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Your search for Matthew Stenger matches 7287 pages

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sarcoma

Nab-sirolimus in Advanced Malignant Perivascular Epithelioid Cell Tumors: AMPECT Trial Final Analysis

As reported in the Journal of Clinical Oncology by Wagner et al, final analysis of the phase II AMPECT trial has shown a median duration of response of more than 3 years in patients with advanced malignant perivascular epithelioid cell tumors treated with nab-sirolimus. The primary analysis of the...

global cancer care
survivorship

Cancer Prevalence in Europe as of 2020

In a study reported in The Lancet Oncology, De Angelis et al estimated the numbers of patients alive after a cancer diagnosis in Europe as of 2020.   Study Details The study used data from the EUROCARE-6 study to estimate the prevalence of cancer in 29 European countries and the 27 countries in the ...

breast cancer

Metastatic Triple-Negative Breast Cancer: Sacituzumab Govitecan vs Single-Agent Chemotherapy in Previously Treated Patients

As reported in the Journal of Clinical Oncology by Aditya Bardia, MD, MPH, and colleagues, final results of the phase III ASCENT trial showed continued superior progression-free and overall survival with sacituzumab govitecan-hziy, an anti–trophoblast cell surface antigen 2 (Trop-2) antibody-drug...

neuroendocrine tumors

Sunitinib in Metastatic Progressive Pheochromocytomas and Paragangliomas

In a phase II trial (FIRSTMAPPP) reported in The Lancet, Eric Baudin, MD, and colleagues found that the multikinase inhibitor sunitinib was active in patients with metastatic progressive pheochromocytomas and paragangliomas. As stated by the investigators, “No randomized controlled trial has ever...

lung cancer
immunotherapy

Immunotherapy Trials for Metastatic NSCLC: FDA Pooled Analysis

In a U.S. Food and Drug Administration (FDA) pooled analysis reported in The Lancet Oncology, Bernardo Haddock Lobo Goulart, MD, and colleagues found that response rate and progression-free survival were only moderately correlated with overall survival in first-line immunotherapy trials for...

prostate cancer

Patients With Biochemical Recurrence of Prostate Cancer: Ga-68–RM2 PET-MRI vs MRI Alone for Lesion Detection

In a single-center phase II/III imaging trial reported in The Lancet Oncology, Duan and colleagues found that gallium Ga-68–labeled RM2 (Ga-68–RM2) positron-emission tomography (PET)-magnetic resonance imaging (MRI) outperformed MRI alone in positive findings and number of lesions detected in...

solid tumors
issues in oncology

Variations in Use of Radiotherapy in Patients With Newly Diagnosed Common Cancers

In an International Cancer Benchmarking Partnership study reported in The Lancet Oncology, McPhail et al found wide interjurisdictional variation in the use of radiotherapy among patients with newly diagnosed common cancers in Norway, the United Kingdom, Canada, and Australia. Study Details The...

colorectal cancer

Fruquintinib in Refractory Metastatic Colorectal Cancer

On November 8, 2023, fruquintinib (Fruzaqla) was approved for adults with metastatic colorectal cancer who received prior fluoropyrimidine-, oxaliplatin-, and irinotecan-based chemotherapy; an anti-VEGF therapy; and—if RAS wild-type and medically appropriate—an anti-EGFR therapy.1 Supporting...

colorectal cancer

Primary Tumor Resection Before Chemotherapy in Patients With Colon Cancer and Unresectable Metastases

In a pooled analysis reported in the Journal of Clinical Oncology, Rahbari et al found that primary tumor resection before chemotherapy did not extend survival compared with upfront chemotherapy in patients with colon cancer and unresectable metastases. Study Details The study involved data from...

supportive care
breast cancer
gastrointestinal cancer

Topical Diclofenac to Prevent Capecitabine-Associated Hand-Foot Syndrome

In an Indian single-center phase III trial (D-TORCH) reported in the Journal of Clinical Oncology, Santhosh et al found that topical diclofenac gel significantly reduced the risk of capecitabine-associated hand-foot syndrome vs placebo gel in patients with breast or gastrointestinal cancer who were ...

hematologic malignancies
immunotherapy

Factors Associated With Myeloid Neoplasms Following CAR T-Cell Therapy

In an analysis reported in a research letter in JAMA Oncology, Gurney et al identified factors associated with an increased risk of myeloid neoplasms after chimeric antigen receptor (CAR) T-cell therapy. Study Details Investigators identified adults who received CAR T-cell therapy between June 2016 ...

leukemia

Novel CD123-Targeting Antibody-Drug Conjugate in Relapsed or Refractory AML

In a phase I/II study reported in The Lancet Oncology, Naval Daver, MD, and colleagues found that  pivekimab sunirine (IMGN632), a novel CD123-targeting antibody-drug conjugate, showed activity in patients with CD123-positive relapsed or refractory acute myeloid leukemia (AML). Study Details...

gynecologic cancers

Low-Risk Cervical Cancer: Pelvic Recurrence With Simple vs Radical Hysterectomy

As reported by Marie Plante, MD, and colleagues in The New England Journal of Medicine, the phase III CX.5 SHAPE trial has shown noninferiority of simple vs radical hysterectomy in terms of pelvic recurrence in women with low-risk cervical cancer. Simple hysterectomy was associated with a reduced...

solid tumors
global cancer care

Variations in Use of Chemotherapy in Patients With Newly Diagnosed Common Cancers

In an International Cancer Benchmarking Partnership study reported in The Lancet Oncology, McPhail et al found wide interjurisdictional variation in chemotherapy use among patients with newly diagnosed common cancers in Norway, the United Kingdom, Canada, and Australia. Study Details The study...

issues in oncology
covid-19

HPV Vaccination Among Young Adults Prior to and During the COVID-19 Pandemic

In a study reported in JAMA Network Open, Sonawane et al found that no increase in human papillomavirus (HPV) vaccination rates among young adults was observed during the COVID-19 pandemic in the United States, contrary to the increased rates observed prior to the pandemic. Study Details The study...

breast cancer

Racial/Ethnic Differences in Treatment Outcomes Among Patients With Triple-Negative Breast Cancer

In a study reported in the Journal of Clinical Oncology, Woriax et al identified racial/ethnic differences in pathologic complete response rates and overall survival among women with triple-negative breast cancer who received neoadjuvant chemotherapy. Study Details The study involved data from the...

breast cancer

Circulating Leukocyte Subsets After Breast Cancer Diagnosis and Treatment

In an analysis reported in JAMA Network Open, Jacob K. Kresovich, PhD, and colleagues identified differences in circulating leukocyte subsets between women who were diagnosed and treated for breast cancer vs those not diagnosed with breast cancer. As stated by the investigators: “Changes in...

multiple myeloma
immunotherapy

Advanced Multiple Myeloma: Prediction Model for Outcomes After BCMA-Directed CAR T-Cell Therapy

As reported in the Journal of Clinical Oncology, Gagelmann et al have developed a predictive model (Myeloma CAR-T Relapse [MyCARe] model) for outcomes after B-cell maturation antigen (BCMA)-directed chimeric antigen receptor (CAR) T-cell therapy in patients with relapsed or refractory multiple...

head and neck cancer

Nasopharyngeal Carcinoma: Radiotherapy vs Chemoradiotherapy After Induction Chemotherapy

In a Chinese phase III study reported in JAMA Oncology, Dai et al found that induction chemotherapy followed by radiotherapy alone was noninferior in terms of progression-free survival vs induction chemotherapy followed by concomitant chemoradiotherapy in the first-line treatment of locoregionally...

cns cancers

Novel Monotherapy in Recurrent H3 K27M–Mutant Diffuse Midline Glioma

In an analysis reported in the Journal of Clinical Oncology, Arrillaga-Romany et al found that single-agent ONC201 (dordaviprone), a first-in-class imipridone, showed activity in recurrent histone 3 (H3) K27M-mutant diffuse midline glioma. As noted by the investigators, “H3 K27M–mutant diffuse...

head and neck cancer
survivorship

Risk of Stroke in Survivors of Head and Neck Cancer

In a Singaporean study reported in JAMA Network Open, Yip et al found that survivors of head and neck cancer were at an increased risk of stroke compared with the general population. Study Details The registry-based cross-sectional study involved 9,803 survivors—excluding those with a history of...

lymphoma

Romidepsin Plus CHOP in Previously Untreated Peripheral T-Cell Lymphoma: Final Analysis of Ro-CHOP Trial

As reported in the Journal of Clinical Oncology by Camus et al, the final analysis of the phase III Ro-CHOP trial showed no significant progression-free or overall survival benefit with the addition of romidepsin (Ro) to CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone) in previously...

gastroesophageal cancer
gastrointestinal cancer

Adding First-Line Nivolumab to Chemotherapy in Advanced Gastric, Gastroesophageal Junction, and Esophageal Adenocarcinoma

As reported in the Journal of Clinical Oncology by Yelena Y. Janjigian, MD, and colleagues, 3-year follow-up of the phase III CheckMate 649 trial has shown the continued benefit of the addition of nivolumab to chemotherapy in the first-line treatment of advanced gastric, gastroesophageal junction,...

hematologic malignancies

Rusfertide for Erythrocytosis in Polycythemia Vera

In the phase II REVIVE trial reported in The New England Journal of Medicine, Marina Kremyanskaya, MD, PhD, and colleagues found that the hepcidin mimetic rusfertide reduced the number of phlebotomies (during a dose-finding phase) and improved response rate vs placebo (during a randomized phase) in ...

breast cancer
lymphoma
survivorship

Doxorubicin Exposure and Risk of Breast Cancer in Survivors of Hodgkin Lymphoma

In a Dutch study reported in the Journal of Clinical Oncology, Neppelenbroek et al found that doxorubicin treatment was associated with an increased risk of breast cancer among adolescent and adult Hodgkin lymphoma survivors. Study Details The study involved a cohort of 1,964 female 5-year Hodgkin...

colorectal cancer

Stool-Based Colorectal Cancer Screening: Comparison of Fecal Immunochemical Tests

In a Dutch study reported in The Lancet Oncology, Wisse et al found that a multitarget fecal immunochemical test (mtFIT) improved detection of advanced adenomas vs standard FIT in colorectal cancer screening. The mtFIT used in the study measures hemoglobin, calprotectin, and serpin family F member...

leukemia
lymphoma
covid-19

COVID-19 Risk in Pediatric Patients Receiving Treatment for Acute Lymphoblastic Leukemia or Lymphoma

In a retrospective case series reported in JAMA Network Open, Hashmi et al found that more than one-third of pediatric patients receiving treatment for newly diagnosed acute lymphoblastic leukemia/lymphoblastic lymphoma (ALL/LL) developed COVID-19 infection during a recent 2-year period. Study...

breast cancer

8-Year Follow-up of MINDACT Trial: Locoregional Breast Cancer Recurrence in Patients Undergoing Breast-Conserving Surgery

In a long-term analysis of the EORTC 10041/BIG 03-04 MINDACT trial reported in the Journal of Clinical Oncology, Alaeikhanehshir et al found that the 70-gene signature was not independently predictive of locoregional recurrence among women undergoing breast-conserving surgery for early breast...

pain management

SBRT vs Conventional External-Beam Radiotherapy for Painful Bone Metastases

In a systematic review and meta-analysis reported in JAMA Network Open, Bindels et al found no difference in overall pain response rates between stereotactic body radiotherapy (SBRT) and conventional external-beam radiotherapy (cEBRT) in terms of relief of pain for patients with painful bone...

prostate cancer

Metastatic Castration-Resistant Prostate Cancer: Tumor Mutational Burden and Response to Checkpoint Inhibition

In a single-center retrospective study reported as a research letter in JAMA Oncology, Zang et al found that high tumor mutational burden (TMB) was associated with better outcomes of checkpoint inhibition in patients with metastatic castration-resistant prostate cancer.  Study Details The study...

breast cancer

Enobosarm in Previously Treated Patients With AR-Positive, ER-Positive, HER2-Negative Advanced Breast Cancer

In a phase II trial (Study G200802) reported in The Lancet Oncology, Palmieri et al found that the novel selective androgen receptor (AR) modulator enobosarm was active in previously treated patients with AR-positive, estrogen receptor (ER)-positive, HER2-negative locally advanced or metastatic...

bladder cancer

High-Risk Non–Muscle-Invasive Bladder Cancer: Reduced Induction Courses of BCG

As reported by Katims et al in JAMA Oncology, long-term follow-up of a single-center phase II study showed benefit with two induction courses of bacillus Calmette-Guérin (BCG) without maintenance in patients with high-risk non–muscle-invasive bladder cancer. The strategy markedly reduced the number ...

breast cancer

Long-Term Follow-up of the Anthracyclines in Early Breast Cancer (ABC) Trials

As reported in the Journal of Clinical Oncology by Charles E. Geyer Jr, MD, and colleagues, long-term follow-up of the ABC trials (USOR 06-090, NSABP B-46-I/USOR 07132, and NSABP B-49 [NRG Oncology]) showed that noninferiority of adjuvant nonanthracycline therapy was not demonstrated vs...

breast cancer
pain management
symptom management

Hyperbaric Oxygen Therapy for Late Local Toxic Effects in Patients Receiving Adjuvant Radiotherapy for Breast Cancer

In a Dutch study (HONEY) reported in JAMA Oncology, van der Molen et al found that patients with breast cancer and late local toxic effects after adjuvant radiotherapy who completed hyperbaric oxygen therapy (HBOT) had reductions in pain and fibrosis. However, only a minority of patients offered...

supportive care
issues in oncology

Postdiagnosis Mental Disorders Among AYAs With Cancer

In a Canadian study reported in the Journal of Clinical Oncology, Oberoi et al found that adolescents and young adults (AYAs) with cancer were at an increased risk of mental disorders compared with cancer-free matched population-based and sibling cohorts. Study Details The retrospective...

bladder cancer

Final Results of the POUT Trial: Adjuvant Chemotherapy vs Surveillance After Nephroureterectomy for Upper Tract Urothelial Cancer

As reported in the Journal of Clinical Oncology by Alison Jane Birtle, MD, MBBS, MRCP, FRCR, and colleagues, final results of the UK-based phase III POUT trial showed survival benefits with adjuvant platinum-based chemotherapy vs surveillance after radical nephroureterectomy in patients with upper...

breast cancer
genomics/genetics

Genetic Alterations Associated With Interval Breast Cancer Diagnosis

In a Swedish study reported in JAMA Oncology, Rodriguez et al identified characteristics of interval breast cancers—those diagnosed between two screening examinations—compared with screen-detected cancers on the basis of analysis of rare germline genetic deleterious protein-truncating variants. As...

cns cancers

TBI and Risk of Brain Cancer in Veterans of the Iraq and Afghanistan Wars

In a retrospective cohort study reported in JAMA Network Open, Stewart et al found that U.S. veterans of the Iraq and Afghanistan wars with moderate/severe or penetrating traumatic brain injury (TBI) were at an increased risk of brain cancer compared to those without TBI. Study Details The study...

issues in oncology

Analysis of Cancer Diagnoses After Recent Weight Loss

In a study reported in JAMA, Wang et al found that individuals with a weight loss of more than 10% during the prior 2 years had a higher risk of cancer diagnosis over the subsequent 12 months vs those with no weight loss. Study Details The retrospective cohort analysis included women aged at least...

leukemia

PEGasparaginase Dosing and Risk of Hypersensitivity Reactions in Pediatric ALL

In a Dutch study reported in the Journal of Clinical Oncology, van der Sluis et al found that continuous dosing of PEGasparaginase was associated with a significantly reduced incidence of hypersensitivity reactions vs standard noncontinuous dosing in newly diagnosed pediatric patients with...

breast cancer

Adjuvant Olaparib for Germline BRCA1/2-Mutant, High-Risk HER2-Negative Early Breast Cancer: Patient-Reported Outcomes From the OlympiA Trial

In a patient-reported outcomes analysis from the phase III OlympiA trial reported in the Journal of Clinical Oncology, Patricia A. Ganz, MD, FASCO, and colleagues found no clinically important differences in fatigue—the outcome of primary interest—between adjuvant olaparib and placebo in patients...

pancreatic cancer

System to Improve Clinical Staging in Localized Pancreatic Cancer

In a Trans-Atlantic Pancreatic Surgery Consortium study reported in the Journal of Clinical Oncology, Dekker et al found that the “ABC” clinical staging system could be used to differentiate overall survival outcomes in patients with localized pancreatic ductal adenocarcinoma. Study Details The...

breast cancer

Molecular Subtype–Based Therapy in the First-Line Treatment of Metastatic or Recurrent Triple-Negative Breast Cancer

In a Chinese single-institution phase II trial (FUTURE-SUPER) reported in The Lancet Oncology, Fan et al found that molecular subtype–based therapy produced promising results in the first-line treatment of metastatic or recurrent triple-negative breast cancer.  Study Details In the open-label...

skin cancer

MIA Calculator for Predicting Recurrence-Free and Overall Survival in Stage II Melanoma

In a study reported in the Journal of Clinical Oncology, Varey et al developed the Melanoma Institute Australia (MIA) calculator for predicting recurrence-free and overall survival in stage II melanoma and found that it outperformed modeling based on American Joint Committee on Cancer (AJCC)-8th...

breast cancer

Postmenopausal Patients With ER-Rich/HER2-Negative Breast Cancer: Neoadjuvant Therapies

In a phase III trial reported in JAMA Oncology, Cynthia X. Ma, MD, PhD, and colleagues found that neither neoadjuvant fulvestrant nor anastrozole plus fulvestrant improved the endocrine-sensitive disease (ESD) rate vs anastrozole alone among postmenopausal patients with phase II to III estrogen...

gynecologic cancers

Trabectedin vs Chemotherapy in Recurrent Ovarian Cancer With BRCA Mutation or BRCAness Phenotype

As reported in the Journal of Clinical Oncology by Domenica Lorusso, MD, PhD, and colleagues, the Italian phase III MITO-23 trial showed no overall survival benefit with trabectedin vs chemotherapy in women with recurrent ovarian cancer with a BRCA mutation or BRCAness phenotype. Study Details In ...

leukemia

Crenolanib and Intensive Chemotherapy in Newly Diagnosed FLT3-Mutated AML

In a pilot study reported in the Journal of Clinical Oncology, Eunice S. Wang, MD, and colleagues found that the combination of crenolanib and intensive chemotherapy produced high response rates in adults with newly diagnosed FLT3-mutated acute myeloid leukemia (AML). Crenolanib is a...

breast cancer

Invasive Breast Cancer Incidence by Race, Stage, and Hormone-Receptor Status in U.S. Women With Breast Cancer

In a study reported in JAMA Network Open, Xu et al identified incidence of primary invasive breast cancer according to race/ethnicity, disease stage, and hormone receptor status among U.S. women with breast cancer aged 20 to 49 years diagnosed between 2000 and 2019. Study Details The study used...

lung cancer

Osimertinib vs Sequential Gefitinib/Osimertinib in Advanced EGFR-Mutant NSCLC

As reported in the Journal of Clinical Oncology by Jordi Remon, MD, PhD, and colleagues, the final analysis of overall survival in the phase II EORTC APPLE trial showed no significant difference between the strategies of upfront osimertinib vs sequential gefitinib/osimertinib in previously...

colorectal cancer

Multiplex Analysis of Intratumoral Immune Infiltrate and Prognosis in Colorectal Cancer

In an analysis reported by Frei et al in The Lancet Oncology, multiplex immunofluorescence staining of tissue microarrays of samples from patients with stage II to III colorectal cancer showed that densities of CD8-positive and Foxp3-positive cells were associated with recurrence-free interval. As...

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