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Showing 5051 - 5100The Worst Part of Having Cancer Was the Guilt
When I was diagnosed with small cell lung cancer in 1992, at age 38, I remember thinking, “I wish I had breast cancer.” Breast cancer elicits such sympathy from people. A diagnosis of small cell lung cancer mainly gets you stern looks of disapproval and disappointment. There is so much stigma...
Cancer Researcher and Drug Developer, Joseph R. Bertino, MD, Dies at 91
Over the arc of his notable career, Joseph R. Bertino, MD, garnered many honors for his scientific contributions leading to curative treatments for leukemia and lymphoma, such as ASCO’s David A. Karnofsky Award. Yet his legacy was perhaps most prominently punctuated by the multitude of patients...
ASTRO Honors 2021 Gold Medalists and Others
The American Society for Radiation Oncology (ASTRO) recognized the recipients of its 2021 Gold Medal awards and other honors at the 63rd ASTRO Annual Meeting, held October 24 to 27 in Chicago. ASTRO Gold Medal Colleen A.F. Lawton, MD, FASTRO, and Lori J. Pierce, MD, FASTRO, FASCO, received the Gold ...
AML Pioneer and ‘Gentle Soul,’ Elihu H. Estey, MD, Dies at 75
“A lot of times, younger bright physicians are afraid to say what they really think, out of fear of challenging the dogma. One of the things I do when mentoring is to ask why we are doing a particular therapy or intervention. I tell my mentees not to let the data interfere with your knowledge,”...
Early Experiences in the United States Helped Shape an International Oncology Career for Aleix Prat, MD, PhD
In this installment of the Living a Full Life series, guest editor Jame Abraham, MD, spoke with Aleix Prat, MD, PhD, Head of the Medical Oncology Department, Hospital Clinic of Barcelona. Dr. Prat, a breast cancer researcher, is currently working to identify strategies to tailor treatment for...
CDK4/6 Inhibitors Combined With Fulvestrant for Hormone Receptor–Positive, HER2-Negative Advanced Breast Cancer: FDA Analysis of Overall Survival
In an exploratory U.S. Food and Drug Administration (FDA) pooled analysis reported in The Lancet Oncology, Jennifer J. Gao, MD, and colleagues found that the addition of CDK4/6 inhibitor treatment to fulvestrant resulted in a consistent overall survival benefit vs placebo plus fulvestrant in...
Hossein Borghaei, DO, MS, Honored With Lung Cancer Heroes Award
Hossein Borghaei, DO, MS, Chief of the Division of Thoracic Medical Oncology at Fox Chase Cancer Center, has been named one of three winners of the second annual Lung Cancer Heroes awards program. Dr. Borghaei, who is a co-leader of the Molecular Therapeutics Program at Fox Chase and an authority...
Study Examines Breakthrough COVID-19 Infection in Vaccinated Patients With Hematologic Cancers
People with blood cancers are at a higher risk than healthy individuals for severe infection with COVID-19; furthermore, research suggests that they do not always achieve optimal protection from vaccination. A new study published by Pagano et al in the journal Blood—the first to report on...
Fox Chase Cancer Center Welcomes Teresa Y. Lee, MD, PhD
Fox Chase Cancer Center recently announced the hiring of Teresa Y. Lee, MD, PhD, as Assistant Professor. Dr. Lee will focus on caring for patients with sarcoma and head and neck cancer. Dr. Lee began her tenure at Fox Chase following her completion of a hematology/oncology fellowship at Thomas...
Expert Point of View: Benjamin Besse, MD
Invited discussant Benjamin Besse, MD, of Gustave Roussy Cancer Center, Villejuif, France, was generally positive about the findings of Impower010 but said that longer-term follow-up of overall survival will be very important. “IMpower010 is the first adjuvant study establishing an immune...
Arginine May Enhance Effectiveness of Radiation Therapy for Brain Metastases
Treatment with arginine, an amino acid, enhanced the effectiveness of radiation therapy in patients with cancer and brain metastases in a proof-of-concept, randomized clinical trial published by Marullo et al in Science Advances. The recently published paper reported the results of administering...
Health-Related Quality of Life With Pembrolizumab vs Chemotherapy for Advanced Esophageal Cancer
In a study reported in the Journal of Clinical Oncology, Adenis et al found that health-related quality of life was maintained with both pembrolizumab and chemotherapy in the pivotal phase III KEYNOTE-181 trial, which included patients with advanced esophageal cancer who had received previous...
Fear of Side Effects and Lack of Awareness: Barriers to Greater Use of Risk-Reducing Medications for Breast Cancer
A “big problem, maybe the major one,” with risk-reducing medications for breast cancer is low uptake among women at high risk of breast cancer,” Seema A. Khan, MD, told participants at the 2021 Annual Lynn Sage Breast Cancer Symposium.1 Dr. Khan is Professor of Surgery and the Bluhm Family...
Risk-Reducing Medications for Breast Cancer Are Becoming Safer and More Tolerable
Risk-reducing medications for breast cancer may be effective for many women, and recently reported and ongoing trials have led to improvements in their tolerability and safety, Seema A. Khan, MD, reported at the 2021 Annual Lynn Sage Breast Cancer Symposium (virtual).1 Dr. Khan is Professor of...
Optimizing Adjuvant Therapy for Women With Estrogen Receptor–Positive, Node-Positive Breast Cancer
“Nodal status remains the single most important prognostic marker in outcomes for women with estrogen receptor–positive, HER2-negative breast cancer. For that reason, it makes sense to think about optimizing adjuvant therapy, including endocrine treatments, chemotherapy, and targeted therapy,”...
Racial Disparities in Use of Prostate MRI After Detection of Elevated PSA Levels
In a study published by Abashidze et al in JAMA Network Open, the investigators found that Black men were at least 23.6% less likely than White men to undergo magnetic resonance imaging (MRI) following an elevated prostate-specific antigen (PSA) test result. They also found that Hispanic and Asian...
Study Finds Lack of Health Insurance May Hinder Recommended Cancer Screening in Unemployed Adults
In a recent study published by Stacey Fedewa, PhD, and colleagues in the journal Cancer, unemployed individuals were less likely to have health insurance and be up to date on getting recommended cancer screening tests. Analyses revealed that their lack of health insurance coverage accounted for...
COVID-19 Sequelae Prevalence, Risk Factors, and Outcomes in Patients With Cancer
In a retrospective European study reported in The Lancet Oncology, David J. Pinato, PhD, and colleagues found that among patients with cancer who recovered from COVID-19 infection, a substantial proportion have sequelae that can affect survival and oncologic outcomes. Among patients on systemic...
Effect of Geriatric Assessment and Management Recommendations on Adverse Events Related to Cancer Treatment
In a U.S. cluster-randomized trial (GAP70+) reported in The Lancet, Supriya G. Mohile, MD, and colleagues found that geriatric assessment and management recommendations reduced the incidence of grade ≥ 3 toxicity vs usual care among patients aged ≥ 70 years with incurable advanced cancers who were...
Early Warning System Model May Help to Predict Deterioration of Hospitalized Patients With Cancer
About 9% of patients with cancer experience complications while hospitalized that lead to a deterioration in their condition, a transfer to the intensive care unit, or death. A multidisciplinary team of researchers at Washington University in St. Louis is developing a machine learning–based early...
Ibrutinib Plus R-CHOP for Younger Patients With DLBCL
New evidence suggests that adding the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib to a standard chemotherapy regimen may improve survival among younger people with a specific form of diffuse large B-cell lymphoma (DLBCL). The findings, published by Wyndham Wilson, MD, PhD, in Cancer Cell,...
Adjuvant Internal Mammary Node Irradiation in Node-Positive Breast Cancer
In a Korean phase III trial reported in JAMA Oncology, Kim et al found that the addition of internal mammary node irradiation to adjuvant regional nodal irradiation did not improve 7-year disease-free survival in women with node-positive breast cancer. In an ad hoc analysis, however, benefit was...
Study Finds Patients Infected With COVID-19 Who Underwent Recent Cancer Treatment Are at Higher Risk of Adverse Outcomes
In a cohort study reported in JAMA Oncology, Mariana Chavez-MacGregor, MD, MSc, and colleagues found that patients with cancer infected with COVID-19 had poorer outcomes vs patients without cancer if they had received recent cancer treatment. Patients with cancer who had not received recent...
Erin Murphy, MD, on Low-Grade Glioma: Neurocognitive Function Following Treatment
Erin Murphy, MD, of Cleveland Clinic, discusses new data that show no apparent difference in cognitive performance up to 2 years post-treatment among adults with low-grade glioma who were treated with concurrent radiotherapy and temozolomide (Abstract 3258).
Risks and Benefits Associated With Gastrostomy Tubes for Patients With Cancer
In a study published by Gauvin et al in JNCCN–Journal of the National Comprehensive Cancer Network, researchers examined over 200 patients with gastrostomy tubes and highlighted the need for a multidisciplinary approach to palliative care decision-making for patients with cancer. A gastrostomy tube ...
Studies Find B7-H3 Protein May Be a Target for Prostate Cancer Treatment
The immune checkpoint protein B7-H3 may be a potential new target in treatment-resistant prostate cancers, according to two studies presented recently at the European Society for Medical Oncology (ESMO) Congress 2021. “Virtually every prostate cancer cell expresses some degree of B7-H3, which...
ESMO Women for Oncology Studies Examine Female Leadership in Oncology Over Time
Results of the European Society for Medical Oncology’s (ESMO) Women for Oncology monitoring and authorship studies were recently published by Berghoff et al in ESMO Open. They revealed that women continue to be underrepresented in leadership positions despite making up an increasing proportion of...
Retrospective Study Examines Real-World Survival in U.S. Women Treated for Early-Stage Breast Cancer
In a retrospective cohort study reported in JCO Oncology Practice, Gidwani et al found that among U.S. patients treated for early-stage breast cancer, those who were considered to be unrepresented in clinical trials have significantly poorer survival than those categorized as well represented....
Expert Point of View: Michaela A. Dinan, PhD
The invited discussant of the study on out-of-pocket costs of cancer care, Michaela A. Dinan, PhD, Co-Leader of Cancer Prevention and Control at Yale Cancer Center and Associate Professor of Chronic Disease Epidemiology at the Yale School of Public Health, Connecticut, underscored the study’s key...
Out-of-Pocket Costs on the Rise for the Four Most Common Cancers, Study Finds
Rising cost-sharing requirements from private insurance have exacerbated the financial burden for patients with cancer, according to research presented at the 2021 ASCO Quality Care Symposium.1 Analysis of claims data on the four most prevalent cancers in the United States—female breast,...
Study Finds Type I Interferon May Enhance the Antileukemia Effect of Allogeneic Transplantation
In a study published by Magenau et al in the journal Blood Advances, researchers found that patients with high-risk acute myeloid leukemia (AML) who received a form of type I interferon after allogeneic hematopoietic stem cell transplant experienced reduced rates of disease relapse. Additionally,...
Role of Age at Smoking Start and Cessation in Risk of Overall Cancer Mortality Among Current Smokers vs Never-Smokers
In a study reported in a research letter in JAMA Oncology, Thomson et al found that current smokers had a threefold greater risk of overall cancer mortality between the ages of 25 and 79 years vs never-smokers, with risk being modulated according to age at smoking initiation and age at cessation in ...
Do Solid Organ Transplant Recipients With a Previous Cancer Diagnosis Have High Cure Probabilities?
In a study reported in the Journal of Clinical Oncology, Engels et al found that patients with a previous cancer diagnosis who underwent solid organ transplantation had high cancer cure probabilities. Additionally, posttransplantation cancer-specific survival was associated with cancer cure...
FDA Pipeline: Novel Treatments in Lymphoma, Nasopharyngeal Cancer, Solid Tumors, and More
Recently, the U.S. Food and Drug Administration (FDA) granted Priority Review to agents for several kinds of lymphoma, as well as nasopharyngeal cancer; a Breakthrough Therapy designation for a treatment for patients with NTRK-positive advanced solid tumors; and Fast Track designation for...
Karen M. Winkfield, MD, PhD, on Digital Health to Improve Patient Outcomes and Experience
Karen M. Winkfield, MD, PhD, of Vanderbilt University Medical Center, who co-chaired a session (PS 02) on digital health, summarizes the talks, which included ways to reduce disparities with digital innovations and the importance of patient input, especially in the form of patient-reported outcomes ...
Patient-Reported Outcomes in Gastrointestinal Cancers: Predicting Treatment Response and Survival Outcomes
According to data presented during the 2021 ASCO Quality Care Symposium,1 1-month changes in patient-reported outcomes may predict treatment response and survival outcomes in patients with advanced gastrointestinal cancers. The results of a prospective study of 159 patients with metastatic...
Effect of Social Determinants of Health on Receipt of Survivorship Care Plans
Survivorship care plans are an important tool to help cancer survivors transition from active treatment to follow-up care, but a study published by Timsina et al in Supportive Care in Cancer has found that a number of vulnerable groups have a lower likelihood of receiving such plans. Cancer...
Characteristics, Effects, and Outcomes of SARS–CoV-2 Infection in Pediatric Patients With Cancer
In an article published in the Journal of Clinical Oncology, Emily E. Johnston, MD, MS, and colleagues detailed characteristics, effects on cancer treatment, and outcomes of SARS–CoV-2 infection in pediatric patients with cancer based on data from The Pediatric Oncology COVID-19 Case Report...
Primary Transoral Surgery and Reduced-Dose Adjuvant Radiation Therapy for HPV-Positive Locally Advanced Oropharyngeal Cancer
As reported in the Journal of Clinical Oncology by Robert L. Ferris, MD, PhD, and colleagues, the phase II ECOG-ACRIN E3311 trial has shown high progression-free survival rates and good functional outcomes in patients with intermediate-risk human papillomavirus (HPV; p16)-positive locally advanced...
Five-Year Follow-up of Olaparib Maintenance for Newly Diagnosed Patients With Advanced BRCA-Mutant Ovarian Cancer
As reported in The Lancet Oncology by Susana Banerjee, MBBS, PhD, and colleagues, 5-year follow-up of the pivotal phase III SOLO-1/GOG 3004 trial has shown a median progression-free survival of 56 months with maintenance olaparib following response to platinum-based chemotherapy in newly diagnosed...
Study Evaluates Virtual vs In-Person Visits and Access to Lung Cancer Screening
Findings from a novel telemedicine effort to screen patients for lung cancer screening during the COVID-19 pandemic show that virtual single-visit screenings may be just as effective as single-visit screenings done in person, according to a study presented by Magarinos et al at the American College ...
Definitive Radiotherapy Without Systemic Therapy for Oligometastatic Renal Cell Carcinoma
In a single-center phase II study reported in The Lancet Oncology, Tang et al found that definitive radiotherapy in place of systemic therapy was feasible and effective for the treatment of oligometastatic renal cell carcinoma. As stated by the investigators, “The role of radiotherapy in metastatic ...
Modified FOLFIRINOX vs Cisplatin/Gemcitabine for Advanced Biliary Tract Cancer
In the phase II portion of a French phase II/III trial (PRODIGE 38 AMEBICA) reported in the Journal of Clinical Oncology, Phelip et al found that modified (m) FOLFIRINOX (oxaliplatin, irinotecan, leucovorin, and fluorouracil) did not improve 6-month progression-free survival vs the combination of...
Overall Survival With Laparoscopic vs Open Distal Gastrectomy for Locally Advanced Gastric Cancer
As reported in JAMA Surgery by Huang et al, the Chinese phase III CLASS-01 trial has shown no difference in 5-year overall survival in patients with locally advanced gastric cancer who underwent laparoscopic vs open distal gastrectomy. The previously reported primary analysis of the trial showed no ...
FDA Approves Asciminib for Philadelphia Chromosome–Positive CML
On October 29, the U.S. Food and Drug Administration (FDA) granted accelerated approval to the kinase inhibitor asciminib (Scemblix) for patients with Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) in chronic phase who have been previously treated with two or more tyrosine...
FDA Authorizes Pfizer-BioNTech COVID-19 Vaccine for Emergency Use in Children Aged 5 Through 11 Years
On October 29, the U.S. Food and Drug Administration (FDA) authorized the emergency use of the Pfizer-BioNTech COVID-19 vaccine for the prevention of COVID-19 to include children aged 5 through 11 years. The authorization was based on the FDA’s thorough and transparent evaluation of the data that...
Do Diet-Related Molecules Play a Role in the Development of Aggressive Prostate Cancer?
Cleveland Clinic researchers have shown that diet-associated molecules in the gut may be associated with aggressive prostate cancer, suggesting dietary interventions may help reduce risk. These findings were published by Reichard et al in Cancer Epidemiology, Biomarkers & Prevention. While...
Study Finds Incidence of Pancreatic Cancer May Be Rising in Younger Women
The incidence of pancreatic cancer—which historically has been higher in men than in women—has increased among both men and women during the past decade, with a significantly greater relative increase observed in women younger than age 55 years, and especially among those aged 15 to 34 years. These ...
Integrated Molecular-Morphologic Risk Predictor for Recurrence of Meningioma
In a study reported in the Journal of Clinical Oncology, Maas et al developed a novel integrated molecular-morphologic risk classification score that improved prediction of disease recurrence in patients with meningioma. Study Details The study involved DNA methylation, copy-number, and mutation...
Rates of Occult Gastric Carcinoma in Patients With Hereditary Lobular Breast Cancer Due to CDH1 Genetic Variants
In a single-institution prospective cohort study reported in JAMA Surgery, Gamble et al found that patients with hereditary lobular breast cancer due to CDH1 variants also had a high prevalence of occult signet ring cell gastric carcinoma. Study Details The study involved 283 patients from 151...
