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2016 Oncology Meetings

APRIL 16th Pan Arab Cancer ConferenceApril 28-30 • Cairo, EgyptFor more information:www.pacc16.org ONS 41st Annual CongressApril 28-May 1 • San Antonio, Texas For more information: http://congress.ons.org 11th European International Kidney Cancer SymposiumApril 29-30 • Barcelona, Spain For more...

Ed Sauter, MD, PhD, Named Director of Breast Surgery Program at Hartford HealthCare Cancer Institute

Hartford HealthCare Cancer Institute announced the appointment of Ed Sauter, MD, PhD, as Director of the Breast Surgery Program at the Hartford HealthCare Cancer Institute (HHCCI). He will lead the breast surgery programs at each of the Institute’s five cancer centers. Dr. Sauter is joining the...

issues in oncology

Friends of Cancer Research Encourages FDA to Modernize and Consolidate

“In order to take advantage of today’s advancements in science, drug development, and patient treatment, the U.S. Food and Drug Administration’s (FDA’s) structure needs reorganization to focus its resources and ensure the best outcomes for patients. Friends of Cancer Research (Friends) proposes...

Larry W. Kwak, MD, PhD, Awarded Ho-Am Prize in Medicine

Physician and scientist Larry W. Kwak, MD, PhD, Director of City of Hope’s Toni Stephenson Lymphoma Center, has been awarded the 2016 Ho-Am Prize in Medicine, which recognizes people of Korean heritage who have made impressive contributions in clinical and research areas that contributed to the...

thyroid cancer

Raising Awareness of Medullary Thyroid Carcinoma

I’m used to having bumps and cysts pop up on my body, so when I felt a lump on the front of my throat, just below my Adam’s apple, I brushed it off. But when it was still there 6 months later, I became concerned and decided to see an ear, nose, and throat specialist. He performed a fine-needle...

2016–2017 HOPA President Sarah Scarpace, PharmD, MPH, BCOP, Takes Office

The Hematology/Oncology Pharmacy Association (HOPA) has elected Sarah Scarpace, PharmD, MPH, BCOP, to serve as President for the 2016–2017 term. Dr. Scarpace recently took office at the 12th HOPA Annual Conference, held March 16–19 in Atlanta, Georgia. Dr. Scarpace has served as President-Elect...

Susannah Koontz, PharmD, BCOP, FHOPA, Named HOPA President-Elect for 2016–2017 Term

Susannah Koontz, PharmD, BCOP, FHOPA, took office as President-Elect of the Hematology/Oncology Pharmacy Association (HOPA) at the recent 12th HOPA Annual Conference, held March 16–19 in Atlanta, Georgia. Dr. Koontz will serve as President-Elect for the 2016–2017 term and assume the office of...

Radiation: Myths, Facts, Dangers and Benefits

For many, the word “radiation” conjures up images of mushroom clouds and the nightmarish nuclear disaster at Chernobyl. It also brings to mind those pesky dental x-rays and lifesaving cancer treatments. However, to most people, radiation is a mysterious invisible power to be feared and embraced...

issues in oncology

Immunotherapy Could Be the Wave of the Future, but Problems and Challenges Cannot Be Ignored

Immunotherapy is on its way. A few agents have already been approved: ipilimumab (Yervoy) in 2011 for melanoma; nivolumab (Opdivo) in 2015 for non–small cell lung cancer (NSCLC) and then later that year for renal cell carcinoma; and pembrolizumab (Keytruda) for NSCLC. In addition, many clinical...

geriatric oncology

Supportive Care in the Older Adult With Cancer: What You Need to Know

The median age of patients at the first diagnosis of cancer in the United States is 65 years, and the majority of patients with cancer are older adults.1 As we have learned from previous articles in this series, older patients with cancer require more complex care. Older adults are more likely to...

ASCO Urges Aggressive Efforts to Increase HPV Vaccination and Prevent Cancer

Use of human papillomavirus (HPV) vaccines should be rapidly expanded to protect thousands of young people in the United States—and millions worldwide—from life-threatening cancers, ASCO said April 11 in a policy statement. Published by Bailey et al in the Journal of Clinical Oncology,1 the...

breast cancer

Praise for the ACS/ASCO Breast Cancer Survivorship Care Guideline

The recent publication of the American Cancer Society (ACS)/ASCO breast cancer survivorship care guideline is a tremendous contribution to the literature and should provide a roadmap for providers who care for patients with a history of breast cancer for years to come.1,2 The guideline, reported by ...

breast cancer

ACS/ASCO Breast Cancer Survivorship Care Guideline

The American Cancer Society (ACS) and ASCO have issued a Breast Cancer Survivorship Care guideline, published jointly in the Journal of Clinical Oncology and CA: A Cancer Journal for Clinicians.1,2 The guideline recommendations were formulated by a multidisciplinary expert work group and are based...

Seven New Members Elected to Interurban Clinical Club

The historic Interurban Clinical Club has announced the election of seven new members. They were elected at the group’s 213th meeting on April 1 in New York and will be welcomed at the group’s next meeting in November 2016 in Philadelphia. James E. Bradner, MD: Staff Physician at Dana-Farber...

Leena Gandhi, MD, PhD, Named Director of Thoracic Medical Oncology at NYU Langone’s Perlmutter Cancer Center

New York University (NYU) Langone Medical Center has announced the appointment of physician-scientist Leena Gandhi, MD, PhD, as Director of Thoracic Medical Oncology at its Laura and Isaac Perlmutter Cancer Center. In this new role, Dr. Gandhi will be tasked with building a robust program in lung...

Johns Hopkins Launches Immunotherapy Center With $125 Million Gift

A new institute studying immunology was announced on March 29 at Johns Hopkins by Vice President Joe Biden, Michael R. Bloomberg, and more than a dozen additional supporters of this initiative. Embracing the Vice President’s “moonshot” initiative to cure cancer, the new Bloomberg–Kimmel Institute...

cost of care

Drug Prices and Value: Finding Middle Ground

The advent of targeted therapies along with complex personalized treatment regimens has added many effective tools to the oncology armamentarium. But progress has a price tag. Although the oncology community needs new drugs, there is growing concern that the price of many newer compounds is...

Timothy J. Eberlein, MD, Elected Chairman of the NCCN Board of Directors

Timothy J. Eberlein, MD, of the Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine, has been elected Chairman of the National Comprehensive Cancer Network® (NCCN®) Board of Directors. Dr. Eberlein previously served as Vice Chair of the Board, and succeeds...

Podcast Discusses Finding Easy-to-Understand Cancer Information

It’s easy for patients to find information about cancer on the Internet, but finding information that is both accurate and understandable may not be so easy. Cancer.Net’s Editor-in-Chief Lidia Schapira, MD, FASCO, recently joined Fergal McGovern on Empowered Patient Radio to discuss the challenges...

ASCO Convenes Obesity Work Group Meeting on Multidisciplinary Collaboration

ASCO recently held a work group meeting with 18 organizations that focused on addressing obesity through multidisciplinary collaboration. The purpose of the meeting was to review current challenges in addressing obesity within the health-care provider communities and identify potential...

2016 Special Awards: Researchers and Scientists Recognized for Significant Contributions to Cancer Care

Researchers, patient advocates, and global oncology community leaders dedicated to enhancing cancer prevention, treatment, and patient care will be honored with ASCO’s highest honor, its Special Awards, during the 2016 ASCO Annual Meeting. Among this year’s awardees are a lung cancer luminary who...

Meet W. Charles Penley, MD, FASCO

A Partner at Tennessee Oncology, PLLC, W. Charles Penley, MD, FASCO, has been an ASCO member since 1988. He has served on the Conquer Cancer Foundation Board of Directors since 2005 and currently holds the role of Immediate Past Chair. What led you to oncology? WCP: While it may sound silly to say ...

breast cancer
survivorship

AACR 2016: Genomic Variants May Influence Risk for Breast Cancer After Chest Radiotherapy to Treat Childhood Cancer

Among females who received radiotherapy to the chest as part of treatment for a childhood cancer, those who had either of two specific genetic variants were at significantly higher risk of developing breast cancer later in life, according to research presented by Morton et al at the 2016 AACR...

colorectal cancer

AACR 2016: Cologuard Detected Colorectal Cancer in Previously Unscreened Patients

A noninvasive colorectal cancer-screening test detected the disease in patients who had previously avoided more invasive screening measures, according to research presented by Prince et al at the 2016 AACR Annual Meeting (Abstract LB-296). The study of nearly 400 patients revealed four patients...

cns cancers

KIR3DL1 and HLA-B Allele Combinations May Impact Response to Treatment in Neuroblastoma

In a study reported in the Journal of Clinical Oncology, Forlenza et al found that noninteracting KIR3DL1 and HLA-B subtypes were associated with better response to anti-GD2 antibody treatment in neuroblastoma. Study Details Treatment of neuroblastoma with anti-GD2 monoclonal antibody (eg, the...

head and neck cancer

AACR 2016: Nivolumab Improved Survival for Patients With Head and Neck Squamous Cell Carcinoma

For the latest information on CheckMate-141, click here, here, or here. Treatment with the immunotherapeutic nivolumab (Opdivo) improved survival for patients with recurrent or metastatic head and neck squamous cell carcinoma that progressed after platinum-based chemotherapy compared with...

breast cancer

Adjuvant Trastuzumab May Be Insufficiently Used in Older Women With Breast Cancer

Reeder-Hayes et al found that adjuvant trastuzumab (Herceptin) may be underused in older women with early-stage HER2-positive breast cancer and reported their study results in the Journal of Clinical Oncology. Adjuvant trastuzumab also was used less often in black women than in white women. Rates...

lymphoma

Adding Rituximab to Dose-Dense Chemotherapy May Be of Benefit in Burkitt Lymphoma

In a French phase III trial reported in The Lancet, Ribrag et al showed that adding rituximab (Rituxan) to dose-dense chemotherapy improved event-free survival among adults with Burkitt lymphoma. Study Details In the open-label trial, 260 patients were randomized between October 2004 and...

integrative oncology

Boswellia

The ASCO Post’s Integrative Oncology series is intended to facilitate the availability of evidence-based information on integrative and complementary therapies commonly used by patients with cancer. We chose Boswellia for this issue because of its increasing use by patients with cancer....

Blue Ribbon Panel to Help Guide National Cancer Moonshot Initiative

On April 4, 2016, The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), announced a Blue Ribbon Panel of scientific experts, cancer leaders, and patient advocates that will inform the scientific direction and goals at NCI of Vice President Joe Biden’s National Cancer ...

Scott A. Armstrong, MD, PhD, to Lead Department of Pediatric Oncology at Dana-Farber Cancer Institute

Scott A. Armstrong, MD, PhD, has been named Chair of the Department of Pediatric Oncology at Dana-Farber Cancer Institute and the David G. Nathan Professor of Pediatrics at Dana-Farber Cancer Institute, Boston Children’s Hospital, and Harvard Medical School. He will also serve as Associate Chief of ...

Expert Point of View: Thierry Facon, MD

Thierry Facon, MD, of Lille University Hospital in France, told The ASCO Post that he believes elotuzumab (Empliciti) works better with an immunomodulatory drug than with bortezomib (Velcade), at least according to the results of these two studies. “I think what’s most impressive is the ELOQUENT-2 ...

multiple myeloma

Updates on Elotuzumab in Multiple Myeloma Show Persistence of Benefit

Studies presented at the 2015 ASH Annual Meeting bolstered support for elotuzumab (Empliciti) given in combination with lenalidomide (Revlimid) for the treatment of multiple myeloma.  Elotuzumab is an immunostimulatory monoclonal antibody. It has a dual mechanism of action, directly activating...

Expert Point of View: Thierry Facon, MD

Thierry Facon, MD, of Lille University Hospital in France, spoke to The ASCO Post about the preliminary results of the pembrolizumab studies. Dr. Facon cautioned that a response rate of 76% overall “is not so impressive,” given about 65% of patients respond to lenalidomide/dexamethasone alone....

multiple myeloma

Pembrolizumab Looks Promising in Multiple Myeloma

Monoclonal antibodies targeting the programmed cell death protein (PD-1) receptor look promising in multiple myeloma, according to early reports presented at the 2015 ASH Annual Meeting and Exposition. Early signs of activity in heavily pretreated patients may indicate that, as in solid tumors,...

prostate cancer

Active Surveillance Has Become Standard Care for Men With Low-Risk Localized Prostate Cancer

Active surveillance has been increasingly adopted as a standard approach for men with Gleason score ≤ 6 localized prostate cancer, with major guidelines and consensus statements encouraging this approach,1 including a recently published guideline from Cancer Care Ontario (CCO),2 and endorsement of...

breast cancer

DigniCap Scalp-Cooling System Now Available for Women With Breast Cancer at 10 U.S. Cancer Treatment Centers

Dignitana Inc. recently announced that the DigniCap scalp cooling system, which was cleared by the U.S. Food and Drug Administration (FDA) in December 2015 to effectively reduce the likelihood of chemotherapy-induced hair loss in women with breast cancer, is now available at 10 cancer treatment...

prostate cancer

ASCO Endorses Cancer Care Ontario Guideline on Active Surveillance for Management of Localized Prostate Cancer

As reported by Ronald C. Chen, MD, MPH, of the University of North Carolina at Chapel Hill, and colleagues in the Journal of Clinical Oncology, ASCO has endorsed, with qualifications, the 2015 Cancer Care Ontario (CCO) guideline on active surveillance for management of localized prostate cancer....

Michael A. Caligiuri, MD, Named AACR President-Elect 2016–2017

The members of the American Association for Cancer Research (AACR) have elected Michael A. Caligiuri, MD, as their President-Elect for 2016–2017. He officially became President-Elect at the AACR Annual Meeting 2016, held in New Orleans, April 16–20, and will assume the presidency in April 2017 at...

Steven J. Cohen, MD, Fox Chase GI Medical Oncology Chief, Elected as NCI Task Force Vice Chair

Steven J. Cohen, MD, Chief of Gastrointestinal Medical Oncology at Fox Chase Cancer Center, has been elected by his peers to serve as Vice Chair of the National Cancer Institute (NCI) Pancreas Task Force of the Gastrointestinal Steering Committee (GISC). “I am honored to be elected to serve as the ...

colorectal cancer

CDX2 in Stage II Colon Cancer: Ready for Prime Time?

In a recent issue of The New England Journal of Medicine, Dalerba et al published an impressive article describing a novel bioinformatics approach to identifying new prognostic and predictive biomarkers in patients with stage II and III colon cancer (see summary in this issue of The ASCO Post).1...

leukemia

City of Hope Awarded NCI Research Grant for Potential Acute Myeloid Leukemia Drug

A City of Hope research team led by Steven T. Rosen, MD, City of Hope’s Provost and Chief Scientific Officer, has been awarded a $2.3 million Research Project Grant (R01) from the National Cancer Institute (NCI) to fund studies associated with a phase I/II clinical trial in relapsed/refractory...

colorectal cancer

Transcription Factor CDX2 May Be a Prognostic Biomarker in Stage II and III Colon Cancer

In a study reported in The New England Journal of Medicine, Piero Dalerba, MD, of Columbia University, and colleagues found that absence of the transcription factor CDX2 was prognostic for poor outcome in patients with stage II and III colon cancer vs cancers with CDX2 expression.1 However,...

breast cancer

Neoadjuvant Endocrine Therapy Vastly Underutilized by U.S. Clinicians

Neoadjuvant endocrine therapy in the management of breast cancer is woefully underutilized by U.S. clinicians, according to advocates of this approach who made their case at the 2016 Miami Breast Cancer Conference.1 In postmenopausal women with estrogen receptor–rich tumors, neoadjuvant endocrine...

Expert Point of View: Patrick Borgen, MD

Patrick Borgen, MD, Chair of the Department of Surgery at Maimonides Medical Center, Brooklyn, New York, called these findings important and clinically relevant. “This study was an enormous undertaking, to review the detailed clinical records on 3,000 consecutive patients. It’s an amazing and...

breast cancer

In Ductal Carcinoma in Situ, Benefit of Wider Margins Tied to Radiation Use

The relationship between margin width and risk of recurrence after breast-conserving surgery for ductal carcinoma in situ depends on the use of radiation, according to a surgical oncologist who sought to determine the optimal margin width in these patients.1 “Positive margins are associated with an ...

Expert Point of View: Douglas A. Levine, MD

In the discussion session, Douglas A. Levine, MD, Head of Gynecology Research Laboratory at Memorial Sloan Kettering Cancer Center, said that while advanced genomics can help to predict outcomes, stratify treatment, and understand biology, one of the problems of precision medicine is that...

gynecologic cancers

Liquid Biopsies Predict Treatment Response and Survival in Gynecologic Cancers

A new study has demonstrated for the first time that personalized circulating tumor DNA (ctDNA) biomarkers in gynecologic cancers can detect the presence of residual tumor earlier than currently used serum and imaging studies.1,2 According to the data, undetectable levels of ctDNA at the completion ...

Expert Point of View: Kian Behbakht, MD

Kian Behbakht, MD, Professor of Gynecologic Oncology at the University of Colorado School of Medicine, Aurora, said that the study underscored the surgical importance of getting to no visible residual disease in ovarian cancer.  “Based on today’s data,” said Dr. Behbakht, “it seems as though it’s...

breast cancer

AACR 2016: Delays in Radiation Therapy Increase Chance of Breast Tumor Development in Women Treated for DCIS

Women who underwent treatment for ductal carcinoma in situ (DCIS) were at higher risk of developing malignant breast tumors if they did not receive timely radiation therapy as part of their treatment, according to a study presented by Liu et al at the 2016 AACR Annual Meeting (Abstract 2576). DCIS ...

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