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leukemia
lymphoma
lymphoma

ASH 2015: Engineered Donor T Cells May Eradicate Progressive Disease After Stem Cell Transplant

A study (Abstract 99) to be reported today by Brudno et al at the 57th American Society of Hematology (ASH) Annual Meeting was the first clinical trial to use engineered donor immune cells to prevent progressive cancer after stem cell transplantation. The findings were presented at a...

hematologic malignancies
issues in oncology

ASH 2015: American Society of Hematology Releases Compilation of Top Choosing Wisely Recommendations Relevant to Hematology

The American Society of Hematology (ASH) has released a list of five hematology-related tests and procedures to question based on recommendations from other medical societies taking part in the American Board of Internal Medicine (ABIM) Foundation’s Choosing Wisely® campaign. This list...

issues in oncology

Researchers Use Ovarian Follicles to Preserve Fertility in Preclinical Models

Researchers at the University of Michigan have identified a potential new approach to fertility preservation for young cancer patients that addresses concerns about beginning cancer treatment immediately and the possibility of reintroducing cancer cells during the fertility-preservation process....

palliative care
prostate cancer

Study Shows Abiraterone Acetate Is Useful Even in the Most Aggressive Prostate Cancers

In 1,048 prostate cancer patients previously treated with docetaxel, and 996 metastatic, castration-resistant patients, treatment with the androgen-lowering drug abiraterone acetate (Zytiga) led to longer overall disease control, even when a very high Gleason score indicated especially aggressive...

lung cancer
issues in oncology

RSNA 2015: Subsolid Lung Nodules Pose Greater Cancer Risk to Women Than Men

Women with a certain type of lung nodule visible on lung cancer screening computed topography (CT) exams face a higher risk of lung cancer than men with similar nodules, according to a new study (SSA04-02) presented by Boiselle et al November 29 at the Annual Meeting of the Radiological Society of...

gynecologic cancers
issues in oncology
issues in oncology

Study Identifies Ovarian Cancer Cell Hierarchy

Can any cancer cell form another tumor, or is it only select cancer stem cells that give rise to new cancer cells? The answer, a new study finds, is both. Researchers at the University of Michigan Comprehensive Cancer Center looked at human ovarian cancer cells, and found that, for the most part,...

prostate cancer
issues in oncology
issues in oncology

Majority of Men Who Forgo Aggressive Treatment for Prostate Cancer Are Not Monitored Appropriately

An increasing number of men diagnosed with low-risk prostate cancer are opting for active surveillance rather than aggressive treatment to avoid the debilitating potential side effects of surgery and radiation, such as erectile and urinary dysfunction. However, a new study by University of...

breast cancer
issues in oncology

RSNA 2015: Study Suggests Breast Density Alone Not a Risk Factor for Cancer

Breast density may not be a strong independent factor for breast cancer risk, according to a new study presented (BR267-SD-THA1) by Katavic et al December 2, 2015, at the Annual Meeting of the Radiological Society of North America (RSNA) in Chicago. Prior research has shown an association between...

breast cancer
health-care policy
issues in oncology

RSNA 2015: Medicaid Expansion Improves Breast Cancer Screening for Low-Income Women

Low-income women in Medicaid expansion states in the United States are more likely to have a breast screening performed than those in nonexpansion states, according to a study (HP207-SD-MOA2) by Fazeli Dehkordy et al presented November 30, 2015, at the Annual Meeting of the Radiological Society of...

breast cancer

Female Hormone Supplements With Estrogen and Progestin Linked to Breast Cancer Risk in African American Women

Postmenopausal African American women who use female hormone supplements containing estrogen and progestin (“combination” therapy) are at an increased risk for estrogen receptor–positive breast cancer. The study, published by Rosenberg et al in the Journal of the National Cancer...

multiple myeloma

FDA Approves Elotuzumab in Combination With Lenalidomide and Dexamethasone for Multiple Myeloma

The U.S. Food and Drug Administration (FDA) granted approval for elotuzumab (Empliciti) in combination with two other therapies to treat patients with multiple myeloma who have received one to three prior medications. “We are continuing to learn about the ways the immune system interacts...

breast cancer
issues in oncology

Breast MRI After Mammography May Identify Additional Aggressive Cancers

Additional breast cancers found with magnetic resonance imaging (MRI) are sometimes larger and potentially more aggressive than those found on mammography, according to a study published by Iacconi et al in Radiology. Researchers said that in some cases, MRI findings of additional cancers not seen...

palliative care
breast cancer
issues in oncology
issues in oncology
issues in oncology
issues in oncology

Researchers Develop Mathematical Model to Forecast Metastatic Breast Cancer Survival Rates

University of Southern California (USC) researchers have developed a mathematical model to forecast metastatic breast cancer survival rates using techniques usually reserved for weather prediction, financial forecasting, and surfing the Web. For decades, medical schools have taught doctors that...

skin cancer

FDA Approves Single-Agent Nivolumab for Previously Untreated BRAF Wild-Type Advanced Melanoma

The U.S. Food and Drug Administration (FDA) today approved the programmed cell death protein 1 (PD-1) inhibitor nivolumab (Opdivo) as a single agent for the treatment of patients with BRAF V600 wild-type unresectable or metastatic melanoma. Clinical Trial Results The approval is based on data...

lung cancer

FDA Approves Necitumumab Combination for Metastatic Squamous NSCLC

The U.S. Food and Drug Administration today approved necitumumab (Portrazza) in combination with gemcitabine and cisplatin for first-line treatment of patients with metastatic squamous non–small cell lung cancer (NSCLC). Necitumumab is not indicated for treatment of nonsquamous NSCLC....

colorectal cancer
issues in oncology

Citywide Effort Boosts New York City's Colorectal Cancer Screening Rates

A coalition formed by the New York City Department of Health and Mental Hygiene (DOHMH) to increase colorectal cancer screening rates in New York resulted in a 40% increase in screening rates over 4 years. The program may serve as a foundation for other communities to boost cancer screening rates,...

issues in oncology
prostate cancer

Vigorous Exercise and Healthy Habits May Dramatically Reduce Chance of Lethal Prostate Cancer for Men Over 60

A study that tracked tens of thousands of middle-aged and older men for more than 20 years has found that vigorous exercise and other healthy lifestyle habits may cut their chances of developing a lethal type of prostate cancer by up to 68%. While most prostate cancers are clinically indolent, a...

kidney cancer

FDA Approves Nivolumab to Treat Advanced Kidney Cancer

The U.S. Food and Drug Administration today approved nivolumab (Opdivo) to treat patients with metastatic renal cell carcinoma who have received a prior antiangiogenic therapy. Nivolumab is a monoclonal antibody that binds to the PD-1 receptor and blocks its interaction with PD-L1 and PD-L2,...

gynecologic cancers

Risk of Undetected Cancer in Gynecologic Surgery Higher Than Previously Thought

Minimally invasive gynecologic surgeries have advantages for patients, including shorter hospital stays, quicker recoveries, and less pain. However, power morcellation, a technique that cuts the uterus or fibroid into small pieces in order to extract them from the abdomen through a small incision,...

Chitosane-Based Injectable Biogel Delivers Anticancer Agents Directly Into Tumors in Laboratory Setting

A new, injectable “biogel” is effective in delivering anticancer agents directly into cancerous tumors and killing them, according to a study published by Monette et al in Biomaterials. The technology was developed by researchers at the University of Montreal Hospital Research Centre...

multiple myeloma

FDA Approves Ixazomib in Combination With Lenalidomide and Dexamethasone for Multiple Myeloma

The U.S. Food and Drug Administration (FDA) granted approval for ixazomib (Ninlaro) in combination with two other agents to treat patients with multiple myeloma who have received at least one prior therapy. “As we learn more about the underlying biology of multiple myeloma, we are encouraged ...

pancreatic cancer
issues in oncology
issues in oncology
issues in oncology

Study Advances Potential Test to Distinguish Precancerous Pancreatic Cysts From Harmless Ones

In a retrospective analysis of data from 130 patients with pancreatic cysts, scientists at Johns Hopkins have used gene-based tests and a fixed set of clinical criteria to more accurately distinguish precancerous cysts from those less likely to do harm. The findings may eventually help some...

breast cancer
issues in oncology
cost of care

Patients With Breast Cancer Who Have Prescription Drug Benefits, Higher Incomes More Likely to Start and Continue Hormonal Therapy

A University of Colorado Cancer Center study published by Bradley et al in Breast Cancer Research and Treatment showed that patients with breast cancer whose health insurance plans included prescription drug benefits were 10% more likely to start important hormonal therapy than patients who did not ...

palliative care
issues in oncology
prostate cancer

Two Studies Find Protein May Inhibit Prostate Cancer Bone Metastasis

Scientists from Lawrence Livermore National Laboratory (LLNL), in collaboration with researchers from University of California Merced and Davis, have found that a secreted protein predominantly expressed in bone inhibits prostate cancer metastasis to bone. Their research was published recently by...

gynecologic cancers
supportive care

Researchers Find Experimental Drug Reduces Ascites With Minimal Side Effects in Preclinical Studies

Women who have ovarian cancer often develop a condition called ascites, which is a buildup of fluids in the abdomen. The most common treatment for ascites is puncturing the abdomen and manually draining the fluid, which is painful, risky, and must be repeated every few weeks. University of...

prostate cancer
supportive care
integrative oncology

Yoga Helps Maintain Quality of Life, May Lessen Side Effects in Men Undergoing Prostate Cancer Treatment

Men with prostate cancer who are undergoing radiation therapy can benefit from yoga, researchers at the Perelman School of Medicine at the University of Pennsylvania reported at the Society for Integrative Oncology’s 12th International Conference. The new, first-of-its-kind study, led...

kidney cancer
lung cancer
skin cancer
lymphoma
kidney cancer
head and neck cancer

Kidney Failure and Its Treatment May Impact Cancer Risk

For patients with kidney failure, poor kidney function and immunosuppressant medications may increase their risk of developing different types of cancer. The findings, which are published by Yanik et al in the Journal of the American Society of Nephrology, suggest the need for persistent cancer...

gynecologic cancers
issues in oncology

Healthy Diet May Reduce Risk of Ovarian Cancer in African American Women

A healthy diet may reduce the risk of ovarian cancer in African American women, according to data presented at the Eighth American Association for Cancer Research (AACR) Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held November...

colorectal cancer
issues in oncology

Disparities in Colorectal Cancer Death Rates Take a Large Economic Toll

Disparities in colorectal cancer death rates take a large toll on the national economy, with poorer, less-educated communities bearing the greatest burden, according to data presented at the Eighth American Association for Cancer Research (AACR) Conference on the Science of Cancer Health...

lung cancer
issues in oncology

Rates of Curative Lung Cancer Surgery Vary by State

The likelihood of receiving curative-intent surgery for patients with early-stage non–small cell lung cancer (NSCLC) varies substantially from state to state, according to data presented at the Eighth American Association for Cancer Research (AACR) Conference on the Science of Cancer Health...

multiple myeloma

FDA Approves Daratumumab for Patients With Previously Treated Multiple Myeloma

Today the U.S. Food and Drug Administration granted accelerated approval for daratumumab (Darzalex) to treat patients with multiple myeloma who have received at least three prior treatments, including a proteasome inhibitor and an immunomodulatory agent, or who are double-refractory to a proteasome ...

palliative care
lung cancer
issues in oncology

FDA Approves Osimertinib for EGFR T790M Mutation–Positive Non–Small Cell Lung Cancer After Progression on Prior EGFR-Blocking Therapy

The U.S. Food and Drug Administration (FDA) granted accelerated approval for an oral medication to treat patients with advanced non–small cell lung cancer (NSCLC). Osimertinib (Tagrisso) is now approved for patients whose tumors have a specific epidermal growth factor receptor (EGFR) mutation ...

breast cancer
issues in oncology
issues in oncology

Blood Test Detects Resistance to Aromatase Inhibitors in Breast Cancer Treatment

Scientists have developed a highly sensitive blood test that can spot when breast cancers become resistant to standard hormone treatment, and have demonstrated that this test could guide further treatment. The test gives an early warning of resistance to aromatase inhibitors, which are used to...

supportive care

Researchers Call for Hospitals to Establish Bereavement Programs for Families of Deceased Patients

Backed by a growing body of research, investigators at Dana-Farber Cancer Institute are calling for all hospitals to establish bereavement programs for families of deceased patients. In a report published by Morris and Block in the Journal of Palliative Medicine, researchers say such...

breast cancer
issues in oncology

Some Rare HER2 Mutations May Not Be Capable of Causing Breast Cancer Growth

Results of a new laboratory study by Johns Hopkins Kimmel Cancer Center researchers suggest that some rare “missense” mutations in the HER2 gene are apparently not—on their own—capable of causing breast cancer growth or spread. In a related finding, the research team said...

pancreatic cancer

Preclinical Study Reveals Why Chemotherapy May Be Compromised in Patients With Pancreatic Cancer

A study at The University of Texas MD Anderson Cancer Center may explain why chemotherapy drugs such as gemcitabine are not effective for many patients with pancreatic cancer and perhaps point to new approaches to treatment, including enhancing gemcitabine's ability to stop tumor growth. The MD...

gynecologic cancers

Previous Oral Contraceptive Use May Be Associated With Better Outcomes in Patients With Ovarian Cancer

Patients who develop ovarian cancer appear to have better outcomes if they have a history of oral contraceptive use, according to a study by Mayo Clinic researchers published by Jatoi et al in BMC Cancer. “Multiple studies from a variety of sources have indicated that oral contraceptives are ...

kidney cancer
issues in oncology

Increased Meat Consumption May Be Linked to Elevated Kidney Cancer Risk

Diets high in meat may lead to an increased risk of developing renal cell carcinoma through intake of carcinogenic compounds created by certain cooking techniques, such as barbecuing and pan-frying. As part of a new study from The University of Texas MD Anderson Cancer Center, published by...

skin cancer

FDA Approves Cobimetinib in Combination With Vemurafenib for Advanced Melanoma

The U.S. Food and Drug Administration (FDA) approved cobimetinib (Cotellic) to be used in combination with vemurafenib (Zelboraf) to treat metastatic or unresectable melanoma, with the BRAF V600E or V600K mutation. “As we continue to advance our knowledge of tumor biology, we have...

survivorship

Cancer Survivors Are Less Likely to Receive Callbacks From Potential Employers

Job applicants who are cancer survivors are less likely to receive callbacks from potential retail employers than those who did not disclose their health history, according to a recent study by Rice University and Pennsylvania State University researchers. Study Findings The study, published by...

palliative care
breast cancer
survivorship

ABC3: Experts Create New Consensus Guidelines for Advanced Breast Cancer Treatment

Although advanced breast cancer is incurable, there are some patients who have just a few small metastases who would respond well to systemic treatments such as chemotherapy and hormone therapy. In new guidelines agreed on by participants at the Advanced Breast Cancer Third International Consensus...

issues in oncology

Liquid Biopsy Promotes Precision Medicine by Tracking Patient's Cancer

A team of researchers, including scientists from the Translational Genomics Research Institute (TGen), has reported that analyzing circulating tumor DNA (ctDNA) can track how a patient's cancer evolves and responds to treatment. In a study published in Nature Communications, Muhammed Murtaza, PhD, ...

cns cancers

Experimental Drug Shown to Prevent Neuroblastoma in Preclinical Study

Australian scientists have identified a critical molecular “feedback loop” that helps initiate and drive neuroblastoma, a cancer of the nervous system in children that is triggered in embryonal nerve cells. This feedback loop massively accelerates cancer development. The research team...

cns cancers
survivorship

Chemotherapy-Induced Hearing Loss Affects Cognition in Pediatric Brain Tumor Survivors

More children are surviving malignant brain tumors than in the past, thanks to the use of intense treatments using platinum-based chemotherapy (cisplatin and high-dose carboplatin). Unfortunately, the therapy has a known side effect of permanent hearing loss, resulting from damage to the inner ear. ...

issues in oncology
gynecologic cancers
gynecologic cancers

Protein CK5 a Marker for Cisplatin-Resistant Ovarian Cancer

A University of Colorado Cancer Center study recently published by Corr et al in the International Journal of Gynecological Cancer shows that protein cytokeratin 5 (CK5), known to be a marker of poor prognosis in breast cancer, also marks ovarian cancers likely to be resistant to the common...

breast cancer

ABC3: Higher Insulin Is an Independent Prognostic Factor in Advanced Breast Cancer

Patients with metastatic breast cancer who have higher insulin levels than normal, but are not diabetic, have a significantly worse prognosis compared with those who have normal insulin levels, according to data being presented (Abstract BP129) at the Advanced Breast Cancer Third International...

breast cancer
survivorship
cost of care

ABC3: Patients Speak Out Against 'Damaging Messages' About Metastatic Breast Cancer, Call for Inclusion in Discussion About Treatment Costs

Organizations that issue “damaging messages” about advanced breast cancer need to be identified and educated to change the way they talk about the disease, a patient told the Advanced Breast Cancer Third International Consensus Conference in Lisbon, Portugal, on November 5, 2015. In...

prostate cancer
cost of care

Study Shows Wide Variation in Costs to Treat Low-Risk Prostate Cancer

University of California, Los Angeles (UCLA) researchers have described costs across the entire care process for low-risk prostate cancer—from the time a patient checks in for his first appointment to his post-treatment follow-up testing—using time-driven activity-based costing. For the ...

pancreatic cancer
issues in oncology

Only 1 in 5 U.S. Patients With Pancreatic Cancer Gets Key Blood Test at Diagnosis

Only 1 in 5 patients with pancreatic cancer in the United States receives a widely available, inexpensive blood test at diagnosis that can help predict relative outcome (compared to others with the same disease stage) and guide treatment accordingly, a Mayo Clinic study showed. People who test...

breast cancer
survivorship

Breast Cancer Adjuvant Therapy Benefit Can Wax and Wane Over Time

After breast cancer surgery, women are prescribed adjuvant therapies such as chemotherapy and endocrine drugs to reduce the risk of the cancer returning. It has been assumed that the treatment effects of these therapies remain constant over time, but a new study from the Cancer Therapy &...

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