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By Syed Ali Abutalib, MD, and L. Jeffrey Medeiros, MD  / July 25, 2020

The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues

The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that occasionally quizzes readers on issues in hematology. In this installment, Drs. Abutalib and Medeiros highlight the rare primary diffuse large B-cell lymphoma (DLBCL) of the central nervous system (CNS). For each ...

By The ASCO Post Staff  / COVID-19 and Cancer Care

Miguel-Angel Perales, MD, and Syed A. Abutalib, MD, on Bone Marrow Transplants During the COVID-19 Pandemic

Syed A. Abutalib, MD, of Cancer Treatment Centers of America, talks with Miguel-Angel Perales, MD, of Memorial Sloan Kettering Cancer Center, about the challenges and concerns related to transplants for patients with hematologic malignancies who are particularly vulnerable to infection with the...

By Syed Ali Abutalib, MD, and L. Jeffrey Medeiros, MD  / June 25, 2020

The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues

Question 1 Which of the following statements about mixed-cellularity classic Hodgkin lymphoma is correct? A. It has a female predominance. B. This type of classic Hodgkin lymphoma is relatively more common in developing nations and is frequently associated with Epstein-Barr virus (EBV) positivity....

By Syed Ali Abutalib, MD, and L. Jeffrey Medeiros, MD  / June 25, 2020

The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues

The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that occasionally quizzes readers on issues in hematology. In this first-part of a two-part installment, Drs. Abutalib and Medeiros highlight the histologically rare lymphocyte-rich type of classic Hodgkin lymphoma,...

By Syed Ali Abutalib, MD and Saad Z. Usmani, MD, FACP  / June 10, 2020

Cancer and COVID-19: Considerations About Neutropenia, Anemia, and Thrombocytopenia

GUEST EDITORS Dr. Abutalib is Associate Director of the Hematology and Cellular Therapy Program and Director of the Clinical Apheresis Program at Cancer Treatment Centers of America, Zion, Illinois; Associate Professor at the Roseland Franklin University of Medicine and Science; and Founder and...

Coagulation Issues in Patients With COVID-19: Part 2

In part 2 of our conversation with Dr. Syed Abutalib, Associate Director of the Hematology and Cellular Therapy Program and Director of the Clinical Apheresis Program at Cancer Treatment Centers of America, Zion, Illinois; Associate Professor at the Roseland Franklin University of Medicine and...

By Alice Goodman  / May 25, 2020

Treating Patients With Leukemia During the COVID-19 Era at MD Anderson Cancer Center

As part of a series of interviews with cancer experts during the COVID-19 pandemic, The ASCO Post spoke with Hagop Kantarjian, MD, Professor and Chair of the Department of Leukemia at The University of Texas MD Anderson Cancer Center, Houston, about the impact of the pandemic on treatment of...

Coagulation Issues in Patients With COVID-19: Part 1

This week, we spoke with Dr. Syed Abutalib, Associate Director of the Hematology and Cellular Therapy Program and Director of the Clinical Apheresis Program at Cancer Treatment Centers of America, Zion, Illinois; Associate Professor at the Roseland Franklin University of Medicine and Science; and...

By Syed Ali Abutalib, MD, and Jean M. Connors, MD  / May 25, 2020

Hypercoagulability in Critically Ill Patients With COVID-19: Where Do We Stand?

“Life is short, art long, opportunity fleeting, experience treacherous, judgment difficult.” ―Hippocrates The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that occasionally quizzes readers on issues in hematology. In this installment, Drs. Abutalib and Connors...

By Syed Ali Abutalib, MD, AND Sonali M. Smith, MD, FASCO  / April 25, 2020  / 2019 ASH Annual Meeting & Exposition

Selected ASH Abstracts on Novel Treatments for Non-Hodgkin Lymphomas

To complement The ASCO Post’s continued comprehensive coverage of the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on novel therapies for patients with non-Hodgkin lymphomas (NHLs). For full...

By Syed Ali Abutalib, MD, and Parameswaran Hari, MD  / April 10, 2020

Highlights From Transplantation and Cellular Therapy Meetings of ASTCT and CIBMTR

The Combined Annual Meetings of the American Society for Transplantation and Cellular Therapy (ASTCT) and the Center for International Blood & Marrow Transplant Research (CIBMTR) were held in Orlando, Florida, from February 19–23, 2020. The scientific program addressed the most timely issues in ...

By Syed Ali Abutalib, MD, and John M. Pagel, MD, PhD  / March 25, 2020  / 2019 ASH Annual Meeting & Exposition

Selected ASH Abstracts on Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

ABSTRACT 355: MURANO study: Four-year analysis confirms sustained benefit (compared to bendamustine and rituximab; n = 195) of time-limited venetoclax/rituximab (n = 194) in relapsed or refractory chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL; ClinicalTrials.gov NCT02005471)1...

By Syed Ali Abutalib, MD, and John M. Pagel, MD, PhD  / March 25, 2020  / 2019 ASH Annual Meeting & Exposition

Selected ASH Abstracts on Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma

To complement The ASCO Post’s continued comprehensive coverage of the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on novel therapies for newly diagnosed chronic lymphocytic leukemia (CLL) and...

By Alice Goodman  / March 25, 2020

HAPLO2019: Advances in Haploidentical Transplantation and Other Novel Cellular Therapies

Now in its seventh year, the Haploidentical Transplant Symposium (HAPLO) continues to explore advances in haploidentical and other novel cellular therapies. The most recent of these meetings—HAPLO2019—met in Orlando, Florida, 2 days before the start of the 2019 American Society of Hematology (ASH)...

By Syed Ali Abutalib, MD, and Daniel J. DeAngelo, MD, PhD  / March 10, 2020  / 2019 ASH Annual Meeting & Exposition

Selected ASH Abstracts on Novel Treatments in Acute Lymphoblastic Leukemia

To complement The ASCO Post’s continued comprehensive coverage of the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on novel therapies for newly diagnosed and relapsed or refractory acute...

By Syed Ali Abutalib, MD, and Navneet Majhail, MD, MS  / February 25, 2020  / 2019 ASH Annual Meeting & Exposition

Updates in Hematopoietic Cell Transplantation

To complement The ASCO Post’s continued comprehensive coverage of the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic and autologous hematopoietic cell transplantation. For full...

By SYED ALI ABUTALIB, MD, AND SATTVA S. NEELAPU, MD  / February 10, 2020

CAR T-Cell Gene Therapy in Non-Hodgkin Lymphomas: Present and Future

To complement The ASCO Post’s continued comprehensive coverage of the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on novel immunotherapies for patients with different types of non-Hodgkin...

By SYED ALI ABUTALIB, MD, and ALAN F. LIST, MD  / February 10, 2020

Selected ASH Abstracts on Myelodysplastic Syndromes

To complement The ASCO Post’s continued comprehensive coverage of the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on novel therapies for myelodysplastic syndromes (MDS), including the...

By Syed Ali Abutalib, MD  / January 25, 2020  / 2019 ASH Annual Meeting & Exposition

Selected Abstracts on Novel Therapies for Chronic Myeloid Leukemia

To complement The ASCO Post’s comprehensive coverage of the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on novel therapeutic regimens for chronic myeloid leukemia (CML). For full details of...

By Syed Ali Abutalib, MD, and Ola Landgren, MD, PhD  / January 25, 2020  / 2019 ASH Annual Meeting & Exposition

Selected Abstracts on New Therapies for Newly Diagnosed Multiple Myeloma

To complement The ASCO Post’s comprehensive coverage of the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on novel therapeutic regimens including the monoclonal antibody daratumumab in combination ...

By Syed A. Abutalib, MD, and Margaret Kasner, MD, MSCE  / December 25, 2019  / 2019 ASH Annual Meeting & Exposition

Selected Abstracts From the 2019 ASH Annual Meeting & Exposition

To complement The ASCO Post’s comprehensive coverage of the 2019 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on novel therapeutic regimens for acute myeloid leukemia (AML). For full details of these...

By Syed A. Abutalib, MD, and L. Jeffrey Medeiros, MD  / December 25, 2019

The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues

The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that quizzes readers on issues in hematology. In this installment, Syed Ali Abutalib, MD, and L. Jeffrey Medeiros, MD, explore the updated World Health Organization (WHO) classification of hematopoietic and lymphoid ...

By Syed Ali Abutalib, MD, and L. Jeffrey Medeiros, MD  / November 25, 2019

Answers to Hematology Expert Review Questions

Question 1 Which of the following statements about nodular lymphocyte-predominant HL is correct? Correct answer: A. Nodular lymphocyte-predominant HL can transform into large B-cell lymphoma. Expert Perspective Nodular lymphocyte-predominant HL is a B-cell neoplasm characterized by a nodular or...

By Syed Ali Abutalib, MD, and L. Jeffrey Medeiros, MD  / November 25, 2019

The World Health Organization Classification of Tumors of Hematopoietic and Lymphoid Tissues

The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that quizzes readers on issues in hematology. In this installment, Drs. Abutalib and Medeiros explore the updated World Health Organization (WHO) classification of nodular lymphocyte-predominant Hodgkin lymphoma. For...

By Syed Ali Abutalib, MD; Hamza Hashmi, MD; and David L. Porter, MD  / November 25, 2019

Answers to Hematology Expert Review Questions

Question 1 Which of the following statements about cytokine-release syndrome and neurotoxicity after tisagenlecleucel infusion is correct? Correct answer: B. The median time to onset of cytokine-release syndrome is 3 days. Expert Perspective Following tisagenlecleucel infusion, cytokine-release...

By Syed Ali Abutalib, MD; Hamza Hashmi, MD; and David L. Porter, MD  / November 25, 2019

CAR T-Cell Gene Therapy: Toxicities and Management Principles

“Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.”                                                                                                                  —Marie Curie The ASCO Post is pleased to present Hematology ...

By Syed A. Abutalib, MD, and Uroosa Ibrahim, MD  / October 10, 2019

Gene Therapy: A March Forward!

GUEST EDITORS Dr. Abutalib is Associate Director, Hematology and Cellular Therapy Program and Director, Clinical Apheresis Program Cancer Treatment at Centers of America, Zion, Illinois; Associate Professor, Rosalind Franklin University of Medicine and Science; and Founder and Co-Editor of...

By Syed Ali Abutalib, MD, and Sonali M. Smith, MD, FASCO  / September 25, 2019  / 2019 ASCO Annual Meeting

Update on Treatments Under Study for Chronic Lymphocytic Leukemia

The ASCO Post has offered comprehensive coverage of the 2019 ASCO Annual Meeting. To complement this news coverage, here are featured clinical trials of several treatments in chronic lymphocytic leukemia (CLL). They focus on the monoclonal antibody obinutuzumab in combination therapy in the CLL14...

By Syed Ali Abutalib, MD, and David L. Porter, MD  / September 10, 2019

Update on FDA-Approved CAR T-Cell Gene Therapy for B-Cell Lymphomas

On October 18, 2017, the U.S. Food and Drug Administration (FDA) granted approval to axicabtagene ciloleucel for the treatment of adult patients with relapsed or refractory large B-cell lymphoma. Specifically, this treatment can be used after two or more lines of systemic therapy for diffuse...

By Syed Ali Abutalib, MD, and Sonali M. Smith, MD, FASCO  / August 10, 2019  / 2019 ASCO Annual Meeting

Treatment Update on Selected Non-Hodgkin Lymphomas

As part of The ASCO Post’s coverage of the 2019 ASCO Annual Meeting, featured here are four abstracts from different clinical trials evaluating newer treatments for Waldenström’s macroglobulinemia and T-cell lymphomas. Waldenström’s Macroglobulinemia ABSTRACT 7509: Outcomes with bendamustine plus ...

By Syed Ali Abutalib, MD, and Sonali M. Smith, MD, FASCO  / July 25, 2019  / 2019 ASCO Annual Meeting

Update on Newer Treatments in Non-Hodgkin Lymphomas

As part of The ASCO Post’s coverage of the 2019 ASCO Annual Meeting, featured here are summaries of five abstracts of different clinical trials evaluating newer treatments for follicular and marginal zone lymphomas as well as diffuse large B-cell lymphoma. Follicular and Marginal Zone Lymphomas...

By Syed Ali Abutalib, MD, and Ola Landgren, MD, PhD  / June 10, 2019  / 2019 ASCO Annual Meeting

Selected Abstracts From the 2019 ASCO Annual Meeting

To complement The ASCO Post’s comprehensive coverage of the 2019 ASCO Annual Meeting, here are several abstracts selected from the meeting proceedings focusing on novel therapeutic regimens for plasma cell dyscrasias, particularly multiple myeloma. For full details of these study abstracts, visit ...

By Syed A. Abutalib, MD, and L. Jeffrey Medeiros, MD  / May 10, 2019

The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues

GUEST EDITORS Dr. Abutalib is Assistant Director, Hematology and Hematopoietic Cell Transplantation Director, Hematopoietic Cell Transplant Apheresis Service, Cancer Treatment Centers of America, Zion, Illinois, Editor-in-Chief, Advances in Cell & Gene Therapy. Dr. Medeiros is Professor and...

By Syed Ali Abutalib, MD, and Navneet Majhail, MD, MS  / April 10, 2019  / 2018 ASH Annual Meeting & Exposition

Allogeneic Hematopoietic Cell Transplantation and Cell Therapy

As part of The ASCO Post’s continued coverage of the 2018 American Society of Hematology (ASH) Annual Meeting & Exposition, here is an update on several studies of allogeneic hematopoietic cell transplantation (allo-HCT) and cellular therapy, as used in myelodysplastic syndromes (MDS), acute...

By Syed Ali Abutalib, MD, and Matthew Lunning, DO  / March 10, 2019  / 2018 ASH Annual Meeting & Exposition

Update on Newer Treatments in Non-Hodgkin Lymphomas

AS PART of The ASCO Post’s continued coverage of the 2018 American Society of Hematology (ASH) Annual Meeting & Exposition, here is an update on several different studies on new therapeutics in non-Hodgkin lymphomas (NHLs), including follicular lymphoma, diffuse large B-cell lymphoma (DLBCL), ...

By Alice Goodman  / March 10, 2019

Advances in Haploidentical Transplantation and Cellular Therapies

With advances in the field, the number of haploidentical stem cell transplants being performed (ie, using human leukocyte antigen [HLA] half-matched donor stem cells) has been increasing. In recognition of evolving strategies to improve outcomes, a group of transplant physicians started the...

By Syed Ali Abutalib, MD, and Bruce L. Levine, PhD  / February 25, 2019

Update on FDA-Approved CAR T-Cell Products

AXICABTAGENE CILOLEUCEL (also known as CAR19) is an anti-CD19 chimeric antigen receptor (CAR) T-cell product approved by U.S. Food and Drug Administration to treat selected hematologic malignancies.1 To appreciate the clinical trial findings summarized here, from selected abstracts presented at the ...

By Syed Ali Abutalib, MD, and Bruce L. Levine, PhD  / February 25, 2019

Update on FDA-Approved CAR T-Cell Products

TISAGENLECLEUCEL IS an anti-CD19 chimeric antigen receptor (CAR) T-cell product approved by U.S. Food and Drug Administration to treat selected hematologic malignancies.1,2 To appreciate the clinical trial findings summarized here, from selected abstracts presented at the 2018 American Society of...

By Syed Ali Abutalib, MD, and Alan F. List, MD  / February 10, 2019  / 2018 ASH Annual Meeting & Exposition

Novel Treatments of Myelodysplastic Syndromes

AS PART of The ASCO Post’s continued coverage of the 2018 American Society of Hematology (ASH) Annual Meeting & Exposition, here is an update on seven different studies on new therapeutics in myelodysplastic syndromes (MDS). Among the treatments highlighted here are the erythroid maturation...

By Syed Ali Abutalib, MD, and Kenneth C. Anderson, MD  / January 25, 2019  / 2018 ASH Annual Meeting & Exposition

Novel Therapeutics for Relapsed or Refractory Multiple Myeloma, Part 2

Here is an update on several different studies focusing on novel treatments for patients with relapsed or refractory multiple myeloma presented at the 2018 American Society of Hematology (ASH) Annual Meeting & Exposition. The featured therapeutics include the oral agent selinexor in...

By Syed Ali Abutalib, MD, and Kenneth C. Anderson, MD  / January 25, 2019  / 2018 ASH Annual Meeting & Exposition

Novel Treatments in Newly Diagnosed Multiple Myeloma, Part 1

Here is an update on several different studies focusing on novel treatments for patients with newly diagnosed multiple myeloma presented at the 2018 American Society of Hematology (ASH) Annual Meeting & Exposition. Featured therapeutics include daratumumab plus lenalidomide and dexamethasone, ...

By Alexander B. Pine, MD, PhD, and Alfred I. Lee, MD, PhD  / December 25, 2018

Clinician Survey to Explore Direct-Acting Oral Anticoagulants vs Low–Molecular-Weight Heparin in Cancer-Related VTE

Injectable low–molecular-weight heparin has long been considered the standard of care for treatment of venous thromboembolism (VTE) in patients with cancer. However, low–molecular-weight heparin is costly and often disliked by patients due to injection-related discomfort and bruising....

By Syed Ali Abutalib, MD, and Ruben A. Mesa, MD, FACP  / December 25, 2018  / 2018 ASH Annual Meeting & Exposition

Study Findings on Myeloproliferative Neoplasms Including Systemic Mastocytosis

HERE IS AN UPDATE on six different studies featured at the 2018 American Society of Hematology (ASH) Annual Meeting & Exposition. Topics focused on novel treatments for myelofibrosis, polycythemia vera and essential thrombocythemia, as well as systemic mastocytosis. Myelofibrosis ABSTRACT...

By Syed A. Abutalib, MD, and L. Jeffrey Medeiros, MD  / November 10, 2018

The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues

The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that quizzes readers on issues in hematology. In this installment, Drs. Abutalib and Medeiros explore the recently updated World Health Organization (WHO) classification of hematopoietic and lymphoid tissue...

By The ASCO Post Staff  / July 25, 2018

New International Journal Advances in Cell & Gene Therapy Now Available, Names Editors-in-Chief, Deputy Editors

A NEW INTERNATIONAL JOURNAL, Advances in Cell & Gene Therapy, recently published its inaugural issue in May 2018. The new publication aims to provide a forum for authors to share their newest results, views, and visions in the field of cell and gene therapy. The journal will be published on a...

By Syed A. Abutalib, MD, and L. Jeffrey Medeiros, MD  / July 25, 2018

The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues

The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that quizzes readers on issues in hematology. In this installment, Drs. Abutalib and Medeiros explore the recently updated World Health Organization (WHO) classification of hematopoietic and lymphoid tissue...

By Syed A. Abutalib, MD, and Ola Landgren, MD, PhD  / April 25, 2018

Updated International Myeloma Working Group Criteria: Diagnostic Challenges

The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that quizzes readers on issues in hematology. In this installment, Drs. Abutalib and Landgren review the underlying data that shaped the updated International Myeloma Working Group (IMWG) diagnostic criteria for...

By Syed A. Abutalib, MD, and L. Jeffrey Medeiros, MD  / March 10, 2018

Answers to Hematology Expert Review Questions

GUEST EDITORS: Dr. Abutalib is Assistant Director, Hematology and Hematopoietic Cell Transplantation Director, Hematopoietic Cell Transplant Apheresis Service, Cancer Treatment Centers of America, Zion, Illinois, Editor-in-Chief, Advances in Cell & Gene Therapy. Dr. Medeiros is Professor and...

By Syed A. Abutalib, MD, and L. Jeffrey Medeiros, MD  / March 10, 2018

The WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues

The ASCO Post is pleased to present Hematology Expert Review, an ongoing feature that quizzes readers on issues in hematology. In this installment, Drs. Abutalib and Medeiros explore the recently updated World Health Organization (WHO) classification of hematopoietic and lymphoid tissue...

By The ASCO Post Staff  / February 25, 2018

New Edition of Hematology: Basic Principles and Practice Now Available

THE 7th AND LATEST EDITION of Hematology: Basic Principles and Practice has been published by Elsevier. This authoritative reference in the field of hematology delivers expert scientific content and clinical guidance to enhance problem-solving skills and make optimal use of the newest diagnostic...