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Your search for ASCO matches 14368 pages

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lung cancer
immunotherapy

Incorporating Immunotherapy Into Treatment of Early-Stage NSCLC

There is a strong rationale for incorporating immunotherapy into the treatment of early-stage non–small cell lung cancer (NSCLC), given the breakthrough results with PD-1 checkpoint inhibitors as monotherapy, combined with immunotherapy, or combined with chemotherapy in advanced-stage NSCLC. As...

Juanita L. Merchant, MD, PhD, Appointed to Ludwig Institute’s Scientific Advisory Committee

Ludwig Cancer Research recently welcomed Juanita L. Merchant, MD, PhD, to the Scientific Advisory Committee of the Ludwig Institute for Cancer Research. Dr. Merchant is a practicing clinician and an accomplished researcher at the University of Arizona, Tucson, where she is Professor and Chief of...

covid-19

Measuring the Impact of the Plunge in Cancer Screenings During the COVID-19 Pandemic

As outbreaks of the COVID-19 pandemic spiked across the country earlier this year, federal health officials and cancer societies advised people to delay seeking routine cancer screenings, including mammograms and colonoscopies, to keep them out of medical centers and away from potential exposure to ...

Memorial Sloan Kettering Launches Women in Science Endeavor

Memorial Sloan Kettering Cancer Center (MSK) recently announced the establishment of the Marie-Josée Kravis Women in Science Endeavor (WiSE) to provide financial and professional support to women scientists pursuing biomedical research at MSK, pledging its commitment to gender equity in science and ...

Fred Hutch Announces New Additions and Leadership to Board of Trustees

Fred Hutchinson Cancer Research Center announced the addition of two new members to its Board of Trustees, along with a new Chair and Vice Chair. Kathy Surace-Smith, JD, will take over the Board Chair position from Matt McIlwain, MBA, who now becomes immediate Past Chair. Ms. Surace-Smith, who is...

SNMMI Names Alan B. Packard, PhD, as President, and Richard L. Wahl, MD, as President-Elect

The Society of Nuclear Medicine and Molecular Imaging (SNMMI) held its 2020 Virtual Annual Meeting on July 11–14, during which officers for the current term were elected, including Alan B. Packard, PhD, as President, and Richard L. Wahl, MD, as President-Elect. Raising Recognition “SNMMI’s strength ...

issues in oncology

Pediatric Hematologist/Oncologist Yoram Unguru, MD, MS, MA, Explains the Economic Origins of Drug Shortages and Other Ethical Issues

Improvements in protocol-driven clinical trials and supportive care for children and adolescents with cancer have markedly reduced mortality rates over the past 5 decades. Yet, along with clinical advances, oncologists and their young patients with cancer face a host of ethical issues, made more...

covid-19

Jessica Y. Islam, PhD, MPH, on COVID-19 Preventive Behaviors Among Cancer Survivors

Jessica Y. Islam, PhD, MPH, of the UNC Lineberger Comprehensive Cancer Center, discusses findings from the COVID-19 Impact Survey, which showed that cancer survivors are adhering to many of the recommended COVID-19 preventive behaviors, such as wearing masks and social distancing.

covid-19

Nancy E. Davidson, MD, on Bringing Patients With Cancer Back to the Clinic During the COVID-19 Pandemic

Nancy E. Davidson, MD, of Fred Hutchinson Cancer Research Center, talks about a panel she moderated in which speakers discussed the importance of communicating with patients to ease their concerns about cancer care during the COVID-19 pandemic, allocating protective gear for the most vulnerable...

breast cancer
covid-19

Increased Time to Breast Cancer Surgery May Not Impact Overall Survival for Patients With Early-Stage Disease

A new study published by Minami et al in the Journal of the American College of Surgeons found that longer time from diagnosis to surgical treatment did not lower overall survival in women with early-stage breast cancer. These findings may be reassuring for women with early-stage breast cancer who...

integrative oncology

A Brief Primer on Managing Anxiety in Older Adults With Cancer

Cancer-related anxiety has negative impacts on emotional, physical, and social well-being, with data indicating older patients are likely to remain undiagnosed, leading to poor outcomes. In this installment of The ASCO Post’s Integrative Oncology series, Drs. Trevino, Saracino, and Roth highlight...

leukemia

Refinement of European LeukemiaNet Classification Recommendations for Younger Adults With AML

Findings from a study published by Eisfeld et al in the journal Leukemia could refine an important set of prognostic and treatment recommendations for younger adult patients with acute myeloid leukemia (AML). The retrospective study evaluated the molecular characteristics and outcomes of 863...

kidney cancer
lung cancer
myelodysplastic syndromes
solid tumors
skin cancer
lymphoma
pancreatic cancer
breast cancer
immunotherapy

FDA Pipeline: Designations in Kidney and Lung Cancers, Myelodysplastic Syndromes, and More

Over the past few weeks, the U.S. Food and Drug Administration (FDA) has issued designations and accepted applications for novel agents, as well as approved companion diagnostics. We summarize these regulatory movements below. Breakthrough Therapy Designation for MK-6482 in von Hippel-Lindau...

multiple myeloma
immunotherapy

FDA Grants Accelerated Approval to Belantamab Mafodotin-blmf for Pretreated Patients With Relapsed or Refractory Multiple Myeloma

On August 5, the U.S. Food and Drug Administration (FDA) granted accelerated approval to belantamab mafodotin-blmf (Blenrep), an anti-B-cell maturation antigen antibody-drug conjugate, for adult patients with relapsed or refractory multiple myeloma who have received at least four prior therapies,...

issues in oncology

Antoni Ribas, MD, PhD, on Turning Science Into Life-Saving Care

Antoni Ribas, MD, PhD, of the University of California, Los Angeles, Jonsson Comprehensive Cancer Center, summarizes the opening plenary session that addressed epigenetics and early detection, how the aging microenvironment governs response to therapy, AI-driven precision medicine, reprogramming...

covid-19

Antoni Ribas, MD, PhD, on AACR Virtual Meeting: COVID-19 and Cancer Highlights

Antoni Ribas, MD, PhD, of the University of California, Los Angeles, Jonsson Comprehensive Cancer Center, and the President of AACR, discusses this special conference that focused on emerging data related to COVID-19 and cancer, ways in which the coronavirus pandemic has altered treatment of...

covid-19

Catherine H. Marshall, MD, MPH, on Promoting Recovery From COVID-19 Infection With Endocrine Therapy

Catherine H. Marshall, MD, MPH, of Johns Hopkins Hospital, discusses phase II trial results on bicalutamide, an oral antiandrogen used to treat prostate cancer. Bicalutamide may be helpful in downregulating the TMPRSS2 and ACE proteins needed for the SARS-CoV-2 virus; upregulating estradiol to help ...

covid-19

Karen E. Knudsen, MBA, PhD, on the Challenges of Using Telehealth in Cancer Care

Karen E. Knudsen, MBA, PhD, of the Sidney Kimmel Cancer Center at Jefferson Health, summarizes a panel she moderated on telehealth, which included discussion of usage in urban vs rural populations, preventing the technology from becoming a new source of disparities in cancer care, and uncertainties ...

covid-19

Arthur L. Caplan, PhD, on Ethics, Cancer, and COVID-19

Arthur L. Caplan, PhD, of New York University–Langone Health, discusses the areas in cancer care that need to be improved in the midst of the coronavirus pandemic, including a better definition of essential medical services based on the potential to save lives, offer good quality of life, and ease...

supportive care
immunotherapy

ASCO Guideline Supports Continued Use of Dexamethasone for Patients Receiving Checkpoint Inhibitors and Emetogenic Chemotherapy

The ASCO guideline on the use of antiemetics has been updated to include new anticancer agents, antiemetics, and regimens.1 The guideline also addresses a growing concern among some oncologists that corticosteroids and their immunosuppressive abilities could potentially compromise the efficacy of...

survivorship

Severe Hearing Impairment Associated With Neurocognitive Deficits in Childhood Cancer Survivors

Findings from a report published by Bass et al in JAMA Oncology show that childhood cancer survivors with severe hearing loss are at a significant increased risk for neurocognitive deficits, independent of what type of therapy they receive. This study is the first to objectively measure hearing and ...

immunotherapy

Ralph R. Weichselbaum, MD, on Radiotherapy and Immunotherapy in Oligometastatic Disease

Ralph R. Weichselbaum, MD, of the University of Chicago Cancer Research Center, explores the question of whether radiotherapy is the principal curative treatment with immunotherapy or activates immunotherapy. He also discussed how to improve the interaction of these treatments, perhaps with...

lung cancer

Ramaswamy Govindan, MD, on Differences Among Male and Female Patients With Lung Cancer

Ramaswamy Govindan, MD, of Washington University School of Medicine, discusses sex differences in lung cancer, including variations in treatment response, and the state of research in the field (Session ED20).

immunotherapy

Silvia Formenti, MD, on Testing Radiation and Immune Checkpoint Blockade in Different Tumor Settings

Silvia Formenti, MD, of Weill Cornell Medical College, discusses her continuing work, and the promising results emerging, in combining radiotherapy with immunotherapy to boost abscopal response rates. This combination therapy extends the use of radiotherapy to promote antitumor T-cell responses for ...

myelodysplastic syndromes
genomics/genetics

Role of TP53 Mutations on Disease Severity in Myelodysplastic Syndromes

Considered the “guardian of the genome,” TP53 is the most commonly mutated gene in patients with cancer. TP53's normal function is to detect DNA damage and prevent cells from passing this damage on to daughter cells. When TP53 is mutated, the protein made from this gene, called p53, can no longer...

ASH Annual Meeting Announced as an All-Virtual Event

The American Society of Hematology (ASH) announced its decision not to hold the 62nd ASH Annual Meeting in San Diego as planned given the continuing threat of the COVID-19 pandemic. The meeting will be offered as a virtual experience from December 5–8, 2020. The Society commented, “While there is...

covid-19

Nationwide Trends Show Fewer Patients With Cancer in the United States Seeking Care Since Start of the COVID-19 Pandemic

Research published by London et al in JCO Clinical Cancer Informatics found significant decreases nationwide in the number of patients seen for cancer-related care as the COVID-19 pandemic progressed during the first few months of 2020. The most significant decline was seen in encounters related to ...

lymphoma

FDA Approves Tafasitamab-cxix Combined With Lenalidomide to Treat Adults With Relapsed/Refractory DLBCL

On July 31, the U.S. Food and Drug Administration (FDA) approved tafasitamab-cxix (Monjuvi) in combination with lenalidomide for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL)–not otherwise specified, including DLBCL arising from low-grade...

palliative care

Overcoming the Challenges of Improving Psychosocial Care for Patients With Cancer

Although the United States spends billions of dollars each year on cancer research, very little of that funding is dedicated to mental health research in patients with cancer, despite the fact that cancer survivors have a six-time higher risk for psychological disability than people without...

prostate cancer

Pan-BET Bromodomain Inhibitor Plus Enzalutamide in Advanced Prostate Cancer

A new multi-institution, dose-determining clinical trial of a compound for patients with metastatic, castration-resistant prostate cancer showed the combination “demonstrated acceptable tolerability and potential efficacy,” reported Aggarwal et al in Clinical Cancer Research. The phase Ib/IIa study ...

covid-19

ESMO Issues Consensus on the Management of Patients With Cancer During the COVID-19 Pandemic

A European Society for Medical Oncology (ESMO) interdisciplinary expert consensus paper on how to manage patients with cancer during the COVID-19 pandemic was published by Giuseppe Curigliano, MD, PhD, and colleagues in Annals of Oncology. The guidance encourages medical oncologists worldwide not...

skin cancer
immunotherapy

FDA Approves Atezolizumab Plus Cobimetinib/Vemurafenib for Advanced BRAF V600–Mutated Melanoma

On July 30, the U.S. Food and Drug Administration (FDA) approved the PD-L1 inhibitor atezolizumab (Tecentriq) plus the MEK inhibitor cobimetinib (Cotellic) and the selective BRAF kinase inhibitor vemurafenib (Zelboraf) for the treatment of patients with advanced BRAF V600 mutation–positive...

supportive care
symptom management

Updated ASCO Guideline Revisits Evidence on Prevention and Treatment of Chemotherapy-Induced Neuropathy

Peripheral neuropathy is one of the most prominent chronic side effects of chemotherapy and can linger for years, causing discomfort as well as impaired functionality and quality of life. Yet oncologists have struggled to identify definitive treatment and prevention strategies. In an effort to help ...

colorectal cancer

Xavier Llor, MD, PhD, on Colorectal Cancer: Why Are More Younger People Being Affected?

Xavier Llor, MD, PhD, of Yale University School of Medicine, discusses the steep rise of early-onset colorectal cancer over the past 15 years, which cannot be explained by genetic predisposition but may be prompted by environmental factors (Session ED35).

colorectal cancer

Does Periodontal Disease Increase the Risk of Colorectal Cancer?

Periodontal disease was associated with an increased risk of two precursors of colorectal cancer, according to results of a study published by Lo et al in Cancer Prevention Research. “Periodontal disease is prevalent among adults, with periodontitis affecting more than 40% of the U.S. population,”...

gynecologic cancers

American Cancer Society Updates Guideline for Cervical Cancer Screening

An updated cervical cancer screening guideline from the American Cancer Society released today has called for less—and more simplified—screening. The guideline was published by Fontham et al in CA: A Cancer Journal for Clinicians. The updated guideline recommends that individuals with a cervix...

covid-19

Top Scientists Share Early Research on Intersection of COVID-19 and Cancer Care at AACR Virtual Meeting

The American Association for Cancer Research (AACR) Virtual Meeting: COVID-19 and Cancer took place from July 20 to 22, 2020, attracting top scientific minds from around the world to present preliminary research on the ever-evolving COVID-19 pandemic and its intersection with cancer care. In an...

issues in oncology

Leonard B. Saltz, MD, on Interventional Pharmacoeconomics: A Pathway to Better Cancer Care

Leonard B. Saltz, MD, of Memorial Sloan Kettering Cancer Center, discusses interventional pharmacoeconomics as an important tool that can offer patients with cancer more efficacious and cost-effective care. Pharmacoeconomics may help reduce the high costs of cancer therapy, with evidence-based...

issues in oncology

Antoni Ribas, MD, PhD, on Racism and Racial Inequities in Cancer Research

Antoni Ribas, MD, PhD, of the University of California, Los Angeles, Jonsson Comprehensive Cancer Center, summarizes a special panel discussion on ways to eliminate cancer health disparities among racial and ethnic minorities. Increasing minority representation in clinical trials, thus ensuring...

issues in oncology

Study Finds Lack of Parental Intent to Initiate and Complete HPV Vaccination in the United States

Study results documenting parental hesitancy to begin and complete their child's human papillomavirus (HPV) vaccine series were published by Sonawane et al in The Lancet Public Health. The Centers for Disease Control and Prevention recommends a two-dose HPV vaccination regimen for children if the...

issues in oncology
leukemia

Alfonso Bencomo Álvarez, PhD, on ALL, AML, and CML: Survival for Hispanic Patients Living Near the US/Mexico Border

Alfonso Bencomo Álvarez, PhD, of Texas Tech University Health Sciences Center, discusses his retrospective study of the incidence and survival for patients with hematologic malignancies residing at the United States/Mexico border. The analysis showed that 10-year survival rates for Hispanic...

San Antonio Breast Cancer Symposium to Be Held Virtually

Today, the San Antonio Breast Cancer Symposium (SABCS) Executive Committee announced that the San Antonio Breast Cancer Symposium will take place in 2020. However, in response to the novel coronavirus (COVID-19) global pandemic, the Executive Committee has made the decision—out of necessity to...

covid-19

Are Patients With a Longer-Established Diagnosis of Cancer at Higher Risk for More Severe Infection or Death From COVID-19?

According to research published by Russell et al in Frontiers in Oncology, patients with a longer-established diagnosis of cancer are at increased risk for more severe infection with COVID-19, as well as death from the virus. Patients of Asian ethnicity or who were receiving palliative treatment...

lung cancer

Treatment of Mesothelioma

Hear from thoracic oncology experts Drs. Ramaglingam, Brahmer, and Wakelee about the current and emerging treatment landscape for mesothelioma. In this video, they discuss first-line treatment data from the DREAM, PrECOG, and CheckMate 743 trials, as well as second-line gemcitabine plus ramucirumab ...

lung cancer

Treatment of Small Cell Lung Cancer

In this video, Drs. Ramaglingam, Brahmer, and Wakelee discuss the latest in emerging data on the treatment of small cell lung cancer. They highlight several recent clinical trials, including IMpower133, CASPIAN, ECOG-ACRIN EA5161, and KEYNOTE-604 in the first-line setting, and phase II data on...

lung cancer
genomics/genetics

Treatment of KRAS G12C Mutation

Drs. Ramalingam, Brahmer, and Wakelee review the role of KRAS G12C mutation in lung cancer, which is found is 13% of all non–small cell lung cancer. They highlight two investigational therapies, AMG 510 and MRTX 849, and discuss recently presented data.

lung cancer

Adjuvant EGFR Inhibition

Listen to three experts in the field of thoracic oncology—Drs. Ramalingam, Brahmer, and Wakelee—discuss the latest advances in the treatment of EGFR-mutant, early-stage non–small cell lung cancer, including recent data from the ADAURA and CTONG1104 trials, both presented during the ASCO20 Virtual...

lung cancer
immunotherapy

Combination Immunotherapy Approaches

In this video, Drs. Ramalingam, Brahmer, and Wakelee discuss the latest in emerging data on chemo/immunotherapy and immunotherapy-based combination approaches for the treatment of non–small cell lung cancer. They review recent data presented during the ASCO20 Virtual Scientific Program, including...

issues in oncology

Stacey A. Fedewa, PhD, on Cancers in Younger Populations: Current Trends

Stacey A. Fedewa, PhD, of the American Cancer Society, discusses the increasing incidence rates of colorectal, breast, kidney, thyroid, uterine corpus, and cervical disease in younger patients. Data show that colorectal cancer is increasing most rapidly, while breast cancer—the most common cancer...

Jonathan W. Friedberg, MD, MMSc, Named Next Editor-in-Chief of the Journal of Clinical Oncology

Jonathan W. Friedberg, MD, MMSc, has been appointed as the next Editor-in-Chief of the Journal of Clinical Oncology (JCO), the flagship journal of ASCO. JCO publishes cutting-edge research on the diagnosis and treatment of patients with cancer and is one of the most highly cited oncology journals...

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