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Roswell Park Researchers Awarded Nearly $5 Million to Support Research Projects

Several faculty members at Roswell Park Cancer Institute have been awarded nearly $5 million in grant funding from public and private organizations to further their efforts to find new and better ways to detect and treat cancer and improve patients’ quality of life. The 13 awards, including two for ...

2014 Oncology Meetings

OCTOBER 18th SIS World Congress on Breast HealthcareOctober 16-19 • Orlando, Florida For more information: www2.kenes.com/sis/Pages/Home.aspx 2014 Quality Care SymposiumOctober 17-18 • Boston, MassachusettsFor more information: quality.asco.org Atlanta Lung Cancer SymposiumOctober 18 • Atlanta,...

The Audacity of Courage

We have toolsWe have ghoulsBut nowhere are there more foolsThan in the rulesfrom those who govern the tools!        In the bias       That climbs on the shoulders       To bring plausibility       Through implied causality,Where is ignorance?Where is reality?Where are all the tools of Reason?       ...

integrative oncology

Integrative Oncology: Mind, Body, and More

Bookmark Title: Integrative Oncology (Second Edition)Editors: Donald I. Abrams, MD, and Andrew T. Weil, MDPublisher: Oxford University PressPublication date: September 3, 2014Price: $65.00; Paperback, 848 pages   In 1990, David Eisenberg, MD, from the Harvard School of Public Health, conducted a...

survivorship

New Books by Authors at Memorial Sloan Kettering Cancer Center Address Aging, Survivorship

Bookmark Title: Survivorship: Living Well During and After CancerAuthor: Barrie Cassileth, PhDFormat: PaperbackISBN: 978-1-938170-35-5Pages: 216Publication Date: April 1, 2014Dimensions: 5.5 × 8.5Also Available: eBook   Bookmark Title: Lighter as We Go: Virtues, Character Strengths, and...

integrative oncology

Milk Thistle

The use of dietary supplements by patients with cancer has increased significantly over the past 2 decades despite insufficient evidence of safety and effectiveness. Finding reliable sources of information about dietary supplements can be daunting. Patients typically rely on family, friends, and...

Ketan K. Badani, MD, Additional Staff, Appointed to Mount Sinai Health System

Ketan K. Badani, MD, Professor of Urology, Icahn School of Medicine at Mount Sinai in New York, has been named Vice Chairman of Urology and Robotic Operations and Director of the Comprehensive Kidney Cancer Program for the Mount Sinai Health System. Dr. Badani will also serve as Director of Robotic ...

colorectal cancer
lung cancer
gastroesophageal cancer

Researchers at Roswell Park Receive Grants to Study New Anticancer Agent in Lung, Colorectal, and Gastrointestinal Cancers

Researchers at Roswell Park Cancer Institute have been awarded three of four grants by the National Comprehensive Cancer Network (NCCN) Oncology Research Program to evaluate and define the clinical effectiveness of the investigational compound nintedanib. Nintedanib is an investigational...

breast cancer

Clinical Trials Actively Recruiting Patients With Breast Cancer

The information contained in this Clinical Trials Resource Guide includes actively recruiting clinical studies for people with breast cancer. The studies include phase I and II, interventional, and observational trials evaluating new therapies; diagnostic tools; genetic counseling; the association ...

lung cancer

James Herman, MD, Named Co-Leader of UPCI Lung Cancer Program

A leader in the field of epigenetics whose work has led to important discoveries into how cancer develops and progresses has been named the co-leader of the Lung Cancer Program at the University of Pittsburgh Cancer Institute (UPCI), partner with UPMC CancerCenter. James Herman, MD, comes to...

prostate cancer

Primary Androgen Deprivation Does Not Improve Long-Term Survival in Older Patients With Localized Prostate Cancer

Primary androgen-deprivation therapy has been widely used in localized prostate cancer, despite the absence of definitive evidence of benefit in early-stage disease. In a large population-based cohort study reported in JAMA Internal Medicine, Grace L. Lu-Yao, MPH, PhD, of Rutgers Cancer Institute...

gynecologic cancers

Genetic ‘Hotspot’ Linked to Endometrial Cancer Aggressiveness

Parents of twins often tell them apart through subtle differences such as facial expression, moles, voice tone, and gait. Similarly, physicians treating women with endometrial cancer must be able to distinguish between different versions of this disease form that, on the surface, appear the same....

solid tumors

Sluys-Kessler Radium Apparatus, Paris, 1930

Devices to accurately deliver high-dose radium therapy became extremely sophisticated during the late 1920s. In this photograph, the patient is being treated for a carcinoma of the back by a Sluys-Kessler machine. This apparatus could also accurately deliver therapy for a wide variety of internal...

lymphoma

Lympho-Sarcoma Treated by Radiation, Patient of Francis H. Williams, MD, Boston, 1902

One of the miracles produced by the x-ray was the relatively easy treatment of inoperable or disfiguring tumors. If not a cure, the results frequently gave the patients at least some time to look and feel normal. The young patient shown in these photographs had a remarkable response. Images such as ...

breast cancer

First Photographs of Breast Surgery, New York City, 1886

Antiseptic principles delivered the promise of safe surgery, while asepsis allowed safe major dissections and invasion of body cavities. The physicians who were using these techniques recognized the amazing difference in their surgical results and corresponding mortality rates and proselytized to...

gynecologic cancers

Woman With Ovarian Tumor, Daguerreotype, Wellington, Ohio, June 1851

In June 1851, Philip J. Bruckner, MD, hired a daguerreotypist to photograph this 275-pound, 33-year-old woman, who had borne five children while developing this massive tumor. Dr. Bruckner learned of this patient when Charles Breech, MD, of Wellington, Ohio, presented her case at a medical meeting. ...

100 Years of Progress in Oncology Treatment

In his powerful 2010 best-seller, The Emperor of All Maladies: A Biography of Cancer (Scribner), Siddhartha Mukherjee, MD, chronicles the evolution of cancer from the oldest known description of the disease written on a papyrus from about 1600 BC to the present day’s understanding of the biology of ...

supportive care

One in Three People With Cancer Has Anxiety or Other Mental Health Challenges

Researchers in Germany report that nearly a third of more than 2,100 patients with cancer interviewed at inpatient and outpatient care centers experienced a clinically meaningful level of mental or emotional distress that meets the strict diagnostic criteria for mental disorders including anxiety...

Addressing the Needs of Patients With Children

Often, the children of patients with cancer are the invisible sufferers of the disease and its aftermath. These online resources can help patients talk with their children about a cancer diagnosis, treatment, and prognosis, and their potential impact on the children. American Cancer Society:...

issues in oncology
palliative care

Helping Patients Talk to Their Children About Cancer

Although the focus of an oncologist’s attention is understandably attuned to the needs of the patient, when a patient is a parent, quality oncology care should also include attention to the patient’s role as a parent and to the needs of the patient’s children, according to Paula K. Rauch, MD,...

issues in oncology

Choosing Wisely® Campaign Identifies Five Radiation Treatments Not for Routine Use

The American Society for Radiation Oncology (ASTRO) reported a second list of five radiation oncology treatments that should not be used routinely in clinical practice on day 1 of the Society’s 56th Annual Meeting.1 These five treatments should be discussed in depth with patients prior to being...

issues in oncology

ASCO Calls for New Action to Address Obesity and Cancer

ASCO has called for increased education, research, and advocacy to reduce the toll of obesity, both as a leading cause of cancer and a complication in the care of patients with cancer. The Society’s recommendations outline four critical priorities, including increased education and awareness about...

issues in oncology

Now in Its 71st Year, CancerCare Looks to  Expand Services to Patients and Caregivers

Eleven days before Patricia J. ­Goldsmith, joined CancerCare as its CEO last May, she received the unexpected news that she had early-stage colorectal cancer. While the diagnosis was shocking, Ms. Goldsmith said it gave her a unique perspective on what it means to have this serious disease and a...

global cancer care

Effective Prevention Measures Urgently Needed to Prevent Global Cancer Crisis

Earlier this year the International Agency for Research on Cancer (IARC), an agency of the World Health Organization, launched a World Cancer Report 2014. The report, a collaboration of over 250 leading scientists from more than 40 countries, described multiple aspects of cancer research and...

global cancer care
breast cancer

Book Review: Breast Cancer, Break the Silence

This date has a special place in my heart, as well as the hearts of my children, my family and my loved ones. It was the day when my life—and my priorities—took a whole new direction.” So begins Breast Cancer, Break the Silence, a slim yet powerful and highly revealing booklet by Saudi Arabian...

breast cancer
global cancer care

Breaking the Silence About Breast Cancer in the Arab World

In 1974, First Lady Betty Ford spoke publicly about her breast cancer diagnosis and treatment. Remarkably, at the time of her action, public discussion of breast cancer in the United States was seen as off limits. Four decades later, cultural barriers to women’s health still exist, particularly in...

Radiation Oncologist Stephen Hahn, MD, to Join MD Anderson

Stephen Hahn, MD, has been named as the Division Head of Radiation Oncology and Chair of the Department of Radiation Oncology at The University of Texas MD Anderson Cancer Center. He joins MD Anderson on January 1, 2015. Dr. Hahn comes to MD Anderson from the University of Pennsylvania’s Perelman...

issues in oncology

On Being A Mentee and the Value of the Conquer Cancer Foundation’s Career Development Award

At the ASCO Annual Meeting in June, the Conquer Cancer Foundation presented the 2014 recipients of prestigious grants and awards, including the Young Investigator Award, Career Development Award, and the Advanced Clinical Research Award in Breast Cancer. In announcing the awards, Charles W. Penley, ...

issues in oncology

The Value of Lifelong Mentorship in Career Development

While the development of mentorship relationships is critical in launching and nurturing the academic careers of young investigators, it is also an essential component for continued success throughout their careers, according to Jennifer R. Brown, MD, PhD. Dr. Brown, Director of the CLL Center at...

global cancer care
gastrointestinal cancer

IARC Calls on Countries With High Stomach Cancer Burden to Act to Prevent the Disease

A new report from the International Agency for Research on Cancer (IARC), an agency of the World Health Organization, urges health authorities of countries with high stomach cancer burden to include stomach cancer in their national cancer control programs and allocate more resources to control the...

sarcoma

Treating Sarcomas in 2014

In 2014, about 15,000 people in the United States will be diagnosed with some form of sarcoma, and of those, approximately 5,000 adults and children are expected to die of the disease. Sarcomas are a heterogeneous group of mesenchymal malignancies that have historically been difficult to diagnose...

prostate cancer

Enzalutamide in Metastatic Castration-Resistant Prostate Cancer

In the Clinic provides overviews of novel oncology agents, addressing indications, mechanisms, administration recommendations, safety profiles, and other essential information needed for the appropriate clinical use of these drugs.   On September 10, 2014, the androgen receptor inhibitor...

supportive care

Improving Treatment of Depression in Patients With Cancer: The SMaRT Oncology-2 Trial

Clinical depression is highly prevalent, associated with significant morbidity, often underrecognized, and inadequately treated in cancer patients.  Professor Michael Sharpe and Jane Walker, PhD, and their colleagues’ seminal work on enhancing treatment of depression in cancer patients using a...

supportive care

Integrated Collaborative Care Program Highly Successful in Treating Major Depression in Patients With Cancer

In the Scottish SMaRT Oncology-2 study reported in The Lancet, Michael Sharpe, MD, and Jane Walker, PhD, of University of Oxford, United Kingdom, and colleagues found that an integrated collaborative treatment program for depression (“depression care for people with cancer”) was associated with...

cns cancers

Failure of Cilengitide in Newly Diagnosed Glioblastoma With Methylated MGMT Promoter

Temozolomide in combination with radiation for newly diagnosed glioblastoma was approved by the U.S. Food and Drug Administration in 2005—almost 10 years ago—but we have unfortunately made little progress in improving survival for this incurable brain tumor. Despite recent completion of three...

cns cancers

CENTRIC Trial Shows No Benefit of Adding Cilengitide to Therapy in Glioblastoma With Methylated MGMT Promoter

In the phase III CENTRIC/European Organisation for Research and Treatment of Cancer (EORTC) 26071-22072 trial reported in The Lancet ­Oncology, Roger Stupp, MD, of University Hospital Zurich, and colleagues found that adding the selective αvβ3 and αvβ5 integrin inhibitor cilengitide to standard...

hematologic malignancies

Louis J. DeGennaro, PhD, Named President and Chief Executive Officer of The Leukemia & Lymphoma Society

The Leukemia & Lymphoma Society has announced that Louis J. DeGennaro, PhD, has been appointed as President and Chief Executive Officer, effective immediately. “Dr. DeGennaro has tirelessly dedicated himself for almost a decade of service to the Leukemia & Lymphoma Society mission and to...

global cancer care

ASCO Seeks Editor for New Global Oncology Journal

The American Society of Clinical Oncology (ASCO) is seeking candidates for the position of founding Editor-in-Chief for a new online-only, open-access journal focusing on cancer care, research, and care delivery issues unique to limited health-care resource countries and settings. The new journal...

ASCO President Peter P. Yu, MD, FASCO, Discusses CancerLinQ at Stanford  Medicine X Conference

ASCO President Peter P. Yu, MD, FASCO, recently delivered a talk entitled “Learning from Every Patient” at the 2014 Stanford Medicine X Conference. Dr. Yu’s presentation focused on CancerLinQ and ASCO’s vision for using big data to drive progress in cancer care. To view Dr. Yu’s presentation, go to ...

CMS Announces ICD-10 Testing Weeks in Preparation for October 1, 2015, Compliance Deadline

Leading up to the October 1, 2015 ICD-10 compliance deadline, the Centers for Medicare and Medicaid Services (CMS) has announced the following three ICD-10 testing weeks: November 17 to 21, 2014 March 2 to 6, 2015 June 1 to 5, 2015 These weeks are intended to create provider interest and...

ASCO, AACR Urge FDA to Regulate All Tobacco Products—Including E-Cigarettes

ASCO and the American Association for Cancer Research (AACR) sent a joint letter to the U.S. Food and Drug Administration (FDA) urging the agency to regulate electronic cigarettes, cigars, and all other tobacco products and to strengthen the proposed regulations for newly deemed products. The...

The Latest Information for Patients From ASCO’s Symposia

The 2014 ASCO Quality Care Symposium is taking place this week, from October 17 to 18, and the new Palliative Care in Oncology Symposium is next week, from October 24 to 25. Direct your patients to www.cancer.net/blog to learn what the research announced prior to the symposia means and how it...

New Series Features Interviews With Authors of JCO and JOP Research

Journal of Clinical Oncology (JCO) and Journal of Oncology Practice (JOP) “Exclusive Coverage” summaries, available on ASCO.org and ASCO Connection, are designed to provide quick insight and additional author perspectives on select recently published studies. Based on interviews conducted with the...

For Your Patients: Video Series for Newly Diagnosed Patients on Navigating Common Challenges to Quality Care

The American Society of Clinical Oncology (ASCO) recently launched a new video series for people newly diagnosed with cancer through its patient education website, Cancer.Net. This initiative was made possible by a grant from the LIVESTRONG Foundation to the Conquer Cancer Foundation. After a...

issues in oncology

Fellows’ Expectations of Work-Life Balance Not in Line With Realities of Practice

Oncology fellows just years away from entering the profession full time may have unrealistic expectations of their future career, according to data published recently in the Journal of Clinical Oncology. The study by Tait D. Shanafelt, MD, of the Mayo Clinic, Rochester, Minnesota, and colleagues...

survivorship
cost of care

Cancer Survivors Face Lasting Financial Struggles Long After Treatment Ends, New Study Reports

The majority (62%) of America’s middle-income cancer survivors say they were not financially prepared for cancer diagnosis and treatment, according to a new study released by the Washington National Institute for Wellness Solutions (IWS). The study, “Insights from Survivors: Managing the Personal,...

lymphoma

ECOG E4402/RESORT Trial: When ‘Black and White’ Results Are Actually Gray

The results of the ECOG E4402/RESORT trial recently reported by Kahl and colleagues,1 and reviewed in this issue of The ASCO Post, provide interesting new information on the use of maintenance rituximab (Rituxan) vs retreatment with rituximab at progression in patients with low–tumor burden...

lymphoma

Time to Treatment Failure Similar With Rituximab Retreatment vs Maintenance in Low–Tumor Burden Follicular Lymphoma

Maintenance rituximab (Rituxan) has been shown to improve progression-free survival vs observation in low–tumor burden follicular lymphoma. In the Eastern Cooperative Oncology Group (ECOG) E4402 Trial ­(RESORT), reported in the Journal of Clinical Oncology, Brad S. Kahl, MD, of the University of...

pancreatic cancer

Early Study Reports Modified Vitamin D Has Potential in Treatment for Pancreatic Cancer

Researchers at the Salk Institute have reported on a synthetic derivative of vitamin D able to collapse the barrier of cells shielding pancreatic tumors, making this challenging cancer more susceptible to therapeutic drugs. The discovery has led to human trials for pancreatic cancer, even in...

colorectal cancer

Colonoscopic Polypectomy and Predicting Cancer Risk: A Work in Progress

Colon cancer screening using colonoscopy has significantly decreased the incidence and mortality of colorectal cancer in the United States. In the National Polyp Study (NPS), colorectal cancer was prevented by removal of adenomatous polyps.1 A more recent study looking at long-term follow-up from...

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