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Showing 32201 - 32250Study Links Paternal Age to Child’s Risk of Developing Blood and Immune System Cancer in Adulthood
A new study links a father's age at birth to the risk that his child will develop blood and immune system cancers as an adult, particularly for only children. The study, published by Teras et al in the American Journal of Epidemiology, found no association between having an older mother and these...
Women With Inherited KRAS-Variant Mutation May Be at Increased Breast Cancer Risk Due to Acute Estrogen Withdrawal
Researchers at UCLA Jonsson Comprehensive Cancer Center have discovered that for women with a relatively common inherited mutation, known as the KRAS-variant, abrupt lowering of estrogen may increase their breast cancer risk and impact breast cancer biology. Scientists also found that women with...
Regorafenib Improves Overall Survival in Asian Patients With Previously Treated Metastatic Colorectal Cancer
In the phase III CONCUR trial reported in The Lancet Oncology, Li et al found that the multikinase inhibitor regorafenib (Stivarga) improved overall survival vs placebo in Asian patients with previously treated metastatic colorectal cancer. Regorafenib has been approved by the U.S. Food and Drug...
Hedgehog Inhibitor Sonidegib Active in Advanced Basal Cell Carcinoma
In the phase II BOLT trial reported in The Lancet Oncology, Migden et al found that the hedgehog pathway signaling inhibitor sonidegib produced responses in patients with locally advanced or metastatic basal cell carcinoma at 200-mg and 800-mg dose levels. The lower dose appeared to be associated...
Multimodal Therapy Benefits Men With Prostate Cancer Experiencing Biochemical Recurrence After Local Therapy
In men who experience biochemical disease recurrence after local therapy for prostate cancer, docetaxel, bevacizumab (Avastin), and androgen-deprivation therapy may be beneficial, according to a study by McKay et al in Cancer. Further evaluation of this combination treatment is warranted to...
First-in-Class Antibody Mixture Shows Clinical Activity Against Treatment-Resistant, Advanced Colorectal Cancer
Patients with advanced colorectal tumors without mutations in the RAS genes derive substantial benefit from anti-EGFR (epidermal growth factor receptor) therapies; however, the disease eventually progresses, leaving these patients with few alternative therapeutic options. Over the past decade, some ...
Pazopanib Plus Octreotide Active in Patients With Advanced Well-Differentiated Pancreatic Neuroendocrine Tumors
In a phase II study reported in The Lancet Oncology, Phan et al found that the VEGFR-1, -2, -3 inhibitor pazopanib (Votrient) plus depot octreotide produced responses in patients with advanced well-differentiated neuroendocrine tumors. No responses were observed in patients with carcinoid tumors....
Obesity Poses Greater Prostate Cancer Risk for African American vs White Men
In an analysis of participants in the SELECT prevention trial reported in JAMA Oncology, Barrington et al found that obesity in African American men was associated with a greater risk of prostate cancer than in white men. African American men have the highest prostate cancer incidence and mortality ...
Polish Study Shows Inherited PALB2 Mutation Confers Greater Risk and Poorer Outcome of Breast Cancer
In a Polish prospective cohort analysis reported in The Lancet Oncology, Cybulski et al found that PALB2 mutation carriers had increased risk of breast cancer and that those with breast cancer had significantly reduced long-term survival. Study Details In the study, genotyping for two...
Family History of Breast Cancer Doesn't Mean a Poor Prognosis for Women Who Develop the Disease
A new study finds that women who are diagnosed with breast cancer and have a family history of the disease face no worse a prognosis after treatment than other women with breast cancer. The study, which was published by Eccles et al in the British Journal of Surgery, offers a positive message for...
More Than One-Third of Patients Diagnosed With Hepatocellular Carcinoma as Outpatients Have Diagnostic Delays
Nearly 20% of patients with hepatocellular carcinoma “wait more than 3 months from presentation to diagnosis, which can contribute to interval tumor growth,” Patel et al concluded in the Journal of the National Comprehensive Cancer Network. They based their conclusions on a review of...
ASCO Releases Proposal for Payment Reform to Support Higher-Quality, More Affordable Cancer Care
Expanding on the Consolidated Payments for Oncology Care (CPOC) payment model circulated last year to improve the quality and affordability of care for patients with cancer, ASCO’s new Patient-Centered Oncology Payment: Payment Reform to Support Higher Quality, More Affordable Cancer Care...
Omega-3 Fatty Acids and Placebo Reduce Aromatase Inhibitor–Related Musculoskeletal Pain in Early Breast Cancer
In the SWOG S0927 trial reported in the Journal of Clinical Oncology, Hershman et al found that both omega-3 fatty acids and placebo resulted in marked persistent reductions in aromatase inhibitor–related arthralgia among patients with early breast cancer, with no difference between...
FDA Fast Track Designation Granted to AG-120 for Treatment of Patients With IDH1-Mutated Acute Myeloid Leukemia
The U.S. Food and Drug Administration had granted Fast Track designation to AG-120 for the treatment of patients with acute myeloid leukemia who harbor an isocitrate dehydrogenase-1 (IDH1) mutation. Agios Pharmaceuticals’ AG-120 is a first-in-class, oral, selective, potent inhibitor of the...
Sacituzumab Govitecan Receives Fast Track Designation for Non–Small Cell Lung Cancer Therapy
The U.S. Food and Drug Administration has granted Fast Track designation to Immunomedics’ lead antibody-drug conjugate sacituzumab govitecan (IMMU-132) for the treatment of patients with relapsed/refractory metastatic non–small cell lung cancer (NSCLC) who have failed two prior lines of ...
Patients’ Desire for Rapid Notification of Skin Biopsy Results Leads to Preference for Phone Call Over In-Person Discussion
Patients’ preference for how they receive biopsy results “has shifted from face-to-face visit to discussion over the telephone because of a desire for rapid notification,” according to a survey of 301 patients recruited at three different melanoma clinics. A total of 67.1% of the...
Histologic Subtype Classification of Lung Adenocarcinoma Predicts Disease-Free but Not Overall Survival Benefit From Adjuvant Chemotherapy
In an analysis reported in the Journal of Clinical Oncology, Tsao et al found that classification by histologic subtype for invasive lung adenocarcinoma was not predictive of overall survival benefit of adjuvant therapy in patients undergoing complete resection but did appear to predict benefit of...
AUA 2015: Studies Evaluate Effectiveness of Active Surveillance in Prostate Cancer Patients
Active surveillance has become a viable option for many men with low-risk prostate cancer who choose not to undergo active treatment such as surgery or radiotherapy. Four studies evaluating effectiveness, trends, and other considerations for active surveillance in managing prostate cancer were...
AUA 2015: New Studies Call for Smarter Approach to Prostate Cancer Screening
Prostate cancer is one of the most common cancers in American men, yet controversy over the utilization and frequency of prostate-specific antigen (PSA) screening methods remains, due to the overdiagnosis and overtreatment of men with low-grade, less-aggressive forms of the disease. At the 110th...
AUA 2015: Sperm Banking Rates Increase With Fertility Counseling for Cancer Patients
Fertility counseling for men with cancer, prior to initiating treatment, can increase the rate of sperm preservation, according to a new survey by Rotker et al presented during the 110th Annual Scientific Meeting of the American Urological Association (AUA; Abstract PD52-11). Chemotherapy can...
Updated Meta-Analysis Confirms Survival Benefit of Adding Chemotherapy to Radiotherapy in Nasopharyngeal Cancer
In an updated patient-level meta-analysis reported in The Lancet Oncology, Blanchard et al of the Meta-Analysis of Chemotherapy in Nasopharyngeal Carcinoma (MAC-NPC) collaborative group found that the addition of chemotherapy to radiotherapy improved overall survival in patients with nasopharyngeal ...
German Trial Shows Reduced Risk of Venous Thromboembolism With Prophylactic Enoxaparin in Ambulatory Patients With Advanced Pancreatic Cancer
In the German CONKO-004 trial reported in the Journal of Clinical Oncology, Pelzer et al found that prophylactic treatment with the low-molecular-weight heparin enoxaparin reduced the risk of symptomatic venous thromboembolic events in ambulatory patients receiving first-line chemotherapy for...
Improved Pathologic Complete Response Rate With Addition of Bevacizumab to Neoadjuvant Therapy in HER2-Negative Early Breast Cancer
In the phase III ARTemis trial reported in The Lancet Oncology, Earl et al found that the addition of bevacizumab (Avastin) to standard neoadjuvant therapy resulted in a higher pathologic complete response rate in women with HER2-negative early breast cancer. Study Details In this open-label...
Urine-Based Test Improves on PSA for Detecting Prostate Cancer
A new urine-based test improved prostate cancer detection—including detecting more aggressive forms of prostate cancer—compared to traditional models based on prostate-specific antigen (PSA) levels. The results were published by Tomlins et al in European Urology. The test, developed at ...
Stereotactic Ablative Radiotherapy Achieves Better Overall Survival Than Surgery in Stage I NSCLC
Patients with operable stage I non–small cell lung cancer (NSCLC) could achieve better overall survival rates if treated with stereotactic ablative radiotherapy rather than the invasive surgery, the current standard of care, according to research from a phase III randomized international...
Physical Activity Programs Produce Benefits in Patients Receiving Adjuvant Therapy for Breast Cancer
In the Dutch PACES trial reported in the Journal of Clinical Oncology, van Waart et al found that both a moderate/high-intensity supervised exercise program and a low-intensity home-based program provided benefits vs usual care in women undergoing adjuvant chemotherapy for breast cancer. Benefits,...
American College of Physicians Offers Advice on High-Value Screening in Five Cancers
To provide guidance on high-value cancer care screening strategies, the American College of Physicians (ACP) recently reviewed clinical guidelines issued by various medical organizations for screening strategies in five common cancers for asymptomatic, average-risk adults. The five cancers focused...
Poorer Melanoma-Specific Survival With Stage ≥ T2b Tumors With NRAS or BRAF Mutation
In a population-based study reported in JAMA Oncology, Thomas and colleagues found significantly poorer disease-specific survival among melanoma patients with stage ≥ T2b tumors with NRAS or BRAF mutation. Study Details The study included data from 912 U.S. or Australian patients in the...
ASCO 2015: Experimental Immunotherapy Shows High Response Rate in Advanced Lung Cancer
An early-phase study testing the anti–PD-L1 agent MPDL3280A in combination with standard chemotherapy in the treatment of advanced non–small cell lung cancer (NSCLC) has provided promising early results, prompting multiple phase III studies in lung cancer. The findings are being...
Study Finds Noninvasive Colon Cancer Screening May Be Promising for African Americans
In a first-of-its-kind clinical trial, physician-scientists at University Hospitals (UH) Case Medical Center, Seidman Cancer Center, and Case Western Reserve University School of Medicine found that a new, noninvasive technology for colon cancer screening is a promising alternative to colonoscopy...
Germline BRCA Mutations Found in Almost 5% of Patients With Pancreatic Adenocarcinoma
In a study reported in the Journal of Clinical Oncology, Holter et al found that 4.6% of a large clinic population of patients with pancreatic adenocarcinoma harbored pathogenic germline BRCA mutations. The study involved analysis of 306 unselected, consecutive, incident patients with pancreatic...
ASCO Provisional Clinical Opinion Update: HBV Screening for Cancer Patients Before Cancer Therapy
As reported in the Journal of Clinical Oncology by Hwang et al, ASCO has released a provisional clinical opinion update on screening of cancer patients for hepatitis B virus (HBV) infection before cancer treatment to reduce the risk of HBV reactivation. The ASCO consensus panel providing the update ...
Breast Density Should Not Be the Only Criterion for Supplemental Breast Cancer Screening
A large prospective study investigating the association between dense breast tissue and the risk for interval breast cancer has found that breast density alone should not be the sole criterion for recommending supplemental breast imaging, because not all women with dense breasts have high interval...
Nine-Valent HPV Vaccine Protects Against 80% of Cervical Cancers
The new nine-valent human papillomavirus (HPV) vaccine (Gardasil 9) can potentially prevent 80% of cervical cancers in the United States, if given to all 11- or 12-year-old children before they are exposed to the virus. Additionally, the new vaccine, which includes seven cancer-causing...
Certain Treatments for Childhood Cancer May Increase Obesity Risk Later in Life
Individuals who had cancer as a child may be at increased risk of being obese due to the therapies they received during their youth. The finding comes from a new study published early by Wilson et al in Cancer. The study’s results suggest the need for effective counseling and weight loss...
Combining Ixabepilone and Bevacizumab Appears Safe and Effective in Recurrent Uterine and Ovarian Cancers
In patients with recurrent/persistent uterine or ovarian/primary peritoneal/fallopian tube cancers, ixabepilone (Ixempra), especially with the addition of biweekly bevacizumab (Avastin), appears to be safe and effective, according to a study by Roque et al in Gynecologic Oncology. Further...
Dutch Analysis Questions Breast Cancer Protective Effect of Salpingo-Oophorectomy in Healthy BRCA1/2 Mutation Carriers
In a Dutch study reported in the Journal of the National Cancer Institute, Heemskerk-Gerritsen et al in the Hereditary Breast and Ovarian Cancer in the Netherlands (HEBON) study group found no apparent reduction in the risk for breast cancer with salpingo-oophorectomy in healthy BRCA1/2 mutation...
Androgen-Deprivation Therapy May Lead to Cognitive Impairment in Prostate Cancer Patients
Cognitive impairment can occur in cancer patients who are treated with a variety of therapies, including radiation therapy, hormone therapy, and chemotherapy. This side effect, when occurring with chemotherapy, is commonly referred to as “chemobrain.” Signs of cognitive impairment...
Study Shows Tomosynthesis Detects More Breast Cancers Than Traditional Mammography
One-view digital breast tomosynthesis detects 40% more breast cancers than two-view digital mammography does, according to a major screening study from Lund University in Sweden. The study’s results were published by Lång et al in European Radiology. This is the first large-scale study ...
Meta-Analysis Shows Increased Benefit of EGFR Tyrosine Kinase Inhibitors vs Chemotherapy in Subgroups of Patients With EGFR-Mutant NSCLC
In a meta-analysis reported in the Journal of Clinical Oncology, Lee et al found that increased progression-free survival benefit of EGFR tyrosine kinase inhibitor treatment vs chemotherapy was exhibited in patients with exon 19 deletion, never-smokers, and women. Study Details The meta-analysis...
High Symptom Distress in Children With Advanced Cancer
As reported in the Journal of Clinical Oncology by Wolfe et al, the Pediatric Quality of Life and Evaluation of Symptoms Technology (PediQUEST) study found a high prevalence of disease symptoms in children with advanced cancer, with most symptoms being associated with high distress level. Study...
ASCO 2015: Augmenting Standard Therapies Increases Cure Rates for High-Risk Wilms Tumor
Two phase III Children’s Oncology Group studies found that augmenting therapy with additional drugs improved outcomes for children with a high-risk form of Wilms tumor. These patients have a specific chromosomal abnormality associated with a poorer prognosis. In prior research, such patients...
ASCO 2015: Adding Chemotherapy to Initial Therapy Improves Survival in Patients With Advanced, Hormone-Naive Prostate Cancer
The UK-led STAMPEDE trial found that adding docetaxel chemotherapy to standard hormone therapy markedly improved survival for men with newly diagnosed advanced prostate cancer not previously treated with hormone therapy (hormone-naive). Men who received docetaxel plus standard therapy lived on...
ASCO 2015: Oral Vitamin Reduces Risk of Common Nonmelanoma Skin Cancers in High-Risk Patients
The Australian ONTRAC trial showed that a form of vitamin B3 called nicotinamide significantly reduced the rates of new skin cancers in people at high risk of the disease. Taken as a twice-daily pill, nicotinamide reduced the incidence of new nonmelanoma skin cancers by 23%. These findings were...
ASCO 2015: Adding Elotuzumab Significantly Reduces Risk of Progression for Relapsed Multiple Myeloma
Interim results of a phase III trial suggest an innovative immune-based therapy may offer a new option for patients with relapsed multiple myeloma. The new monoclonal antibody elotuzumab, added to standard lenalidomide (Revlimid) and dexamethasone therapy, extended the duration of remissions by...
No Significant Difference in Outcome for ABVD Plus Radiotherapy vs Stanford V in Stage I or II Bulky Mediastinal Hodgkin Lymphoma
As reported in the Journal of Clinical Oncology by Advani et al, a subset analysis of the phase III North American Intergroup E2496 trial showed no significant difference in failure-free or overall survival between ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) plus radiotherapy vs the...
Increased Risk of Long-Term Pulmonary Dysfunction in Survivors of Childhood Cancer Who Received Pulmonary Toxic Treatments
In a single-center study reported in the Journal of Clinical Oncology, Armenian et al found that childhood cancer survivors who had received potentially pulmonary toxic treatment were at a significantly increased risk of long-term pulmonary dysfunction compared with healthy controls. Study Details ...
Targeted Massively Parallel Sequencing Study Indicates Similarity of Somatic Driver Mutations in NSCLC for African American vs European Ancestry
In a study reported in the Journal of Clinical Oncology, Araujo et al used targeted massively parallel sequencing to produce an in-depth molecular profile of non–small cell lung cancer (NSCLC) in African Americans. Comparison with findings in patients of European/white ancestry with NSCLC...
TAS-102 Significantly Improves Overall Survival in Patients With Metastatic Colorectal Cancer
A large, phase III international study of the oral agent TAS-102 in patients with heavily pretreated metastatic colorectal cancer has found that the therapy improved overall survival by 1.8 months and also delayed disease progression. TAS-102 had few side effects and was also effective in patients...
Good Prognosis for Parenthood for Women Treated for Hodgkin Lymphoma During Childhood or Adolescence
In a German study reported in The Lancet Oncology, Brämswig et al found that women treated for Hodgkin lymphoma during childhood or adolescence had a good prognosis for achieving parenthood. Study Details This prospective longitudinal study included 467 female patients aged < 18 years at...
