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Showing 5901 - 5950FDA Approves Pembrolizumab for the First-Line Treatment of MSI-H/dMMR Colorectal Cancer
On June 29, the U.S. Food and Drug Administration (FDA) approved pembrolizumab (Keytruda) for the first-line treatment of patients with unresectable or metastatic microsatellite instability–high (MSI-H) or mismatch repair–deficient (dMMR) colorectal cancer. KEYNOTE-177 Approval was based on...
FDA Approves Combination of Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf for HER2-Positive Breast Cancer
On June 29, the U.S. Food and Drug Administration (FDA) approved a new fixed-dose combination of pertuzumab, trastuzumab, and hyaluronidase-zzxf (Phesgo) for subcutaneous injection in the following indications: Use in combination with chemotherapy as: Neoadjuvant treatment for patients with...
Parameswaran Hari, MD, on Multiple Myeloma: Expert Commentary on Four Key Abstracts
Parameswaran Hari, MD, of the Medical College of Wisconsin, discusses data from four trials and their clinical implications for the treatment of patients with multiple myeloma: the KarMMa and EVOLVE studies on CAR T cell therapies; SWOG-1211 on bortezomib, lenalidomide, and dexamthasone...
Biomarker Combination May Help Predict Response to Immunotherapy in Patients With Metastatic Urothelial Carcinoma
In patients with metastatic urothelial carcinoma, a novel combination of biomarkers from baseline tumor tissues was predictive of improved clinical responses and prolonged survival following treatment with immune checkpoint inhibitors, according to findings published by Goswami et al in Science...
COVID-19 Research From the ASCO20 Virtual Scientific Program
With this week bringing record highs of COVID-19 infection across the nation, on The ASCO Post Podcast, we’re revisiting two presentations from the ASCO20 Virtual Scientific Program on the effect of the virus on patients with cancer.
Variant in Gene May Increase Cancer Risk in Those With Common TP53 R337H Mutations
Scientists studying a common TP53 R337H variant found among people of Brazilian descent discovered that a variant in the tumor-suppressor gene XAF1 increases cancer risk when combined with the inherited TP53 R337H mutation. These findings were published by Pinto et al in Science Advances. “We...
Sedentary Behavior and Risk of Cancer Mortality
In a study that investigated objective measures of sedentary behavior and cancer mortality, researchers found that greater inactivity was independently associated with a higher risk of dying from cancer. An accelerometer was used to measure physical activity, rather than relying on participants to...
Conquer Cancer Honors Early-Career Medical Professionals From Around the World
Conquer Cancer®, the ASCO Foundation honored recipients of the 2020 Medical Student Rotation for Underrepresented Populations (MSR), Resident Travel Awards for Underrepresented Populations (RTA), Long-Term International Fellowship (LIFe), and International Development and Education Awards (IDEA)...
Association of American Cancer Institutes Issues Statement About Racial Discrimination
In further statements from professional oncology organizations about inequities and disparities among racial and ethnic minorities and underserved populations, as well as racism and discrimination, the Association of American Cancer Institutes (AACI) issued the following statement: The AACI...
I’m Not Too Young for Colorectal Cancer
The first symptoms I had of colorectal cancer—blood in my stool and abdominal pain—coincided with surgery I had to remove my appendix in the spring of 2017. My surgeon attributed the symptoms to the appendectomy and to the medications I received both before and after the surgery. In addition to...
AMA Announces New President and President-Elect
Susan R. Bailey, MD, an allergist from Fort Worth, recently took office as the 175th President of the American Medical Association (AMA), the nation’s premier physician organization. Dr. Bailey is the third consecutive woman to hold the office, a record for the AMA. In addition, the organization...
AMA Board of Trustees Pledges Action Against Racism and Police Brutality
At a virtual Special Meeting of the American Medical Association (AMA) House of Delegates, the AMA Board of Trustees pledged action to confront systemic racism and police brutality. The AMA released the following statement that was approved at its meeting on June 5, 2020: The AMA recognizes that...
New Information From NCCN on Overcoming Challenges for People With Head and Neck Cancer
The National Comprehensive Cancer Network® (NCCN®) has now published a third book to complete the NCCN Guidelines for Patients®: Head and Neck Cancers series. Each book contains detailed, expert guidance on what to expect and management options for various cancers that impact the mouth and throat....
Initiate Conversations About Radiation Therapy for Bone Metastases
Although the American Society for Radiation Oncology (ASTRO) has recommended extended-fraction radiation therapy (more than 10 fractions) not be routinely used for palliation of bone metastases,1 a recently published retrospective cohort study using Medicare data for more than 12,000 patients found ...
Extended-Fraction Radiation Therapy for Bone Metastases Represents Low-Value Care but Continues to Be Widely Practiced
An analysis of radiation therapy patterns among more than 12,000 Medicare patients treated for bone metastases found that 23.4% received extended-fraction radiation therapy, “wasting both health-care dollars and precious patient time,” according to the investigators.1 One-third of the treating...
An Honored Poet Explores a Lust for Life on the Boundaries of Near Death
"When the technician leaves the room, I turn my head toward the screen to interpret neoplasms, the webs of nerves, the small lit fonts in which my pathology and/or future or future end might be written. The first tumor I ever saw was a darkness on that screen, round with a long craggy finger...
Advanced Practitioner Society Issues Statement Against Systemic Racism, Discrimination
In further statements from professional oncology organizations about inequities and disparities among racial and ethnic minorities and underserved populations, as well as racism and discrimination, the Advanced Practitioner Society for Hematology and Oncology (APSHO) issued the following ...
NCI Renews Comprehensive Cancer Center Designation for Norris Cotton Cancer Center
The National Cancer Institute (NCI) has renewed its Cancer Center Support Grant to Dartmouth and Dartmouth-Hitchcock Norris Cotton Cancer Center (NCCC). The 5-year, $15.5 million grant will provide continued support for NCCC’s clinical care and research missions. NCI recognized the cancer center...
Special Report Provides Guidance to Oncology Practices on Resuming Care During the COVID-19 Pandemic
As pandemic-related restrictions gradually begin to ease, oncology practices are trying to understand how to safely restore patient access to critical cancer care services. In response, ASCO released the ASCO Special Report: A Guide to Cancer Care Delivery During the COVID-19 Pandemic, which...
AACR Stands Against Racial Discrimination and Inequality
On June 4, 2020, the American Association for Cancer Research (AACR) released this statement: [AACR] is outraged and saddened about the pervasive racism and social injustices toward African Americans in our country and all people of color around the world. As a scientific organization focused on...
Pigeon English
The ASCO Post is pleased to reproduce installments of Art of Oncology as published previously in the Journal of Clinical Oncology. These articles focus on the experience of tolerating cancer or of caring for people diagnosed with cancer, and they include narratives, topical essays, historical...
Small Study Finds Olanzapine Reduces Nausea and Vomiting Caused by Advanced Cancer
The antipsychotic agent olanzapine may be helpful in reducing nausea and vomiting caused by advanced cancer, according to results of a study by Loprinzi et al published recently in JAMA Oncology. “There was a dramatic reduction [in nausea and vomiting] within 24 hours in the people who received...
Penn Medicine Announces Appointment of Daniel Yoshor, MD, as Chair, Department of Neurosurgery
Neurosurgeon and neuroscientist Daniel Yoshor, MD, has been named Chair of the Department of Neurosurgery in the Perelman School of Medicine at the University of Pennsylvania and Vice President of Clinical Integration and Innovation for the University of Pennsylvania Health System in Philadelphia. ...
American Urological Association Recognizes Roswell Park Surgeon Eric Kauffman, MD
Eric Kauffman, MD, was recently recognized by the American Urological Association for his novel approach to prostate cancer surgery, receiving a Best Video award for 2020. Dr. -Kauffman is a surgeon in the Department of Urology at Roswell Park Comprehensive Cancer Center, Buffalo. His video...
The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues
Question 1 Which of the following statements about mixed-cellularity classic Hodgkin lymphoma is correct? A. It has a female predominance. B. This type of classic Hodgkin lymphoma is relatively more common in developing nations and is frequently associated with Epstein-Barr virus (EBV) positivity....
The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues
The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that occasionally quizzes readers on issues in hematology. In this first-part of a two-part installment, Drs. Abutalib and Medeiros highlight the histologically rare lymphocyte-rich type of classic Hodgkin lymphoma,...
Seattle Cancer Care Alliance Opens New Clinic Dedicated to Gastrointestinal Cancer Care
Seattle Cancer Care Alliance (SCCA) announced the opening of a Gastrointestinal (GI) Care Neighborhood, a new cancer clinic aimed at improving the experience for patients with GI cancers, which features dedicated GI-related cancer care services on one floor of SCCA’s South Lake Union campus. “We...
Study Confirms Effective, Less-Toxic Alternative to Standard Treatment of Adults With Burkitt Lymphoma
In a recent study reported in the Journal of Clinical Oncology,1 an alternative treatment regimen that is less toxic than standard dose-intensive chemotherapy was found to be highly effective for adults with Burkitt lymphoma across all age groups and independent of HIV status. In addition to being...
Woman With an Ovarian Tumor
The text and photograph here are excerpted from a four-volume series of books titled Oncology: Tumors & Treatment, A Photographic History, The Anesthesia Era: 1845–1875 by Stanley B. Burns, MD, FACS, and Elizabeth A. Burns. The photograph appears courtesy of Stanley B. Burns, MD, and The Burns...
Study Identifies Potential Approach to Treat Severe Respiratory Distress in Patients With COVID-19
Early data from a clinical study published in Science Immunology1 suggest that blocking the Bruton’s tyrosine kinase (BTK) protein provided clinical benefit to a small group of patients with severe COVID-19 infection.1 Roschewski et al observed that the off-label use of the BTK inhibitor...
Survey Shows Young-Onset Colorectal Cancer May Be Overlooked in Exam Rooms
The Colorectal Cancer Alliance recently released findings from its latest survey of patients with young-onset colorectal cancer and survivors. The Never Too Young Survey shares the self-reported medical, psychosocial, and quality-of-life experiences of this often-overlooked population to better...
American Association for Cancer Research Announces Distinguished Public Service Award Recipients
The American Association for Cancer Research (AACR) recently announced the presentation of Distinguished Public Service Awards to four individuals whose work has exemplified the AACR’s mission to prevent and cure all cancers through research, education, communication, collaboration, science policy, ...
MSK–Hackensack Meridian Health Partnership Collaborate on Immunology Research Projects
Memorial Sloan Kettering Cancer Center (MSK) and Hackensack Meridian Health recently announced they have formed an Immunology Research Collaboration. Through this joint initiative, researchers can apply for funding to support innovative investigations exploring the power of the immune system and...
Jackson Laboratory Cancer Center Receives Continued Recognition, Funding by NCI
The Jackson Laboratory (JAX), a basic science research center with locations throughout the state of Maine, recently announced the National Cancer Center has renewed its Cancer Center Support Grant for the 34th year. The Jackson Laboratory is one of seven basic research centers with this...
Fox Chase–Temple University Hospital Announces Bone Marrow Transplant Program
The Fox Chase–Temple University Hospital Bone Marrow Transplant (BMT) Program recently announced it will introduce a Department of Bone Marrow Transplant and Cellular Therapies on July 1, 2020. Henry Chi Hang Fung, MD, FACP, FRCPE, Current Director of the Bone Marrow Transplant Program and Vice...
Cancer Researcher Grzegorz Ira, PhD, Honored With Baylor’s DeBakey Award
Select Baylor College of Medicine faculty are honored annually through the Michael E. DeBakey, MD, Award for Excellence in Research for outstanding published scientific contributions to clinical and basic science research over a 3-year period. Included among the honorees for this year’s DeBakey...
AACR Inaugurates New Leadership
The American Association for Cancer Research (AACR) welcomes Antoni Ribas, MD, PhD, FAACR, as President of the organization for 2020–2021. He was inaugurated during the AACR Annual Business Meeting, held virtually on April 29, 2020. Dr. Ribas is Professor of Medicine at the David Geffen School of...
Determining the Best Place to Die for Patients With Cancer
Studies have shown a disconnect between where patients say they want to die and where they actually die. According to research from Stanford School of Medicine, although an overwhelming majority of Americans—about 80%—would prefer to die at home, just 20% do. In fact, 60% die in acute care...
Ganesh Rao, MD, Named Chair of Neurosurgery at Baylor College of Medicine
Baylor College of Medicine recently announced that Ganesh Rao, MD, has been named the new Chair of the Department of Neurosurgery. In this role, he also will hold the Marc J. Shapiro Endowed Chair at Baylor and will serve as the Neurosurgery Service Line Chief across the Catholic Health...
Blood Test Improves Screening for Hepatocellular Carcinoma
Researchers at the National Institutes of Health have developed a new test that may help identify individuals who may be likely to develop hepatocellular carcinoma. A study of the new approach was led by researchers at the National Cancer Institute (NCI). The findings were published in the journal...
Global Study Indicates Oncology Pharmacists Face Restricted Access to Essential PPE
Oncology pharmacy practitioners around the world are fighting to provide patients who have cancer with high-quality care despite increasingly limited and sometimes restricted personal protective equipment (PPE) as well as impaired access to essential anticancer medication, according to study...
ASCO Survey on Early Impact of COVID-19 on Performance of Oncology Clinical Trials
In an article published in JCO Oncology Practice, David Waterhouse, MD, MPH, of Oncology Hematology Care, Cincinnati, Ohio, and colleagues presented the results of a recent ASCO survey of clinical programs on the early impact of the COVID-19 pandemic on the performance of oncology clinical...
First-Line Atezolizumab Plus Platinum-Based Chemotherapy vs Chemotherapy Alone in Advanced Urothelial Cancer
As reported in The Lancet by Matthew D. Galsky, MD, of Icahn School of Medicine at Mount Sinai, Tisch Cancer Institute, New York, and colleagues, the phase III IMvigor130 trial has shown prolonged progression-free survival with first-line atezolizumab plus platinum-based chemotherapy vs...
Northwell Health Cancer Institute of New York Appoints Oncology Experts to Lead New Programs
The Northwell Health Cancer Institute of Northwell Health in New Hyde Park, New York, has recruited four experts to strengthen its cancer care management, survivorship programs, oncology nursing, cancer research, and oncology surgery at locations throughout Long Island and Westchester county:...
ASCO20 Virtual Scientific Program Convened Record Number of Oncology Professionals From Across the Globe
ASCO announced record-breaking attendance at its 3-day ASCO20 Virtual Scientific Program, held online from May 29 through May 31. More than 42,700 attendees from 138 countries have participated thus far, learning virtually about new clinical cancer advances in every area of cancer research....
Repeat Breast Preservation: First Consideration in a Second Ipsilateral Breast Tumor Event
Worldwide, nearly 1.7 million women will be diagnosed with breast cancer. Of that number, nearly 300,000 Americans and more than 500,000 Europeans will be diagnosed with both invasive and in situ breast cancers.1,2 Breast-preserving surgery will initially be performed on approximately 60% of...
FDA Approves Pembrolizumab for Recurrent or Metastatic Cutaneous Squamous Cell Carcinoma
On June 24, the U.S. Food and Drug Administration (FDA) approved pembrolizumab (Keytruda) for patients with recurrent or metastatic cutaneous squamous cell carcinoma that is not curable with surgery or radiation. KEYNOTE-629 Efficacy was investigated in KEYNOTE-629, a multicenter, multicohort,...
International Consortium Aims to Enhance Decision-Making in Hodgkin Lymphoma
Harmonization of big data in examining acute and long-term outcomes with contemporary treatment for pediatric and adult patients with Hodgkin lymphoma is yielding a new approach to inform future clinical trial design and enhance clinical decision-making, according to a statement by Rutgers Cancer...
Highlights From Complementary and Integrative Medicine Research and Implications for Clinical Practice
Due to COVID-19, this year’s ASCO Annual Meeting was convened using a virtual format. It was multidisciplinary, featuring more than 250 oral and 2,500 poster presentations from around the world in 24 disease-based and specialty tracks. Among the exciting talks in the session on symptoms and...
Underrepresentation of Black Patients in Cancer Clinical Trials: Public vs Pharmaceutical Sponsorship
Black patients are better represented in taxpayer-funded cancer clinical trials compared to trials run by pharmaceutical companies, although they remain underrepresented in clinical trials, regardless of sponsor. These results were published by Joseph M. Unger, PhD, and colleagues in JNCI Cancer...
