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hematologic malignancies
supportive care

FDA Approves Axatilimab-csfr for Chronic GVHD

On August 14, the U.S. Food and Drug Administration (FDA) approved axatilimab-csfr (Niktimvo), a colony-stimulating factor–1 receptor–blocking antibody, for the treatment of chronic graft-vs-host disease (GVHD) after failure of at least two prior lines of systemic therapy in adult and pediatric...

breast cancer

Completion Axillary Lymph Node Dissection to Select Adjuvant Treatment in Breast Cancer and Associated Impairment of Arm Function

In an analysis involving the phase III SENOMAC trial reported in The Lancet Oncology, de Boniface et al found that the use of completion axillary lymph node dissection (cALND) to identify pN2-3 status (at least four nodal metastases) in patients with breast cancer, and thus qualification for...

skin cancer
immunotherapy

Combination Immunotherapies May Boost T-Cell Responses in Patients With Melanoma

Researchers may have uncovered how combination immunotherapies targeting the immune checkpoints PD-1 and LAG-3 may work together to activate immune responses in patients with melanoma, according to two recent studies published by Cillo et al and Andrews et al in Cell. The findings may shed light on ...

ARPA-H Awards to Develop Novel Technologies in Cancer Surgery

More than 2 years ago, President Joe Biden and First Lady Jill Biden reignited the Cancer Moonshot with the goals of reducing the cancer death rate in the United States by at least half (preventing more than 4 million cancer deaths) by 2047 and improving the experience of people who are touched by...

leukemia

Discontinuation of CML Therapy: Which Patients Are Ideal Candidates?

With the introduction of tyrosine kinase inhibitors, chronic myeloid leukemia (CML) has become a chronic disease for most patients. Furthermore, we now know that some patients can successfully stop treatment and remain in remission. “Stopping tyrosine kinase inhibitor therapy is something we get a...

colorectal cancer

T-DXd in HER2-Positive Advanced Colorectal Cancer

As reported in The Lancet Oncology by Kanwal Raghav, MD, and colleagues, the phase II DESTINY-CRC02 trial has identified the preferred dosage of single-agent fam-trastuzumab deruxtecan-nxki (T-DXd) in patients with HER2-positive advanced colorectal cancer. Study Details In the international study, ...

skin cancer

Resected Melanoma: Subsequent Systemic Therapy After Recurrence on Adjuvant Nivolumab

In an analysis from the phase III CheckMate 238 trial reported in the Journal of Clinical Oncology, Jeffrey Weber, MD, PhD, and colleagues found that progression-free and overall survival were improved with subsequent systemic therapy following late vs early recurrence with adjuvant nivolumab in...

gynecologic cancers
issues in oncology

Salpingectomy vs Tubal Occlusion

Women whose fallopian tubes are removed during sterilization via laparoscopy may have only marginally more surgical complications compared with those whose tubes are cut during tubal occlusion, according to a recent study published by Strandell et al in The Lancet Regional Health–Europe. The...

solid tumors
issues in oncology

Cancer Cases and Mortality Among Men Predicted to Increase Globally

Investigators have uncovered disparities in the projected rates of future cancer incidence and mortality among men based on age and country’s socioeconomic status, according to a recent study published by Bizuayehu et al in Cancer. Background Prior research has shown that men may face higher rates...

breast cancer
cns cancers
issues in oncology

Sacituzumab Govitecan May Be Effective at Treating Breast Cancer–Related Brain Tumors

The antibody-drug conjugate sacituzumab govitecan-hziy may be effective in treating patients with breast cancer who have brain metastases or recurrent glioblastoma multiforme, according to a recent study published by Balinda et al in Nature Communications. Background About 50% of all female...

skin cancer
immunotherapy
issues in oncology

Pattern in Protein Production May Be Predictive of Side Effects From Immunotherapy in Patients With Melanoma

An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases may predict the occurrence of severe side effects from immunotherapy in patients with melanoma, according to a recent study published by Monson et al in Clinical Cancer Research. Background...

colorectal cancer

Association of Regular Aspirin Use With Colorectal Cancer Risk According to Lifestyle Factors

In a study reported in JAMA Oncology, Sikavi et al found that regular aspirin use was associated with a reduced risk of colorectal cancer overall and among individuals with less healthy vs more healthy lifestyles. Study Details The prospective cohort study focused on data from 107,655 participants...

head and neck cancer

Cannabis Use and Risk of Head and Neck Cancer

In a study reported in JAMA Otolaryngology–Head & Neck Surgery, Gallagher et al found that individuals with cannabis-related disorder were at an increased risk of head and neck cancer vs those without cannabis-related disorder. Cannabis-related disorders are defined by the excessive use of...

breast cancer
issues in oncology

Gestational Diabetes and Risk for Breast Cancer

Women who develop gestational diabetes may not have a higher likelihood of being diagnosed with breast cancer, according to recent findings that will be presented by Christensen et al at the upcoming European Association for the Study of Diabetes Annual Meeting 2024 (Abstract 180). Background...

pancreatic cancer
issues in oncology

Metastasis-Directed Radiation Therapy Plus Chemotherapy in Oligometastatic Pancreatic Cancer

Researchers have demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy may improve progression-free survival in patients with oligometastatic pancreatic cancer, according to a recent study published by Ludmir et al in the Journal of Clinical Oncology and...

lung cancer

Can Neoadjuvant Atezolizumab Set a New Standard for Unresectable Stage III NSCLC?

Immune checkpoint inhibitors, including atezolizumab, have been evaluated in several phase II trials for neoadjuvant therapy in resectable lung cancer, both with and without chemotherapy, such as the LCMC3 trial and CheckMate 816. Ongoing studies, including the IMpower030 trial, are further...

lung cancer

Visceral Pleural Invasion and Recurrence Risk in Patients Undergoing Surgery for NSCLC

In an analysis from the CALGB 140503 trial reported in JAMA Oncology, Nasser Altorki, MD, and colleagues found that pathologically identified visceral pleural invasion was associated with poorer outcomes in patients undergoing surgery for non–small cell lung cancer (NSCLC). Study Details The trial ...

skin cancer

Merkel Cell Carcinoma: Association of ctDNA With Recurrence Risk

In a study reported in the Journal of Clinical Oncology, Akaike et al found that detection of circulating tumor DNA (ctDNA) was associated with an increased risk of recurrence in patients with Merkel cell carcinoma. Study Details In the study, a tumor-informed ctDNA assay was used in 319 patients...

lymphoma
skin cancer
immunotherapy

FDA Approves Immunotherapy for Relapsed or Refractory CTCL

On August 8, the U.S. Food and Drug Administration (FDA) approved denileukin diftitox-cxdl (Lymphir), a novel immunotherapy for the treatment of adult patients with relapsed or refractory cutaneous T-cell lymphoma (CTCL) who have received at least one prior systemic therapy. Denileukin diftitox is...

solid tumors

Cancer of Unknown Primary: Molecularly Guided Therapy After Disease Control on Platinum-Based Chemotherapy

In the phase II CUPISCO trial reported in The Lancet, Krämer et al found that molecularly guided therapy in patients with unfavorable nonsquamous cancer of unknown primary who had disease control on first-line platinum-based therapy resulted in better progression-free survival vs patients who...

hematologic malignancies
issues in oncology

Efficacy of a JAK2/mTOR Inhibitor Combination in Controlling Acute Graft-vs-Host Disease

Adding a Janus kinase 2 (JAK2) inhibitor to standard immunosuppressive drugs may not improve prevention of acute graft-vs-host disease in patients with hematologic malignancies undergoing treatment with allogeneic hematopoietic cell transplantation, according to a recent study published by Pidala...

breast cancer
issues in oncology

Primary Ovarian Insufficiency, Early Menopause May Be Linked to Increased Risk of Breast Cancer

The risk of developing breast cancer may be increased among some women who undergo menopause prior to age 46, according to a recent study published by Allen-Brady et al in The Journal of Clinical Endocrinology & Metabolism. Background Early menopause occurs in women aged 40 to 45 years. Primary ...

lung cancer
immunotherapy

Metastatic NSCLC Survival Rates in the Immunotherapy Era

The survival rates of patients with advanced non–small cell lung cancer (NSCLC) have improved since the introduction of the first immunotherapeutic in this population in the United States in 2015, according to a recent study published by Wang et al in Cancer. NSCLC accounts for up to 90% of all...

cns cancers

FDA Approves IDH1/2 Inhibitor for Certain Patients With Astrocytoma or Oligodendroglioma

The U.S. Food and Drug Administration (FDA) has approved vorasidenib (Voranigo), an isocitrate dehydrogenase-1 (IDH1) and -2 (IDH2) inhibitor, for adult and pediatric patients aged 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation, following...

head and neck cancer

Radiation Alone May Be as Effective as Chemoradiation in Patients With Low-Risk Nasopharyngeal Cancer

Nasopharyngeal carcinoma is a rare and aggressive malignant head and neck cancer that is highly prevalent in the southern and southwestern provinces of China. Although the incidence of the cancer is less than 1 per 100,000 in Europe, the United States, and the Pacific, data from the International...

gastroesophageal cancer

Active Surveillance May Enable Patients With Esophageal Cancer to Delay or Avoid Surgery

Although esophageal cancer in the United States is relatively rare—affecting about 22,400 people each year and making up about 1% of all cancer cases—the disease is common in East and Central Asian countries. Nearly 90% of patients with esophageal cancer in Asia are diagnosed with the squamous cell ...

skin cancer

Adjuvant Dabrafenib Plus Trametinib for Stage III BRAF V600–Mutated Melanoma: Final Results of the COMBI-AD Trial

Georgina V. Long, MD, PhD, of the Melanoma Institute Australia and the University of Sydney, and colleagues reported the final follow-up analysis of the phase III COMBI-AD trial at the 2024 ASCO Annual Meeting (Abstract 9500) and published their findings in The New England Journal of Medicine.1...

lung cancer

Should Low-Dose CT Screening Be Recommended for Those at Low Risk for Lung Cancer?

Lung cancer remains the leading cause of cancer-related deaths worldwide. Detecting this disease in its early stages significantly improves survival rates, making low-dose computed tomography (CT) screening an essential component in the fight against lung cancer. Recent studies, particularly from...

issues in oncology
solid tumors

Daily E-Cigarette Use May Be Linked to Higher Combustible Cigarette Cessation

U.S. adults who use e-cigarettes daily and smoke combustible cigarettes may be more likely to quit smoking traditional cigarettes compared with those who smoke but use e-cigarettes less frequently, according to a recent study published by Kasza et al in JAMA Network Open. The findings suggest that...

lung cancer
genomics/genetics

EGFR-Mutated NSCLC: Tepotinib/Osimertinib in Patients With MET Amplification

In the phase II INSIGHT 2 trial reported in The Lancet Oncology, Yi-Long Wu, MD, and colleagues found that the combination of tepotinib plus osimertinib showed clinically meaningful activity in patients with advanced or metastatic EGFR-mutated non–small cell lung cancer (NSCLC) with MET...

hematologic malignancies
issues in oncology

Investigating Fungal Bloodstream Infections in Bone Marrow Transplant Recipients

Researchers may have uncovered the mechanisms behind fungal bloodstream infections in patients who receive bone marrow transplants, according to a recent study published by Zhai et al in Nature Medicine. Background A phenomenon known as heteroresistance occurs when a tiny fraction of bacteria...

colorectal cancer
prostate cancer
pancreatic cancer
breast cancer
gynecologic cancers
issues in oncology
supportive care

Common Blood Tests May Improve Early Cancer Diagnosis

The results of routine blood tests could be used to speed up cancer diagnoses among patients with abdominal symptoms, according to a recent study published by Rafiq et al in PLOS Medicine. Background Most patients who report symptoms of abdominal pain or bloating to their physicians are referred...

sarcoma

FDA Grants Accelerated Approval to T-Cell Therapy for Unresectable or Metastatic Synovial Sarcoma

On August 2, the U.S. Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel (Tecelra), a melanoma-associated antigen A4 (MAGE-A4)-directed genetically modified autologous T-cell immunotherapy, for adults with unresectable or metastatic synovial sarcoma who have ...

lymphoma

Extranodal Marginal Zone Lymphoma: Is Overtreatment Common?

Most patients with extranodal marginal zone lymphoma (MZL) are overtreated, according to Emanuele Zucca, MD, of the Oncology Institute of Southern Switzerland and Institute of Oncology Research in Bellinzona and the Università della Svizzera Italiana in Lugano. “Aggressive therapy is not needed in...

breast cancer
cardio-oncology

Heart-Sparing Radiation Therapy Technique in Left-Sided Breast Cancer: Benefits and Costs

A model-based analysis reported in JACC: CardioOncology by Busschaert et al suggested that the heart-sparing deep inspiration breath-hold vs free-breathing radiation therapy technique is cost-effective—despite increasing treatment time—and may improve the long-term cardiovascular health of patients ...

lymphoma

Glofitamab Combination Therapy Shows Survival Benefit in Relapsed or Refractory Diffuse Large B-Cell Lymphoma

A novel treatment regimen with the bispecific antibody glofitamab has demonstrated improvements in survival outcomes for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), according to data presented at the European Hematology Association (EHA) 2024 Congress.1 The phase III ...

colorectal cancer
hepatobiliary cancer
issues in oncology

Liver Transplantation vs Standard Therapies in Patients With Colorectal Cancer Liver Metastasis

Certain patients with colorectal cancer that has metastasized to the liver may experience improved progression-free survival with liver transplantation compared with standard therapies, according to a recent study published by Byrne et al in JAMA Surgery. Background Colorectal cancer often...

issues in oncology

Education Level, Social Media Awareness May Be Linked to Cancer Fatalism

Investigators have found that patients with a lower level of education and social media awareness may hold more fatalistic beliefs about cancer compared with those who are more skilled at finding information through social media, according to a recent study published by Stimpson et al in Cancer...

lung cancer

New Report Shows Vaping and Smoking Together Increases Lung Cancer Risk Fourfold Compared to Smoking Alone

People who use e-cigarettes in conjunction with cigarette smoking are four times more likely to develop lung cancer than people who just smoke cigarettes, according to new study published by Harris et al the Journal of Oncology Research and Therapy. These findings were consistent across gender and...

gynecologic cancers
global cancer care

In Remembrance of My Friend, Lyn Denny, MD, PhD: I Will Never Forget Her

I first met Lyn Denny, MD, PhD, in Ghana, in 2004, when she became the Secretary Treasurer of AORTIC and brought the organization back to life. We’ve been friends ever since. I equate Lyn’s unwavering dedication to bringing health equity to women in Africa to Nelson Mandela’s fight for social...

gynecologic cancers
global cancer care

Gynecologic Oncologist Lynette Ann Denny, MD, PhD, Dies at Age 66

The global oncology and public health communities are mourning the death of Lynette Ann Denny, MD, PhD, a world-renowned gynecologic oncologist and a leading researcher in the prevention of cervical cancer in low-resource settings. Dr. Denny died on June 9, 2024, in Cape Town, South Africa, of...

multiple myeloma

FDA Approves Daratumumab and Hyaluronidase-fihj With VRd for Multiple Myeloma

On July 30, the U.S. Food and Drug Administration (FDA) approved daratumumab and hyaluronidase-fihj (Darzalex Faspro) in combination with bortezomib, lenalidomide, and dexamethasone (VRd) for induction and consolidation in patients with newly diagnosed multiple myeloma who are eligible for...

breast cancer

Endocrine-Resistant Metastatic Breast Cancer

This is Part 3 of Next-Generation Therapies for Metastatic Hormone Receptor–Positive Breast Cancer: Where Are We Headed?, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable.   In this video, Drs. Virginia Kaklamani, William Gradishar, and Komal Jhaveri...

breast cancer

PIK3CA-Mutated Metastatic Breast Cancer

This is Part 2 of Next-Generation Therapies for Metastatic HR-Positive Breast Cancer: Where Are We Headed?, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable.   In this video, Drs. Virginia Kaklamani, William Gradishar, and Komal Jhaveri discuss the...

breast cancer

ESR1-Mutated Metastatic Breast Cancer

This is Part 1 of Next-Generation Therapies for Metastatic HR-Positive Breast Cancer: Where Are We Headed?, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable.   In this video, Drs. Virginia Kaklamani, William Gradishar, and Komal Jhaveri discuss the...

global cancer care

Making a Difference in Global Oncology

“Making a difference in global oncology means framing positive system changes. To me, Dr. Khalid El Bairi is among the global cancer researchers I know who so far has made the largest achievements. “Since the very first interaction with Khalid, what I have captured is passion for the community he...

global cancer care

Cancer Research and Care Beyond Borders for Global Oncologist Dario Trapani, MD

In this installment of The ASCO Post’s Living a Full Life series, I interviewed Dario Trapani, MD, a medical oncologist at the European Institute of Oncology, Milan and Assistant Professor at the Department of Oncology and Haemato-Oncology of the University of Milan, in Italy. Dr. Trapani is a...

skin cancer
immunotherapy

Key Immune Cells for Combating Aggressive Merkel Cell Carcinoma Uncovered

Researchers may have uncovered why some patients with Merkel cell carcinoma do not respond to immune checkpoint blockade therapy, according to a recent study published by Reinstein et al in Cancer Discovery. Background Merkel cell carcinoma—a rare but highly aggressive type of skin cancer—is known...

gastroesophageal cancer
hepatobiliary cancer
immunotherapy
issues in oncology

Fecal Microbiota Transplant May Help Patients With Gastrointestinal Cancers Overcome Immunotherapy Resistance

Fecal microbiota transplants may improve the effectiveness of immunotherapy in patients with gastrointestinal cancers, according to a recent study published by Kim et al in Cell Host & Microbe. Background Although immune checkpoint inhibitors have revolutionized cancer treatment, many patients...

hematologic malignancies
supportive care

Effect of Posttransplantation Cyclophosphamide-Based GVHD Prophylaxis on Patients With Hematologic Malignancies

In an analysis reported in the Journal of Clinical Oncology, Shaffer et al found that use of post–allogeneic hematopoietic cell transplantation (HCT) cyclophosphamide (PTCy)-based graft-vs-host disease (GVHD) prophylaxis resulted in comparable overall survival and GVHD-free, relapse-free survival...

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