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Your search for The ASCO Post matches 11854 pages

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prostate cancer

Daniel E. Spratt, MD, on Prostate Cancer: Relugolix vs Leuprolide

Daniel E. Spratt, MD, of the University of Michigan Rogel Cancer Center, discusses phase III results of the HERO trial, which suggested benefits of the oral medication relugolix: a substantially faster time to castration with longer duration, fewer cardiac events, and a faster return to normal...

prostate cancer

Cynthia Menard, MD, on Prostate Cancer: PSMA PET- and CT-Guided Intensification of Radiotherapy

Cynthia Menard, MD, of the University of Montreal, discusses a study on the use of prostate-specific membrane antigen PET and CT to guide treatment. The scans led to high rates of new lesion detection and therefore intensification of radiotherapy for patients with prostate cancer, without an...

genomics/genetics

Next-Generation BRAF Inhibitor Shows Activity in Phase I/II Trial

A new drug designed to treat cancers in patients with an altered BRAF gene showed activity and had a favorable safety profile in an early-phase trial. These findings were presented by Janku et al at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics (Abstract LBA-05)....

colorectal cancer

USPSTF Issues Draft Recommendation on Screening for Colorectal Cancer

On October 27, the U.S. Preventive Services Task Force (USPSTF) posted a draft recommendation statement on screening for colorectal cancer. For the first time, the Task Force is recommending that screening start at age 45. This is a B recommendation, meaning the USPSTF recommends the service; that...

breast cancer

Youssef Zeidan, MD, PhD, on HER2-Positive Breast Cancer: De-intensifying Radiation Therapy

Youssef Zeidan, MD, PhD, of the American University of Beirut Medical Center, discusses study findings showing that breast-conserving surgery, whole-breast irradiation, and trastuzumab offer effective local tumor control for patients with HER2-positive breast cancer. An additional radiation boost...

prostate cancer

Paul Sargos, MD, on Prostate Cancer: Adjuvant or Early Salvage Radiotherapy Plus Androgen Deprivation

Paul Sargos, MD, of the Institut Bergonié, discusses phase III findings from the GETUG-AFU 17 study, which compared adjuvant vs early salvage radiotherapy, both combined with short-term androgen-deprivation therapy after radical prostatectomy for localized prostate cancer. Although lacking...

supportive care
pain management

Arjun Sahgal, MD, on Reducing the Pain of Spinal Metastases: SBRT vs Palliative Radiotherapy

Arjun Sahgal, MD, of the Sunnybrook Health Sciences Centre, discusses results of the first phase III trial to suggest that dose escalation with stereotactic body radiotherapy may be superior to conventional palliative radiotherapy in improving pain outcomes for patients with spinal bone metastases...

prostate cancer

Neha Vapiwala, MD, on Prostate Cancer: Imaging and the Decision to Treat With Radiation

Neha Vapiwala, MD, of the University of Pennsylvania, who served as a discussant for LBA1, summarizes her review of this study of patients with prostate cancer who had biochemical recurrence in the post-prostatectomy setting, who were candidates for salvage radiotherapy, and who received either...

breast cancer
gynecologic cancers
prostate cancer
genomics/genetics

FDA Approves Companion Diagnostic for Three Targeted Therapies for Advanced Ovarian, Breast, and Non–Small Cell Lung Cancers

On October 27, the U.S. Food and Drug Administration (FDA) approved the FoundationOne Liquid CDx test for three new companion diagnostic indications to help match patients who may benefit from treatment with specific FDA-approved targeted therapies. The new indications are for alpelisib (Piqray) in ...

genomics/genetics

Targeted Inhibitor of Mutant KRAS Gene Shows Activity in Early Trial

Adagrasib (MRTX849), a novel agent that targets a mutated form of the KRAS gene—the most commonly altered oncogene in human cancers, and one long considered “undruggable”—caused tumor shrinkage in most patients in a clinical trial, with manageable side effects, researchers reported at the 32nd...

solid tumors
genomics/genetics

Companion Diagnostic to Identify NTRK Fusions in Patients With Solid Tumors Eligible for Treatment With Larotrectinib Approved by the FDA

On October 23, the U.S. Food and Drug Administration (FDA) approved the next-generation sequencing–based FoundationOne CDx test as a companion diagnostic to identify fusions in the neurotrophic receptor tyrosine kinase (NTRK) genes NTRK1, NTRK2, and NTRK3 in DNA isolated from tumor tissue specimens ...

covid-19

Survey Shows Many Patients With Cancer Willing to Take Part in Clinical Trials Despite Coronavirus

Patient Power, a patient-driven cancer news organization, reported that a majority of patients with cancer still want to participate in clinical trials despite the COVID-19 pandemic, according to a recent survey of 1,485 patients. The Patient Power COVID-19 Cancer Trial Survey, the second Patient...

SHP2 Inhibition May Counter Resistance Mechanisms in Lung Cancer

Recent preclinical research from The University of Texas MD Anderson Cancer Center and BridgeBio Pharma, an affiliate of Navire Pharma, found that the novel SHP2 inhibitor IACS-13909 may be able to overcome therapeutic resistance mechanisms in non–small cell lung cancer (NSCLC). The data, which...

colorectal cancer

Becoming Acquainted With Cancer

Editor’s Note: The ASCO Post learned of the death of Patrick Beauregard due to colorectal cancer on September 6, 2020.  Just weeks after my wedding in late summer of 2017, I had a sudden bout of abdominal pain so severe that it sent me to the emergency room. I was just 29 years old and in great...

Remembering Patrick H. Beauregard: ‘Selfless in His Efforts to Raise Awareness’ of Colorectal Cancer in Young Adults

The editors of The ASCO Post are sad to report the death of Patrick H. ­Beauregard on September 6, 2020. The cause was colorectal cancer. Diagnosed with stage IV disease in 2017 at the age of 29, Mr. Beauregard dedicated the last 3 years of his life to raising awareness of colorectal cancer in...

Early-Career ASCO Member and Breast Medical Oncologist, Tomas Lyons, MB BCh, BAO, MRCPI, Dies at 38

Tomas Lyons, MB BCh, BAO, MRCPI, a medical oncologist at the Evelyn H. Lauder Breast Center Memorial Sloan Kettering Cancer Center in New York, died suddenly on September 29 at the age of 38. During his career at Memorial Sloan Kettering (MSK), he was a celebrated collaborator on multidisciplinary ...

Joan H. Marks, Pioneer in Genetic Counseling, Dies at 91

Joan H. (Rosen) Marks, a pioneer in genetic counseling, died on September 14, 2020. She was 91. Ms. Marks received an honorary Doctor of Science degree from Sarah Lawrence College in Bronxville, New York, in 2019, in recognition of her contributions and leadership to the College and to society, the ...

breast cancer

Expect Questions About Increased Cancer Mortality Risk Among Patients Diagnosed With DCIS

A large cohort study1 finding that the risk of dying of breast cancer was increased threefold after a DCIS diagnosis may cause patients diagnosed with DCIS to ask what they can do to reduce that risk. Currently, there is little that most patients can do. “The lifetime risk of death following DCIS...

breast cancer

Focus on Preventing Invasive Recurrence in Women With DCIS Does Not Sufficiently Address Breast Cancer Mortality

A study published recently by Giannakeas et al looked at the risk of death from breast cancer for women diagnosed with ductal carcinoma in situ (DCIS).1 The investigators anticipated that treatment would eliminate the risk of invasive ipsilateral recurrence and prevent subsequent mortality from...

Emily Whitehead, Early Recipient of CAR T-Cell Therapy for ALL, Celebrates 8 Years Cancer-Free

Among the success stories in the treatment of acute lymphoblastic leukemia (ALL) in children and young adults is the development of chimeric antigen receptor (CAR) T-cell therapy. The field of cellular immunotherapy was still in its infancy in 2012 when Emily Whitehead, then 7, became the first...

UICC Welcomes New President, President-Elect, and Board of Directors for 2020–2022

At the recent General Assembly of the Union for International Cancer Control (UICC), which was held virtually for the first time, Anil D’Cruz, MD, of India, was welcomed as the organization’s new President. Full member organizations also elected the 2020–2022 Board of Directors, including...

Breast Cancer and Radiation Researcher David Gius, MD, PhD, Joins Mays Cancer Center

David Gius, MD, PhD, a breast cancer and radiation researcher, has joined the Mays Cancer Center, home to The University of Texas Health San Antonio MD Anderson. He was recruited to the Mays Cancer Center from the Robert H. Lurie Comprehensive Cancer Center at Northwestern University with a $6...

The Secret History of Cancer Chemotherapy

“The summons came in the middle of the night. He was awake at the first harsh jangle of the telephone…. Always a light sleeper, Lieutenant Colonel Stewart Francis Alexander attributed the trait to his father, an old-fashioned family practitioner whose response to every late-night distress call was...

A Gritty Journey Into a Rare Cancer and Back

Over the past decade, a prolific number of cancer memoirs have been published, and some have been award-winning bestsellers. When entering a crowded genre, it is best to have something that sets your story apart. Judith Dwyer Fugate did just that with a memoir about a rare tumor that has seldom if...

Cleveland Clinic Announces Oncology Staff Appointments

Cleveland Clinic recently announced the following additions to its oncology staff: Ruth Keri, PhD, has joined Cleveland Clinic Lerner Research Institute Department of Cancer Biology. She will study breast cancer, focusing on identifying the molecular processes that control the formation of breast...

skin cancer

UCLA Researchers’ Efforts in Melanoma Receive $13M Boost From NIH

University of California, Los Angeles (UCLA) researchers have received a $13 million grant from the National Institutes of Health (NIH) to find new ways to overcome melanoma resistance to some of the most promising targeted therapies and immunotherapies. There have been significant advancements in...

issues in oncology

Pay-for-Performance Program to Reimburse Oncology Practices for Prescribing Evidence-Based Cancer Drugs

A pay-for-performance program that offers enhanced reimbursement to oncology practices for prescribing high-quality, evidence-based cancer drugs increased use of these drugs without significantly changing total spending on care, Penn Medicine researchers reported in a study published in the Journal ...

Dana-Farber/Harvard Cancer Center Wins Federal Grant to Accelerate Ovarian Cancer Research

Dana-Farber/Harvard Cancer Center (DF/HCC) has been awarded a $12 million grant from the National Cancer Institute (NCI) to bring promising ovarian cancer research from the laboratory to clinical practice. The highly competitive Specialized Programs of Research Excellence (SPORE) grant will help...

Isabelle Tabah-Fisch, MD, Drug Researcher, Industry Executive, Dies at 64

Isabelle Tabah-Fisch, MD, a medical oncologist in Paris who contributed greatly to drug development, died August 28, 2020, at age 64. An announcement about Dr. Tabah-Fisch’s death was made by GamaMabs, where she served as Chief Medical Officer until her retirement in March 2020. Under her...

Susan G. Komen to Present 2020 Brinker Awards for Scientific Distinction

Susan G. Komen is recognizing  two widely respected and innovative breast cancer researchers—Donald McDonnell, PhD, and Laura Esserman, MD, MBA—as this year’s recipients of their highest scientific honor, the Brinker Awards. Established by Komen in 1992, the awards recognize advances in the...

Lesley Solomon, MBA, of Dana-Farber, Receives Extraordinary Women Advancing Healthcare Award

Lesley Solomon, MBA, Senior Vice President for Innovation and Chief Innovation Officer at Dana-Farber Cancer Institute, has received the 2020 Extraordinary Women Advancing Healthcare Award from The Commonwealth Institute, a nonprofit organization devoted to advancing women in leadership positions....

City of Hope Launches Innovative Support Model for Employers

City of Hope in Duarte, California, announced the formal launch of AccessHope, a wholly owned subsidiary dedicated to serving employers and their health-care partners. Instead of requiring patients to travel to City of Hope, AccessHope exports insights from National Cancer Institute–level...

ASTRO Calls for Changes to Benefits Manager Policy That Disrupts Patient/Physician Decision-Making for Cancer Radiotherapy

Radiation oncologists have expressed serious concerns about a new private insurance coverage policy that could undermine patient-centered care for two of the most common cancers in the United States. Leaders of the American Society for Radiation Oncology (ASTRO) urge eviCore, a radiation oncology...

head and neck cancer

Dana-Farber Announces Center for Salivary and Rare Head and Neck Cancers

Dana-Farber Cancer Institute has launched the Center for Salivary and Rare Head and Neck Cancers to treat patients with rare and occasionally aggressive cancers arising from the head and neck. The Center is among the first in the country specifically dedicated to the care and therapeutic research...

issues in oncology
covid-19

How Telemedicine Is Impacting Oncology Care During the COVID-19 Pandemic

The expansion of telemedicine has been one of the most important developments during the COVID-19 pandemic. Here, we discuss some of the legal and ethical dimensions of expanding telemedicine services in oncology practices. As Royce et al discussed in a recent JAMA Oncology article, Congress...

2020 NIH Director’s Early Independence Awards Announced

The National Institutes of Health (NIH) Director’s Early Independence Award, established in 2010, is part of the High-Risk, High-Reward Research program managed by the Common Fund. The award provides an opportunity for exceptional junior scientists to skip the traditional postdoc and start an...

Mountainside Medical Center Appoints Co–Medical Director

Mountainside Medical Center has announced that Lori Leslie, MD, has been named Co–Medical Director of the hospital’s Cancer Program, which is affiliated with John Theurer Cancer Center at Hackensack University Medical Center. Dr. Leslie joins the Cancer Program leadership, serving alongside Donna...

geriatric oncology

Cancer in Older Adults: The History of Geriatric Oncology, Part 2: 1990–2020

In part 1 of this three-part article, which was published in the October 10, 2020, issue of The ASCO Post, we chronicled the progress made in geriatric oncology up to the decade of the 1990s, which saw an explosion of research activity in the study of aging and cancer. In part 2, we review the...

James K. McCloskey II, MD, Named Division Chief of the Division of Leukemia at John Theurer Cancer Center

James K. McCloskey II, MD, was named Division Chief of the Division of Leukemia at Hackensack Meridian John Theurer Cancer Center (JTCC), part of Hackensack University Medical Center. Dr. McCloskey previously served as Interim Chief for the Division of Leukemia and will continue in his role as...

FDA Awards Six Grants to Fund New Clinical Trials of Medical Products for Treatment of Rare Diseases

The U.S. Food and Drug Administration (FDA) announced it has awarded six new clinical trial research grants to principal investigators from academia and industry, totaling more than $16 million over the next 4 years. These grants, awarded through the Congressionally funded Orphan Products Grants...

lymphoma

The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues

The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that quizzes readers on issues in hematology. In this installment, Drs. Syed Ali Abutalib and L. Jeffrey Medeiros explore the updated World Health Organization (WHO) classification of hematopoietic and lymphoid tissue...

UICC Launches New Program at the Start of Breast Cancer Awareness Month

As the cancer community marks Breast Cancer Awareness Month this October, the Union for International Cancer Control (UICC) is starting a new 5-year program aimed at accelerating progress in breast cancer control. “While the incidence of breast cancer is generally higher in more developed regions, ...

Lourdes A. Báezconde-Garbanati, PhD, Receives AACR Distinguished Lectureship on Cancer Health Disparities

The American Association for Cancer Research (AACR) awarded Lourdes A. Báezconde-Garbanati, PhD, the 2020 AACR Distinguished Lectureship on the Science of Cancer Health Disparities. Dr. Báezconde-Garbanati presented her award lecture, “Optimizing Engagement to Reduce Disparities Among...

Anthony Fauci, MD, to Receive Lifetime Achievement Award From National Minority Quality Forum

The National Minority Quality Forum announced that Anthony Fauci, MD, will receive its 2020 Bernard J. Tyson Lifetime Achievement Award, which recognizes health-care leaders who have helped to decrease health disparities and to build sustainable healthy communities. Dr. Fauci—who has served as...

Yale Cancer Center Awarded NIH SPORE Grant for Head and Neck Cancer Research

Yale Cancer Center (YCC) researchers were awarded a 5-year, $11.7 million grant from the National Institutes of Health (NIH) to fund the Yale Head and Neck Cancer Specialized Program of Research Excellence (SPORE). The SPORE program harnesses the strengths of academic cancer centers by bringing...

Thinking Out of the Box to Advance the Management of Chronic Graft-vs-Host Disease

Over the past decade, the field of allogeneic hematopoietic cell transplantation has made great strides, evolving into a curative procedure for blood cancers that once were almost always fatal. However, chronic graft-vs-host disease, whose biologic etiology remains unclear, continues to be the...

Rutgers Cancer Institute of New Jersey Awarded $1.6M for Youth Science Program

Rutgers Cancer Institute of New Jersey has received a $1.6 million, 5-year grant from the National Cancer Institute to support the Rutgers Youth Enjoy Science (RUYES) Program. RUYES seeks to increase the diversity of the biomedical, cancer research workforce to reduce cancer disparities in New...

Florida Surgeon Steven D. Wexner, MD, FACS, Elected Vice-Chair of Board of Regents of American College of Surgeons

Steven D. Wexner, MD, PhD (Hon), FACS, FRCS (Eng), FRCS (Ed), FRCSI (Hon), Hon FRCS (Glasg), was recently elected Vice-Chair of the Board of Regents of the American College of Surgeons (ACS) during the College’s virtual Clinical Congress 2020, held October 3–7. Dr. Wexner is Chair of the...

Emmanuelle Charpentier, PhD, and Jennifer A. Doudna, PhD, Honored With Nobel Prize in Chemistry 2020

On October 7, 2020, The Royal Swedish Academy of Sciences announced that the Nobel Prize in Chemistry 2020 would be awarded to Emmanuelle Charpentier, PhD, and Jennifer A. Doudna, PhD, “for the development of a method for genome editing,” the CRISPR/Cas9 genetic scissors. “There is enormous power...

2020 Nobel Prize in Physiology or Medicine Awarded to Team Who Discovered Hepatitis C Virus

This year’s Nobel Prize in Physiology or Medicine was awarded to three scientists who have made a decisive contribution to the treatment of blood-borne hepatitis, a major global health problem that causes cirrhosis and liver cancer in people around the world. Harvey J. Alter, MD; Michael Houghton,...

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