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Showing 7151 - 7200The Need for Solid Data During a Global Pandemic
The rapid outbreak of COVID-19 disease on a global scale found the community of clinicians and scientists largely unprepared to face the devastating effects of the pandemic. The stress on health-care systems revealed their weaknesses and brought about associated financial crises. Defining the...
Clifford A. Hudis, MD, and Allen S. Lichter, MD, on Oncology Drug Pricing in the United States: What You Need to Know
Allen S. Lichter, MD, of the Value in Cancer Care Consortium, interviews Clifford A. Hudis, MD, Chief Executive Officer of ASCO, on the question of whether cancer drug prices in the United States are the problem, or just the symptom, of a larger systemic issue.
T-DM1 in Patients With HER2-Positive Breast Cancer and Brain Metastases: KAMILLA Trial
An exploratory subgroup analysis of the KAMILLA trial represents the largest reported cohort of patients with HER2-positive breast cancer and brain metastases treated with the anti-HER2 antibody-drug conjugate ado-trastuzumab emtansine, or T-DM1, in a prospective setting. Researchers observed...
Updated CCC19 Data Offer Insights on Treatment for Patients With Cancer and COVID-19 Infection
Newly released data on treatment outcomes of patients with cancer infected with COVID-19 revealed a racial disparity in access to remdesivir, an antiviral drug that has been shown to shorten hospital stays, and increased mortality associated with dexamethasone, a steroid that has had the opposite...
Adam C. Palmer, PhD, on Immune Checkpoint Inhibitors: Additive to or Synergistic With Other Treatments?
Adam C. Palmer, PhD, of the University of North Carolina at Chapel Hill, discusses combining immune checkpoint inhibitors with other cancer therapies to provide patients with more chances of a response. In principle, similar benefits may result from sequential or biomarker-stratified treatments,...
Nasser K. Altorki, MD, on Lung Cancer: Radiotherapy and Immune Checkpoint Blockade in the Neoadjuvant Setting
Nasser K. Altorki, MD, of Weill Cornell Medical College, discusses study findings that suggest neoadjuvant low-dose focal stereotactic body radiation plus immune checkpoint blockade (ICB) is safe and causes no surgical delays in early-stage lung cancer, and that major pathologic response rates are...
EAU Virtual: EUPROMS Study Investigates Effect of Prostate Cancer Treatment on Quality of Life
Findings from the first international prostate cancer quality-of-life study showed that significant numbers of men treated for the disease are struggling with continence and sexual problems after treatment. Results suggest that any treatment apart from active surveillance may negatively affect...
Miguel-Angel Perales, MD, and Syed A. Abutalib, MD, on Bone Marrow Transplants During the COVID-19 Pandemic
Syed A. Abutalib, MD, of Cancer Treatment Centers of America, talks with Miguel-Angel Perales, MD, of Memorial Sloan Kettering Cancer Center, about the challenges and concerns related to transplants for patients with hematologic malignancies who are particularly vulnerable to infection with the...
ASCO and ACCC Join Forces to Increase Participation of Racial and Ethnic Minority Populations in Cancer Treatment Trials
The American Society of Clinical Oncology (ASCO) and Association of Community Cancer Centers (ACCC) have announced a new collaboration to foster participation in oncology clinical trials to more fully reflect the diversity of people at risk for or living with cancer. The joint ASCO-ACCC initiative...
Andrew H. Wei, MBBS, PhD, on AML: Venetoclax Plus Cytarabine in Older Patients
Andrew H. Wei, MBBS, PhD, of The Alfred Hospital, Monash University, discusses phase III data from the VIALE-C trial, which appear to support the use of venetoclax plus low-dose cytarabine as a front-line treatment for older patients with acute myeloid leukemia, as well as for those who cannot...
FDA Pipeline: Novel Treatments for Hematologic Malignancies
Recently, the U.S. Food and Drug Administration (FDA) granted Priority Review to pembrolizumab for the second-line treatment of patients with relapsed or refractory Hodgkin lymphoma, and also accepted a supplemental new drug application for selinexor for pretreated patients with multiple myeloma....
Eric Zhou, PhD, on Insomnia in Young Cancer Survivors: Online Program May Improve Quality of Life
Eric Zhou, PhD, of Dana-Farber Cancer Institute, discusses an existing online program called SHUTi (Sleep Healthy Using the Internet), that he and his team adapted to the needs of adolescent and young adult cancer survivors. After six online cognitive behavior therapy sessions delivered over 8...
SNMMI 2020: First Results of Total-Body Dynamic PET Scan in Patients With Cancer
Results from the first study using uEXPLORER to conduct total-body dynamic positron-emission tomography (PET) scans in patients with cancer suggested that it can be used to generate high-quality images of metastatic cancer. The research was presented at the Society of Nuclear Medicine and Molecular ...
SNMMI 2020: Role of PSMA PET/CT in the Management of Recurrent Prostate Cancer
New research outlines the role of prostate-specific membrane antigen (PSMA) positron-emission tomography/computed tomography (PET/CT) in the detection and management of recurrent disease in prostate cancer patients. In initial results from a multicenter trial assessing the impact of F-18 DCFPyL...
SNMMI 2020: Novel PET Radiotracer for Glioblastoma
A first-in-human study presented at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2020 Annual Meeting and published by Zhang et al in the Journal of Nuclear Medicine has demonstrated the safety and favorable pharmacokinetic and dosimetry profile of Cu-64 EBRGD, a new, relatively...
Mark J. Ratain, MD, and Daniel Goldstein, MD, on Value in Cancer Care: How the Paradigm Is Shifting
Mark J. Ratain, MD, of the University of Chicago, and Daniel Goldstein, MD, of the Rabin Medical Center, discuss the challenges of achieving cancer care value, evolution of the “more-is-better” philosophy when it comes to oncology drugs, and highlights of the First International Summit on...
Study Links Mental Health Treatment to Possible Improved Cancer Survival
For people with cancer who have a mental health disorder, getting mental health treatment may help them live longer, a new study published by Berchuck et al in JAMA Oncology suggests. In the retrospective study, of more than 50,000 veterans treated for lung cancer within the Veterans Affairs (VA)...
Study Identifies Factors That May Predict Toxicities in Patients Treated With CAR T-Cell Therapy
Chimeric antigen receptor (CAR) T-cell therapy has proved to be a valuable treatment option for patients with lymphoma in whom other therapies have failed. In clinical trials, the cellular immunotherapy was shown to provide durable remissions for nearly 40% of patients with large B-cell lymphoma....
Deborah Schrag, MD, MPH, on Clinical Trial Design: Statistical Options and Challenges
Deborah Schrag, MD, MPH, of Dana-Farber Cancer Institute, offers her perspective on near-equivalence, Bayesian noninferiority, and the value of cancer drug optimization.
Deborah Schrag, MD, MPH, on Clinical Trial Design: Statistical Options and Challenges
Deborah Schrag, MD, MPH, of Dana-Farber Cancer Institute, offers her perspective on near-equivalence, Bayesian noninferiority, and the value of cancer drug optimization.
Two Studies Focus on Emerging Treatment Options for Patients With Neuroendocrine Tumors
Two new studies led by Renuka Iyer, MD, Section Chief for Gastrointestinal Oncology at Roswell Park Comprehensive Cancer Center, and published in Oncotarget and Cancer, respectively, highlight possible new treatment options for patients with neuroendocrine tumors. SurVaxM The first report,...
Lung Cancer in Nonsmoking Individuals: Differences in Genetics and Response to Treatment
Lung cancer in nonsmokers is a diverse and distinct disease from lung cancer in smokers and is likely to respond differently to targeted treatments, according to results from a new study published by Chen et al in the journal Cell. Scientists studied a patient population in Taiwan with high rates...
Experimental COVID-19 Vaccine Generates Immune Response, Deemed Safe in Phase I Trial
According to a press release from the National Institutes of Health, an investigational vaccine designed to protect against SARS-CoV-2, the virus that causes COVID-19—mRNA-1273—was generally well tolerated and prompted neutralizing antibody activity in healthy adults. These interim results were...
Expert Point of View: Craig Hofmeister, MD, MPH
“The IKEMA trial is based on the interest of adding a CD38 naked antibody to a carfilzomib-plus-dexamethasone skeleton, a protocol nearly identical to the recently presented CANDOR trial,” said Craig Hofmeister MD, MPH, Associate Professor of Hematology and Oncology at the Winship Cancer Institute...
Mark J. Ratain, MD, on Chronic Lymphocytic Leukemia: Making a Case for Low-Dose Ibrutinib
Mark J. Ratain, MD, of the University of Chicago, talks about why ibrutinib—which can lead to cardiotoxicities—should be studied at a lower dose for patients with chronic lymphocytic leukemia. Data suggest a reduced dose may prevent dose interruption due to adverse events and may have a better...
Presence of ctDNA and CTCs and Prediction of Disease Recurrence in Patients With Triple-Negative Breast Cancer
In a preplanned secondary analysis of the BRE12-158 trial published in JAMA Oncology, Milan Radovich, PhD, and colleagues found that the presence of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) in the plasma of women who have received neoadjuvant treatment for stage I, II, or...
Common Hypertension Medications May Also Reduce Risk of Colorectal Cancer
Medications commonly prescribed to treat high blood pressure may also reduce the risk of colorectal cancer, according to new research published by Cheung et al in the journal Hypertension. Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARB) are often prescribed...
R. Donald Harvey, PharmD, BCOP, FCCP, FHOPA, on Cutting Cancer Care Costs With Alternative Pharmacologic Options
R. Donald Harvey, PharmD, BCOP, FCCP, FHOPA, of Emory University, discusses the ways in which clinical pharmacology can help yield cost savings without sacrificing efficacy by, for example, altering regimens to extend drug supplies, lowering doses, dosing less frequently, or shortening the duration ...
Blase N. Polite, MD, MPP, on Optimizing Cancer Policies in the United States
Blase N. Polite, MD, MPP, of the University of Chicago Medical Center, discusses his belief that, in the next few years, we can bend the cancer drug cost curve and tame health-care costs if physicians, pharmaceutical companies, payers, and government come together and agree on the value of...
Trends in Policy Coverage for ctDNA Testing
New research published by Douglas et al in JNCCN—Journal of the National Comprehensive Cancer Network examined coverage trends for circulating tumor DNA (ctDNA) testing, also known as liquid biopsy. In the first-ever study to analyze insurance coverage for ctDNA-based panel tests, researchers found ...
American Cancer Society Updates Guideline for HPV Vaccination
The American Cancer Society (ACS) has updated its guideline for human papillomavirus (HPV) vaccination, adapting a 2019 update from the Federal Advisory Committee on Immunization Practices (ACIP). The ACS first issued a guideline for routine use of the HPV vaccine in 2007, with an update issued in...
Facing Death and Appreciating Life
I have had to come to terms with my own mortality three times in my life and I’m only 46. When I was 17, I was diagnosed with end-stage renal disease and experienced renal failure 2 years later. I underwent my first kidney transplant at 21, just before starting medical school. Finally, I thought my ...
Expect Questions About Minimally Invasive Surgery for Early-Stage Cervical Cancer
A recent systematic review and meta-analysis found that women with early-stage cervical cancer treated with minimally invasive radical hysterectomy had a 71% increased risk of disease recurrence and a 56% increased risk of death compared with those treated with open radical hysterectomy.1 “These...
Higher Risk of Disease Recurrence and Death With Minimally Invasive vs Open Surgery for Early-Stage Cervical Cancer
Women with early-stage cervical cancer treated with minimally invasive radical hysterectomy had a 71% increased risk of recurrence and a 56% increased risk of death compared with those treated with open radical hysterectomy, according to a systematic review and meta-analysis of 15 studies involving ...
Patricia S. Steeg, PhD, Receives Women in Cancer Research Charlotte Friend Lectureship
The American Association for Cancer Research (AACR) has honored Patricia S. Steeg, PhD, with its 2020 Women in Cancer Research Charlotte Friend Memorial Lectureship. Dr. Steeg, Co-Director of the Office of Translational Resources and Associate Director of the Center for Cancer Research at the...
Christopher I. Amos, PhD, Receives Award for Research Excellence in Cancer Epidemiology and Prevention
The American Association for Cancer Research (AACR) is honoring Christopher I. Amos, PhD, with the 2020 AACR–American Cancer Society (ACS) Award for Research Excellence in Cancer Epidemiology and Prevention. Dr. Amos, the Selzman Endowed Professor, Director of the Institute for Clinical and...
Benjamin F. Cravatt, PhD, Receives Award for Outstanding Achievement in Chemistry in Cancer Research
The American Association for Cancer Research (AACR) is honoring Benjamin F. Cravatt, PhD, with the 2020 AACR Award for Outstanding Achievement in Chemistry in Cancer Research. Dr. Cravatt, Professor at the Skaggs Institute for Chemical Biology and the Gilula Chair of Chemical Biology for the...
Charles L. Sawyers, MD, FAACR, Voted AACR Academy President-Elect for 2020–2021
The Fellows of the American Association for Cancer Research (AACR) Academy have chosen Charles L. Sawyers, MD, FAACR, as President-Elect for 2020–2021. Dr. Sawyers will assume the presidency during the 2021 AACR Annual Meeting. Dr. Sawyers holds the Marie-Josée and Henry R. Kravis Chair in Human...
Neil Spector, MD, Physician-Scientist, Mentor, Author, Dies at 63
Neil Spector, MD, a physician-scientist, translational research leader, and oncology mentor died on June 14, 2020. He was 63. Dr. Spector was the Sandra Coates Associate Professor in the Department of Medicine, Associate Professor of Pharmacology and Cancer Biology, and a member of the Duke Cancer ...
Beth Levine, MD, Renowned Doctor and Researcher in the Field of Autophagy, Dies at 60
Beth Levine, MD, Professor of Internal Medicine and Microbiology, Director of the Center for Autophagy Research, and Charles Cameron Sprague Distinguished Chair in Biomedical Sciences at The University of Texas Southwestern Medical Center (UT Southwestern), and an investigator at the Howard Hughes ...
Oscar Colegio,MD, PhD, Expert on Skin Cancers Linked to Immunodeficiencies, Dies at 47
Oscar Colegio, MD, PhD, the Lawrence P. & Joan Castellani Family Endowed Chair in Dermatology at Roswell Park Comprehensive Cancer Center, Buffalo, New York, died unexpectedly on June 13, 2020, at a family residence in Connecticut. He was 47. Dr. Colegio had relocated to Buffalo when he was...
New James Cancer Diagnostic Center to Expedite Access to Diagnostic Testing
A recently opened center at The Ohio State University Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC–James) gives patients direct, expedited access to diagnostic testing for cancer. The goal, said Chief Medical Officer David Cohn, MD,...
The Piano
The ASCO Post is pleased to reproduce installments of the Art of Oncology, as published previously in the Journal of Clinical Oncology. These articles focus on the experience of suffering from cancer or of caring for people diagnosed with cancer, and they include narratives, topical essays,...
Cancer Genome Atlas Founding Members and Current Project Team Awarded 2020 AACR Team Science Awards
During its recent Virtual Annual Meeting II, the American Association for Cancer Research (AACR) presented its 2020 Team Science Awards to the founding members and the current project team associated with The Cancer Genome Atlas (TCGA). TCGA began in 2006 as a joint effort between the National...
Kunle Odunsi, MD, PhD, FRCOG, FACOG, Elected At-Large Director of SITC Board of Directors
Elected by a body of fellow immunotherapy researchers from across the globe, Roswell Park Comprehensive Cancer Center Deputy Director Kunle Odunsi, MD, PhD, FRCOG, FACOG, has been named At-Large Director of the Society for Immunotherapy of Cancer (SITC) Board of Directors. Dr. Odunsi will begin his ...
Do Not Rush to High-Dose Twice-Daily Radiation for Limited Small Cell Lung Cancer
Bjørn Henning Gronberg, MD, PhD, presented a paper at the ASCO20 Virtual Scientific Program reporting astounding positive results favoring higher-dose, twice-daily radiation therapy in limited-stage small cell lung cancer.1 This was a phase II study (large for phase II but small for phase III)...
Elderberry
The ASCO Post’s Integrative Oncology series is intended to facilitate the availability of evidence-based information on integrative and complementary therapies sometimes used by patients with cancer. In this installment, Yen Nien Hou, PharmD, DiplOM, LAc, and Jyothirmai Gubili, MS, focus on...
New Recommendations Offer Guidance for Clinicians and Patients on Genetic Testing for Prostate Cancer
An international panel of experts led by researchers and thought leaders at the Sidney Kimmel Cancer Center–Jefferson Health (SKCC) and the Department of Urology at Jefferson have published the first multidisciplinary, consensus-driven, prostate cancer genetic implementation framework for the...
IMbrave150: A New Standard of Care to Treat Hepatocellular Cancers?
In 2007, sorafenib became the first approved systemic therapy for hepatocellular cancers and the first agent to improve overall survival in these patients.1 In a similar multikinase inhibitor strategy, lenvatinib was found to be noninferior to sorafenib in overall survival in the same patient...
FDA Collaborating on Use of Real-World Data to Inform COVID-19 Response Effort
On June 18, 2020, the U.S. Food and Drug Administration (FDA) took an additional step in harnessing real-world data to help inform the agency’s overall response to the COVID-19 public health emergency. The FDA announced its participation in the COVID-19 Diagnostics Evidence Accelerator, a...
