adult Patients With Relapsed/Refractory B-Cell ALL

Elias Jabbour, MD, discusses long-term findings and predictors of sustained remission among adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia (ALL) who did not undergo a stem cell transplant, but received the chimeric antigen receptor (CAR) T-cell therapy obecabtagene...

colorectal cancer

Study Finds Personalized Risk Messages Had No Effect in Raising Colorectal Cancer Screening Participation

A randomized controlled trial investigating the effect of providing personalized risk information to patients and their providers about the patient’s risk for advanced colorectal neoplasia has found no difference in screening uptake with either the personalized risk messages or provider...

covid-19

Could a Nasal Spray Help Protect Patients With Cancer Against COVID-19 Infection?

Use of a daily interferon-α nasal spray could significantly reduce the risk of COVID-19 infection among adult patients with cancer, according to the results of a multicenter, randomized trial published in Clinical Infectious Diseases.  The results suggest that the nasal spray could be a potential...

breast cancer

New Report on Breast Reconstruction Preferences Among African American Women

For African American patients undergoing mastectomy, the risk of complications and the postoperative appearance of the breast are among the important drivers of preferences about breast reconstruction, according to a new report published by Shammas et al in Plastic and Reconstructive Surgery....

breast cancer

Model to Identify Patients With Clinical High-Risk Early Breast Cancer Who May Avoid Escalated Adjuvant Therapy

As reported in the Journal of Clinical Oncology, Bidard et al developed a model that may identify a subgroup of patients with clinical high-risk estrogen receptor (ER)-positive/HER2-negative early breast cancer who might derive no additional distant recurrence benefit from escalation of adjuvant...

breast cancer

AI Shear Wave Elastography Model for Diagnosing Breast Cancer in BI-RADS 3 or 4 Masses

In a study (INSPiRED 006) reported in the Journal of Clinical Oncology, Cai et al found that an artificial intelligence–guided shear wave elastography (AI-SWE) model provided accuracy similar to expert reading of B-mode ultrasound in the diagnosis of breast cancer in women with Breast Imaging...

head and neck cancer

Lifileucel Demonstrates Feasibility and Disease Stability in Advanced Head and Neck Squamous Cell Carcinoma

A single administration of autologous tumor-infiltrating lymphocyte cell therapy with lifileucel led to disease stability in patients with recurrent and/or metastatic head and neck squamous cell carcinoma, even among patients whose disease had progressed or did not respond to multiple prior...

issues in oncology

How the AI-Powered ASCO® Guidelines Assistant Is Improving Clinical Decision-Making

This past May, ASCO announced its collaboration with Google Cloud to launch the ASCO® Guidelines Assistant, a new interactive tool that allows clinicians to quickly access ASCO’s evidence-based clinical guidelines to facilitate critical clinical decision-making. Developed with Google Cloud’s Vertex ...

breast cancer
survivorship

Study Shows That After Early Breast Cancer Diagnosis, Risk of a Second Cancer is Low

For individuals diagnosed with early breast cancer, the long-term risk of developing a second primary cancer is low—around 2% to 3% greater than the general population)—according to findings published by McGale et al in The BMJ. The researchers say this information can help reassure many breast...

issues in oncology

Public Awareness of HPV, HPV Vaccine, and the Association of HPV With Cancer

In a U.S. state-level study reported as a research letter in JAMA Oncology, Garg et al found that awareness of human papillomavirus (HPV), HPV vaccination, and the association between HPV infection and development of cancers was “overwhelmingly low.” As stated by the investigators, “Each year, an...

cardio-oncology

IDO1 Inhibition Mitigates Diet-Induced Risk of Cancer-Associated VTE in Preclinical Models

Patients with cancer who have a diet high in tryptophan, or protein-rich foods, have an increased risk for developing cancer-associated venous thromboembolism, according to preclinical findings published in Blood Advances.  This increased risk could potentially be mitigated by treatment with an...

colorectal cancer

Addition of Sintilimab to Total Neoadjuvant Treatment in Locally Advanced Rectal Cancer

In a Chinese single-center phase II trial (SPRING-01) reported in The Lancet Oncology, Tian et al found that the addition of the PD-1 inhibitor sintilimab to chemotherapy following short-course radiotherapy as part of total neoadjuvant treatment significantly improved the pathologic complete...

hematologic malignancies

FDA Approves BTK Inhibitor for ITP

The U.S. Food and Drug Administration (FDA) has approved rilzabrutinib (Wayrilz), a Bruton’s tyrosine kinase (BTK) inhibitor, for adults with persistent or chronic immune thrombocytopenia (ITP) who have had an insufficient response to a previous treatment. The approval was based on the pivotal LUNA ...

gynecologic cancers
breast cancer

Do Breast and Gynecologic Cancers Contribute to Job Resignation in Working Women?

In a matched-cohort study reported in JAMA Network Open, Iwakura et al found that women with breast or gynecologic cancer had a higher risk of job resignation compared with their unaffected counterparts, especially among those who were older, had lower income, or had a history of depression. “These ...

leukemia
geriatric oncology

Geriatric Assessment–Guided Approach to Treatment Intensity in Older Adults With AML

Based on the results of a single-center phase II trial published by Bhatt et al in the American Journal of Hematology, pretreatment geriatric assessment in older adults with acute myeloid leukemia (AML) appeared to be feasible, to identify several functional impairments, to help guide the selection ...

Understanding Accelerated Aging in Survivors of Childhood Cancers

Each year in the United States, nearly 16,000 children and adolescents between the ages of birth and 19 are diagnosed with cancer.1 And although survival rates have greatly improved for many types of childhood cancers, with more than 8 in 10 children and adolescents surviving at least 5 years after ...

gastrointestinal cancer

Gastrointestinal Tumor Microbes May Predict Prognosis and Therapeutic Response

Microbes inside cancerous tumors can influence the spread of disease and the effectiveness of treatment, and those roles make them appealing targets for new therapies. Tumor microbiota–based tools could also help identify high-risk patients and those most susceptible to metastases, and possibly be...

pancreatic cancer

Conversion of Unresectable Into Resectable Pancreatic Cancer: Chemoradiotherapy vs Chemotherapy

In a German phase III trial (CONKO-007) reported in the Journal of Clinical Oncology, Fietkau et al found that although adding chemoradiotherapy (CRT) to chemotherapy vs chemotherapy alone following induction therapy did not improve overall R0 resection rate in all patients with initially...

survivorship
cost of care

Government Housing Assistance Linked to Reduced Medical Financial Hardship Among Cancer Survivors

Cancer survivors receiving government-subsidized rent were found to have a lower risk of experiencing financial hardships around medical expenses compared with those not receiving housing assistance, according to the results of a cross-sectional study published as a research letter in JAMA Network...

symptom management

Real-World Incidence and Management of Infusion-Related Reactions to Monoclonal Antibody Therapy

In a retrospective analysis published in JCO Oncology Practice, Smolders et al investigated the incidence and clinical course of infusion-related reactions among patients treated with at least one monoclonal antibody in routine practice. The study evaluated real-world data to compare observed...

sarcoma

Mifamurtide Plus Chemotherapy for Nonmetastatic High-Grade Osteosarcoma

In a pooled analysis of the Italian Sarcoma Group (ISG/OS-2) and Spanish Sarcoma Group (GEIS-33) trials reported in the Journal of Clinical Oncology, Palmerini et al found evidence of activity with the addition of mifamurtide to chemotherapy in patients with nonmetastatic high-grade osteosarcoma...

How to Adapt to the Era of AI and the Changing Interactions With Patients: Lessons From a Low-Resource Setting

After 2 decades of practicing medicine across multiple disciplines and health systems, I’ve witnessed the dramatic transformation of patient-physician interactions, and none more dramatic than what I’m seeing in this era of artificial intelligence (AI) and its impact on cancer care. Early in my...

hepatobiliary cancer

Adding Dendritic Cell Vaccination to Hepatocellular Carcinoma Therapy

Patients with intermediate-stage hepatocellular carcinoma who received a vaccine of dendritic cells in addition to transarterial chemoembolization (TACE) and preconditioning cyclophosphamide experienced longer progression-free survival than those who received cyclophosphamide and TACE alone. The...

cns cancers

Identifying CNS Tumors With Multianalyte Cerebrospinal Fluid Test

A novel, multianalyte test has been developed to identify central nervous system cancers from small samples of cerebrospinal fluid (CSF). In findings published in Cancer Discovery, the study authors reported that the test, called CSF-BAM, achieved a sensitivity of 81% and a specificity of 100%....

head and neck cancer

Lu-177 Dotatate in Progressive Metastatic Pheochromocytomas and Paragangliomas

In an interim analysis of a National Institutes of Health phase II study reported in the Journal of Clinical Oncology, Lin et al found that lutetium Lu-177 dotatate (Lu-177 dotatate) was active in progressive metastatic pheochromocytomas and paragangliomas (PPGLs). As stated by the investigators,...

issues in oncology

Survey Finds Discordance Between Treatment Preferences and Clinical Care for Advanced Cancer

Patients with advanced cancer reported in survey responses that their treatment often focused on optimizing longevity over maintaining comfort and quality of life, despite their goals that prioritized the opposite, according to study results published in Cancer.  Additionally, the findings...

gynecologic cancers

Disparities in U.S. County–Level Cervical Cancer Screening Coverage Lead to Differences in Outcomes

In a study reported as a research letter in JAMA Network Open, Amboree identified U.S. counties with low or high cervical cancer screening coverage and associated risks of cervical cancer incidence and mortality. As stated by the investigators, “Recent research shows that cervical cancer incidence...

breast cancer

Analysis Shows No Major Racial Differences in Somatic Mutations of Triple-Negative Breast Cancer

A landmark study of the tumor mutational landscape of African American women with triple-negative breast cancer revealed that the mutational profile was largely similar with that of Asian and non-Hispanic White women, except for the presence of TP53 mutations in almost all African American...

issues in oncology

Association of Germline Pathogenic/Likely Pathogenic Mutations and Subsequent Neoplasms in Childhood Cancer Survivors

In an analysis from the Children’s Oncology Group ALTE03N1 Study reported in the Journal of Clinical Oncology, Zhou et al found a fourfold increased risk of subsequent neoplasms (SNs) among childhood cancer survivors with germline pathogenic/likely pathogenic (P/LP) mutations. Study Details The...

gastroesophageal cancer

Pembrolizumab Plus Chemotherapy vs Chemotherapy in Advanced Gastric Cancers: Final Survival Analysis From KEYNOTE-585

As reported in the Journal of Clinical Oncology by Shitara et al, the final overall survival analysis from the phase III KEYNOTE-585 study showed a numeric—but statistically nonsignificant—benefit with pembrolizumab plus chemotherapy vs chemotherapy in perioperative therapy for patients with...

What We Wish We Knew During Fellowship

July marks a significant transition for many professionals, particularly those beginning structured training programs on July 1. This article is designed to support new and current hematology-oncology fellows and trainees in making the most of their training experience. Although not all suggestions ...

ASCO Thanks Richard L. Schilsky, MD, FACP, FSCT, FASCO, for His Vision and Leadership of TAPUR

ASCO extends its thanks and appreciation to Richard L. Schilsky, MD, FACP, FSCT, FASCO, for his decade of leadership and dedication as the inaugural Principal Investigator of the groundbreaking Targeted Agent and Profiling Utilization Registry (TAPUR) Study. The ASCO-sponsored TAPUR study is a...

breast cancer
cardio-oncology

Case 3: Cardiac Risk Stratification

This is Part 3 of Managing Cardiovascular Risk in Metastatic Breast Cancer: Clinical Insights on CDK4/6 Inhibitors, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable.   In this video, Drs. Kelly McCann, Hope Rugo, and Avirup Guha discuss a challenging...

breast cancer
cardio-oncology

Case 2: CDK4/6 Inhibitor Choice in Medically Fragile Patients With Heart Failure

This is Part 2 of Managing Cardiovascular Risk in Metastatic Breast Cancer: Clinical Insights on CDK4/6 Inhibitors, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable.   In this video, Drs. Kelly McCann, Hope Rugo, and Avirup Guha discuss managing...

breast cancer
cardio-oncology

Case 1: Management of Cardiovascular Risk Factors

This is Part 1 of Managing Cardiovascular Risk in Metastatic Breast Cancer: Clinical Insights on CDK4/6 Inhibitors, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable.   In this video, Drs. Kelly McCann, Hope Rugo, and Avirup Guha discuss cardiovascular ...

issues in oncology

Can Baseline Kidney Function Predict Chronic Kidney Disease After Cisplatin Treatment?

A population-based prognostic study published in JAMA Oncology found cisplatin treatment to be associated with a predictable decrease in the estimated glomerular filtration rate. According to Grant et al, their findings place patients with lower baseline kidney function at the highest risk for...

breast cancer
survivorship

BWEL Weight-Loss Trial Reports Success for Patients With Breast Cancer at 1-Year Mark

Patients with stage II or III breast cancer who participated in a remote weight-loss intervention program lost an average of 4.7% of their baseline body weight after 1 year, whereas those in the education-only control group gained an average 1% of their baseline weight, according to a recent report ...

hepatobiliary cancer

Which First-Line Systemic Therapy Balances Survival and Quality of Life in Advanced Hepatocellular Carcinoma?

A network meta-analysis reported in JAMA Oncology found that among first-line systemic therapy options, immunotherapy-based combinations—particularly atezolizumab plus bevacizumab—offered the most favorable therapeutic balance between survival benefit and quality-of-life preservation in...

symptom management

Factors Influencing Symptom Burden in Pediatric Patients With Cancer: Insights From Routine Screening

As pediatric cancer survival rates continue to improve, attention has shifted to quality of life and symptom management. While a majority of patients experience problematic symptoms during treatment, these symptoms usually go undocumented and untreated. In a secondary analysis of a cluster...

breast cancer

Adding Everolimus to Chemotherapy Reduces Risk for Advanced Triple-Negative Breast Cancer

The addition of everolimus to standard carboplatin chemotherapy led to a 52% reduction in the risk of disease progression or death compared with carboplatin alone in patients with advanced triple-negative breast cancer, according to the results of a randomized phase II trial published in Breast...

issues in oncology

Unmet Social Needs Distort Trust in Cancer Information, Study Shows

Researchers have found that unmet social needs was associated with less trust in cancer information received from doctors and the health-care system, according to study findings led by the American Cancer Society and published in Psycho-Oncology.  “Public trust in health authorities is so essential ...

skin cancer

Basal Cell Carcinoma: Early Research on a Novel Topical Fluorescent Imaging Technique

A topical fluorescent molecular contrast agent, PARPi-FL (a poly[adenosine diphosphate ribose] polymerase 1 [PARP1] inhibitor–targeted fluorescent contrast agent) detected basal cell carcinoma through intact skin in as little as 5 minutes in ex vivo human tissues, according to new preclinical...

multiple myeloma
lymphoma

Rare Secondary Cancer After CAR T-Cell Therapy Successfully Treated, Case Report Shows

In a case presentation published in The New England Journal of Medicine, targeted treatment was successful for chimeric antigen receptor (CAR)-positive peripheral T-cell lymphoma developed after CAR T-cell therapy for multiple myeloma.  Using advanced genomic, phenotypic, and functional profiling...

pancreatic cancer

Racial and Ethnic Disparities in Guideline-Concordant Pancreatic Cancer Care Among Older Adults

In a study published in the Journal of Clinical Oncology Practice, Herb et al investigated racial and ethnic disparities in the receipt of guideline-concordant care among older adults with pancreatic cancer. Using data spanning 15 years, the researchers examined whether differences in treatment...

Advertisement

Advertisement




Advertisement