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skin cancer
issues in oncology

AACR 2025: Pretrained AI Models Could Help Accurately Diagnose Nonmelanoma Skin Cancers in Resource-Limited Settings

Artificial intelligence (AI) models pretrained on vast data sets may outperform standard baseline models in identifying nonmelanoma skin cancers from digital images of tissue samples, according to new findings presented by Song et al at the 2025 American Association for Cancer Research (AACR)...

solid tumors
hematologic malignancies
issues in oncology
immunotherapy
survivorship

Richard Pazdur, MD, Honored With 2025 AACR Enduring Impact Award for Transformative Service to Cancer Science and Medicine

During the 2025 American Association for Cancer Research (AACR) Annual Meeting, Richard Pazdur, MD, Director of the Oncology Center of Excellence at the U.S. Food and Drug Administration (FDA), accepted the 2025 AACR Enduring Impact Award for Transformative Service to Cancer Science and Medicine...

solid tumors

AACR 2025: Novel Targeted Therapy Under Study in Selected Patients With Advanced Solid Tumors

The first-in-class covalent Werner helicase inhibitor (RO7589831) demonstrated early signals of efficacy as well as general tolerability in patients with advanced solid tumors harboring certain genetic defects, according to results from a phase I trial. Agents in this class target the DNA repair...

lung cancer

AACR 2025: Oral HER2-Targeted Therapy for Advanced HER2-Mutated Lung Cancer

The novel HER2-targeted tyrosine kinase inhibitor zongertinib elicited durable responses in patients with advanced, previously treated non–small cell lung cancer (NSCLC) that harbored a HER2 mutation, according to the preliminary results of the early-phase Beamion LUNG-1 trial. These findings were...

lung cancer
issues in oncology
genomics/genetics

AACR 2025: Zoldonrasib May Elicit Objective Responses in Patients With KRAS G12D–Mutated NSCLC

The oral KRAS G12D inhibitor zoldonrasib could provide clinical benefit in patients with previously treated non–small cell lung cancer (NSCLC) whose tumors harbored a KRAS G12D mutation, according to new findings presented by Arbour et al at the 2025 American Association for Cancer Research (AACR)...

immunotherapy

AACR 2025: Nonoperative Management of Mismatch Repair–Deficient Tumors

PD-1 blockade with the PD-1 inhibitor dostarlimab-gxly induced complete tumor clearance and resolved the need for surgery in patients with locally advanced, mismatch repair–deficient (dMMR) cancers, according to preliminary results from a phase II trial presented at the 2025 American Association...

head and neck cancer

Addition of Neoadjuvant/Adjuvant Pembrolizumab Significantly Improves Outcomes in Locally Advanced HNSCC

The addition of neoadjuvant and adjuvant pembrolizumab to standard-of-care therapy significantly improved event-free survival over the standard of care alone for patients with locally advanced head and neck cancer in the phase III KEYNOTE-689 trial, according to results presented at the American...

colorectal cancer
issues in oncology

Childhood Exposure to Bacterial Toxin May Trigger Early-Onset Colorectal Cancer

Researchers may have identified the bacterial toxin colibactin as a potential factor contributing to the concerning rise in early-onset colorectal cancer, according to a novel study published by Díaz-Gay et al in Nature. The findings demonstrated a substantial enrichment of colibactin-related...

leukemia

Use of Statins in CLL/SLL

Statin use during targeted therapy treatment led to a 61% improvement in the risk of dying of cancer for patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL), according to the results of a study published in Blood Advances. The investigators sought to determine the...

W. Kimryn Rathmell, MD, PhD, FASCO, Named CEO of The Ohio State’s James Cancer Hospital and Solove Research Institute

Following a comprehensive national search, W. Kimryn Rathmell, MD, PhD, FASCO, former Director of the National Cancer Institute (NCI), has accepted the role of Chief Executive Officer (CEO) of The Ohio State University Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J....

head and neck cancer

FDA Approves Anti–PD-1 Antibody for Nasopharyngeal Cancer

The U.S. Food and Drug Administration (FDA) has approved the humanized IgG1 monoclonal anti–PD-1 antibody penpulimab-kcqx with cisplatin or carboplatin and gemcitabine for the first-line treatment of adults with recurrent or metastatic nonkeratinizing nasopharyngeal carcinoma (NPC). The FDA also...

WHI Funding Future Unclear

Women’s Health Initiative (WHI) investigators were informed on April 21 that the Department of Health and Human Services (HHS) will terminate WHI Regional Center (RC) contracts at the end of the current fiscal year (September 2025). The WHI Clinical Coordinating Center (CCC) will continue...

hepatobiliary cancer

Combination Immunotherapy Approved for Unresectable or Metastatic Hepatocellular Carcinoma

On April 11, 2025, the U.S. Food and Drug Administration (FDA) approved nivolumab (Opdivo) with ipilimumab (Yervoy) for the first-line treatment of adults with unresectable or metastatic hepatocellular carcinoma. (See here for details on approval of this combination immunotherapy for colorectal...

neuroendocrine tumors

Cabozantinib Approved for Treatment of Neuroendocrine Tumors

The U.S. Food and Drug Administration (FDA) recently approved the tyrosine kinase inhibitor cabozantinib (Cabometyx) for adult and pediatric patients aged 12 years and older with previously treated, unresectable, locally advanced or metastatic, well-differentiated pancreatic neuroendocrine tumors...

Karen E. Knudsen, MBA, PhD, Appointed Chief Executive Officer of the Parker Institute for Cancer Immunotherapy

The Parker Institute for Cancer Immunotherapy (PICI) announced the appointment of Karen E. Knudsen, MBA, PhD, as its new Chief Executive Officer (CEO). A visionary leader in oncology, health-care delivery, scientific innovation, and strategic transformation, Dr. Knudsen joins PICI at a pivotal time ...

gynecologic cancers

Use of Investigational Tool to Detect Advanced-Stage Invasive Cervical Cancer

At the 2025 Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer, Kersten Rothnie, MBBS, a gynecologic oncology fellow at Northwell Health in New York City, shared study findings on an investigational tool on behalf of her colleagues.1 These results suggested the presence of...

supportive care
lung cancer

Managing Dermatologic Reactions to Combination Therapy for Patients With EGFR-Mutated NSCLC

Nicolas Girard, MD, a thoracic oncologist at the Institut Curie, Paris, presented the results of an interim analysis of the open-label phase II COCOON study, at the European Lung Cancer Congress (ELCC) 2025.1 A readily available preventive regimen (the COCOON regimen) reduced moderate-to-severe...

SGO’s President-Elect Brings Professional Experience and Passion to Her New Role

Society of Gynecologic Oncology (SGO) President-Elect Karen Lu, MD, assumed her official duties on March 17, 2025. Dr. Lu, who is also Executive Vice President and Physician-in-Chief at Moffitt Cancer Center in Tampa, Florida, brings many years of professional experience and active SGO membership...

colorectal cancer
issues in oncology

Benefits of Walnut Consumption: Curbing Inflammation, Colorectal Cancer Risk

Researchers have uncovered that eating walnuts may improve systemic inflammation and reduce the risk for colorectal cancer, according to a recent study published by Moussa et al in Cancer Prevention Research. Background Ellagitannins—plant-derived polyphenol compounds found in walnuts—have been...

solid tumors
immunotherapy

Response to Immune Checkpoint Inhibitors Not Affected by Age

Older patients with a solid tumor responded with similar clinical outcomes to younger patients treated with immune checkpoint inhibitors, the results of a study published in Nature Communications showed. However, older patients did have divergent immune phenotypes compared with younger patients,...

hematologic malignancies
issues in oncology
immunotherapy

Role of Pathologists in Improving Access to Safer, More Effective Allogeneic Cell Therapies

Researchers are working to accelerate the clinical adoption of novel allogeneic cell therapies to improve cancer care and treatment, according to a new report from the College of American Pathologists (CAP). Background Allogeneic cell therapy—which uses cells from a healthy donor rather than a...

genomics/genetics
cost of care

Medicare Claim Denials for Cancer-Related NGS Testing Show Uncertainty of Coverage

More than 20% of cancer-related claims for next-generation sequencing (NGS) from Medicare beneficiaries were denied between 2016 and 2021. Findings from a cohort study published in JAMA Network Open suggested that there is continued uncertainty about the boundaries of coverage for NGS, even with...

pancreatic cancer

Detecting Invasive Nodules Could Be Key to Preventing Unnecessary Pancreatic Cancer Surgery

Some pancreatic cysts may be benign, whereas others have the potential to develop into pancreatic cancer. A recent Japanese study followed 257 patients for an average of 5 years and evaluated the presence or absence of invasive nodules in pancreatic cysts and whether these cysts are benign or...

head and neck cancer
issues in oncology

Updated CAP Guideline Aims to Address Rising Rates of HPV-Associated Squamous Cell Carcinomas

The College of American Pathologists (CAP) updated its testing guideline to capture new research and emerging technologies to improve the diagnostic accuracy of human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinomas, according to a guideline update published by Lewis et al in...

breast cancer

Patient Support Found for AI Use as Second Reader of Mammograms

A survey study has shown cautious patient support for the use of artificial intelligence (AI) as a second reader in screening mammograms, according to results published in Radiology: Imaging Center.   The study authors sought to determine the sentiments of patients regarding AI use in mammogram...

breast cancer
neuroendocrine tumors

CAP Issues New and Updated Cancer Protocols

New protocols for endocrine tumors and updated existing protocols for breast cancer diagnoses are now available from the College of American Pathologists (CAP). These and other updates to protocols reflect the latest scientific advancements, ensuring that pathology reports provide oncologists with...

thyroid cancer

Early-Life Exposure to Environmental Carcinogens May Increase Risk of Pediatric Papillary Thyroid Cancer

Perinatal and early-life exposure to ambient fine particulate matter air pollution (PM2.5) and outdoor artificial light at night (O-ALAN) may be associated with a statistically significant increased risk of papillary thyroid cancer in children and young adults up to 19 years old, according to the...

breast cancer
survivorship
issues in oncology

Metabolic Syndrome May Increase Risk of Cancer Recurrence, Subsequent Mortality Among Breast Cancer Survivors

Breast cancer survivors with metabolic syndrome may have an elevated likelihood of breast cancer recurrence and subsequent breast cancer–related mortality, according to new findings to be presented by Harborg et al at the European Congress on Obesity (ECO) 2025, taking place between May 11 and 14...

breast cancer

Renowned Breast Cancer Physician-Scientist Hope S. Rugo, MD, FASCO, to Lead Women’s Cancers Program at City of Hope

Hope S. Rugo, MD, FASCO, recently joined the staff of City of Hope as the new Director of the Women’s Cancers Program, Division Chief of Breast Medical Oncology, and Professor in the Department of Medical Oncology and Therapeutics Research. In her role, she will lead and enhance City of Hope’s...

lung cancer
health-care policy

How Does Medicaid Expansion Affect Access to Care in Patients With NSCLC?

A recent study published by Hooda et al in The Annals of Thoracic Surgery suggests that Medicaid expansion under the Affordable Care Act has significantly improved access to timely treatment and high-volume hospitals for patients with early-stage non–small cell lung cancer (NSCLC). These findings...

breast cancer
issues in oncology

Poor Agreement Reported Among Diagnostic Tests for Breast Cancer–Related Lymphedema

Various tests, ranging from a tape measure to sophisticated imaging technology, show low to moderate agreement in diagnosing breast cancer–related lymphedema, according to a recent study published by Brunelle et al in Rehabilitation Oncology. Background Breast cancer–related lymphedema is...

lung cancer

Dual Use of Cigarettes and E-Cigarettes on Par With Sole Cigarette Use in Terms of Toxic Exposure

Individuals who reported exclusive use of combustible cigarettes as well as those who reported dual use of both cigarettes and e-cigarettes showed similarly high toxicant exposure, according to the results of a study published in Nicotine & Tobacco Research. Both groups of smokers showed higher ...

Germline Variants May Impact Unique Nature of a Patient’s Cancer, Study Shows

Research into germline genetic variants has identified ways that an individual’s genetic makeup can shape the biology of their cancer. The report, published in Cell, shows how these findings could potentially be applied to future treatment strategies to make cancer treatment more personalized.   A...

skin cancer
genomics/genetics

Can ctDNA Monitoring Help to Predict Melanoma Recurrence?

A new study showed that approximately 80% of patients with stage III melanoma who had detectable levels of circulating tumor DNA (ctDNA) before they started treatment to suppress their tumors went on to experience recurrence. Researchers also found that the disease returned more than four times...

gynecologic cancers

Parasitic Infection and Its Treatment Linked to Cancer-Related Gene Activity in the Cervix

New research has revealed that Schistosoma haematobium, a parasitic infection affecting millions globally, can trigger cancer-related gene activity in the cervical lining, with changes becoming even more pronounced after treatment. Presented at ESCMID Global 2025, this pivotal study sheds new light ...

hepatobiliary cancer
issues in oncology

Novel Drug/Device Combination May Improve Outcomes in Metastatic Uveal Melanoma

Percutaneous hepatic perfusion using a melphalan hepatic delivery system (melphalan/HDS) may be an effective treatment option in patients with unresectable uveal melanoma that has metastasized to the liver, according to a recent study published by Zager et al in the Annals of Surgical Oncology....

multiple myeloma

ADAR1 Gene and Response to Lenalidomide in Patients With Multiple Myeloma

Investigators have identified a key component inhibiting responses to lenalidomide in patients with multiple myeloma, according to the results of a study recently published in Blood. They identified adenosine deaminase acting on RNA1 (ADAR1) as a novel driver of acquired resistance to lenalidomide...

colorectal cancer
pancreatic cancer

Incidence Rates of Colorectal and Pancreatic Cancers Are Rising Most Among Young Adults

The incidence rates of colorectal and pancreatic adenocarcinomas have risen the most among young adults over the past 2 decades, suggesting the need for heightened awareness among clinicians for these diseases in this patient population, according to a report published by Bussetty et al in JAMA...

issues in oncology

Link Between CT Scans and Future Cancer Incidence?

At current use and radiation dose levels, computed tomography (CT) scans may eventually account for 5% of all cancers annually, according to a recent modeling study published by Smith-Bindman et al in JAMA Internal Medicine. The danger is greatest for infants, followed by children and...

cns cancers
skin cancer
lung cancer
immunotherapy

Immunotherapy, Radiosurgery Combination and Risk of Radiation Necrosis in Patients With Cancer Who Have Brain Metastases

Patients with melanoma and lung cancer who have brain metastases may experience severe inflammatory reactions after receipt of immunotherapy drugs combined with radiation therapy, according to a recent study published by Vaios et al in JAMA Network Open. Study Methods and Results In this study,...

global cancer care

Most Pediatric Cancer Deaths Occur in Regions of Conflict

Almost 60% of all deaths from pediatric cancers occur in regions of armed conflict, according to the results of a study published in The Lancet Oncology.   Investigators from St. Jude Children’s Research Hospital, Duke University, and other institutions sought to reveal the relationship between...

cns cancers
colorectal cancer
kidney cancer
lung cancer
gynecologic cancers

FDA Approves Bevacizumab Biosimilar

The U.S. Food and Drug Administration (FDA) has approved bevacizumab-nwgd (Jobevne), a biosimilar to bevacizumab (Avastin), for intravenous use. Bevacizumab-nwgd is a recombinant humanized monoclonal antibody and a vascular endothelial growth factor (VEGF) inhibitor that binds with VEGF and blocks...

issues in oncology
genomics/genetics
solid tumors
bladder cancer
skin cancer
lung cancer

Novel Strategy May Enhance Sensitivity, Accuracy of Monitoring Cancer in Blood Samples

A whole-genome sequencing–based, error-corrected method for detecting cancer from blood samples could be more sensitive and accurate in monitoring disease status posttreatment among patients with cancer compared with prior methods, according to a recent study published by Cheng et al in Nature...

hepatobiliary cancer

FDA Approves Nivolumab Plus Ipilimumab for Unresectable or Metastatic HCC

On April 11, 2025, the U.S. Food and Drug Administration approved nivolumab (Opdivo) with ipilimumab (Yervoy) for the first-line treatment of adult patients with unresectable or metastatic hepatocellular carcinoma (HCC). Efficacy was evaluated in CheckMate-9DW (ClinicalTrials.gov identifier...

supportive care

Low-Dose vs Regular-Dose Apixaban for Prevention of VTE Recurrence in Patients With Cancer

Patients with active cancer who developed venous thromboembolism (VTE) and were treated with anticoagulants for at least 6 months, followed by an additional 12 months of low-dose apixaban, experienced similar VTE recurrences and less bleeding as similar patients who received a full dose of the oral ...

leukemia
issues in oncology
covid-19

Pausing vs Continuing BTK Inhibitors at Time of COVID-19 Vaccination in Patients With CLL

Researchers have found that patients with chronic lymphocytic leukemia (CLL) should continue to receive Bruton tyrosine kinase (BTK) inhibitors while being vaccinated against COVID-19 infections, according to a recent study published by Cook et al in The Lancet Haematology. Background CLL is the...

pancreatic cancer
issues in oncology

Study Illuminates Disparities in Treatment, Survival in Metastatic Pancreatic Ductal Adenocarcinoma

Investigators may have uncovered factors that may impact the quality of cancer care and outcomes among patients with metastatic pancreatic ductal adenocarcinoma, according to a recent study published by Tsilimigras et al in JNCCN–Journal of the National Comprehensive Cancer Network. Study Methods...

American Cancer Society Launches CEO Search

The American Cancer Society (ACS) and the American Cancer Society Cancer Action Network (ACS CAN) announced the launch of a nationwide search to find the organizations’ next Chief Executive Officer (CEO). In November, the ACS Board of Directors appointed Wayne A.I. Frederick, MD, MBA, to serve as...

breast cancer

Frailty Following Chemotherapy May Be Linked to Poorer Survival in Older Women With Breast Cancer

The results of a longitudinal cohort study published in JAMA suggest that frailty following adjuvant chemotherapy may be associated with long-term survival among older women with nonmetastatic breast cancer.   Women who experienced rapid frailty progression, or nonresilience, following their...

issues in oncology
health-care policy

Crossing State Borders: Addressing Residential Barriers to Cancer Care

A high proportion of Medicare beneficiaries cross state borders to access cancer care, particularly patients residing in rural areas, according to a recent study published by Moen et al in JAMA Network Open. The findings have significant implications for telehealth policies and physician licensure, ...

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