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solid tumors
issues in oncology

FDA Launches Pilot Program to Help Reduce Risks Associated With Using Laboratory Developed Tests to Identify Cancer Biomarkers

The U.S. Food and Drug Administration (FDA) announced a new voluntary pilot program to help physicians select safe and effective cancer treatments, with guidance on in vitro companion diagnostic tests to determine which corresponding oncology drugs may provide the most benefit for their patients....

survivorship
leukemia
lymphoma
cns cancers

Late-Onset Memory Impairment in Adult Survivors of Childhood Cancer

In an analysis reported in JAMA Network Open, Phillips et al found that adult survivors of childhood cancer were at an increased risk of new-onset memory impairment vs their siblings. Modifiable factors associated with increased risk of impairment among survivors were identified. Study Details The...

lung cancer
cns cancers

Adagrasib Shows Activity in Patients With KRAS G12C–Mutated NSCLC and Untreated Brain Metastases

The KRAS G12C inhibitor adagrasib may be effective at suppressing cancer growth not only within the lungs but also in brain metastases for patients with KRAS G12C–mutated non–small cell lung cancer (NSCLC), according to a new study published by Negrao et al in the Journal of Clinical Oncology....

colorectal cancer

Patients With Refractory Metastatic Colorectal Cancer May Experience Survival Benefits With Fruquintinib

Targeted therapy with fruquintinib may improve overall survival and progression-free survival  in patients with refractory metastatic colorectal cancer, according to a novel study published by Dasari et al in The Lancet. Background According to the American Cancer Society, colorectal cancer is the...

breast cancer
survivorship

Aromatase Inhibitors May Limit Effectiveness of Weight Loss Medications in Breast Cancer Survivors

Aromatase inhibitors may interfere with the efficacy of weight loss medications in breast cancer survivors, according to a new study presented by Fansa et al at the 2023 Endocrine Society Annual Meeting. Background Aromatase inhibitors are designed to block the activity of the aromatase enzyme,...

breast cancer
survivorship
geriatric oncology

Older Breast Cancer Survivors May Experience Accelerated Aging, Worse Functional Outcomes Following Chemotherapy

Investigators have found that older breast cancer survivors—particularly those exposed to chemotherapy—may experience greater epigenetic aging and poorer outcomes than those without a history of cancer, according to a new study published by Rentscher et al in Cancer. Background Epigenetic aging...

prostate cancer

VISION Trial: Health-Related Quality of Life With the Addition of Lu-177 Vipivotide Tetraxetan to Standard of Care in Patients With Advanced Prostate Cancer

In an analysis from the phase III VISION trial reported in The Lancet Oncology by Karim Fizazi, MD, PhD, and colleagues, the addition of lutetium (Lu-177) vipivotide tetraxetan to standard of care was associated with improved health-related quality of life in patients with prostate-specific...

colorectal cancer

Patient-Reported Outcomes From the PROSPECT Trial: Neoadjuvant FOLFOX vs Chemoradiation for Locally Advanced Rectal Cancer

In an analysis from the PROSPECT trial (Alliance N1048) reported in the Journal of Clinical Oncology, Ethan Basch, MD, MSc, FASCO, and colleagues identified patient-reported outcome patterns among those receiving neoadjuvant FOLFOX (fluorouracil, leucovorin, oxaliplatin) or pelvic chemoradiation...

colorectal cancer

Longitudinal ctDNA Methylation Status and Risk of Recurrence After Surgery in Patients With Stage I to III Colorectal Cancer

In a Chinese study reported in JAMA Oncology, Mo et al found that longitudinal measurement of circulating tumor DNA (ctDNA) methylation permitted early detection of disease recurrence in patients undergoing surgery for stage I to III colorectal cancer.  Study Details In the prospective cohort...

lymphoma
immunotherapy

FDA Grants Accelerated Approval to Glofitamab-gxbm for Relapsed or Refractory DLBCL

On June 15, the U.S. Food and Drug Administration (FDA) granted accelerated approval to glofitamab-gxbm (Columvi) for the treatment of adult patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL) not otherwise specified or large B-cell lymphoma arising from follicular lymphoma,...

breast cancer
colorectal cancer
gynecologic cancers
issues in oncology

Impact of Historic Redlining Practices on Cancer Screening Rates

Although redlining was outlawed more than 50 years ago, individuals who currently live in historically redlined areas may be less likely to be screened for breast cancer, colorectal cancer, and cervical cancer than individuals who live in areas not associated with redlining practices, according to...

breast cancer
genomics/genetics

Study Evaluates Clinical Utility of Novel Liquid Biopsy-Breast Cancer Methylation Prototype Assay

A novel, automated liquid biopsy test—the Liquid Biopsy for Breast Cancer Methylation assay—may be effective at predicting early disease progression and potential survival outcomes in patients with metastatic breast cancer after as little as 1 month of treatment, according to a study published by...

multiple myeloma
genomics/genetics

Research Sheds Light on the Evolution of Precursor Conditions to Multiple Myeloma

Researchers have shared novel insights into the evolution of multiple myeloma from precursor disease, which may help physicians better identify patients whose disease is likely to progress as well as develop new interventions, according to a recent study published by Dang et al in Cancer Cell. How...

lung cancer
issues in oncology

Alectinib May Be More Effective When Taken With Larger Meals in Some Patients With NSCLC

Researchers have found that when the small molecule kinase inhibitor alectinib was taken in combination with a fuller breakfast or lunch, it resulted in significantly higher drug concentrations than when taken with a low-fat breakfast in patients with non–small cell lung cancer (NSCLC), according...

gastrointestinal cancer
palliative care

Perioperative Palliative Care and Health-Related Quality of Life in Patients Undergoing Curative-Intent Surgery for Upper Gastrointestinal Cancers

In a study reported in JAMA Network Open, Aslakson et al found that perioperative surgeon/palliative care team co-management did not improve health-related quality of life vs surgeon team management alone in patients undergoing curative-intent surgery for upper gastrointestinal cancers. Study...

breast cancer
issues in oncology

Mortality Rates From Second Cancers in Hispanic and Non-Hispanic Black Breast Cancer Survivors

Hispanic and non-Hispanic Black breast cancer survivors may experience higher rates of mortality after being diagnosed with a second primary cancer than breast cancer survivors of other ethnic and racial groups, according to a new study published by Deng et al in the Journal of the National Cancer...

cns cancers
issues in oncology
symptom management

Preoperative Stereotactic Radiosurgery May Help Patients With Metastatic Brain Tumors Reduce the Risk of Disease Progression and Adverse Effects

Researchers have found that preoperative stereotactic radiosurgery is associated with low rates of tumor recurrence, adverse radiation effects, and meningeal disease in patients with metastatic brain tumors, according to a novel study published by Prabhu et al in JAMA Oncology. Background As...

survivorship

Risk Factors for Primary Bone Cancer in Childhood Cancer Survivors: Bone Tissue Radiation Exposure and Alkylating Agent Dose

In a case-control study reported in the Journal of Clinical Oncology, Reulen et al found that an increased risk of primary bone cancer was associated with increasing radiation dose to bone tissue and increasing alkylating agent dose among survivors of childhood cancer. As noted by the...

lymphoma

Noncovalent BTK Inhibitor Pirtobrutinib in Patients With Mantle Cell Lymphoma Previously Treated With Covalent BTK Inhibitors

In the phase I/II BRUIN trial reported in the Journal of Clinical Oncology, Michael Wang, MD, and colleagues found that the noncovalent (reversible) Bruton’s tyrosine kinase (BTK) inhibitor pirtobrutinib produced durable responses in patients with mantle cell lymphoma who were previously treated...

skin cancer
genomics/genetics

Personalized mRNA Vaccines May Transform the Treatment of Melanoma

The rates of survival and disease recurrence improved significantly when a personalized mRNA vaccine tailored to the patients’ tumor genetics was coupled with immunotherapy in those who had undergone surgery for high-risk melanoma, according to novel findings presented by Khattak et al at the 2023...

leukemia
genomics/genetics

Exposure to Ultraviolet Radiation May Propel Transformation of BPDCN Cells to Leukemia in the Skin

For some precancerous cells, traveling from the bone marrow to the skin can trigger genetic transformations that can result in leukemia, according to a novel study published by Griffin et al in Nature. The new findings may have shed light on what researchers have termed the “genetic travelogue” of...

Clifford A. Hudis, MD, on ASCO 2023 Perspectives: The Power of Connecting and Collaborating

Clifford A. Hudis, MD, ASCO Chief Executive Officer, talks about extending the reach and impact of ASCO by partnering with patients who play a key role in advancing science through clinical trial participation. With near-record numbers of registered attendees, the 2023 Annual Meeting fostered new...

lung cancer

Factors Associated With Nonadherence to Lung Cancer Screening Recommendations

In a single-institution retrospective cohort study reported in JAMA Network Open, Lin et al identified factors associated with nonadherence to lung cancer screening recommendations among patients undergoing screening—and found that negative findings on two successive screenings were associated with ...

breast cancer

Study Finds Preoperative MRI Does Not Significantly Impact Margin Status in Patients With Breast Cancer

The use of preoperative magnetic resonance imaging (MRI) did not significantly reduce positive margins after breast-conserving surgery, according to data presented during a press briefing at the 2023 American Society of Breast Surgeons Annual Meeting.1 Although MRI has been shown to detect...

lymphoma
issues in oncology

New Data May Inform Treatment of Pregnant Patients With Relapsed or Refractory Lymphoma

In a new study reported by Farooq et al in Blood Advances, patients with relapsed or refractory lymphoma during pregnancy had a progression-free survival rate of 24% and an overall survival rate of 83%. Background Receiving a lymphoma diagnosis during pregnancy may be uncommon but can occur for...

lymphoma
issues in oncology

Patients With Lymphoma Who Have Depression or Anxiety May Experience Worse Survival Outcomes

Investigators have found that patients who had depression and/or anxiety prior to their diagnosis of diffuse large B-cell lymphoma (DLBCL) may have had shorter survival times than patients who didn’t have a mental health condition prior to their DLBCL diagnosis, according to a new study published...

solid tumors
genomics/genetics

NCI’s ComboMATCH Initiative Will Evaluate New Drug Combinations Guided by Tumor Biology

The National Cancer Institute (NCI) has launched a new set of large, precision medicine–based clinical trials—known as the ComboMATCH initiative—that will examine the efficacy of novel drug combinations targeting specific tumor mutations in adult and pediatric patients with cancer. The new...

gynecologic cancers

Olvimulogene Nanivacirepvec–Primed Immunochemotherapy in Platinum-Resistant or Platinum-Refractory Ovarian Cancer

In the phase II VIRO-15 trial reported in JAMA Oncology, Holloway et al found that virotherapy with the modified oncolytic vaccinia virus olvimulogene nanivacirepvec plus platinum-based chemotherapy with or without bevacizumab showed activity in patients with platinum-resistant or...

bladder cancer

Risk of Dementia and Mortality With BCG Vaccine in Non–Muscle-Invasive Bladder Cancer

In a study reported in JAMA Network Open, Weinberg et al found that receipt of the bacillus Calmette-Guérin (BCG) vaccine in patients with non–muscle-invasive bladder cancer was associated with a lower risk of Alzheimer’s disease and related dementias—as well as a lower risk of mortality—compared...

pancreatic cancer

Early Detection of Pancreatic Cancer Saved My Life

When my sister was diagnosed with breast cancer 25 years ago, her medical team suggested we undergo genetic testing for the BRCA gene mutation. I knew that being a BRCA carrier put me at greater risk for breast and ovarian cancers, but I had no idea it also increased my risk for pancreatic cancer....

hematologic malignancies

Polatuzumab Vedotin-piiq for Previously Untreated DLBCL–Not Otherwise Specified and High-Grade B-Cell Lymphoma

On April 19, 2023, polatuzumab vedotin-piiq was approved for use with a rituximab product, cyclophosphamide, doxorubicin, and prednisone (R-CHP) for patients with diffuse large B-cell lymphoma (DLBCL)–not otherwise specified or those with high-grade B-cell lymphoma who have an International...

supportive care

Addressing Racial Disparities in Cancer Pain Management: A Potential Role for Music Therapy

Guest Editor’s Note: Despite its high prevalence, cancer pain remains undertreated. Racial disparities present further challenges to assessing and managing pain. Music therapy, a nonpharmacologic intervention, has been documented to be effective in controlling cancer pain. In this article, Kevin T. ...

breast cancer

Interruption of Endocrine Therapy to Attempt Pregnancy in Women With Hormone Receptor–Positive Early Breast Cancer

In a study reported in The New England Journal of Medicine, Ann H. Partridge, MD, MPH, of Dana-Farber Cancer Institute, and colleagues found that temporary interruption of adjuvant endocrine therapy to attempt pregnancy was not associated with increased short-term risk of breast cancer events among ...

solid tumors

Can Bariatric Surgery Decrease the Risk of Obesity-Related Cancers?

A new study presented at Digestive Disease Week 2023 has shown that just 4% of patients with obesity who underwent bariatric surgery developed obesity-associated cancer in a 10-year follow-up, compared with 8.9% among those who did not have a weight-loss procedure.1 These findings indicate that the ...

issues in oncology

ASCO Updates Guideline for Management of Anxiety and Depression in Adult Cancer Survivors

Cancer takes a significant psychological toll on affected individuals. Cancer survivors have a significantly elevated risk of developing a mental health disorder compared with the general population, yet their psychological symptoms are often underrecognized and undertreated. To help equip...

Expert Point of View: Devraj Basu, MD, PhD, FACS

Devraj Basu, MD, PhD, FACS, of the Perelman School of Medicine, University of Pennsylvania, an expert in human papillomavirus (HPV)-related oropharyngeal cancer, commented on this study: “This abstract shows lack of awareness of multiple types of HPV-associated cancer and a reduced awareness of...

solid tumors

Better Awareness of HPV-Associated Cancers Is Still Needed in the United States, Study Finds

Awareness of the link between the human papillomavirus (HPV) and HPV-associated cervical cancers has declined over time, and awareness of other HPV-associated cancers, such as oral, penile, and anal, remains low, according to a cross-sectional study of the U.S. population presented at the 2023...

breast cancer

Two Studies of Atezolizumab-Based Regimens in Early-Stage, Triple-Negative and HER2-Positive Breast Cancers

Immunotherapy regimens involving the PD-L1 monoclonal antibody atezolizumab have demonstrated promising results in patients with early-stage, triple-negative breast cancer and HER2-positive breast cancer, according to a pair of studies presented at the European Society for Medical Oncology (ESMO)...

lung cancer

Toripalimab Plus Chemotherapy Improves Event-Free Survival in Resectable Stage III NSCLC

Findings from a phase III, randomized trial highlight the benefit derived from perioperative immunotherapy in patients with early-stage resectable non–small cell lung cancer (NSCLC), according to data presented during the ASCO Plenary Series: April 2023 Session.1 Interim analysis of the Neotorch...

gynecologic cancers

Pembrolizumab Added to Chemotherapy Improves Survival in Advanced Cervical Cancer Regardless of PD-L1 Expression

The addition of pembrolizumab to chemotherapy with or without bevacizumab led to improved overall survival and progression-free survival in women with persistent, recurrent, or metastatic cervical cancer in the final protocol-specified overall survival analysis of the KEYNOTE-826 trial presented at ...

issues in oncology

Rethinking Prior Authorization

Prior authorization of medical procedures, services, and medications has been a standard requirement of health-care providers for decades. Rising health-care costs, specifically the escalating prices of cancer drug therapies, have led to a new focus by payers, providers, and policymakers on prior...

breast cancer

Endocrine Therapy Switch With or Without Ribociclib After Disease Progression on Endocrine Therapy and CDK4/6 Inhibition for Metastatic Breast Cancer

In the phase II MAINTAIN trial reported in the Journal of Clinical Oncology, Kevin Kalinsky, MD, MS, and colleagues found that a switch in endocrine therapy plus continued CDK4/6 inhibitor treatment with ribociclib was associated with improved progression-free survival in patients with hormone...

bladder cancer

5α-Reductase Inhibitor Use and Progression of Bladder Cancer in South Korean Males

In a Korean cohort study reported in JAMA Network Open, An et al found that men with prescriptions for 5α-reductase inhibitors prior to diagnosis of urothelial bladder cancer had better outcomes than those with no prior prescriptions. Study Details The study analyzed patient claims data from the...

survivorship
issues in oncology

Cancer Survivors Who Quit Smoking May Have 36% Lower Cardiovascular Risk Than Those Who Continue Smoking

Patients who continue smoking after a cancer diagnosis may have almost a twofold risk of experiencing a heart attack, stroke, or death as a result of cardiovascular disease compared with nonsmokers, according to a new study published by Lee et al in the European Heart Journal. Background According...

solid tumors
hematologic malignancies
issues in oncology

NCCN Addresses Ongoing Chemotherapy Shortages as New Survey Suggests More than 90% of Cancer Centers May Be Impacted

Results of a new survey from the National Comprehensive Cancer Network (NCCN) have shed light on the widespread impact of the current carboplatin and cisplatin shortages. In a separate statement, the NCCN called on the whole oncology community to work together on solutions. Background Carboplatin...

issues in oncology

Involving All of Society to End Cancer as We Know It

This has been a year of firsts and seconds for Monica M. Bertagnolli, MD, FACS, FASCO. This past October, Dr. Bertagnolli became the 16th Director of the National Cancer Institute (NCI), the first woman and the first clinical trials cooperative group chair to hold that position. Then, 2 months...

Expert Point of View: Mikkael A. Sekeres, MD

Mikkael A. Sekeres, MD, Professor of Medicine and Chief of the Division of Hematology, Sylvester Cancer Center, University of Miami, said the COMMANDS trial delivered promising results for the treatment of lower-risk myelodysplastic syndrome (MDS). “Without question, the COMMANDS study met its...

hematologic malignancies

COMMANDS Trial: First-Line Luspatercept Boosts Chance of Transfusion Independence in Lower-Risk MDS

In the global phase III COMMANDS trial of patients with low-risk transfusion-dependent myelodysplastic syndrome (MDS), with or without ring sideroblasts, treatment with luspatercept essentially doubled the likelihood of achieving transfusion independence and an increase in hemoglobin level,...

breast cancer

Allostatic Load and Mortality in Patients With Breast Cancer

In a study reported in JAMA Network Open, Samilia Obeng-Gyasi, MD, MPH, and colleagues found that allostatic load—defined as “a cumulative measure of physiologic damage secondary to cognitive-emotional responses and perceptions to socioenvironmental stressors (ie, low socioeconomic status)”—was...

solid tumors
issues in oncology

Black and Hispanic Cancer Survivors May Have Highest Risk of Death From Subsequent Primary Cancers and Cardiovascular Disease

Black and Hispanic cancer survivors with subsequent primary malignancies may have a higher risk of mortality compared with White patients, according to new findings presented by Sung et al at the 2023 ASCO Annual Meeting (Abstract 12093). The new research demonstrated that Black patients with...

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