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Showing 1351 - 1400ASCO Guideline Update Highlights the Importance of Early Integration of Palliative Care for Patients With Cancer
Growing awareness of the benefits of palliative care in patients with cancer has prompted ASCO to update its recommendations for clinicians, patients, caregivers, and health-care organizations on integrating palliative care in oncology.1 The updated guideline reinforces prior recommendations in the ...
Can Alternative Criteria Help Identify Patients Who May Benefit From Lung Cancer Screening?
Researchers have developed an alternative set of simple criteria using a prediction model to identify groups of patients who may benefit most from lung cancer screening but are disproportionately excluded by current eligibility criteria, according to a new study published by Kearney et al in the...
Exercise Program May Improve Symptoms, Quality of Life in Patients With Metastatic Breast Cancer
Researchers have shown that participating in an exercise program may improve pain, fatigue, and the quality of life in patients with metastatic breast cancer, according to a recent study published by Hiensch et al in Nature Medicine. Background “Although there’s substantial evidence for the...
An Integrated Approach to Treating Cancer and Cardiovascular Disease: When Oncologists and Cardiologists Collaborate
At the 2024 Debates and Didactics in Hematology and Oncology Conference, sponsored by Emory’s Winship Cancer Institute, cardiologist-by-training Anant Mandawat, MD, FACC, briefly reviewed how the emerging field of cardio-oncology is blazing a path toward “bigger and bolder cancer care” and offered...
Detecting Residual Disease After Neoadjuvant Chemoradiation in Esophageal Squamous Cell Carcinoma
Although esophageal cancer in the United States is relatively rare, affecting about 22,400 people each year and making up about 1% of all cancer cases,1 the disease is common in East and Central Asia countries. Nearly 90% of patients with esophageal cancer in Asia are diagnosed with the squamous...
New Modeling Data Show Effective Detection and Health-Care Savings Associated With the Multitarget Stool DNA Test
New modeling data have been released that describe the projected impact of the first and only multitarget stool DNA test (marketed as Cologuard) on patients, health-care professionals, and the U.S. health-care system since its U.S. Food and Drug Administration (FDA) approval 10 years ago. About the ...
Gift of Truth: Reflections on a Father’s Cancer Journey
It was a hot and humid Tuesday in July, and I distinctly remember being grateful for the air conditioning in the pastel-shaded waiting room of the oncology outpatient clinic. My father sat silently beside me. We knew this room well, as we did the doctor we had arrived to see. He had been my...
Age Is Just a Number: Treatment Considerations for Endometrial Cancer in Older Women
Endometrial cancer is most frequently diagnosed among women aged 55 to 65, with a median age at diagnosis of 64 years.1 In epidemiologic studies, women diagnosed with endometrial cancer at an older age are more likely to have high-grade disease, aggressive histology, deep myometrial invasion, lower ...
Breast Cancer Index Confirmed as Prognostic in a SOFT Trial–Derived Population
A prospective-retrospective translational study reported in JAMA Oncology by Ruth M. O’Regan, MD, and colleagues confirmed the prognostic value of the Breast Cancer Index (BCI) in a Suppression of Ovarian Function Trial (SOFT) trial–derived population of premenopausal women with early-stage,...
Patients With Rare Cancers May Face Increased Risk of Anxiety and Depression
The risk of developing mental health issues may be higher among patients who have rare cancers compared with those who have common cancers, according to a recent study published by Low et al in eClinicalMedicine. Background Rare cancers—those affecting fewer than 6 out of 100,000 individuals per...
Long-Term Look at Selpercatinib in RET-Activated Thyroid Cancer
In an analysis of the phase I/II LIBRETTO-001 trial reported in the Journal of Clinical Oncology, Lori J. Wirth, MD, and colleagues provided the long-term outcomes of selpercatinib treatment among patients with RET-activated thyroid cancer. Study Details The analysis included patients with...
Causal Attribution of HPV Genotypes to Invasive Cervical Cancer
In a systemic analysis of global literature reported in The Lancet, Wei et al estimated the proportion of invasive cervical cancer cases caused by specific human papillomavirus (HPV) genotypes. Study Details A literature search through February 2024 was performed to identify studies reporting HPV...
What Is the Optimal First-Line Therapy for Chronic Lymphocytic Leukemia?
Is the optimal first-line treatment of chronic lymphocytic leukemia (CLL) monotherapy with a Bruton’s tyrosine kinase (BTK) inhibitor or some combination regimen? This clinical question was explored by two speakers at the 2024 Pan Pacific Lymphoma Conference, sponsored by the University of...
FDA OCE Invites Pediatric Cancer Advocates to Meet on October 15
The U.S. Food and Drug Administration’s Oncology Center of Excellence (OCE) Pediatric Oncology Program invites members of the pediatric cancer advocacy community to participate in the 2024 OCE Pediatric Advocacy Forum on October 15. The purpose of this event is to strengthen collaboration and...
High-Risk Localized HCC: Efficacy of Neoadjuvant Immunotherapy vs Upfront Surgery
Hepatocellular carcinoma is the most common type of primary liver cancer, accounting for about 80% of all primary liver cancers in the United States, and is currently the sixth most common cancer and the fourth most common cause of cancer-related deaths. Although immunotherapy is now a mainstay for ...
Risk of Suicidal Behavior Among Spouses of Patients With Cancer
The risk of suicidal behavior may be increased among the spouses of patients with cancer, according to a retrospective Danish population-based cohort study reported by Liu et al in JAMA Oncology. Clinical and societal awareness was thus deemed essential, particularly during the first year after...
FDA Approves Neoadjuvant/Adjuvant Durvalumab for Resectable NSCLC
The U.S. Food and Drug Administration (FDA) has approved the PD-L1 inhibitor durvalumab (Imfinzi) with platinum-containing chemotherapy as neoadjuvant treatment followed by single-agent durvalumab as adjuvant treatment after surgery for adults with resectable (tumors ≥ 4 cm and/or node positive)...
Mouthwash-Based Test May Help Predict Head and Neck Cancer Recurrence
Researchers have examined whether a mouthwash-based test could detect biomarkers to help physicians predict disease recurrence in patients with head and neck cancer, according to a recent study published by Franzmann et al in JAMA Otolaryngology–Head & Neck Surgery. Background Head and neck...
Are Some Uterine Tumors More Aggressive in Black Patients?
Researchers have discovered that uterine serous carcinoma tumors in Black patients tend to express more aggressive and immunosuppressive features than tumors in White patients, according to a recent study published by Foley et al in Proceedings of the National Academy of Sciences. Uterine serous...
Dietary Risk Factors for Early-Onset Colorectal Cancer
Researchers have found that diet-derived molecules known as metabolites may be the main drivers of early-onset colorectal cancer risk, especially those associated with red and processed meat, according to a recent study published by Jayakrishnan et al in npj Precision Oncology. Background Despite...
Novel Insights May Transform Diagnosis and Treatment of Pediatric Patients With T-Lineage ALL
Researchers have uncovered that T-lineage acute lymphoblastic leukemia (ALL) may be frequently driven by genetic changes in noncoding portions of the DNA, according to a recent study published by Pölönen et al in Nature. The investigators believe these findings may lead to a paradigm shift in...
FDA Approves Axatilimab-csfr for Chronic GVHD
On August 14, the U.S. Food and Drug Administration (FDA) approved axatilimab-csfr (Niktimvo), a colony-stimulating factor–1 receptor–blocking antibody, for the treatment of chronic graft-vs-host disease (GVHD) after failure of at least two prior lines of systemic therapy in adult and pediatric...
Completion Axillary Lymph Node Dissection to Select Adjuvant Treatment in Breast Cancer and Associated Impairment of Arm Function
In an analysis involving the phase III SENOMAC trial reported in The Lancet Oncology, de Boniface et al found that the use of completion axillary lymph node dissection (cALND) to identify pN2-3 status (at least four nodal metastases) in patients with breast cancer, and thus qualification for...
Combination Immunotherapies May Boost T-Cell Responses in Patients With Melanoma
Researchers may have uncovered how combination immunotherapies targeting the immune checkpoints PD-1 and LAG-3 may work together to activate immune responses in patients with melanoma, according to two recent studies published by Cillo et al and Andrews et al in Cell. The findings may shed light on ...
ARPA-H Awards to Develop Novel Technologies in Cancer Surgery
More than 2 years ago, President Joe Biden and First Lady Jill Biden reignited the Cancer Moonshot with the goals of reducing the cancer death rate in the United States by at least half (preventing more than 4 million cancer deaths) by 2047 and improving the experience of people who are touched by...
Discontinuation of CML Therapy: Which Patients Are Ideal Candidates?
With the introduction of tyrosine kinase inhibitors, chronic myeloid leukemia (CML) has become a chronic disease for most patients. Furthermore, we now know that some patients can successfully stop treatment and remain in remission. “Stopping tyrosine kinase inhibitor therapy is something we get a...
T-DXd in HER2-Positive Advanced Colorectal Cancer
As reported in The Lancet Oncology by Kanwal Raghav, MD, and colleagues, the phase II DESTINY-CRC02 trial has identified the preferred dosage of single-agent fam-trastuzumab deruxtecan-nxki (T-DXd) in patients with HER2-positive advanced colorectal cancer. Study Details In the international study, ...
Resected Melanoma: Subsequent Systemic Therapy After Recurrence on Adjuvant Nivolumab
In an analysis from the phase III CheckMate 238 trial reported in the Journal of Clinical Oncology, Jeffrey Weber, MD, PhD, and colleagues found that progression-free and overall survival were improved with subsequent systemic therapy following late vs early recurrence with adjuvant nivolumab in...
Salpingectomy vs Tubal Occlusion
Women whose fallopian tubes are removed during sterilization via laparoscopy may have only marginally more surgical complications compared with those whose tubes are cut during tubal occlusion, according to a recent study published by Strandell et al in The Lancet Regional Health–Europe. The...
Cancer Cases and Mortality Among Men Predicted to Increase Globally
Investigators have uncovered disparities in the projected rates of future cancer incidence and mortality among men based on age and country’s socioeconomic status, according to a recent study published by Bizuayehu et al in Cancer. Background Prior research has shown that men may face higher rates...
Sacituzumab Govitecan May Be Effective at Treating Breast Cancer–Related Brain Tumors
The antibody-drug conjugate sacituzumab govitecan-hziy may be effective in treating patients with breast cancer who have brain metastases or recurrent glioblastoma multiforme, according to a recent study published by Balinda et al in Nature Communications. Background About 50% of all female...
Pattern in Protein Production May Be Predictive of Side Effects From Immunotherapy in Patients With Melanoma
An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases may predict the occurrence of severe side effects from immunotherapy in patients with melanoma, according to a recent study published by Monson et al in Clinical Cancer Research. Background...
Association of Regular Aspirin Use With Colorectal Cancer Risk According to Lifestyle Factors
In a study reported in JAMA Oncology, Sikavi et al found that regular aspirin use was associated with a reduced risk of colorectal cancer overall and among individuals with less healthy vs more healthy lifestyles. Study Details The prospective cohort study focused on data from 107,655 participants...
Cannabis Use and Risk of Head and Neck Cancer
In a study reported in JAMA Otolaryngology–Head & Neck Surgery, Gallagher et al found that individuals with cannabis-related disorder were at an increased risk of head and neck cancer vs those without cannabis-related disorder. Cannabis-related disorders are defined by the excessive use of...
Gestational Diabetes and Risk for Breast Cancer
Women who develop gestational diabetes may not have a higher likelihood of being diagnosed with breast cancer, according to recent findings that will be presented by Christensen et al at the upcoming European Association for the Study of Diabetes Annual Meeting 2024 (Abstract 180). Background...
Metastasis-Directed Radiation Therapy Plus Chemotherapy in Oligometastatic Pancreatic Cancer
Researchers have demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy may improve progression-free survival in patients with oligometastatic pancreatic cancer, according to a recent study published by Ludmir et al in the Journal of Clinical Oncology and...
Can Neoadjuvant Atezolizumab Set a New Standard for Unresectable Stage III NSCLC?
Immune checkpoint inhibitors, including atezolizumab, have been evaluated in several phase II trials for neoadjuvant therapy in resectable lung cancer, both with and without chemotherapy, such as the LCMC3 trial and CheckMate 816. Ongoing studies, including the IMpower030 trial, are further...
Visceral Pleural Invasion and Recurrence Risk in Patients Undergoing Surgery for NSCLC
In an analysis from the CALGB 140503 trial reported in JAMA Oncology, Nasser Altorki, MD, and colleagues found that pathologically identified visceral pleural invasion was associated with poorer outcomes in patients undergoing surgery for non–small cell lung cancer (NSCLC). Study Details The trial ...
Merkel Cell Carcinoma: Association of ctDNA With Recurrence Risk
In a study reported in the Journal of Clinical Oncology, Akaike et al found that detection of circulating tumor DNA (ctDNA) was associated with an increased risk of recurrence in patients with Merkel cell carcinoma. Study Details In the study, a tumor-informed ctDNA assay was used in 319 patients...
FDA Approves Immunotherapy for Relapsed or Refractory CTCL
On August 8, the U.S. Food and Drug Administration (FDA) approved denileukin diftitox-cxdl (Lymphir), a novel immunotherapy for the treatment of adult patients with relapsed or refractory cutaneous T-cell lymphoma (CTCL) who have received at least one prior systemic therapy. Denileukin diftitox is...
Cancer of Unknown Primary: Molecularly Guided Therapy After Disease Control on Platinum-Based Chemotherapy
In the phase II CUPISCO trial reported in The Lancet, Krämer et al found that molecularly guided therapy in patients with unfavorable nonsquamous cancer of unknown primary who had disease control on first-line platinum-based therapy resulted in better progression-free survival vs patients who...
Efficacy of a JAK2/mTOR Inhibitor Combination in Controlling Acute Graft-vs-Host Disease
Adding a Janus kinase 2 (JAK2) inhibitor to standard immunosuppressive drugs may not improve prevention of acute graft-vs-host disease in patients with hematologic malignancies undergoing treatment with allogeneic hematopoietic cell transplantation, according to a recent study published by Pidala...
Primary Ovarian Insufficiency, Early Menopause May Be Linked to Increased Risk of Breast Cancer
The risk of developing breast cancer may be increased among some women who undergo menopause prior to age 46, according to a recent study published by Allen-Brady et al in The Journal of Clinical Endocrinology & Metabolism. Background Early menopause occurs in women aged 40 to 45 years. Primary ...
Metastatic NSCLC Survival Rates in the Immunotherapy Era
The survival rates of patients with advanced non–small cell lung cancer (NSCLC) have improved since the introduction of the first immunotherapeutic in this population in the United States in 2015, according to a recent study published by Wang et al in Cancer. NSCLC accounts for up to 90% of all...
FDA Approves IDH1/2 Inhibitor for Certain Patients With Astrocytoma or Oligodendroglioma
The U.S. Food and Drug Administration (FDA) has approved vorasidenib (Voranigo), an isocitrate dehydrogenase-1 (IDH1) and -2 (IDH2) inhibitor, for adult and pediatric patients aged 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation, following...
Radiation Alone May Be as Effective as Chemoradiation in Patients With Low-Risk Nasopharyngeal Cancer
Nasopharyngeal carcinoma is a rare and aggressive malignant head and neck cancer that is highly prevalent in the southern and southwestern provinces of China. Although the incidence of the cancer is less than 1 per 100,000 in Europe, the United States, and the Pacific, data from the International...
Active Surveillance May Enable Patients With Esophageal Cancer to Delay or Avoid Surgery
Although esophageal cancer in the United States is relatively rare—affecting about 22,400 people each year and making up about 1% of all cancer cases—the disease is common in East and Central Asian countries. Nearly 90% of patients with esophageal cancer in Asia are diagnosed with the squamous cell ...
Adjuvant Dabrafenib Plus Trametinib for Stage III BRAF V600–Mutated Melanoma: Final Results of the COMBI-AD Trial
Georgina V. Long, MD, PhD, of the Melanoma Institute Australia and the University of Sydney, and colleagues reported the final follow-up analysis of the phase III COMBI-AD trial at the 2024 ASCO Annual Meeting (Abstract 9500) and published their findings in The New England Journal of Medicine.1...
Should Low-Dose CT Screening Be Recommended for Those at Low Risk for Lung Cancer?
Lung cancer remains the leading cause of cancer-related deaths worldwide. Detecting this disease in its early stages significantly improves survival rates, making low-dose computed tomography (CT) screening an essential component in the fight against lung cancer. Recent studies, particularly from...
Daily E-Cigarette Use May Be Linked to Higher Combustible Cigarette Cessation
U.S. adults who use e-cigarettes daily and smoke combustible cigarettes may be more likely to quit smoking traditional cigarettes compared with those who smoke but use e-cigarettes less frequently, according to a recent study published by Kasza et al in JAMA Network Open. The findings suggest that...
