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AMA Announces New President and President-Elect

Susan R. Bailey, MD, an allergist from Fort Worth, recently took office as the 175th President of the American Medical Association (AMA), the nation’s premier physician organization. Dr. Bailey is the third consecutive woman to hold the office, a record for the AMA. In addition, the organization...

AMA Board of Trustees Pledges Action Against Racism and Police Brutality

At a virtual Special Meeting of the American Medical Association (AMA) House of Delegates, the AMA Board of Trustees pledged action to confront systemic racism and police brutality. The AMA released the following statement that was approved at its meeting on June 5, 2020: The AMA recognizes that...

issues in oncology

Initiate Conversations About Radiation Therapy for Bone Metastases

Although the American Society for Radiation Oncology (ASTRO) has recommended extended-fraction radiation therapy (more than 10 fractions) not be routinely used for palliation of bone metastases,1 a recently published retrospective cohort study using Medicare data for more than 12,000 patients found ...

issues in oncology

Extended-Fraction Radiation Therapy for Bone Metastases Represents Low-Value Care but Continues to Be Widely Practiced

An analysis of radiation therapy patterns among more than 12,000 Medicare patients treated for bone metastases found that 23.4% received extended-fraction radiation therapy, “wasting both health-care dollars and precious patient time,” according to the investigators.1 One-third of the treating...

Advanced Practitioner Society Issues Statement Against Systemic Racism, Discrimination

In further statements from professional oncology organizations about inequities and disparities among racial and ethnic minorities and underserved populations, as well as racism and discrimination, the Advanced Practitioner Society for Hematology and Oncology (APSHO) issued the following ...

NCI Renews Comprehensive Cancer Center Designation for Norris Cotton Cancer Center

The National Cancer Institute (NCI) has renewed its Cancer Center Support Grant to Dartmouth and Dartmouth-Hitchcock Norris Cotton Cancer Center (NCCC). The 5-year, $15.5 million grant will provide continued support for NCCC’s clinical care and research missions. NCI recognized the cancer center...

covid-19

COVID-19 and Patients With Cancer: A Call to Action for Trainees

As oncology trainees, we develop skills to synthesize complex data and communicate this information with empathy as we accompany our patients through the trenches of a cancer diagnosis. With the current COVID-19 pandemic, an unprecedented layer of challenges has surfaced, as our patients who are...

AACR Stands Against Racial Discrimination and Inequality

On June 4, 2020, the American Association for Cancer Research (AACR) released this statement: [AACR] is outraged and saddened about the pervasive racism and social injustices toward African Americans in our country and all people of color around the world. As a scientific organization focused on...

Pigeon English

The ASCO Post is pleased to reproduce installments of Art of Oncology as published previously in the Journal of Clinical Oncology. These articles focus on the experience of tolerating cancer or of caring for people diagnosed with cancer, and they include narratives, topical essays, historical...

Polio and Cancer Survivor Mickie McGraw Channels the Power of Creative Arts to Heal Broken Bodies and Minds

GUEST EDITOR Dr. Abraham is Professor of Medicine, Lerner College of Medicine, and Chair of the Hematology and Medical Oncology Department at Taussig Cancer Institute, Cleveland Clinic. In this edition of the Living a Full Life series, guest editor Jame Abraham, MD, FACP, spoke with pioneering art ...

Seattle Cancer Care Alliance Opens New Clinic Dedicated to Gastrointestinal Cancer Care

Seattle Cancer Care Alliance (SCCA) announced the opening of a Gastrointestinal (GI) Care Neighborhood, a new cancer clinic aimed at improving the experience for patients with GI cancers, which features dedicated GI-related cancer care services on one floor of SCCA’s South Lake Union campus.  “We...

breast cancer

You-Can-Do-Anything Philosophy Early in Life Inspired Breast Surgeon Laura S. Dominici, MD

Breast surgical oncologist Laura S. Dominici, MD, was born and reared in Litchfield, a small town in the southern portion of New Hampshire. “Our house was on a long dirt road, in a very rural area,” she shared. “There were only about 5,000 residents in the town. My mother was a teacher, and my dad...

American Association for Cancer Research Announces Distinguished Public Service Award Recipients

The American Association for Cancer Research (AACR) recently announced the presentation of Distinguished Public Service Awards to four individuals whose work has exemplified the AACR’s mission to prevent and cure all cancers through research, education, communication, collaboration, science policy, ...

MSK–Hackensack Meridian Health Partnership Collaborate on Immunology Research Projects

Memorial Sloan Kettering Cancer Center (MSK) and Hackensack Meridian Health recently announced they have formed an Immunology Research Collaboration. Through this joint initiative, researchers can apply for funding to support innovative investigations exploring the power of the immune system and...

Jackson Laboratory Cancer Center Receives Continued Recognition, Funding by NCI

The Jackson Laboratory (JAX), a basic science research center with locations throughout the state of Maine, recently announced the National Cancer Center has renewed its Cancer Center Support Grant for the 34th year. The Jackson Laboratory is one of seven basic research centers with this...

Cancer Researcher Grzegorz Ira, PhD, Honored With Baylor’s DeBakey Award

Select Baylor College of Medicine faculty are honored annually through the Michael E. DeBakey, MD, Award for Excellence in Research for outstanding published scientific contributions to clinical and basic science research over a 3-year period. Included among the honorees for this year’s DeBakey...

palliative care

Determining the Best Place to Die for Patients With Cancer

Studies have shown a disconnect between where patients say they want to die and where they actually die. According to research from Stanford School of Medicine, although an overwhelming majority of Americans—about 80%—would prefer to die at home, just 20% do. In fact, 60% die in acute care...

Ganesh Rao, MD, Named Chair of Neurosurgery at Baylor College of Medicine

Baylor College of Medicine recently announced that Ganesh Rao, MD, has been named the new Chair of the Department of Neurosurgery. In this role, he also will hold the Marc J. Shapiro Endowed Chair at Baylor and will serve as the Neurosurgery Service Line Chief across the Catholic Health...

breast cancer

Improving Care for Women With Late-Stage Breast Cancer

The global toll of breast cancer on women is staggering. In 2018, nearly two million new breast cancer cases were diagnosed, an increase of more than 20% since 2008,1 and mortality rates have increased by 14%, bringing the annual number of deaths worldwide from the cancer to more than 611,625.2...

ASCO20 Virtual Scientific Program Convened Record Number of Oncology Professionals From Across the Globe

ASCO announced record-breaking attendance at its 3-day ASCO20 Virtual Scientific Program, held online from May 29 through May 31. More than 42,700 attendees from 138 countries have participated thus far, learning virtually about new clinical cancer advances in every area of cancer research....

breast cancer

Repeat Breast Preservation: First Consideration in a Second Ipsilateral Breast Tumor Event

Worldwide, nearly 1.7 million women will be diagnosed with breast cancer. Of that number, nearly 300,000 Americans and more than 500,000 Europeans will be diagnosed with both invasive and in situ breast cancers.1,2 Breast-preserving surgery will initially be performed on approximately 60% of...

issues in oncology

Responding to Racism and Health Inequality as a Cancer Care Community

Months ago, when I defined a theme for my year as ASCO President, “Equity: Every Patient. Every Day. Everywhere,” I never imagined we would experience a health-care pandemic that would disproportionally impact people of color. Nor could I know this would be the moment when yet another brutal crime ...

colorectal cancer
immunotherapy

Trastuzumab Deruxtecan Shows Benefit in Refractory Colorectal Cancer

Having recently gained approval in metastatic breast cancer, fam-trastuzumab deruxtecan-nxki (T-DXd) is now proving its worth in metastatic colorectal cancer, according to results of the phase II DESTINY-CRC01 study in patients with HER2-positive disease.1 T-DXd is an antibody-drug conjugate...

gynecologic cancers

Lipophilic Statins May Reduce Mortality in Patients With Ovarian Cancer

Lipophilic statins—a type of medication commonly prescribed to lower blood cholesterol—were associated with reduced mortality in patients with ovarian cancer, according to a study presented by Kala Visvanathan, MD, MHS, and colleagues at the American Association for Cancer Research (AACR) Virtual...

gynecologic cancers

ASTRO Issues Clinical Guideline on Radiation Therapy for Cervical Cancer

A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides recommendations for radiation therapy to treat patients with nonmetastatic cervical cancer. The guideline—ASTRO's first for cervical cancer—outlines indications and best practices for external-beam radiation...

Expert Point of View: Scott N. Gettinger, MD

Discussant for the CheckMate 227 and CheckMate 9LA trials, Scott N. Gettinger, MD, of Yale Cancer Center in New Haven, Connecticut, said: “There is tremendous interest in lung cancer to combine nivolumab plus ipilimumab, driven by the melanoma experience. However, combinations of immunotherapy come ...

lung cancer

Positive Findings in NSCLC for First-Line Nivolumab Plus Ipilimumab With or Without Chemotherapy

It is becoming more challenging to select first-line therapy for advanced non–small cell lung cancer (NSCLC) for patients whose tumors have no EGFR or ALK alterations. The results of two different studies presented at the ASCO20 Virtual Scientific Program—CheckMate 227 and CheckMate 9LA—support the ...

genomics/genetics
solid tumors

Young Adults With Cancer May Benefit From Germline Genetic Testing

According to the National Cancer Institute, each year, about 70,000 adolescents and young adults (AYA)—those between the ages of 15 and 39—are diagnosed with cancer. Evidence suggests that some cancers found in AYA patients may have unique genetic and biologic features. A study that investigated...

hepatobiliary cancer

SIR 2020 Virtual: Holographic Visualization for Ablation of Liver Tumors

Data from one of the first clinical uses of augmented reality guidance with electromagnetically tracked tools shows that the technology may help doctors quickly, safely, and accurately deliver targeted liver cancer treatments, according to a research abstract presented during a virtual session of...

colorectal cancer

Cisplatin/Fluorouracil vs Carboplatin/Paclitaxel in Chemotherapy-Naive Patients With Advanced Anal Cancer

In an International Rare Cancers Initiative phase II trial (InterAAct) reported in the Journal of Clinical Oncology, Rao et al found that carboplatin/paclitaxel was associated with less serious toxicity and a trend toward improved overall survival vs cisplatin/fluorouracil in chemotherapy-naive...

survivorship

Role of Genetic Mutations and Treatment Exposures in Increased Subsequent Malignancy Risk for Childhood Cancer Survivors

In a study reported in the Journal of Clinical Oncology, Qin et al identified combinations of pathogenic germline mutations in DNA repair genes and cancer treatment exposures that increased risk of subsequent neoplasms in long-term survivors of childhood cancer. Study Details The study involved...

kidney cancer
immunotherapy

Immunogenomic Characteristics of Advanced Clear Cell Kidney Cancer Treated With Checkpoint Inhibitors

By analyzing tumors from patients treated with immunotherapy for advanced kidney cancer in three clinical trials, scientists have identified several features of the tumors that influence their response to immune checkpoint inhibitors. The research was presented during the ASCO20 Virtual Scientific...

issues in oncology
palliative care

Effect of Functional Impairment on Hospitalized Patients With Cancer

New research published by Lage et al in JNCCN–Journal of the National Comprehensive Cancer Network found 40.2% of hospitalized patients with advanced, incurable cancer were functionally impaired at the time of admission—meaning they needed assistance with activities of daily living like walking,...

breast cancer

Study Finds No Survival Benefit From Local Therapy for de Novo Metastatic Breast Cancer

Women presenting with newly diagnosed de novo metastatic breast cancer derived no additional survival benefit from surgery and radiotherapy given after systemic treatment, although the practice may reduce locoregional progression of disease, according to the results of the phase III E2108 study...

pancreatic cancer
genomics/genetics

First-Line Platinum-Based Chemotherapy for Patients With Metastatic Pancreatic Cancer and Defects in Homologous Recombination Genes

Patients with metastatic pancreatic cancer who had germline or somatic mutations in DNA repair genes had better clinical outcomes after platinum-based chemotherapy compared to patients without these mutations, according to results from a study published by Park et al in Clinical Cancer Research....

issues in oncology

Role of Race, Ethnicity, and Region in Mortality Among Pediatric Patients With Cancer Admitted to the ICU

Black and Hispanic children admitted to pediatric intensive care units for cancer treatment have significantly higher death rates than non-Hispanic white patients, according to findings from a study published by Laurens et al in Pediatric Critical Care Medicine. Nationwide, 8.5% of black and 8.1%...

The Power of mCODE

ASCO Chief Executive Officer Clifford A. Hudis, MD, FACP, FASCO, hosts the ASCO in Action Podcast, which focuses on policy and practice issues affecting providers and patients. An excerpt of a recent episode is shared below; it has been edited for length and clarity. Listen to the full podcast on...

gynecologic cancers

Breastfeeding Associated With Reduced Risk of Invasive Ovarian Cancer, Including High-Grade Serous Disease

In a pooled analysis reported in JAMA Oncology,1 Naoko Sasamoto, MD, MPH, of the Obstetrics and Gynecology Epidemiology Center, Brigham and Women’s Hospital, Boston, and colleagues found that breastfeeding, even for durations of 1 to 3 months per birth, was associated with a significant reduction...

gynecologic cancers

Veliparib Plus Chemotherapy Shows Antitumor Activity in Front-Line Treatment of Ovarian Cancer, but Is It Enough?

An updated analysis of the phase III VELIA/GOG-3005 trial, presented during the 2020 Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer Webinar Series,1 suggested synergy between the poly (ADP-ribose) polymerase (PARP) inhibitor veliparib and platinum chemotherapy in the...

skin cancer
immunotherapy

KEYNOTE-555 Supports 6-Week Pembrolizumab Dosing Schedule in Melanoma

A less-frequent, more-convenient dosing schedule for pembrolizumab (400 mg every 6 weeks) was deemed safe and effective in patients with unresectable or metastatic melanoma, according to interim data from cohort B enrolled in the KEYNOTE-555 trial. These findings were presented at the 2020 Virtual...

covid-19

App Calculates Risk of Delaying Cancer Care During the COVID-19 Pandemic

A team of data scientists and oncologists from the University of Michigan and Pennsylvania State University have developed a free, Web-based application to help in comparing the long-term risk to a patient from a months-long postponement of care to the additional risk posed by potential COVID-19...

AACR Honors Nobel Laureate Phillip A. Sharp, PhD, for Lifetime Achievement

The American Association for Cancer Research (AACR) has recognized Phillip A. Sharp, PhD, Fellow of the AACR Academy and Nobel Laureate, with the 17th AACR Award for Lifetime Achievement in Cancer Research. Dr. Sharp is Professor at Massachusetts Institute of Technology’s David H. Koch Institute...

supportive care
symptom management

New Cancer Cachexia Guideline Addresses Common Quality-of-Life Issue

ASCO recently released a new evidence-based guideline regarding the clinical management of cancer cachexia in adults with advanced cancer.1 The guideline is the result of a literature review that included 20 systematic reviews and 13 randomized clinical trials. An expert panel was convened to...

lymphoma

My Future Is Doled Out in Increments of 6 Months

In the fall of 2015, I was looking forward to a trip to Florida for a visit with my daughter and her family, along with a little relaxation. The evening before the trip, I experienced some abdominal pain that my wife, Angela, and I thought might be appendicitis. Concerned the problem could...

breast cancer

Cognitive Impairment in Women Treated for Early Breast Cancer: Chemoendocrine Adjuvant Therapy vs Endocrine Therapy Alone

Women with early-stage breast cancer who received adjuvant chemoendocrine therapy reported greater cognitive impairment at 3 and 6 months than women receiving adjuvant endocrine therapy alone, according to the results from a subgroup of women participating in the TAILORx trial.1 By 12 months, the...

The Gambler

The ASCO Post is pleased to reproduce installments of Art of Oncology as published previously in the Journal of Clinical Oncology. These articles focus on the experience of suffering from cancer or of caring for people diagnosed with cancer, and they include narratives, topical essays, historical...

breast cancer
issues in oncology

Comprehensive Overview of How to Start or Improve a Breast Cancer Unit on the Global Stage

Breast cancer is the leading cause of cancer death among women worldwide. As populations age, the incidence of cancer inevitably increases—the World Health Organization has predicted a dramatic increase in global breast cancer cases during the next 15 years. Moreover, breast cancer is increasing in ...

skin cancer

Andrew E. Aplin, PhD, Receives Humanitarian Award From the Melanoma Research Foundation

The Sidney Kimmel Cancer Center—Jefferson Health (SKCC) recently announced that Andrew E. Aplin, PhD, was being recognized with the Melanoma Research Foundation Humanitarian Award. Dr. Aplin is the Kalbach-Newton Professor in Cancer Research, Enterprise Associate Director for Basic Research, and...

From Ecuador to Nashville to Dallas: An Early Path to a Career in Medicine for Carlos L. Arteaga, MD

Carlos L. Arteaga, MD, is Director of the Harold C. Simmons Cancer Center and Associate Dean for Oncology Programs, UT Southwestern Medical Center (UTSW), Dallas. He is an expert in breast cancer who has authored more than 350 publications in the areas of oncogenes in breast tumors, targeted...

pancreatic cancer

Relationship Between Type 3c Diabetes and Pancreatic Cancer

According to the results of a European case-control study published by Molina-Montes et al in the journal Gut, one of the most recently identified types of diabetes—type 3c, or pancreatogenic diabetes—could also be an early manifestation of pancreatic cancer. Pancreatic cancer has a high mortality...

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