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Showing 1451 - 1500TAS-102 Significantly Improves Overall Survival in Patients With Metastatic Colorectal Cancer
A large, phase III international study of the oral agent TAS-102 in patients with heavily pretreated metastatic colorectal cancer has found that the therapy improved overall survival by 1.8 months and also delayed disease progression. TAS-102 had few side effects and was also effective in patients...
New Study Finds Racial Differences in Survival Among Men With Breast Cancer
A study by Sineshaw et al has found that black men with early-stage breast cancer who were younger than age 65 had a 76% higher risk of death than whites. However, the disparity was significantly reduced after adjusting for differences in insurance and income, suggesting the importance of...
Long-Term Use of Statins May Reduce Risk of Lung Cancer Death
A large population-based British study of newly diagnosed patients with lung cancer has found that those who had prolonged use of statins, especially simvastatin, had a 19% reduction in lung cancer deaths. Among all patients, those who used statins in the year before their lung cancer diagnosis had ...
American College of Physicians Releases Best Practice Advice for Cervical Cancer Screening in Average-Risk Women
The American College of Physicians (ACP) released its clinical advice for cervical cancer screening in asymptomatic, average-risk women 21 years or older. Women at average risk are defined as those with no history of a precancerous lesion (cervical intraepithelial neoplasia grade 2 or a more severe ...
AZD9291 Shows Durable Responses in Patients With EGFR-Positive Lung Cancers
A clinical trial of the EGFR inhibitor AZD9291 in patients with advanced non–small cell lung cancer (NSCLC) who had disease progression after previous treatment with EGFR tyrosine kinase inhibitors has found that the drug was highly active—achieving a 95% disease control rate—in...
FDA Announces Clinical Trial Endpoints for Approval of Non–Small Cell Lung Cancer Drugs
This week, the U.S. Food and Drug Administration (FDA) released its guidance for industry document Clinical Trial Endpoints for the Approval of Non–Small Cell Lung Cancer Drugs and Biologics, which allows companies to use several types of clinical trial endpoints, including overall survival...
U.S. Preventive Services Task Force Clarifies Mammography Recommendations for Women in Their 40s
The U.S. Preventive Services Task Force (USPSTF) has issued its updated draft recommendation statement on mammography screening guidelines. The revised guidelines still recommend that women aged 50 to 74 get mammography screening for breast cancer every 2 years and now states that the decision to...
Study Finds Large Disparities in Survival Among Adolescents and Young Adults With Differentiated Thyroid Cancer
A large, diverse study of 16,827 adolescents and young adults with differentiated thyroid cancer has found that African Americans and Hispanics were six times and three times more likely, respectively, to die of their cancer than Caucasians. Residing in low-socioeconomic neighborhoods, insurance...
Cancer Experts Find Too Many People Are Being Screened, Diagnosed, and Treated for Disease
A recent commentary published in Annals of Internal Medicine discusses the paradoxical finding that most patients are at below-average risk of disease and can expect to experience less-than-average benefits from a treatment. Yet, argue Vickers et al, too many people are being screened, diagnosed,...
One in Five Medicare Patients With Melanoma Experience Surgical Delays
A large retrospective cohort study of more than 32,000 Medicare beneficiaries diagnosed with melanoma has found that one in five patients experience a delay of surgery that is longer than 1.5 months. Those patients undergoing biopsy and surgery by dermatologists had the lowest risk for delay, which ...
Study Finds Oncology Drug Pricing Models ‘Not Rational’
A statistical analysis of 51 oncology drugs approved by the U.S. Food and Drug Administration (FDA) between January 1, 2009, and December 31, 2013, has found that cancer drug prices are rising faster than the prices in other sectors of health care and that the high cost of the drugs is not...
Circulating Tumor DNA in Blood May Predict Recurrence in Patients With Diffuse Large B-Cell Lymphoma
A study assessing whether circulating tumor DNA encoding the clonal immunoglobulin gene sequence could be detected in the serum of patients with diffuse large B-cell lymphoma has found that surveillance circulating tumor DNA enabled detection of microscopic disease before it could be seen on CT...
Study Finds Both the Number of Childhood Cancer Survivors and the Prevalence of Morbidity Are Increasing
Researchers investigating the prevalence of childhood cancer survivors and the population-level burden of morbidity in these survivors have found that although the number of childhood cancer survivors has increased by nearly 60,000 since 2005, the majority of those who have survived 5 or more years ...
American Gastroenterological Association Releases New Guidelines on the Management of Asymptomatic Neoplastic Pancreatic Cysts
The growing use of sophisticated abdominal imaging techniques, which has led to a marked increase in the findings of incidental pancreatic cysts, has prompted the American Gastroenterological Association (AGA) to issue new recommendations in the management of asymptomatic neoplastic pancreatic...
Genome-Wide CRISPR Screen Provides Better Understanding of Tumor Evolution and Metastasis
Scientists from the Broad Institute and the Koch Institute for Integrative Cancer Research at MIT used CRISPR-Cas9 gene-editing technology to “knock out,” or turn off, all genes across the genome systematically in a mouse model of non–small cell lung cancer cells and then tested...
NIH-Funded Study Suggests Novel Strategy to Improve Vaccine Efficacy in the Treatment of Glioblastoma
Although dendritic cell–based immunotherapy has shown limited promise in the treatment of patients with advanced cancers, including glioblastoma, the factors dictating dendritic cell–based vaccine efficacy have been poorly understood. Now, a clinical trial funded by the National...
Age-Stratified Predictive Model May Provide Surgical Guidelines for Uterine Leiomyomas
A study by Brohl et al investigating the case incidence of unexpected uterine sarcoma following surgery for presumed benign leiomyoma (fibroids or myomas) has found that the risk of unexpected uterine sarcoma varies significantly across age groups, with a more than fivefold difference between the...
AACR Names Nancy E. Davidson, MD, President-Elect for 2015-2016
The American Association for Cancer Research (AACR) today announced the election of Nancy E. Davidson, MD, Director of the University of Pittsburgh Cancer Institute and UPMC CancerCenter in Pittsburgh, as its President-Elect for 2015–2016. Dr. Davidson will officially become President-Elect...
Study Finds Websites That Market Personalized Cancer Care Services Overemphasize Benefits
A recent analysis of 55 Internet websites marketing a broad range of tests and services that promise the ability to personalize cancer treatment has found that the websites often overemphasize their purported benefits and downplay their limitations. In addition, the study results show that the...
NRAS Mutations in Advanced Melanoma Correlate With Increased Benefit From Immunotherapies
Researchers investigating whether tumor genotype correlates with benefit from immune therapy in melanoma has found that patients whose tumors had NRAS mutations had better response to immunotherapy and better outcomes than patients whose tumors had other genetic subtypes. The results suggest that...
Study Finds Immunohistochemistry Is More Effective Than FISH in Detecting EML4-ALK Rearrangments in Lung Cancer
A retrospective study by Pekar-Zlotin et al investigating fluorescence in situ hybridization (FISH) and immunohistochemistry (IHC) for detecting EML4-ALK rearrangement in patients with lung cancer has found that FISH may miss a significant number of patients who tested positive with...
Novel Cell Profiling Technique May Help Personalize Cancer Treatments
Researchers have developed a lab test called Dynamic BH3 Profiling (DBP) to measure early changes in net proapoptotic signaling at the mitochondrion induced by chemotherapeutic agents in cancer cells. In cell-line and clinical experiments, the test accurately predicted chemotherapy response across...
Early Study Suggests Olaparib May Be Effective in Ovarian Cancers Expressing High Levels of POLQ
Last December, the U.S. Food and Drug Administration (FDA) approved olaparib (Lynparza) in the treatment of advanced ovarian cancer in women with BRCA1 or BRCA2 gene mutations. Now, a laboratory study by Ceccaldi et al has found that the drug may also be effective in breast and ovarian tumors that...
ASCO Expresses Concern Over the New CMS Oncology Care Model
On Thursday, February 12, 2015, the U.S. Department of Health and Human Services announced its new Oncology Care Model, a multipayer payment and care delivery model meant to support better health-care coordination for patients with cancer. Although commending the Centers for Medicare & Medicaid ...
Scientists Identify Genetic Variations Linked to Treatment-Related Hearing Loss in Young Patients With Cancer
Using a genome-wide associated study approach, researchers have identified inherited genetic variations in the ACYP2 gene that were linked to as much as a fourfold greater risk of rapid hearing loss in young patients with newly diagnosed brain tumors treated with cisplatin chemotherapy. The study...
Study Finds Metformin May Reduce Lung Cancer Risk Among Diabetic Nonsmokers
A large retrospective cohort study of diabetic patients taking metformin, a first-line treatment for type II diabetes, has found that while metformin use was not associated with lower lung cancer risk overall, the risk was 43% lower among diabetic patients who had never smoked. In addition, the...
Study Finds Fear of Cancer Can Be Either a Facilitator or Deterrent to Getting Colorectal Cancer Screenings
People who worry a lot about cancer are more likely to want to get screened for colon cancer—perhaps due to a desire for reassurance—but having a more visceral negative response to thinking about cancer acted as a deterrent to actually getting screened, according to a British study by...
Study Finds Many Women Lack Understanding of Their Breast Cancer, Especially Minority Patients
A population-based study of women who had undergone surgery for breast cancer has found that many lacked understanding of the basic characteristics of their disease, including stage, grade, and tumor characteristics. Minority patients were less likely than white patients to have the correct...
ASCO Announces Progress in the Development of CancerLinQ, With the First Version Due in Late 2015
The American Society of Clinical Oncology (ASCO) announced today that it will use SAP HANA®, a data management and application platform, in the development of CancerLinQ, the Society’s health information technology platform that will harness Big Data to deliver high-quality care to...
ASCO Releases Annual Report on Progress Against Cancer and Names the Cancer Advance of the Year
ASCO released its report, Clinical Cancer Advances 2015: An Annual Report on Progress Against Cancer, today, and for the first time announced its cancer Advance of the Year: gains made in the treatment of chronic lymphocytic leukemia (CLL). ASCO credits the improvements in CLL care with the...
Prolonged Sedentary Time Linked to Cancer and Other Health Risks Regardless of Exercise Habits
A meta-analysis of published studies evaluating sedentary behavior in adults and health outcomes independent of physical activity has found that sedentary activities, such as prolonged sitting watching television or using a computer, is positively associated with an increased risk for all-cause...
Metabolic Syndrome Linked With Higher Risk of Endometrial Cancer Regardless of Being Overweight or Obese
A large population-based analysis of women 65 and older in the United States diagnosed with endometrial cancer has found that women with metabolic syndrome—characterized by low HDL cholesterol, hypertension, high triglycerides, and elevated waist circumference—have an increased risk of...
Study Identifies Signaling Pathway Responsible for Generating Slowly Proliferating, Chemoresistant Cancer Cells
Although scientists know that all cancers contain a mixture of both rapidly and slowly proliferating cancer cells, which complicates the detection and treatment of patients with cancer and may cause disease relapse long after apparently curative treatment, the circumstances and molecular details of ...
Chemotherapy Plus Targeted Therapy Reduces Recurrence in Women With Early-Stage HER2-Positive Breast Cancer
A phase II clinical study of adjuvant paclitaxel and trastuzumab (Herceptin) in women with stage I HER2-positive breast cancer has found the 3-year rate of survival free from invasive disease was 98.7%. The findings may help establish the combination therapy as the first standard treatment approach ...
Study Finds Whole-Genome Sequencing Is Successful in Identifying Patients’ Risk for Inherited Cancers
After performing whole-genome sequencing on patients found to have BRCA1or BRCA2 mutations as well as on those that were not carriers of either mutation, researchers found cancer risk–related potentially pathogenic variants in those without BRCA mutations. While the results highlight the ...
Scientists Discover the Role of Gene Mutations Involved in 75% of Glioblastomas and Melanomas
After initiating several biophysical computational studies, researchers have identified mutations that destabilize a DNA structure that turns a gene “off.” They found that these mutations occur at four specific sites in the human telomerase reverse transcriptase (hTERT) promoter in over ...
Higher Levels of Physical Activity Improve Survival Among Men With Prostate Cancer
Men with localized prostate cancer who walked or cycled for 20 minutes or more a day had a 30% decreased overall mortality and a 39% decreased prostate cancer–specific mortality compared with men who spent less time engaging in those activities, a large Swedish study has found. The study...
Racial Disparities in Colon Cancer Survival Linked to Advanced Disease and Comorbidities at Diagnosis
Racial disparities in colon cancer survival rates may be explained by differences in the health of the patients at diagnosis—both in the stage of the cancer and comorbid conditions—rather than by differences in subsequent treatment, a new study has found. Focusing efforts on prevention...
CDK7 Inhibitor Effective in Reducing Small Cell Lung Cancer in Preclinical Study
Although small cell lung cancer is an aggressive disease with a high mortality rate, in contrast to other lung carcinomas, there has not been significant progress in the development of therapies for the disease in more than 3 decades. Now, researchers using a high-throughput cellular screen of a...
Bisphosphonates May Block the Development of HER-Driven Tumors, Preventing Breast, Lung, and Colon Cancers
Two studies have found that bisphosphonates may be effective in preventing certain cancers—including lung, breast, and colon—by blocking abnormal growth signals passed through HER family receptors. The studies suggest that bisphosphonates, the most commonly prescribed medications for...
DNA Vaccine Targeting Mammaglobin-A Produces Robust Immune Response in Metastatic Breast Cancer
In a phase I study, a DNA vaccine targeting the breast cancer–associated antigen mammaglobin-A (MAM-A) was found to be safe and effective in eliciting immune responses in women with metastatic breast cancer. Preliminary evidence also suggests that the vaccine improved progression-free...
Exposure to Hookah Smoke Doubles Benzene Uptake, Potentially Increasing Risk for Leukemia
Findings from a new study show that hookah smokers and nonsmokers exposed to hookah (or waterpipe) secondhand tobacco smoke at social events in hookah lounges and in private homes had significant increases in uptake of benzene, a leukemogen that causes lymphohematopoietic cancers, especially acute...
Interactions Between Genetic Variants and Sun Behaviors May Influence Future Melanoma Risk
The combination of different patterns of sun exposure experienced by children and biomarkers of melanoma risk, such as the number of freckles or moles that develop as a result, may play a large role in future melanoma risk, a study investigating gene and environmental interactions has found....
ASCO Calls for Major Medicaid Reform to Improve Quality Cancer Care for Low-Income Americans
ASCO issued its new Policy Statement on Medicaid Reform yesterday, which calls for major changes to the program to ensure access to high-quality cancer care for all low-income individuals. The Society’s recommendations call for Medicaid expansion in all 50 states to close coverage gaps,...
End-of-Life Discussions Are Associated With Longer Survival and Higher Quality of Life
A review of advance care planning and end-of-life communication practices among physicians by the American College of Physicians has found that implementing early discussions about goals of care with seriously ill patients results in better quality of life, reduced use of life-sustaining treatments ...
Oral Cancer–Causing HPV May Be Transmitted Through Oral and Genital Contact
A study investigating the prevalence and risk factors of oral human papillomavirus (HPV) infection among young men has found a higher prevalence of oral HPV among men who had female partners with an oral and/or genital HPV infection, suggesting that transmission may occur through oral or genital...
Ipilimumab/Sargramostim Improves Overall Survival vs Ipilimumab Alone in Patients With Advanced Metastatic Melanoma
A randomized clinical trial of patients with advanced metastatic melanoma treated with ipilimumab (Yervoy), an immune checkpoint inhibitor, in combination with sargramostim (Leukine), an immune stimulant, vs ipilimumab alone, has found a 1-year survival rate of 68.9% vs 52.9% in the ipilimumab-only ...
Protein Linked With HPV-Positive Head and Neck Cancer May Lead to More Effective Therapies for the Disease
Scientists investigating the molecular mechanism of the protein p16 in cisplatin-treated head and neck cancer cells have found that the drug is able to kill the malignant cells by interacting with the protein gigaxonin. Although p16 is commonly produced in human papillomavirus (HPV)-positive...
Survey Finds High Rates of Burnout Among Palliative Care Physicians, With Over 50% Predicted to Leave the Field in 10 Years
Physician burnout in palliative care is higher—over 62%—than the burnout rate reported in medical oncology—45%—according to a large survey of over 1,200 hospice and palliative care clinicians. The factors contributing to professional burnout severity included younger age,...
Personalized Genetic Risk Assessment Does Not Increase Colorectal Cancer Screening in an Average-Risk Population
A large prospective, randomized, controlled trial investigating whether individualized genetic and environmental risk assessment of colorectal cancer susceptibility improves adherence to screening in average-risk persons, has found that the information was not enough to persuade nonadherent...
