Case 3: Patient With Richter Transformation Refractory to Pola-R-CHP
This is Part 3 of CLL Treatment Sequencing: Where Do Next-Generation BTK Inhibitors Fit?, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Mazyar Shadman, MD, MPH, Inhye Ahn, MD, and Deborah M. Stephens, DO, discuss the management of Richter transformation refractory to initial therapy. The patient is a 56-year-old man with CLL who was initially treated with a fixed-duration BTK inhibitor and BCL2 inhibitor combination, achieving a partial response. He was observed off therapy and then presented 2 years later with rapidly enlarging lymphadenopathy, elevated LDH, and biopsy-confirmed clonally related large B-cell lymphoma. He subsequently received first-line chemoimmunotherapy for Richter transformation without response. The faculty highlight the absence of approved therapies specifically for Richter transformation and the critical importance of clinical trial enrollment. They also explore the available off-label options and emerging agents showing activity in this setting, the role of pirtobrutinib as a treatment option with meaningful but time-limited responses, and the importance of early referral to specialized centers for consideration of allogeneic stem cell transplant in eligible patients who achieve remission.
Case 2: Patient With Double-Refractory High-Risk CLL
This is Part 2 of CLL Treatment Sequencing: Where Do Next-Generation BTK Inhibitors Fit?, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Mazyar Shadman, MD, MPH, Inhye Ahn, MD, and Deborah M. Stephens, DO, discuss treatment sequencing in multiply relapsed, high-risk chronic lymphocytic leukemia (CLL) after exposure to multiple drug classes. The patient is a 67-year-old man with CLL who has received three prior lines of therapy, including chemoimmunotherapy, a venetoclax-based regimen, and a second-generation covalent BTK inhibitor, with progressively shorter remissions and the emergence of del(17p) at most recent relapse. He presents with active disease, mild cytopenias, a history of squamous cell carcinomas, and otherwise well-controlled comorbidities. The faculty highlight the distinction between double-exposed and double-refractory CLL and its implications for treatment selection, the role of pirtobrutinib in this heavily pretreated population, the importance of early referral for CAR T-cell therapy or allogeneic stem cell transplant while patients are still responding to therapy, and the potential for pirtobrutinib to serve as effective bridging therapy through the cellular therapy process.
Case 1: Patient With BTK C481S Resistance Mutation Following Acalabrutinib/Obinutuzumab
This is Part 1 of CLL Treatment Sequencing: Where Do Next-Generation BTK Inhibitors Fit?, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Mazyar Shadman, MD, MPH, Inhye Ahn, MD, and Deborah M. Stephens, DO, discuss treatment sequencing in chronic lymphocytic leukemia (CLL) after progression on a covalent BTK inhibitor. The patient is a 72-year-old woman with CLL and high-risk molecular features, including del(17p), TP53 mutation, and unmutated IGHV, who achieved a durable response to first-line acalabrutinib plus obinutuzumab before developing progressive disease with an acquired BTK C481S resistance mutation. She presents with symptomatic progression, cytopenias, and logistical considerations given her distance from the treatment center. The faculty highlight the role of venetoclax-based regimens vs pirtobrutinib as second-line options, the importance of individualizing treatment decisions based on patient comorbidities and practical factors, the significance of sequencing therapy with future options such as CAR T-cell therapy in mind, and the anticipated implications of the BRUIN CLL-322 trial data combining pirtobrutinib, venetoclax, and rituximab.
Jennifer A. Woyach, MD, on Pretreated Relapsed or Refractory CLL/SLL: Ongoing ROCKET-CLL Trial
Jennifer A. Woyach, MD, of The Arthur G. James Cancer Hospital and Richard J. Solove Research Institute at The Ohio State University, discusses the ongoing, actively recruiting ROCKET-CLL trial, which is a phase III study aiming to compare the efficacy of rocbrutinib vs pirtobrutinib in patients with relapsed or refractory chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL) who have been pretreated with Bruton tyrosine kinase covalent inhibitors (Abstract TPS7100). For more information about the trial, visit ClinicalTrials.gov (identifier NCT07342478).
Tafasitamab/Lenalidomide Combination vs R-CHOP in High-Risk DLBCL: Phase III frontMIND Trial
In patients newly diagnosed with high-risk large B-cell lymphoma, the addition of the CD19 monoclonal antibody tafasitamab plus the immunomodulatory drug lenalidomide (Tafa/Len) to standard therapy led to a 25% reduction in the risk of death or progression in the phase III frontMIND trial....
Dai Chihara, MD, on a Regimen for Older, Unfit, or Frail Patients With Newly Diagnosed DLBCL
Dai Chihara, MD, of The University of Texas MD Anderson Cancer Center, reviews results from an open-label, single-arm, phase II trial that investigated the combination of epcoritamab with R-miniCVP (rituximab, cyclophosphamide, vincristine, prednisone) in patients with newly diagnosed diffuse large B-cell lymphoma (DLBCL) classified as unfit or frail per geriatric assessment or not eligible for anthracycline chemotherapy due to reduced ejection function or prior exposure (Abstract 7002).
William G. Wierda, MD, PhD, on Pirtobrutinib in Treatment-Naive Patients With CLL/SLL
William G. Wierda, MD, PhD, of The University of Texas MD Anderson Cancer Center, presents pooled results from the BRUIN CLL-313 and BRUIN CLL-314 trials. BRUIN CLL-313 is comparing pirtobrutinib to bendamustine plus rituximab in treatment-naive patients with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL); BRUIN CLL-314 is comparing pirtobrutinib to ibrutinib in the same patient population (Abstract 7044).
Long-Term Follow-Up of Three First-Line Regimens in Mantle Cell Lymphoma
In an analysis reported in The Lancet, Dreyling et al provided long-term findings with three first-line regimens in the phase III TRIANGLE trial among patients aged 18 to 65 years with mantle cell lymphoma. Study Details In the international (13 European countries and Israel) open-label trial, 870...
Combining Targeted Immunotherapies With Standard R-CHOP Delays Progression of Aggressive B-Cell Lymphomas
Results from the phase III frontMIND trial show that adding tafasitamab and lenalidomide to R-CHOP (rituximab plus cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone) for first-line treatment can reduce tumor progression in patients with aggressive diffuse large B-cell lymphoma...
Jason R. Westin, MD, FASCO, on Updated Safety and Efficacy From the SUNMO Trial in LBCL
Jason R. Westin, MD, FASCO, of The University of Texas MD Anderson Cancer Center, provides an update on the safety and efficacy data from the phase III SUNMO trial, which compared mosunetuzumab and polatuzumab vedotin vs rituximab, gemcitabine, and oxaliplatin in patients with relapsed or refractory large B-cell lymphoma (LBCL) (Abstract 7007).
Thomas A. Jandl, MD, PhD, on DLBCL: First-Line Odronextamab Plus Chemotherapy
Thomas A. Jandl, MD, PhD, of Stony Brook University Hospital, discusses data from part 1B of the OLYMPIA-3 trial, which showed that among patients with diffuse large B-cell lymphoma (DLBCL), the safety profile of the first-line combination of odronextamab and CHOP chemotherapy was generally manageable and preliminary efficacy was encouraging, with no meaningful differences between regimens. Additionally, combination with odronextamab did not impact the delivery of CHOP (Abstract 7009).
John M. Burke, MD, on Newly Diagnosed DLBCL: frontMIND Trial
John M. Burke, MD, of SCRI at Rocky Mountain Cancer Centers I The US Oncology Network, presents findings from the phase III frontMIND trial, which evaluated tafasitamab plus lenalidomide and R-CHOP in patients newly diagnosed with diffuse large B-cell lymphoma (Abstract LBA7000).
Manali Kamdar, MD, on Rapid Oral Abstract Highlights: Three Emerging Trends in Lymphoma Care
Manali Kamdar, MD, of the University of Colorado, discusses a rapid oral abstract session that highlighted three trends in the field of lymphomas: improving outcomes in frontline diffuse large B-cell lymphoma, continued development of cellular therapies, and expanding molecular profiling.
Supriya Gupta, MD, on Investigational CAR T-Cell Therapy in Relapsed or Refractory NHL and CLL
Supriya Gupta, MD, of the University of Minnesota, presents data on azercabtagene zapreleucel, an investigational anti-CD19 allogeneic chimeric antigen receptor (CAR) T-cell therapy, in combination with low-dose interleukin-2 in patients with relapsed or refractory non-Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL) (Abstract 7012).
Case 3: Relapsed/Refractory Follicular Lymphoma in the Third Line and Beyond
This is Part 3 of Relapsed/Refractory Follicular Lymphoma: Choosing the Right Regimen for the Right Patient, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Loretta Nastoupil, Carla Casulo, and Kami Maddocks discuss treatment options for relapsed/refractory high-risk follicular lymphoma in the third line and beyond. The patient is the 62-year-old fit male from Case 1 who, following front-line bendamustine/rituximab and a second-line anthracycline-based regimen, achieves only a partial response with persistent disease on PET. His disease subsequently progresses—presenting the faculty with the challenge of selecting a third-line approach for a young, heavily pretreated patient with high-risk disease characteristics. The faculty explore the role of rebiopsy at each relapse to rule out transformation, particularly in patients with persistent FDG-avid disease after multiple lines of chemoimmunotherapy. They discuss the available third-line options—including single-agent bispecific antibodies, bispecific-based triplet regimens, CAR-T cell therapy, and novel oral combinations—and how patient preferences and disease biology inform sequencing decisions. They also address the importance of infection mitigation strategies, including antimicrobial prophylaxis and IVIG replacement, given the cumulative immunosuppression seen in heavily pretreated patients.
Case 2: Follicular Lymphoma With Relapse After Rituximab Monotherapy
This is Part 2 of Relapsed/Refractory Follicular Lymphoma: Choosing the Right Regimen for the Right Patient, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Loretta Nastoupil, Carla Casulo, and Kami Maddocks discuss the management of follicular lymphoma that has relapsed after rituximab monotherapy. The patient is a 72-year-old woman with hypertension and controlled type 2 diabetes who initially presented with symptomatic anemia and stage IV, low-tumor-burden follicular lymphoma, achieved a response to single-agent rituximab. She now returns 6 years later at age 78 with fatigue, mild thrombocytopenia, recurrent anemia, and small-volume adenopathy, with a strong preference for maintaining her quality of life and daily activities. The faculty explore how patient age, comorbidities, remission duration, and treatment goals should guide second-line therapy selection in older adults with indolent follicular lymphoma. They discuss the rationale for retreatment with single-agent CD20-directed antibody therapy vs more intensive triplet regimens, and address the evolving role of bispecific antibodies and clinical trials in this setting, as well as when chemoimmunotherapy may still be appropriate for patients requiring rapid disease control.
Case 1: Early Relapsed Follicular Lymphoma
This is Part 1 of Relapsed/Refractory Follicular Lymphoma: Choosing the Right Regimen for the Right Patient, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Loretta Nastoupil, Carla Casulo, and Kami Maddocks discuss the management of relapsed/refractory follicular lymphoma after first and early relapse. The patient is a fit, 62-year-old man with no comorbid conditions who was diagnosed with advanced-stage, low-grade follicular lymphoma (FLIPI 4) and achieved a complete response to front-line bendamustine/rituximab. Approximately 2 years later, he returns with symptomatic relapse, high disease burden, and extranodal involvement confirmed on biopsy. The faculty explore the prognostic significance of progression within 24 months of front-line chemoimmunotherapy and the importance of rebiopsy to rule out transformation to large cell lymphoma. They discuss the emerging role of novel triplet regimens—specifically lenalidomide/rituximab combined with either tafasitamab or epcoritamab—as preferred options over chemotherapy in this setting. They also compare practical and logistical considerations for choosing between these two regimens, including administration route, visit burden, toxicity profiles, and biomarkers such as CD20 expression.
Study Finds DLBCL Subtype May Have Higher Mortality Risk in Female Patients
An international research team has shown that a specific subtype of diffuse large B-cell lymphoma (DLBCL) is associated with higher mortality risk in women than in men. The study was led by the laboratory of Ari Melnick, MD, Director of the Josep Carreras Leukaemia Research Institute and the Gebroe ...
Sonrotoclax Receives Accelerated Approval in Relapsed or Refractory MCL
On May 13, the U.S. Food and Drug Administration (FDA) granted accelerated approval to sonrotoclax (Beqalzi), a BCL-2 inhibitor, for adults with relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy, including a Bruton’s tyrosine kinase (BTK) inhibitor....
Inherited Long Telomeres May Increase the Risk of Lymphoid Cancers
Researchers at the Johns Hopkins Kimmel Cancer Center and the Telomere Clinic at Johns Hopkins have identified a genetic syndrome in which unusually long telomeres—the protective caps at the ends of chromosomes—allow immune cells to remain biologically “younger” for longer than normal, predisposing ...
Integrated Molecular Analysis Identifies Determinants of Outcomes in TP53-Mutated DLBCL
In a study reported in the Journal of Clinical Oncology, Uppal et al identified factors associated with poorer outcomes in patients with TP53-mutated diffuse large B-cell lymphoma (DLBCL). Study Details The analysis included clinical and molecular data from 3,091 individuals which was derived from...
Four-Drug Regimen Induces High Complete Response Rate in Early-Stage Classical Hodgkin Lymphoma
High objective response and complete response rates were observed with treatment with brentuximab vedotin and nivolumab in combination with doxorubicin and dacarbazine chemotherapy in patients with early-stage classical Hodgkin lymphoma, according to the results of a phase II trial published in...
Lenalidomide Plus Rituximab in Relapsed or Refractory Indolent Non-Hodgkin Lymphoma: 5-Year Follow-up From AUGMENT
As reported in the Journal of Clinical Oncology by Leonard et al, the 5-year follow-up of the phase III AUGMENT trial has shown continued benefit of lenalidomide plus rituximab (R2) vs rituximab with placebo (R-placebo) in patients with relapsed or refractory indolent non-Hodgkin lymphoma. Study...
Metabolic Tumor Volume Predicts CAR T-Cell Therapy Response in LBCL
Positron-emission tomography (PET)-based metabolic tumor volume could serve as a significant measure of response to chimeric antigen receptor (CAR) T-cell therapy in patients with large B-cell lymphoma, according to the results of a study published in The Journal of Nuclear Medicine. Metabolic...
Bispecific Antibody Shows Deep Remission in Patients With Relapsed/Refractory Follicular Lymphoma
A population of patients with highly refractory follicular lymphoma achieved long-standing responses with few significant adverse events from odronextamab monotherapy, according to findings of the ELM-2 study. The study outcomes were published by Tessoulin et al in Clinical Lymphoma, Myeloma &...
FDA Grants Traditional Approval to Brexucabtagene Autoleucel for Relapsed or Refractory MCL
The U.S. Food and Drug Administration (FDA) has granted traditional approval to the chimeric antigen receptor (CAR) T-cell therapy brexucabtagene autoleucel (Tecartus) for adult patients with relapsed or refractory mantle cell lymphoma (MCL). The full approval now includes efficacy, safety, and...
FDA Approves Chemoimmunotherapy Regimen for Hodgkin Lymphoma
On March 20, the U.S. Food and Drug Administration (FDA) approved nivolumab (Opdivo) with doxorubicin, vinblastine, and dacarbazine (AVD) for adult and pediatric patients aged 12 years and older with previously untreated stage III or IV classical Hodgkin lymphoma. The FDA also granted traditional...
Early Study Evaluates Two-Vaccine Strategy in T-Cell Lymphoma
T-cell lymphomas are notoriously difficult to treat because immunotherapy, despite being one of the most effective therapies for treating cancer, can’t easily distinguish cancerous T cells from healthy ones. Now, scientists at The Wistar Institute have designed a two-vaccine approach that not only...
Lisocabtagene Maraleucel in Relapsed or Refractory MZL
In a phase II trial (TRANSCEND FL) reported in The Lancet, Palomba et al found that the chimeric antigen receptor (CAR) T-cell therapy lisocabtagene maraleucel was active in patients with relapsed or refractory marginal zone lymphoma (MZL). Study Details In the international multicenter trial, 67...
Dietary Influence on Leukemia and Lymphoma Progression
In 2015, LH, a 66-year-old female, was diagnosed with chronic lymphocytic leukemia (CLL), Rai stage 0. Untreated, the woman’s lymphocyte count rose from 5,000/mm3 to 16,000/mm3 in 6 years (doubling time = 4.2 years). She was then advised to stop eating red meat (see the figure). Commercially...
Fifteen-Year Results From SWOG S0016 Suggest Follicular Lymphoma May Be Curable
Advanced-stage follicular lymphoma is currently considered incurable. But a new analysis of long-term data from patients treated for the disease years ago with standard regimens of immunotherapy and a chemotherapy combination known as CHOP suggests that many of those patients can now be considered...
First Results of Phase III OLYMPIA-3: Odronextamab Plus CHOP in Untreated DLBCL
The bispecific antibody odronextamab plus standard CHOP (cyclophosphamide, vincristine, doxorubicin, prednisone) chemotherapy yielded robust and durable responses in treatment-naive patients with diffuse large B-cell lymphoma (DLBCL), based on the first results of the phase III OLYMPIA-3 study...
CLL/SLL: FDA Approves Combination of Acalabrutinib and Venetoclax
On February 19, the U.S. Food and Drug Administration (FDA) approved the Bruton’s tyrosine kinase inhibitor acalabrutinib (Calquence) tablets and capsules in combination with the BCL2 inhibitor venetoclax (Venclexta) for adults with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma...
Epcoritamab Plus R2 in Follicular Lymphoma: A Potential New Treatment Standard
In patients with follicular lymphoma who received at least one prior line of therapy, the combination of the bispecific antibody epcoritamab-bysp and rituximab–lenalidomide (R2) reduced the risk of disease progression or death by almost 80% over R2 alone, based on the primary analysis of the phase...
Case 3: Management of Multiply Relapsed DLBCL
This is Part 3 of Personalizing Treatment Pathways in Relapsed/Refractory DLBCL, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Jeremy Abramson, J. Erika Haydu, and Jacob Soumerai discuss the treatment of multiply relapsed diffuse large B-cell lymphoma (DLBCL). The patient is a 44-year-old man with stage IV, IPI 2, GCB-subtype, MYC/BCL2 double-hit lymphoma who achieved complete remission with front-line dose-adjusted EPOCH-R but relapsed at 18 months. As a young, transplant-eligible patient, he received R-DHAP with the goal of proceeding to autologous stem cell transplant. However, he progressed after two cycles with worsening hepatic dysfunction. In the conversation that follows, the faculty discuss age-based treatment selection for late relapse, the importance of monitoring for cytokine-release syndrome and immune effector cell–associated neurotoxicity, and treatment options after failure of CAR T-cell therapy—especially in the case of antigen loss.
Case 2: Second-Line Management of Relapsed DLBCL
This is Part 2 of Personalizing Treatment Pathways in Relapsed/Refractory DLBCL, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Jeremy Abramson, J. Erika Haydu, and Jacob Soumerai discuss the second-line treatment of relapsed diffuse large B-cell lymphoma (DLBCL). The patient is a 74-year-old woman with stage IV, IPI 4, non-GCB subtype DLBCL who achieved complete remission with front-line Pola-R-CHP (polatuzumab vedotin plus rituximab, cyclophosphamide, doxorubicin, and prednisone) but relapsed 9 months later with symptomatic peritoneal lymphomatosis. Despite being 75 years old at relapse, she is considered eligible for chimeric antigen receptor (CAR) T-cell therapy, but she faces barriers to accessing this treatment and is interested in other options. In the conversation that follows, the faculty discuss CAR T-cell therapy eligibility in older patients, second-line treatment options for patients without CAR-T access, and treatment sequencing considerations.
Case 1: Management of Early Relapsed DLBCL
This is Part 1 of Personalizing Treatment Pathways in Relapsed/Refractory DLBCL, a three-part video roundtable series. Scroll down to watch the other videos from this roundtable. In this video, Drs. Jeremy Abramson, J. Erika Haydu, and Jacob Soumerai discuss the treatment of early relapsed diffuse large B-cell lymphoma. The patient is a 64-year-old woman with stage III, IPI 3, GCB-subtype DLBCL who developed primary refractory disease after R-CHOP therapy, with mixed/progressive findings on interim PET/CT after three cycles. Despite being relatively asymptomatic with an ECOG performance status of 1, confirmatory biopsy demonstrated persistent GCB DLBCL. In the conversation that follows, the faculty discuss the use of CAR T-cell therapy in the second-line treatment of DLBCL, bridging therapy considerations, and the management of cytokine-release syndrome.
Pirtobrutinib Improves Progression-Free Survival vs Bendamustine/Rituximab in Front-Line CLL/SLL
The first prospective, randomized phase III trial of a noncovalent Bruton’s tyrosine kinase (BTK) inhibitor exclusively in treatment-naive patients with chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL)—BRUIN CLL-313—demonstrated a statistically significant and clinically...
Phased Variant ctDNA as Biomarker After First-Line Treatment in LBCL
In a study (DIRECT) reported in the Journal of Clinical Oncology, Krupka et al found that phased variant (PV) ctDNA provided “sensitive and clinically meaningful response assessment” after first-line treatment of large B-cell lymphoma (LBCL). As stated by the investigators, “Tracking tumor-specific ...
Nivolumab Plus AVD Reduces Disease Progression Risk in Adolescents With Advanced Classical Hodgkin Lymphoma
A combination of nivolumab with AVD chemotherapy (doxorubicin, vinblastine, and dacarbazine) demonstrated a significant reduction in the risk of disease progression or death compared with brentuximab vedotin plus AVD in adolescent patients with newly diagnosed advanced classical Hodgkin lymphoma,...
Refractory LBCL: CD19-Targeting CAR T-Cell Therapy Plus Rituximab
A dual-antigen targeting combination of the CD19-targeting chimeric antigen receptor (CAR) T-cell therapy axicabtagene ciloleucel plus the CD20-targeting agent rituximab led to durable responses and reduced relapses in patients with refractory large B-cell lymphoma (LBCL), according to findings...
Addition of Epcoritamab to Lenalidomide Plus Rituximab in Relapsed or Refractory Follicular Lymphoma
As reported in The Lancet by Falchi et al, an interim analysis of the phase III EPCORE FL-1 trial has shown that the addition of the bispecific antibody epcoritamab (for B-cell CD20 and T-cell CD3 antigens) to lenalidomide plus rituximab improved the objective response rate and progression-free...
Addition of Tafasitamab to Lenalidomide Plus Rituximab in Relapsed or Refractory Follicular Lymphoma
In a phase III trial (inMIND) reported in The Lancet, Sehn et al found that the addition of the CD19-targeted Fc-enhanced monoclonal antibody tafasitamab to lenalidomide plus rituximab improved progression-free survival in patients with relapsed or refractory follicular lymphoma. Study Details In...
Lymphocyte Kinetics After CAR T-Cell Infusion May Predict Survival Outcomes in Non-Hodgkin Lymphoma
A higher absolute lymphocyte count (ALC) after receipt of chimeric antigen receptor (CAR) T-cell therapy may be associated with improved progression-free and/or overall survival in patients with non-Hodgkin lymphoma, according to findings from the 2025 American Society of Hematology (ASH) Annual...
FLIPI24: New Prognostic Model for Newly Diagnosed Follicular Lymphoma
As reported in the Journal of Clinical Oncology, Maurer et al have developed FLIPI24, a modern prognostic model for newly diagnosed follicular lymphoma. As stated by the investigators, “Although most patients with … [follicular lymphoma] can expect an indolent course, progressive lymphoma remains...
Follicular Lymphoma: Durable Remissions and Sustained Safety With Third-Line Lisocabtagene Maraleucel
Patients with relapsed or refractory follicular lymphoma treated in the third-line setting with a single infusion of the chimeric antigen receptor (CAR) T-cell therapy lisocabtagene maraleucel continued to show responses after 3 years, according to long-term follow-up results from the TRANSCEND FL...
CD40 Overexpression Emerges as a Potential Biomarker for Angioimmunoblastic T-Cell Lymphoma
Researchers at The University of Texas MD Anderson Cancer Center have identified CD40 overexpression as a potential prognostic biomarker in angioimmunoblastic T-cell lymphoma (AITL), a rare subtype of non-Hodgkin lymphoma that is difficult to diagnose and treat. The results of their study were...
Noninferiority Shown for Pirtobrutinib vs Ibrutinib in CLL/SLL
The noncovalent Bruton's tyrosine kinase (BTK) inhibitor pirtobrutinib achieved noninferiority to the covalent BTK inhibitor ibrutinib in terms of overall response rate in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), according to findings from a randomized...
Epcoritamab Added to Second-Line Lenalidomide/Rituximab Improves Responses in Follicular Lymphoma
When epcoritamab was added to lenalidomide and rituximab, response rates were significantly higher and progression-free survival was prolonged for patients with follicular lymphoma treated in the second-line setting or beyond, according to findings from the phase III EPCORE FL-1 trial presented at...
FDA Approves CAR T-Cell Therapy for Relapsed/Refractory Marginal Zone Lymphoma
On December 4, 2025, the U.S. Food and Drug Administration (FDA) approved the CD19-directed chimeric antigen receptor (CAR) T-cell therapy lisocabtagene maraleucel (Breyanzi) for the treatment of adult patients with relapsed or refractory marginal zone lymphoma who have received at least two prior...
