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Showing 20051 - 20100Immune System–Boosting Agent May Reduce Early-Stage Melanoma Recurrences
Among patients with clinically stage I or stage II melanoma, those treated with the immune system–boosting agent CpG-B were less likely to experience recurrence of their disease than those who received placebo, according to results from two randomized, placebo-controlled phase II clinical...
Brazilian Wasp Venom May Be Active Against Cancer Cells
The social wasp Polybia paulista protects itself against predators by producing venom known to contain a powerful cancer-fighting ingredient. A Biophysical Journal study published by Bueno Leite et al revealed how the venom's toxin—called MP1 (Polybia-MP1)—may selectively kill cancer...
Genetic Sequencing May Impact Treatment for Children With Rare, Aggressive Cancers
For children with rare, aggressive, and advanced cancer, precision medicine may help doctors determine their best treatment options, a new study found. Using information from a patient's entire genome helped to suggest personalized treatment options for nearly half of children with cancer and...
Statistical Model May Identify Patients Most Likely to Benefit From Mesothelioma Surgery
A new statistical model may help predict which patients are most likely to receive life-extending benefits from surgical treatment for malignant pleural mesothelioma, according to a report published by Leuzzi et al in The Annals of Thoracic Surgery. Malignant pleural mesothelioma is an aggressive...
MicroRNA Panel Shows Early Potential as Biomarker of Pancreatic Precancers
Assessing blood plasma levels of certain microRNAs (miRNAs) distinguished individuals with noninvasive pancreatic precancers from healthy individuals and discriminated between patients with high-risk and low-risk neoplasms, according to a preliminary, proof-of-principle study published by...
ASCO Clinical Practice Guideline Update: Systemic Therapy for Stage IV NSCLC
As reported in the Journal of Clinical Oncology by Masters et al, ASCO has issued a clinical practice guideline update on systemic therapy for stage IV non–small cell lung cancer (NSCLC). Recommendations are based on an update committee systematic review of randomized controlled trials...
Synchronous vs Sequential Tumor Resection in Patients With Advanced Colorectal Cancer
About 20% of patients with colorectal cancer have cancers that have metastasized beyond the colon at the time of their diagnosis, with the liver being the most common site for these metastases. The approach to treating primary tumors within the colon and metastatic tumors in the liver continues to...
Study Explores Link Between Breast Cancer Recurrence Score and Chemotherapy Use
A genetic test that helps predict whether some women’s breast cancer will recur might influence how chemotherapy is used, according to a study from Duke Medicine. The study found that low-risk patients who had the test appeared to opt for more treatment, and high-risk patients who were...
FDA Grants Priority Review to Ixazomib for Patients With Relapsed/Refractory Multiple Myeloma
The U.S. Food and Drug Administration (FDA) has granted Priority Review status to the New Drug Application for the investigational oral proteasome inhibitor ixazomib for the treatment of patients with relapsed or refractory multiple myeloma, Takeda Pharmaceuticals announced. The New Drug...
Internationally Acclaimed Cancer Researcher, Gianni Bonadonna, MD, Dies at 81
Gianni Bonadonna, MD, was considered the “Father of Italian Oncology,” but his scientific contributions to the field and his generous collegial spirit extended far beyond the shores of his native land. Dr. Bonadonna was at the forefront in the battle to convince the surgical...
WCLC: Cetuximab May Improve Survival in Some Patients With EGFR-Positive Squamous NSCLC
Analysis of a large phase III trial (S0819) suggested that adding the epidermal growth factor receptor (EGFR)-targeting monoclonal antibody cetuximab (Erbitux) to chemotherapy benefits survival in patients with squamous cell non–small cell lung cancer (NSCLC) with tumors positive...
WCLC: New Study Reveals Genomic Architecture of EGFR Mutations in Lung Cancer
Epidermal growth factor receptor (EGFR) mutations are one of the most common driver oncogenes in lung cancer, typified by high response rates when treated with tyrosine kinase inhibitors and median progression-free survival of 10 months, commonly due to emergence of T790M. The genomic...
WCLC: Effect of EGFR Protein and EGFR Gene Copy Number in SQUIRE Trial
Previously, researchers reporting on the SQUIRE study demonstrated that the addition of necitumumab to gemcitabine-cisplatin improved overall survival in patients with stage IV squamous non–small cell lung cancer (NSCLC). Following up on these findings, Fred R. Hirsch, MD, PhD,...
WCLC: Adding Bevacizumab to Chemotherapy Does Not Improve Overall Survival in Early-Stage NSCLC
Adding the monoclonal antibody bevacizumab (Avastin) to chemotherapy for patients with surgically removed non–small cell lung cancer (NSCLC) did not improve overall survival, according to research (Abstract PLEN04.03) presented at the 16th World Conference on Lung Cancer (WCLC) in Denver,...
WCLC: Smoking Cessation Reduces Mortality in Low-Dose Computed Tomography Screening Volunteers
Smoking cessation among patients enrolled in a low-dose computed tomography screening program is associated with a three- to five-time reduction in mortality, according to research (Abstract PLEN04.07) presented at the 16th World Conference on Lung Cancer (WCLC) in Denver, Colorado. The Conference...
FDA Grants Alectinib Priority Review for ALK‑Positive Lung Cancer
Genentech announced today that the U.S. Food and Drug Administration (FDA) has accepted the company’s New Drug Application (NDA) and granted Priority Review for alectinib, an oral investigational anaplastic lymphoma kinase (ALK) inhibitor, for the treatment of people with ALK-positive,...
WCLC: Results From ROMANA Trials of Anamorelin in Advanced NSCLC Patients With Cachexia
Two phase III studies of anamorelin found that the medication effectively combats wasting and increases body weight and lean body mass in certain patients with lung cancer. Results (Abstract ORAL29.01) from the ROMANA 1 and ROMANA 2 phase III trials of anamorelin were presented at the 16th...
WCLC: IASLC Issues Statement on Tobacco Control and Smoking Cessation
The International Association for the Study of Lung Cancer (IASLC) issued a new statement on Tobacco Control and Smoking Cessation on September 7 at the 16th World Conference on Lung Cancer (WCLC) in Denver, Colorado. The statement calls for higher taxes on tobacco products; comprehensive...
WCLC: Impact of Time to Drug Approval on Potential Years of Life Lost
Every hour lost to the cancer drug regulatory process costs 29 life-years lost in the United States and 260 life-years worldwide, according to research (Abstract ORAL12.05) presented on September 7 at the 16th World Conference on Lung Cancer hosted by the International Association of the...
Online Database Helps Organize Clinically Important Cancer Gene Mutations
Many clinical trials use genome sequencing to learn which genetic mutations are present in a patient’s tumor cells. The question is important, because targeting the right mutations with the right drugs can stop cancer in its tracks. But it can be difficult to determine which particular...
Stiffer Breast Tissue in Obese Women May Promote Tumor Growth
Women who are obese have a higher risk and a worse prognosis for breast cancer, but the reasons why remain unclear. A Cornell study published by Seo et al in Science Translational Medicine suggests that obesity changes the consistency of breast tissue in ways that predispose an individual to tumor...
Survivors of Childhood Cancer Have High Risk of Recurrent Stroke
Recent evidence suggests that survivors of childhood cancer have a high risk of suffering a stroke at a surprisingly young age. A new study from the UC San Francisco Pediatric Brain Center shows that childhood cancer survivors suffering one stroke have double the risk of suffering a second stroke...
FDA Approves Rolapitant for Prevention of Chemotherapy-Induced Nausea and Vomiting
The U.S. Food and Drug Administration (FDA) approved rolapitant (Varubi) to prevent delayed-phase chemotherapy-induced nausea and vomiting. Rolapitant is approved in adults in combination with other antiemetic agents that prevent nausea and vomiting associated with initial and repeat courses of...
Call for APOS 2016 Award Nominations
The American Psychosocial Oncology Society (APOS) will be celebrating 30 years of psychosocial oncology at the 13th Annual APOS Conference, to be held March 3 to 5, 2016, in San Diego. Colleagues, mentors, students, and others who have made an impact on psychosocial oncology can be nominated for an ...
New 'Mutation-Tracking' Blood Test Could Predict Breast Cancer Relapse
Scientists have developed a blood test for breast cancer that may be able to identify which patients will suffer a relapse after treatment, months before tumors are visible on hospital scans. The test may uncover small numbers of residual cancer cells that have resisted therapy by detecting cancer...
FDA Accepts for Priority Review the Biologics License Application for Elotuzumab for the Treatment of Relapsed Multiple Myeloma
Bristol-Myers Squibb and AbbVie today announced that the U.S. Food and Drug Administration has accepted for priority review the Biologics License Application for elotuzumab, an investigational signaling lymphocyte activation molecule (SLAMF7)-directed immunostimulatory antibody, for the...
ASCO Releases Updated Policy Statement on Genetic and Genomic Testing for Cancer Susceptibility
The American Society of Clinical Oncology (ASCO) issued an updated policy statement on genetic and genomic testing for cancer susceptibility. Published in the Journal of Clinical Oncology, the statement reviews the ways in which new technologies are transforming the assessment and identification of ...
AAV2 Virus May Be Linked to Hepatocellular Carcinoma in Patients With No History of Cirrhosis or Other Risk Factors
More than a cause of a simple infection, viruses are often involved in the development of serious diseases. Such is the case with liver cancer, which often develops in an organ that has been weakened by hepatitis B or C virus. Researchers at Inserm, the Paris Public Hospitals (AP-HP), Paris...
High Use of Complementary or Alternative Medicines in Older Patients With Cancer
Alternative medicines are widely thought to be at least harmless, and very often helpful, for a wide range of discomforts and illnesses. However, although they’re marketed as “natural,” they often contain active ingredients that can react chemically and biologically with other...
Fertility Concerns and Side Effects Keep Many Young Women With Breast Cancer From Taking or Completing Tamoxifen
Concerns about fertility kept one-third of young women with breast cancer surveyed in a recent study from taking tamoxifen, despite its known benefit in reducing the risk of breast cancer recurrence. In addition, the study found fertility concerns led one-quarter of women who started...
Pericytes May Help Some Tumors Evade the Immune System
A study by researchers at Sweden's Karolinska Institutet is reportedly the first to suggest that cells in the tumor blood vessels contribute to a local environment that protects the cancer cells from tumor-killing immune cells. The results, published by Hong et al in the Journal of the...
Study Validates Method for Patient Reporting of Cancer Drug–Related Adverse Events
In cancer clinical trials, doctors typically report side effects that patients experience—not patients themselves. Previous research has shown that doctors underreport these symptoms. Ethan Basch, MD, MSc, Director of the UNC Lineberger Cancer Outcomes Research Program and Associate...
Black Women Have Higher Frequency of BRCA Mutations Than Previously Reported
Women who have inherited mutations in the BRCA1 or BRCA2 gene are more likely to develop breast cancer or ovarian cancer, especially at a younger age. Approximately 5% of women with breast cancer in the United States have mutations in BRCA1 or BRCA2, based on estimates in non-Hispanic white women. ...
Longer Colonoscopies Linked to Lower Rate of Colorectal Cancer
Research by a Veterans Affairs team has confirmed that longer-lasting colonoscopies are associated with lower cancer rates. Their findings were published by Shaukat et al in Gastroenterology, and were based on nearly 77,000 screening colonoscopies. Experts already know about the link between...
Beta-Blockers May Prolong Survival in Women With Ovarian Cancer
In a first-of-its-kind study, researchers demonstrated a benefit in overall survival among patients with epithelial ovarian cancer receiving generic beta-blocker heart medications. Survival was shown to be greatest among those prescribed first-generation nonselective beta-blockers. According to...
Patients With Fewer Than 50 Moles May Be at Risk for More Aggressive Melanoma
People with more than 50 moles have an increased risk of developing melanoma, but those with fewer than 50 moles should still be alert for this disease. In fact, according to new research presented at the American Academy of Dermatology’s 2015 Summer Academy Meeting in New York, those with...
Imaging Probe May Be More Accurate Than the Best External Detector for Early Cervical Cancer Diagnosis
An endovaginal magnetic resonance imaging technique is more accurate at detecting early-stage cervical cancer than the best available external detection technique, a new study reported. Researchers at The Institute of Cancer Research and The Royal Marsden Hospital found that using an...
FDA Approves Eltrombopag for Pediatric Patients With Chronic Immune Thrombocytopenia
The U.S. Food and Drug Administration approved eltrombopag (Promacta) for the treatment of thrombocytopenia in pediatric patients aged 1 year and older with chronic immune thrombocytopenia who have had an insufficient response to corticosteroids, immunoglobulins, or splenectomy. The approval was...
Study Identifies Genes Associated With Improved Survival for Patients With Pancreatic Cancer
A multi-institutional study has found a new set of genes that may indicate improved survival after surgery for patients with pancreatic cancer. The study also showed that detection of circulating tumor DNA in the blood could provide an early indication of tumor recurrence. In conjunction with the...
Confocal Fluorescence Microscopy and Proflavine Staining May Speed Up Breast Cancer Diagnosis
New software could speed up breast cancer diagnosis with 90% accuracy without the need for a specialist, according to research published by Dobbs et al in Breast Cancer Research. This method could improve breast cancer management, particularly in developing countries, where pathologists are not...
Black Women Less Likely Than Women of Other Races and Ethnicities to Survive Endometrial Cancer
Non-Hispanic black women with endometrial cancer had worse outcomes than women of other racial/ethnic groups diagnosed with the same subtype of endometrial cancer and at the same stage of disease, according to a study published by Cote et al in Cancer Epidemiology, Biomarkers & Prevention....
Multigene Panel Testing for Hereditary Breast and Ovarian Cancer Risk Assessment
Multigene testing of women who tested negative for BRCA1 and BRCA2 found some of them harbored other harmful genetic mutations—most commonly, moderate-risk breast and ovarian cancer genes, as well as Lynch syndrome genes (which increase the risk of ovarian cancer)—according to an...
Complete Resection of High-Grade Gliomas Yields Better Survival in Children, Especially Girls
For children with aggressive brain cancers called high-grade gliomas, the chances of survival are improved when surgery is successful in eliminating all visible cancer, according to a report published by McCrea et al in Neurosurgery. In addition to showing better survival with gross total...
Organ Transplant Recipients May Be More Likely to Develop Aggressive Melanoma
Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant and three times more likely to die of the skin cancer, suggested new research by a multi-institutional team. The findings, reported by Robbins et al in the Journal of Investigative...
Study Finds Music Therapy Lowers Anxiety During Surgical Breast Biopsies
A first-of-its-kind study published by Bradley Palmer et al in the Journal of Clinical Oncology found that music therapy lessened anxiety for women undergoing surgical breast biopsies for cancer diagnosis and treatment. The 2-year study, conducted at University Hospitals (UH) Seidman Cancer Center, ...
FDA Grants Regular Approval to Brentuximab Vedotin as Post-Transplant Consolidation Therapy for High-Risk Classical Hodgkin Lymphoma
The U.S. Food and Drug Administration has approved brentuximab vedotin (Adcetris) as post–autologous hematopoietic stem cell transplantation consolidation treatment for patients with classical Hodgkin lymphoma at high risk of relapse or progression, Seattle Genetics has announced. The...
Study Reveals Effects of Chemoradiation in Brains of Glioblastoma Patients
A study from Massachusetts General Hospital (MGH) Cancer Center researchers—the first to examine the effects of combined radiation and chemotherapy on the healthy brain tissue of glioblastoma patients—revealed not only specific structural changes within patients’ brains, but also...
Preclinical Study Shows MRI and Chemical Contrast Solution Combination Can Detect Breast Cancer Micrometastases
Researchers have shown that magnetic resonance imaging (MRI) can detect the earliest signs of breast cancer recurrence and fast-growing tumors through detecting micrometastases, breakaway tumor cells with the potential to develop into dangerous secondary breast cancer tumors elsewhere in the body....
Malaria-Causing Parasite May Contribute to Development of Burkitt Lymphoma
In an equatorial African region known as the “lymphoma belt,” children are ten times more likely than in other parts of the world to develop Burkitt lymphoma. This area is also plagued by high rates of malaria, and scientists have spent the past 50 years trying to understand how the two ...
Combining Interleukin-2 With Imiquimod and Topical Retinoid Therapy May Be Effective Against Cutaneous Metastatic Melanoma
A novel combination therapy appears to be effective in treating patients with melanoma skin metastases, according to new research from the University of California (UC) Davis. Led by Emanual Maverakis, MD, of the UC Davis Department of Dermatology, the research found that interleukin-2...
