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breast cancer

Breast Cancer: Genome-Wide Study Identifies Two New Risk Genes in Black South African Women

Investigators have identified two genetic risk loci that may be associated with an increased risk of breast cancer for Black South African women, according to findings from a genome-wide association study published in Nature Communications.   The two risk loci were between UNC13C and RAB27A on...

issues in oncology

A High Proportion of U.S. Adults Are Behind on Cancer Screenings

Investigators have found that a large proportion of U.S. adults are behind on their cancer screenings, according to a new survey from the American Cancer Society Cancer Action Network (ACS CAN). Survey Methods and Findings In the Survivor Views Special Report: National Screening Survey,...

cns cancers
issues in oncology

Gabapentin May Extend Survival in Patients With Glioblastoma

Investigators have found that the antiseizure/pain drug gabapentin may be associated with improved survival in patients with glioblastoma, according to a recent study published by Bernstock et al in Nature Communications. Background With about 12,000 new cases diagnosed annually in the United...

breast cancer

Stromal Disruption Associated With Higher Risk of Developing Aggressive Breast Cancer

Investigators from the National Cancer Institute (NCI) identified changes in stromal breast tissue, called stromal disruption, that may help to identify women with a higher risk of developing breast cancer, according to study findings published in the Journal of the National Cancer Institute. Women ...

prostate cancer

Former President Biden Diagnosed With Metastatic Prostate Cancer

According to his office, Former President Joseph R. Biden Jr has been diagnosed with an “aggressive” type of prostate cancer that has spread to his bones. The New York Times reported that Mr. Biden’s cancer “is characterized by a Gleason score of 9 with metastasis to the bone.” The American Cancer...

gynecologic cancers
issues in oncology

Risk of Gynecologic Cancers After 5 Years of Testosterone Use

Transmasculine and gender-diverse patients receiving testosterone as part of their hormone therapy may not be at an increased risk of developing gynecologic cancers in the first years of treatment, according to a recent study published by Vestering et al in eClinicalMedicine. Background Many...

issues in oncology
symptom management

Novel Prediction Model for Hearing Loss From Chemotherapy in Pediatric Patients With Cancer

In a study reported in the Journal of Clinical Oncology, Millstein et al attempted to develop a predictive model—Pediatric Holistic Evaluation of Auditory Risk (PedsHEAR)—for hearing loss associated with cisplatin chemotherapy in children and adolescents with cancer. Study Details PedsHEAR was...

colorectal cancer

Neoadjuvant Therapy for IBD-Related Rectal Cancer

Total neoadjuvant therapy of intensified chemoradiotherapy was shown to be less effective for treating patients with rectal cancer with inflammatory bowel disease (IBD) than those with sporadic rectal cancer, according to study findings presented during Digestive Disease Week 2025. However, there...

breast cancer

Second-Line Endocrine Therapy With/Without Palbociclib Rechallenge in HR-Positive, HER2-Negative Advanced Breast Cancer

In a phase II trial (PALMIRA) reported in the Journal of Clinical Oncology, Llombart-Cussac et al evaluated whether palbociclib rechallenge with second-line alternative endocrine therapy may improve progression-free survival vs second-line alternative endocrine therapy alone. Study Details In the...

colorectal cancer

Retifanlimab-dlwr Approved for Anal Cancer

On May 15, the U.S. Food and Drug Administration (FDA) approved retifanlimab-dlwr (Zynyz), a PD-1–blocking monoclonal antibody, with carboplatin and paclitaxel for the first-line treatment of adults with inoperable locally recurrent or metastatic squamous cell carcinoma of the anal canal (SCAC)....

breast cancer

Breast Parenchymal Phenotypes and Risk of Breast Cancer

Six parenchymal phenotypes were established that may be associated with a higher risk of developing breast cancer. Studies of these phenotypes identified by radiomics on mammograms demonstrated that these patterns were associated with an increased risk of invasive breast cancer, according to...

lung cancer

FDA Approves Therapy for NSCLC With High c-Met Protein Overexpression

On May 14, the U.S. Food and Drug Administration (FDA) granted accelerated approval to telisotuzumab vedotin-tllv (Emrelis), a c-Met–directed antibody and microtubule inhibitor conjugate, for adults with locally advanced or metastatic, nonsquamous, non–small cell lung cancer (NSCLC) with high c-Met ...

neuroendocrine tumors

FDA Approves First Oral Therapy for Pheochromocytoma and Paraganglioma

On May 14, the U.S. Food and Drug Administration approved the oral hypoxia-inducible factor-2 alpha (HIF-2α) inhibitor belzutifan (Welireg) for patients aged 12 years and older with locally advanced, unresectable, or metastatic pheochromocytoma or paraganglioma (PPGL). This represents the first FDA ...

legislation
health-care policy

Patient Advocacy Groups: Health-Care Programs Are Lifelines—Not Line Items

Forty nonprofit, nonpartisan organizations issued a statement this week to the House Energy & Commerce and Ways & Means Committees in regard to budget cuts and policy changes affecting Medicaid and health-care marketplaces. “As organizations representing millions of patients with serious...

prostate cancer

Elective Nodal Radiotherapy for Oligorecurrent Nodal Prostate Cancer Metastases

In a phase II trial (PEACE V–STORM) reported in The Lancet Oncology, Ost et al found that elective nodal radiotherapy (ENRT) to the pelvis was associated with longer metastasis-free survival vs metastasis-directed therapy (MDT) in patients with pelvic nodal oligorecurrences of prostate cancer....

FDA OCE Announces Project Interface Outreach Initiative

The Oncology Center of Excellence (OCE) at the U.S. Food and Drug Administration (FDA) has launched Project Interface to advance engagement and outreach to patients with cancer, advocacy organizations, and oncology experts.  Its mission is to protect, promote, and advance public health by...

palliative care

AI Model Estimates Biological Age and Predicts Survival in Patients With Cancer

FaceAge, a deep learning system, was developed and validated to estimate biological age from photographs of faces. In a study published in The Lancet Digital Health, FaceAge showed the ability to predict short-term outcomes in patients with cancer.   The study demonstrated that FaceAge could...

breast cancer
gynecologic cancers

Cohort Study Shows Benefits of Bilateral Salpingo-Oophorectomy Without Increased Health Risks

Patients with a history of breast cancer who are carriers of BRCA1 and BRCA2 pathogenic variants benefit from undergoing bilateral salpingo-oophorectomy, the results of a retrospective cohort study published in The Lancet Oncology showed. Women who had their ovaries and fallopian tubes removed...

hematologic malignancies
solid tumors
issues in oncology
supportive care

GLP-1 Receptor Agonists Could Show Anticancer Benefits Beyond Weight Loss

First-generation weight-loss drugs like liraglutide and exenatide could show anticancer benefits beyond weight loss, according to findings from a retrospective, observational study presented by Sagy et al at the European Congress on Obesity (ECO) 2025 and simultaneously published in...

breast cancer
issues in oncology

Combination of Weight Gain, Age at Pregnancy Could Increase Breast Cancer Risk

Investigators have found that the risk of developing breast cancer could be nearly three times higher among women who experience notable weight gain after the age of 20 years and either give birth after age 30 or don’t have children compared with those who give birth before age 30 and whose weight...

solid tumors
hematologic malignancies

Annual or Biennial Multicancer Early Detection Screening Improves Patient Outcomes

The addition of multi-cancer early detection screening using a single blood sample improved patient outcomes whether conducted on an annual or every 2-year basis, according to findings from a modelling study published in BMJ Open.   With earlier detection of disease progression, many cancers could...

gynecologic cancers

FDA Approves At-Home Self-Collection Device for Cervical Cancer Screening

Teal Health announced the U.S. Food and Drug Administration’s (FDA) approval of the Teal Wand™, an at-home vaginal sample self-collection device for cervical cancer screening in the United States. The Teal Wand is a prescription device that will soon be available at getteal.com for individuals aged ...

gynecologic cancers

FDA Approves Doublet for KRAS-Mutated, Recurrent, Low-Grade Serous Ovarian Cancer

Today, the U.S. Food and Drug Administration (FDA) granted accelerated approval to the combination of the dual RAF/MEK inhibitor avutometinib and the FAK inhibitor defactinib (Avmapki Fakzynja Co-pack) for adults with KRAS-mutated, recurrent, low-grade serous ovarian cancer (LGSOC) who have...

issues in oncology

Patterns in Oncology Drug Use After Accelerated Approval Is Withdrawn

The accelerated approval program of the U.S. Food and Drug Administration (FDA) allows certain medications to be marketed if they are indicated for serious disease and there has been preliminary evidence of the drug’s efficacy. Pharmaceutical companies must then conduct postapproval trials to...

breast cancer
issues in oncology

Collaborative Strategy Involving AI, Human Task-Sharing Could Help Minimize Mammogram Costs

When screening for breast cancer, the most effective strategy to utilize artificial intelligence (AI) may involve collaboration with human radiologists, according to a recent study published by Ahsen et al in Nature Communications. The findings could help shape how hospitals and clinics integrate...

breast cancer
issues in oncology

Breast Cancer Radiotherapy: 1- vs 3-Week Course

A 1-week course of postsurgery radiotherapy demonstrated comparable safety and efficacy to the traditional 3-week regimen in patients with early-stage breast cancer, according to new findings presented by Brunt et al at the European Society for Radiotherapy and Oncology (ESTRO) 2025 Annual Meeting...

pancreatic cancer

Ablative Radiation Therapy for Resectable Pancreatic Ductal Adenocarcinoma

Ablative radiation therapy is considered to be an alternative to surgery, providing an effective noninvasive option for local treatment of many types of cancer, but it is unknown whether ablative radiation therapy is effective for pancreatic ductal adenocarcinoma. Surgery provides improved...

Remembering Roswell Park Leader Thomas B. Tomasi, Jr, MD, PhD

Thomas B. Tomasi, Jr, MD, PhD, who led Roswell Park Comprehensive Cancer Center as President and Chief Executive Officer from 1986 to 1996, died on March 23 at age 97. His tenure marked a renaissance at Roswell Park that elevated it to a place among the nation’s top cancer centers. The pinnacle of ...

Keith T. Flaherty, MD, FAACR, Elected as AACR President-Elect for 2025–2026

The members of the American Association for Cancer Research (AACR) have elected Keith T. Flaherty, MD, FAACR, as the AACR President-Elect for 2025–2026. He will assume the Presidency in April 2026 at the AACR Annual Meeting in San Diego. Dr. Flaherty is Director of Clinical Cancer Research and the ...

Rakesh K. Jain, PhD, FAACR, Honored With 2025 AACR Award for Lifetime Achievement in Cancer Research

The 2025 AACR Award for Lifetime Achievement in Cancer Research was presented to Rakesh K. Jain, PhD, FAACR, during the 2025 American Association for Cancer Research (AACR) Annual Meeting in Chicago. This award honors individuals who have made significant fundamental contributions to cancer...

solid tumors
lung cancer
colorectal cancer
prostate cancer
hematologic malignancies
lymphoma
issues in oncology

HIV-Related Structural Barriers in Cancer Care

Patients with human immunodeficiency virus (HIV) are less likely to receive potentially life-saving cancer treatment if they reside in communities with lower income levels and educational attainment, according to a recent study published by Islam et al in Cancer. Study Methods and Results...

breast cancer
issues in oncology
survivorship

Influence of ACA on Breast Reconstruction Disparities

Despite steady increases in the rates of immediate postmastectomy breast reconstruction, racial disparities in receipt of the procedure have persisted in the years since the implementation of the Affordable Care Act (ACA), according to a recent study published by Schafer et al in Plastic and...

prostate cancer

Two- vs 8-Week Course of Radiotherapy for Prostate Cancer: 10-Year Follow-up

The phase III HYPO-RT-PC trial has shown that a shorter course of radiotherapy (2 weeks) for localized prostate cancer is just as safe and effective as the traditional 8-week schedule—even 10 years after treatment. The findings, presented at the European Society for Radiotherapy and Oncology's...

colorectal cancer

Five Major Advances in Radiotherapy for Anal and Rectal Cancer Presented at ESTRO 2025

Five pivotal studies presented at ESTRO 2025 showcase how radiotherapy is reshaping the landscape for anal and rectal cancers. From reduced-dose treatments to cutting-edge combinations with immunotherapy and chemotherapy, these innovations offer safer, more effective, and organ-preserving...

solid tumors
hematologic malignancies
issues in oncology

Smoking Cessation May Be Critical to Mitigate Burden of Second Primary Cancers

Investigators may have discovered a link between smoking and the risk of second primary cancers across various first primary cancer types, according to new findings presented by Sung et al at the 2025 American Association for Cancer Research (AACR) Annual Meeting (Abstract 4942/20). Study Methods...

lymphoma
issues in oncology
genomics/genetics

New Treatment Approach Could Enhance Care for Aggressive Relapsed/Refractory T- and NK-Cell Lymphomas

Investigators have uncovered how a specific sequence of cancer therapies could improve outcomes among patients with relapsed/refractory mature T- and natural killer (NK)-cell lymphomas, according to a recent study published by Sorial et al in the British Journal of Haematology. Background...

colorectal cancer
gastrointestinal cancer

Cancer Briefs From Digestive Disease Week 2025

Cancer-related studies were among the nearly 6,000 abstracts presented at Digestive Disease Week® (DDW) 2025, including research on artificial intelligence (AI) in patient communication, polyp detection, and colonoscopy prep. Use of AI in Patient Communication AI outperformed physicians in...

gastroesophageal cancer

Early-Stage Stomach Cancer Diagnoses on the Rise

Stomach cancers are increasingly being diagnosed at less advanced, more treatable stages—a shift that marks major progress in detecting one of the deadliest forms of cancer, according to a study presented at Digestive Disease Week® (DDW) 2025 (Abstract Sa1374). “These trends suggest that...

gastrointestinal cancer

Anal Cancer Rates Rising Most Among Older White and Hispanic Women

Anal cancer has been steadily increasing in the United States, with the biggest jumps among older women, especially White and Hispanic women, a new study presented at Digestive Disease Week 2025 (Abstract 76) found. According to the investigators, this shift challenges assumptions about high-risk...

issues in oncology
cost of care
solid tumors

Financial Toxicity Tumor Board: Can It Reduce Treatment Costs?

The Atrium Health Levine Cancer Institute established a Financial Toxicity Tumor Board in 2019. The board is the first known institutional-level intervention of its kind and functions like a traditional disease-focused multidisciplinary tumor board—with a singular focus on financial distress. Now,...

leukemia

AML: MRD Testing Led to Survival Benefits in Subset of Patients

Sequential molecular measurable residual disease (MRD) testing and monitoring led to a survival benefit among younger patients with acute myeloid leukemia (AML) and NPM1 and FLT3-ITD mutations, according to the results of a study published in The Lancet Haematology.   Patients with both mutations...

head and neck cancer

Use of CAD/CAM May Improve Jaw Reconstruction Outcomes Among Patients With Head and Neck Cancer

The use of computer-aided design and manufacturing (CAD/CAM) techniques for planning jaw reconstructions for patients with head and neck cancer undergoing free fibula reconstruction of the lower jaw may potentially shorten the duration of the surgery and reduce removal rates due to complications,...

lymphoma
issues in oncology
genomics/genetics

Malaria Subtype May Be Linked to Development of Burkitt Lymphoma

Researchers may have uncovered the role of Plasmodium falciparum malaria in the development of Burkitt lymphoma, according to a recent study published by Ariera et al in The Journal of Immunology. Background Uncomplicated malaria occurs when a patient’s symptoms are nonspecific, including fever,...

colorectal cancer

Cannabis Use Disorder Significantly Increases Mortality Risk in Colorectal Cancer

Patients with colorectal cancer and a history of cannabis use disorder had a more than 20 times higher risk of mortality within 5 years than those without cannabis use order, according to the results of a study published in Annals of Epidemiology.   The 5-year mortality rate in patients with a...

solid tumors
issues in oncology

2025 ACS Cancer Prevention, Early Detection Report: Cancer Screening Rates, Modifiable Risk Factors

Investigators have uncovered mixed progress in major cancer risk factors, preventive behaviors, and screenings in the post–COVID-19 pandemic period among adults in the United States, according to a new study published by Bandi et al in Cancer Epidemiology, Biomarkers & Prevention. Background An ...

thyroid cancer

AACR 2025: Novel CAR T-Cell Therapy Induces Response in Patients With Advanced Thyroid Cancers

A novel chimeric antigen receptor (CAR) T-cell therapy called AIC100, which targets the ICAM-1 protein, demonstrated encouraging responses and an acceptable safety profile in patients with two types of advanced thyroid cancer. Results from a small, first-in-human phase I trial were presented at the ...

colorectal cancer

DDW 2025: 20-Year Screening Program Drives Down Colorectal Cancer Cases, Deaths

A 20-year initiative that offered flexible options for colorectal cancer screening at a major integrated health system doubled colorectal cancer screening rates, cut cancer incidence by a third, halved deaths, and brought racial differences in outcomes to nearly zero, according to a study that will ...

gastrointestinal cancer
genomics/genetics

DDW 2025: Genetic Mutations Linked to Worse Stomach Cancer Outcomes

Using next-generation DNA sequencing, researchers have identified four specific genes whose mutations are linked to the development and progression of lethal stomach cancers. This could potentially enable practitioners to offer targeted treatments that would spare many patients from unnecessarily...

leukemia

AACR 2025: Using Single-Cell RNA Sequencing to Evaluate Cell States in AML

A new gene-expression atlas developed using single-cell RNA sequencing data sheds light on how normal hematopoietic cells differentiate and was used to catalog the multiple ways aberrant differentiation can lead to acute myeloid leukemia (AML). Andy G.X. Zeng, PhD, an MD/PhD candidate at the...

solid tumors
genomics/genetics

AACR 2025: Molecularly Selected, Tumor-Agnostic Phase II Trial Focuses on Combination Therapy

According to the results of a molecularly matched, tumor-agnostic phase II trial, the combination of the PARP inhibitor olaparib and the PD-1 inhibitor pembrolizumab demonstrated antitumor activity with no new safety signals, particularly in patients with BRCA1/2 mutations. Data from this...

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