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Showing 12851 - 12900Obstacles to Early Detection of Skin Cancer in Patients Living in Rural Western States
Residents of rural, sparsely populated “frontier counties” in the western United States have a higher incidence of skin cancer and related mortality rates. New research published by Jensen et al in Psychology, Health & Medicine indicated that the biggest obstacle to early detection and...
CMS Expands Coverage of Next-Generation Sequencing for Patients With Breast or Ovarian Cancer
On January 27, the Centers for Medicare & Medicaid Services (CMS) took action to cover U.S. Food and Drug Administration–approved or –cleared laboratory diagnostic tests using next-generation sequencing (NGS) for patients with germline ovarian or breast cancer. Over the last several years, CMS ...
Expert Point of View: A. Jo Chien, MD
The formal discussant of this abstract on the ATEMPT trial, A. Jo Chien, MD, Associate Professor at UCSF’s Helen Diller Comprehensive Cancer Center, San Francisco, said that a median follow-up of 3-years is relatively short for this trial, considering about 75% of patients had hormone...
Study Reports Similar Efficacy but No Less Toxicity With Adjuvant T-DM1 vs Taxane/Trastuzumab in Early Breast Cancer
The antibody-drug conjugate ado-trastuzumab emtansine (T-DM1) failed to show improved safety when compared with paclitaxel plus trastuzumab as adjuvant therapy in patients with stage 1 HER2-positive breast cancer. These results of the randomized, phase II ATEMPT trial were presented at the 2019 San ...
Scott Kopetz, MD, PhD, on Metastatic Colorectal Cancer: Quality of Life Results on Encorafenib, Cetuximab, and Binimetinib
Scott Kopetz, MD, PhD, of The University of Texas MD Anderson Cancer Center, discusses phase III findings from the BEACON CRC trial, which had demonstrated that the triplet regimen of encorafenib, cetuximab, and binimetinib significantly improved overall survival in patients with a BRAF V600E...
Eileen M. O’Reilly, MD, on Pancreatic Adenocarcinoma: Gemcitabine, Cisplatin, and Veliparib
Eileen M. O’Reilly, MD, of Memorial Sloan Kettering Cancer Center, discusses phase II trial findings showing that cisplatin and gemcitabine, with or without veliparib, exceeded a prespecified response rate for patients with pancreatic adenocarcinoma and a germline BRCA/PALB2 mutation (Abstract 639).
FDA Pipeline: Priority Reviews in Multiple Myeloma, Prostate Cancer
Over the past week, the U.S. Food and Drug Administration (FDA) granted Priority Review to treatments for multiple myeloma and prostate cancer; gave Fast Track designation to a targeted gene therapy for lung cancer; granted Orphan Drug designation to a combination therapy for hepatocellular...
Cemiplimab in Locally Advanced Cutaneous Squamous Cell Carcinoma
As reported in The Lancet Oncology by Migden et al, a phase II trial has shown activity of cemiplimab in patients with locally advanced cutaneous squamous cell carcinoma. The trial supported the September 2018 U.S. Food and Drug Administration approval of cemiplimab in this setting. In this report, ...
2020 GI Cancers Symposium: Cost of Pancreatic Cancer Care Over Time
In a study presented by Picozzi et al at the 2020 Gastrointestinal Cancers Symposium, researchers found that even as drug costs increased over the past decade, total inflation-adjusted pancreatic cancer care expenses declined, as did costs related to quality of life (Abstract 773). Health...
2020 GI Cancers Symposium: Data From Colorectal Cancer Cohorts of TAPUR Study Presented
Positive findings from three Targeted Agent and Profiling Utilization Registry (TAPUR) study cohorts on the potential benefit of various molecularly targeted drugs in patients with advanced colorectal cancer were presented at the 2020 Gastrointestinal Cancers Symposium. The TAPUR study is the first ...
Surgeon General Releases Report Focused on Smoking Cessation
Three decades after the first Surgeon General's report on smoking cessation, the Surgeon General has released a new report that reviews and updates evidence on the importance of quitting smoking. The report finds that more than two-thirds of U.S. adult cigarette smokers report an interest in...
FDA Approves Tazemetostat for Epithelioid Sarcoma
On January 23, the U.S. Food and Drug Administration (FDA) granted accelerated approval to tazemetostat (Tazverik) for adults and pediatric patients aged 16 years and older with metastatic or locally advanced epithelioid sarcoma not eligible for complete resection. “Epithelioid sarcoma accounts...
Elevations in Cancer Incidence Among Responders to the WTC Site After the September 11 Attacks
We’ll begin with a study that focused on elevations in cancer incidence among responders to the World Trade Center site after the September 11, 2001 terrorist attacks. We’ll then turn to an analysis evaluating the effect of proton pump inhibitor use on decreased cognitive functioning among breast...
Expert Point of View: Steven J. Isakoff, MD, PhD
“It is encouraging that the invasive disease–free survival observed in the primary analysis is holding up, particularly in the node-positive population. With longer follow-up, the addition of pertuzumab to chemotherapy and trastuzumab appears to show benefit in hormone receptor–positive patients as ...
APHINITY Update Supports Benefit of Pertuzumab-Based Triplet in Early HER2-Positive, Node-Positive Breast Cancer
Six-year follow-up of the APHINITY trial found a modest, but not statistically significant, overall survival benefit for the addition of pertuzumab to chemotherapy plus trastuzumab vs chemotherapy/trastuzumab as adjuvant therapy in patients with early HER2-positive breast cancer. The benefit was...
Yale Cancer Center Launches Center for Community Engagement and Health Equity
Yale Cancer Center has announced the launch of the Center for Community Engagement and Health Equity (CEHE). Building on the commitment of the Yale Cancer Center to patient-centered cancer care, screening, and prevention across the state of Connecticut, the new center is dedicated to ensuring...
Expert Point of View: Virginia Kaklamani, MD, Steven Vogl, MD, Gary Lyman, MD, MPH, and Ginny Mason, BSN
For several breast cancer experts interviewed by The ASCO Post, the phase III oral paclitaxel study and the drug itself had some limitations. Virginia Kaklamani, MD, of UT Health San Antonio, moderator of a press briefing, thought that the dosing process and the 11 pills or so per day was a...
Expert Point of View: Charles L. Shapiro, MD
Charles L. Shapiro, MD, Professor of Medicine, Hematology and Oncology at the Icahn School of Medicine at Mount Sinai, New York, commented on the Women’s Health Initiative update. “These trials involved more than 27,000 women between the ages of 50 and 79. The women with a uterus were randomly...
Oral Paclitaxel Outperforms Intravenous Formulation in Phase III Trial
In the first reported phase III study of an oral taxane, an investigational oral form of paclitaxel yielded a higher overall response rate and produced less neuropathy than standard intravenous paclitaxel, researchers reported at the 2019 San Antonio Breast Cancer Symposium.1 “Oral paclitaxel...
Studies Find Estrogen Alone Protective, Estrogen Plus Progestin Detrimental in Postmenopausal Women
In postmenopausal women without prior breast cancer, estrogen alone reduced the risk of breast cancer, not only during treatment, but for years after estrogen was stopped. It also reduced deaths as a result of breast cancer and deaths after breast cancer from all causes. However, in contrast,...
Elizabeth Fox, MD, Named Senior Vice President of Clinical Trials Research at St. Jude
St. Jude Children’s Research Hospital announced recently that Elizabeth Fox, MD, has been named Senior Vice President of Clinical Trials Research. In this role, Dr. Fox will oversee clinical trials research administration and strategy at St. Jude. She will also serve as Associate Director for...
Dolores Hambardzumyan, PhD, MBA, Joins Neurosurgery Faculty at Mount Sinai
Dolores Hambardzumyan, PhD, MBA, has been appointed Senior Faculty in the Department of Neurosurgery and a member of The Tisch Cancer Institute at the Icahn School of Medicine at Mount Sinai. Her research focuses on developing novel therapeutic pathways for the treatment of glioblastoma. She is...
Kunle Odunsi, MD, PhD, FRCOG, FACOG, Elected to Lead AACR Immunology Working Group
Chosen for his passion and leadership in immunotherapy research, Roswell Park Comprehensive Cancer Center Deputy Director Kunle Odunsi, MD, PhD, FRCOG, FACOG, was elected as the Cancer Immunology Working Group (CIMM) Chairperson-Elect for 2020–2021. CIMM is a scientific working group within the...
Dana-Farber Cancer Institute to Establish Chen-Huang Center for EGFR-Mutant Lung Cancers
Dana-Farber Cancer Institute will create the Chen-Huang Center for EGFR-Mutant Lung Cancers to stimulate research, promote clinical trials, and strengthen the Institute’s capabilities for studying and treating lung cancer. The Chen-Huang Center is being established with a $5 million gift from...
Expert Point of View: Shelley Hwang, MD, MPH
Shelley Hwang, MD, MPH, the Mary and Deryl Hart Distinguished Professor of Surgery, Duke University School of Medicine in North Carolina, discussed the APBI IMRT Florence trial in a meeting highlights session at the San Antonio Breast Cancer Symposium. She called physician-reported cosmesis “the...
Taking Action Against Cancer: Celebrating 20 Years of World Cancer Day
February 4, 2020, will mark the 20th anniversary of World Cancer Day, an annual event meant to raise cancer awareness and encourage governments, oncology societies, nongovernmental organizations, businesses, and individuals to take action against the global impact of the disease. Formed in...
Partial-Breast Irradiation Favored Over Whole-Breast in Early Breast Cancer
Patients with early breast cancer with small, node-negative tumors can safely be treated with accelerated partial-breast irradiation using intensity-modulated radiotherapy. According to the 10-year median follow-up of the randomized phase III APBI IMRT Florence trial, recurrence rates were low and...
Largest Single-Year Drop in Cancer Mortality Ever Reported: 2016–2017
The cancer death rate declined by 29% from 1991 to 2017, including a 2.2% drop from 2016 to 2017—the largest single-year drop in cancer mortality ever reported. These findings were reported in “Cancer Statistics, 2020,” the latest edition of the American Cancer Society’s annual report on cancer...
Yale Cancer Center Study Suggests New Approaches Needed to Manage Ibrutinib-Related Toxicities in Patients With CLL
New findings by Yale Cancer Center and Smilow Cancer Hospital researchers show that, as the use of ibrutinib increases in patients with chronic lymphocytic leukemia (CLL), so do the rates of patients who stop taking the drug. The study was presented at the 2019 American Society of Hematology (ASH)...
Oral CC-486 Maintenance Therapy Extends Survival in Older Patients With AML
Use of CC-486—an investigational oral form of azacitidine—as maintenance therapy significantly improved overall survival and relapse-free survival in older patients with newly diagnosed acute myeloid leukemia (AML) who were in remission following induction chemotherapy with or without consolidation ...
Innovator and Leader in Radiation Oncology, Eli J. Glatstein, MD, FASCO, Dies
Eli J. Glatstein, MD, FASCO, Morton M. Kligerman Professor, Radiation Oncology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, made a significant impact on how different cancers are diagnosed and treated. His research improved how physicians stage and treat cancer,...
Cleveland Clinic Taussig Cancer Institute Recognizes New Staff, New Appointments
In a news release issued by Cleveland Clinic Taussig Cancer Institute, the following announcements were made. Center Adds Clinical Psychologist to Staff Melissa Walt, PsyD, a clinical psychologist, recently joined the Cleveland Clinic Taussig Cancer Institute. She will focus on the psychological...
ACCC Project Focuses on Improving Care of Older Adults With Cancer
To prepare the multidisciplinary cancer care team for the growing prevalence of cancer and comorbidities among our nation’s graying population, the Association of Community Cancer Centers (ACCC)—in collaboration with The Gerontological Society of America and the International Society of Geriatric...
Olaparib as Maintenance Therapy for Germline BRCA-Mutated Metastatic Pancreatic Adenocarcinoma
On December 27, 2019, the poly (ADP-ribose) polymerase (PARP) inhibitor olaparib was approved for the maintenance treatment of adult patients with deleterious or suspected deleterious germline BRCA-mutated metastatic pancreatic adenocarcinoma, as detected by a U.S. Food and Drug Administration...
AACI Marks Milestone With New Member: Cold Spring Harbor Laboratory
The Association of American Cancer Institutes (AACI) welcomes its newest and 100th member—Cold Spring Harbor Laboratory (CSHL) Cancer Center—one of seven National Cancer Institute–designated basic laboratory cancer centers. The CSHL Cancer Center has nine shared resources that facilitate cancer...
Community Oncology Alliance Elects Officers and New Board Members for 2020
The Community Oncology Alliance (COA) has announced the election of new and re-appointed members to the Board of Directors and Executive Committee. The Board and Committee are comprised of volunteer representatives from community oncology, who direct the management of COA by its Executive ...
ADMIRAL Trial: More Than Standard Chemotherapy Needed for FLT3-Mutant Advanced AML
The important ADMIRAL trial, reported by Perl et al in The New England Journal of Medicine1 and reviewed in this issue of The ASCO Post, shows the efficacy of a specific FLT3 inhibitor in patients with advanced acute myeloid leukemia (AML) and enhances the era of personalized medicine in leukemia. ...
TIVO-3: Third- or Fourth-Line Tivozanib vs Sorafenib in Metastatic Renal Cell Carcinoma
As reported in The Lancet Oncology by Brian I. Rini, MD, and colleagues, the phase III TIVO-3 trial has shown a statistically significant increase in progression-free survival with tivozanib vs sorafenib as a third- or fourth-line treatment for advanced renal cell carcinoma. Study Details The...
First-Line Atezolizumab Plus Nab-paclitaxel in Advanced Triple-Negative Breast Cancer: Second Overall Survival Interim Analysis
As reported in The Lancet Oncology by Peter Schmid, MD, and colleagues, the prespecified second interim analysis of overall survival in the phase III IMpassion130 trial has shown no overall survival benefit with the addition of atezolizumab to nab-paclitaxel as first-line treatment of...
Recurrence Risk in Black and White Women With Borderline Estrogen Receptor–Positive Breast Cancer
In a study reported in the Journal of the National Cancer Institute, Halei C. Benefield, PhD, and colleagues found that black women with borderline estrogen receptor (ER)-positive breast cancer had significantly poorer disease-free interval compared with those with ER-positive disease, irrespective ...
Emerging Fertoprotective Therapeutic Options for Female Fertility Preservation
The trend toward delayed childbearing has meant that many women who plan to have children may be childless at the time they are diagnosed with cancer. The number of these women is likely to further increase concurrently with the increase in cancer survivors, making “the focus on fertility...
Fred Hutch Names Thomas J. Lynch, Jr, MD, as New President and Director
Fred Hutchinson Cancer Research Center recently announced that Thomas J. Lynch, Jr, MD, will become the center’s new President and Director. Dr. Lynch, a cancer expert in solid tumor research, precision medicine, and immuno-oncology, will join Fred Hutch on February 1. Dr. Lynch will become the...
Enfortumab Vedotin-ejfv for Previously Treated Advanced Urothelial Cancer
On December 18, 2019, the antibody-drug conjugate enfortumab vedotin-ejfv (PadcevTM) was granted accelerated approval for the treatment of adult patients with locally advanced or metastatic urothelial cancer who have previously received a programmed cell death protein 1 (PD-1) or programmed cell...
Expert Point of View: Debra A. Patt, MD, MPH, MBA, FASCO, and C. Kent Osborne, MD, FASCO
Debra A. Patt, MD, MPH, MBA, FASCO, Clinical Professor at Dell Medical School at The University of Texas at Austin and Executive Vice President of Public Policy and Strategy Initiatives for Texas Oncology, told attendees in a symposium highlights talk, “We all identify and follow some patients who ...
Fam-trastuzumab Deruxtecan-nxki for Previously Treated Unresectable or Metastatic HER2-Positive Breast Cancer
On December 20, 2019, the antibody-drug conjugate fam-trastuzumab deruxtecan-nxki was granted accelerated approval in the treatment of patients with unresectable or metastatic HER2-positive breast cancer who have received two or more prior anti–HER2-based regimens in the metastatic setting.1,2...
Breast Cancer Chemoprevention Effect Maintained Long After Stopping Anastrozole Therapy
For postmenopausal women at high risk for developing breast cancer—largely based on family history—anastrozole taken for 5 years maintained a preventive effect for at least an additional 7 years after stopping the drug in the IBIS-II trial, which included nearly 4,000 subjects. Women randomly...
Atezolizumab With Chemotherapy for Metastatic Nonsquamous NSCLC Without EGFR/ALK Aberrations
On December 3, 2019, atezolizumab in combination with nab-paclitaxel and carboplatin was approved for first-line treatment of metastatic nonsquamous non–small cell lung cancer (NSCLC) with no EGFR or ALK genomic tumore aberrations.1,2 The approval was based on findings in the open-label phase III...
Practicing Wellness to Reduce Burnout
Numerous wellness strategies are accessible to busy physicians and oncologists, which can be incorporated into their daily routine. Here we discuss such aspects as stress reduction, mindfulness, eating well, sleeping well, and spirituality for the wellness of oncologists. Those who regularly adhere ...
ASH Honors Member of Congress and Leaders of NIDDK and NCI
The American Society of Hematology (ASH) recognized representative Tom Cole (R–OK); the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) Hematology and Training Program Director Terry Bishop, PhD; and National Cancer Institute (NCI) Program Director William Merritt, PhD,...
A Deeper Understanding of the Miracle of the Human Body
Despite millennia of anatomic and biomedical search and discovery, there are parts and functions of the human body that remain a mystery. For years, medical students were taught that there are 78 organs in the human body. In February 2017, that number was revised, with the announcement of a new...
