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Showing 11601 - 11650Why The ASCO Post?
It has been 5 years since ASCO has been part of a new publication, the last being the Journal of Oncology Practice (JOP). As the ASCO Board and leadership evaluated the publication mix we recognized there was a gap that needed to be filled. The Journal of Clinical Oncology (JCO), now 25 years old, ...
Christopher Sweeney, MBBS, and Thomas Powles, MD, PhD, on Urothelial Cancer: The JAVELIN Bladder 100 Study on Avelumab vs Best Supportive Care
Christopher Sweeney, MBBS, of Dana-Farber Cancer Institute, talks with Thomas Powles, MD, PhD, of Queen Mary University of London, about the first study to demonstrate a survival advantage with avelumab for metastatic urothelial cancer. In the trial, avelumab improved median overall survival by...
Expert Point of View: Axel Grothey, MD
Sharing his perspective on KEYNOTE-177 with The ASCO Post was Axel Grothey, MD, Director of GI Cancer Research at the West Cancer Center, OneOncology, Memphis. “This is a very important, highly anticipated study,” he said. “It’s the first randomized trial of any checkpoint inhibitor in...
Pembrolizumab Doubles Progression-Free Survival in MSI-H/dMMR Metastatic Colorectal Cancer
For the first time, upfront treatment with immunotherapy has improved—in fact, doubled—median progression-free survival in a subset of patients with metastatic colorectal cancer. The findings are from the interim analysis of the randomized open-label phase III KEYNOTE-177 trial comparing the...
Expert Point of View: Jonathan E. Rosenberg, MD
“These data are solid, showing a 7-month improvement in overall survival in patients with stable disease or better after first-line chemotherapy. This is roughly a 50% improvement in survival, which is clinically meaningful. Also, progression-free survival was significantly increased with...
Maintenance Avelumab Improves Survival in Advanced Bladder Cancer
Maintenance therapy with avelumab and best supportive care significantly prolonged overall survival vs best supportive care alone in patients with advanced urothelial carcinoma that did not progress on first-line platinum-based chemotherapy, according to an interim analysis of the phase III...
Sources for Better GVHD-Free Relapse-Free Survival After Adult Alternative Donor HCT
In a retrospective study of registry data reported in the Journal of Clinical Oncology, Mehta et al identified alternative donor sources for hematopoietic cell transplantation (HCT) that were associated with better graft-vs-host disease (GVHD)-free (GRFS) and chronic GVHD–free (CRFS) relapse-free...
Use of Symptom Assessment Scale vs Routine Management in Patients With Cancer Receiving Radiotherapy
In a single-institution study reported in JCO Oncology Practice, Goyal et al found that use of the Edmonton Symptom Assessment Scale (ESAS) self-assessment tool during weekly on-treatment physician visits was associated with reduced symptom severity vs routine symptom management in patients...
ESMO Breast 2020: Novel Biomarkers May Predict Immunotherapy Benefit in Metastatic Breast Cancer
Two novel biomarkers have been found to correlate with improved outcomes with immunotherapy in metastatic breast cancer and may help to identify the patients most likely to benefit from this treatment, according to exploratory studies reported at the European Society for Medical Oncology (ESMO)...
ESMO Breast 2020: Study Finds Physical Activity, Supportive Care to Relieve Cancer-Related Fatigue May Be Underutilized by Breast Cancer Survivors
Cancer-related fatigue is a prevalent and potentially persistent issue among breast cancer survivors. A study presented by Di Meglio et al at the ESMO Breast Cancer Virtual Meeting 2020 (Abstract 183O) has now shown that existing recommendations and proven strategies for reducing fatigue—which can...
ESMO Breast 2020: Ipatasertib/Paclitaxel vs Paclitaxel Alone in Advanced Triple-Negative Breast Cancer
Final analysis of the LOTUS trial has shown numerically longer overall survival with ipatasertib plus paclitaxel vs placebo plus paclitaxel in patients with inoperable locally advanced/metastatic triple-negative breast cancer. In all biomarker-defined subgroups (PTEN normal or low, PIK3CA/AKT1/PTEN ...
ESMO Breast 2020: Patient Preference for Subcutaneous vs Intravenous Pertuzumab/Trastuzumab for HER2-Positive Early Breast Cancer
At the European Society for Medical Oncology (ESMO) Breast Cancer Virtual Meeting 2020, Joyce O’Shaughnessy, MD, of Baylor University Medical Center, reported results from an interim analysis of the PHranceSCa study (Abstract 80O). The study investigators found that over 80% of patients preferred...
ASBrS 2020: Analysis of Women Younger Than 40 With Breast Cancer
Patients with breast cancer younger than 40 generally present with a characteristic profile—later-stage disease and more aggressive tumors with poorer prognosis—according to findings from a new study analyzing one of the largest patient data sets compiled to investigate age-related breast cancer...
ASBrS 2020: Phone Outreach and Scheduling Assistance Boost Mammography Uptake at an Urban Safety-Net Hospital
Telephone outreach coupled with scheduling assistance significantly increased screening mammography setup and follow-through in a population characterized by low rates of screening mammography and high rates of advanced breast cancer at diagnosis. These are findings from a new study conducted by...
ASBrS 2020: Cosmetic Outcomes With Lumpectomy for Multiple Ipsilateral Breast Cancer
The majority of women with multiple tumors in a single breast reported good or excellent satisfaction with the cosmetic results of lumpectomy, despite loss of significant breast volume and often multiple incisions. These findings are from an ongoing multicenter prospective trial examining the...
FDA Approves Nivolumab/Ipilimumab Plus Chemotherapy for First-Line Treatment of Metastatic or Recurrent NSCLC
On May 26, the U.S. Food and Drug Administration (FDA) approved the combination of nivolumab (Opdivo) plus ipilimumab (Yervoy) and two cycles of platinum-doublet chemotherapy as first-line treatment for patients with metastatic or recurrent non–small cell lung cancer (NSCLC) with no epidermal...
FDA Approves Brigatinib for ALK-Positive Metastatic NSCLC
On May 22, the U.S. Food and Drug Administration (FDA) approved brigatinib (Alunbrig) for adult patients with anaplastic lymphoma kinase (ALK)-positive metastatic non–small cell lung cancer (NSCLC) as detected by an FDA-approved test. The FDA also approved the Vysis ALK Break Apart FISH Probe Kit...
New Article Analyzes Impact of PBMs on Quality Cancer Care
Recently, an article and accompanying infographic published in JCO Oncology Practice examined the impact pharmacy benefit managers (PBMs) have on cancer care delivery. The article is part of ASCO’s State of Cancer Care in America series, which explores challenges and opportunities in today’s...
New Guidance Released for Oncology Community on Allocation of Limited Resources During the COVID-19 Pandemic
ASCO recently released a set of recommendations to support the oncology community as health-care institutions across the United States face potentially difficult decisions around the allocation of scarce health-care resources during the COVID-19 pandemic. In some geographic areas, the ongoing...
Help Your Patients Manage Their Weight With This ASCO Resource
Do your patients know that being overweight may slow recovery and lower cancer survival? Address this sensitive topic with the help of the Managing Your Weight After a Cancer Diagnosis booklet from ASCO Answers. This resource will help patients manage their weight by providing practical resources...
Fundraising to Help Patients and Oncologists During the COVID-19 Pandemic
Conquer Cancer, the ASCO Foundation, is raising money through COVID Impacts Cancer, an emergency campaign to support patients with cancer, cancer care teams, and researchers. This fund will aid in advancing vital cancer research and expanding support for patients and oncology providers during and...
Milestone Memories: Conquer Cancer Researcher Searches for Colorectal Cancer Cures
On her wedding day, a father—who happens to have colorectal cancer—walks his daughter down the aisle. His oncologist, Rona Yaeger, MD, of Memorial Sloan Kettering Cancer Center, helped him mark this milestone. Currently, patients with BRAF-mutant colorectal cancers face a poor prognosis. Dr....
Tips for First-Time Abstract Presenters
The fundamental goal of scientific meetings is to share knowledge and accelerate scientific advances. Investigators use different types of presentations to disseminate and share their valuable work with others in the field. This is an important aspect of promoting their scientific careers. These...
A Long Crusade Against Some of the World’s Most Virulent Diseases for Anthony S. Fauci, MD
The doctor-patient relationship, a time-honored tradition based on trust and cooperation, is critical for vulnerable patients, as they experience a heightened reliance on the physician’s competence, skills, and good will. That same trust is critical on the public health stage, when a nation is...
Jennifer C. King, PhD, Named CSO of GO2 Foundation
GO2 Foundation for Lung Cancer (GO2 Foundation) has promoted Jennifer C. King, PhD, to the role of Chief Scientific Officer. In her new position, Dr. King will be responsible for leading scientific and research priorities for a global patient advocacy group dedicated to saving, extending, and...
Brain Cancer Prepared Me for the Isolation and Uncertainty of the COVID-19 Pandemic
The symptoms of low-grade oligodendroglioma first appeared in the summer of 2003, when I was 12, but they were vague enough—mild headaches and occasional weird sensations on my right side—to ignore. In the fall, I tripped and fell during a game of rollerblade hockey with my classmates and started...
The Arc of Therapy—From Cure to Humbling Legacy
The ASCO Post is pleased to reproduce installments of Art of Oncology as published previously in the Journal of Clinical Oncology. These articles focus on the experience of suffering from cancer or of caring for people diagnosed with cancer, and they include narratives, topical essays, historical...
A Daughter of Immigrant Doctors, Nina Kadan-Lottick, MD, MSPH, Chose a Career in Pediatric Oncology
In 2003, Nina Kadan-Lottick, MD, MSPH, established the regional Yale HEROS multidisciplinary research and clinical program for long-term survivors of childhood cancer survivors, which is the first of its kind in Connecticut and one of the first in the United States. She intends the HEROS program to ...
Paul G. Marks, MD, Visionary Leader of Memorial Sloan Kettering Cancer Center, Dies at 93
In 1980, Paul G. Marks, MD, became the President and Chief Executive Officer of Memorial Sloan Kettering Cancer Center (MSK), the oldest and largest private cancer center in the world. Over his 19-year reign, he is credited with setting MSK on a more scientific course by encouraging innovative...
Researcher and Leader in Cancer Center Administration, John W. Yarbro, MD, PhD, Dies at 88
Most who leave a mark in life are noted for a single contribution; few are remembered for the breadth of their contributions. Such a man was John W. Yarbro, MD, PhD, who, near the end of his rich life, stepped foot on Antarctica, completing his desire to have visited all of the world’s seven...
Champion in Geriatric Oncology, Rosemary Yancik, PhD, Dies at 86
Rosemary Yancik, PhD, a medical sociologist, was best known for her talent of bringing a group of experts together who shared her interests in improving the prevention and management of cancer in elderly patients. She served many years at the National Institutes of Health in both the National...
What Have I Learned in More Than Half a Century in Cancer Medicine?
My journey in cancer medicine started in June 1968, when I traveled from Lebanon to New York to begin my fellowship in medical oncology at Memorial Sloan Kettering Cancer Center. Since then, and on a daily basis, I have been actively engaged in the treatment of patients with cancer and in cancer...
The Story of Three Patients With Leukemia
The human drama within the oncology world is a never-ending story of triumph, tragedy, and all of the valiant efforts and human emotions in between. The doctor-patient relationship in oncology is deeper and longer than in most medical specialties due to the life-and-death stakes at play after a...
Ancestry and Molecular Makeup of Cancer Evaluated in New Study
A new study by researchers from the National Cancer Institute (NCI) Cancer Genome Analysis Network, a collaborative group with investigators in the United States, Canada and Europe, provides the most comprehensive look to date at the effect of ancestry on the molecular makeup of normal and...
Artificial Blood Substitute
The text and photograph here are excerpted from a four-volume series of books titled Oncology: Tumors & Treatment, A Photographic History, The Radium Era: 1916–1945 by Stanley B. Burns, MD, FACS, and Elizabeth A. Burns. The photograph appears courtesy of Stanley B. Burns, MD, and The Burns...
Gynecologic Oncologist Describes His New Normal in a New York Hospital
During the COVID-19 pandemic, The ASCO Post will be interviewing oncologists on how they and their centers are dealing with the crisis. Here, we speak with Alexander Melamed, MD, MPH, a gynecologic oncologist and Assistant Professor of Obstetrics & Gynecology at NewYork-Presbyterian/Columbia...
NIH Begins Clinical Trial of Combination Regimen to Treat COVID-19
A clinical trial has begun to evaluate whether the malaria drug hydroxychloroquine, given together with the antibiotic azithromycin, can prevent hospitalization and death from COVID-19. The National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health...
Indiana University Researcher Receives $1.6 Million NCI Grant for Multiple Myeloma
G. David Roodman, MD, PhD, of Indiana University (IU) Melvin and Bren Simon Comprehensive Cancer Center, has been awarded a 5-year, $1.6 million grant from the National Cancer Institute (NCI) to study ways to build bone and decrease tumor growth in multiple myeloma bone disease. Dr. Roodman is...
Sleeping Well After Cancer: Patient-Centered Research for Treatment of Insomnia
Insomnia is a persistent sleep disorder that affects nearly 60% of people with cancer, diminishing their quality of life.1,2 Chronic insomnia disorder is defined by trouble falling asleep, staying asleep, or waking too early three times per week for 3 months or more.3 Standard care comprises...
Novel Imaging Application Illuminates Processes in Cancer, COVID-19
Medical images for a wide range of diseases, including COVID-19, can now be more easily viewed, compared, and analyzed using a Web-based imaging platform developed by Massachusetts General Hospital and collaborating researchers. The Open Health Imaging Foundation (OHIF) Web viewer was originally...
Is Estrogen Protective Against COVID-19?
Reports suggest that the severity of coronavirus infection may be significantly more pronounced in men than in women.1 Studies have demonstrated that estrogen reduces both influenza virus replication in human female nasal epithelial cells2 and moderates the cytokine storm in murine models of this...
Roswell Park Investigators Study Immunotherapy Combination in Patients With Cancer Infected With COVID-19
A clinical trial investigating a two-drug immunotherapy combination will soon be available to patients with cancer infected with COVID-19 at Roswell Park Comprehensive Cancer Center in Buffalo. The U.S. Food and Drug Administration (FDA) has authorized clinical researchers at the center to conduct...
Treating Patients With Leukemia During the COVID-19 Era at MD Anderson Cancer Center
As part of a series of interviews with cancer experts during the COVID-19 pandemic, The ASCO Post spoke with Hagop Kantarjian, MD, Professor and Chair of the Department of Leukemia at The University of Texas MD Anderson Cancer Center, Houston, about the impact of the pandemic on treatment of...
ECOG-ACRIN Conducts Smoking Cessation Study in Patients With Cancer
During the outbreak of the coronavirus disease, patients with cancer are at high risk of severe respiratory illness from infection because cancer and its treatments weaken their immune systems. Patients who smoke may be even more immunocompromised and at greater risk of COVID-19. A research study...
NIH Aims to Quantify Undetected Cases of Coronavirus Infection
A new study has begun recruiting at the National Institutes of Health (NIH) in Bethesda, Maryland, to determine how many adults in the United States without a confirmed history of infection with SARS-CoV-2, the virus that causes COVID-19, have antibodies to the virus. The presence of antibodies in...
OneOncology Names Jeff Patton, MD, Chief Executive Officer
Jeff Patton, MD, has been named Chief Executive Officer of OneOncology, a national partnership of independent community oncologists. Dr. Patton has been Acting Chief Executive Officer and President of Physician Services since February. Dr. Patton will continue as Executive Chairman of the Board of ...
Melanoma Research Alliance Announces $11 Million for Grant Awards
In recognition of Melanoma Awareness Month, the Melanoma Research Alliance has announced funding for 26 research awards, totaling $10.9 million. These grant awards are made possible through the significant contributions of individuals, families, institutions, and corporate allies. The 26 awards...
Robert Bona, MD, Named Director of Benign Hematology Program at Yale Cancer Center Smilow Cancer Hospital
Yale Cancer Center has announced the appointment of Robert Bona, MD, as Professor of Medicine (Hematology) and inaugural Director of the Benign Hematology Program at Smilow Cancer Hospital. He will also join as Medical Director of the Hemophilia Treatment Center for the Pediatric Hematology &...
Despites Advances, Treatment-Related Sequelae Remain Problematic in Pediatric Neuro-oncology
The management of pediatric brain and spinal cord tumors is extremely complex, as are the survivorship issues in this highly vulnerable patient population. To shed light on the current clinical reality in this setting, The ASCO Post recently spoke with Katherine E. Warren, MD, an internationally...
Being Interviewed on Zoom? Here Are Some Professional Tips
You’ve agreed to be interviewed on Zoom. If you’re like most people, the technology itself isn’t a barrier. (And if it is, you can consult our step-by-step guide to using Zoom at https://bit.ly/2yxcTN0.) However, you might be less sure about what you can do to make the best impression (and the most ...
