The 2014 Nobel Prize in Physiology or Medicine Awarded to John O’Keefe, PhD, and Jointly to May-Britt Moser, PhD, and Edvard I. Moser, PhD

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The 2014 Nobel Prize in Physiology or Medicine has been awarded with one half to John O’Keefe, PhD, of University College London, and the second half jointly awarded to May-Britt Moser, PhD, and Edvard I. Moser, PhD, of the Norwegian University of Science and Technology in Trondheim, for their discoveries of cells that constitute a positioning system in the brain. The Nobel Assembly at Karolinska Institutet announced the awards in October.

‘Inner GPS’

This year’s Nobel Laureates have discovered a positioning system, an “inner GPS” in the brain that makes it possible to orient ourselves in space, demonstrating a cellular basis for higher cognitive function. In 1971, John O’Keefe discovered the first component of this positioning system. He found that a type of nerve cell in an area of the brain called the hippocampus was always activated when a rat was at a certain place in a room. Other nerve cells were activated when the rat was at other places. Dr. O’Keefe concluded that these “place cells” formed a map of the room.

More than 3 decades later, in 2005, Drs. May-Britt and Edvard Moser discovered another key component of the brain’s positioning system. They identified another type of nerve cell, which they called “grid cells,” that generate a coordinate system and allow for precise positioning and pathfinding. Their subsequent research showed how place and grid cells make it possible to determine position and to navigate.

The discoveries of Drs. O’Keefe, May-Britt Moser, and Edvard Moser have solved a problem that has occupied philosophers and scientists for centuries—how does the brain create a map of the space surrounding us and how can we navigate our way through a complex environment?

A Place for Maps in the Human Brain

Recent investigations with brain imaging techniques, as well as studies of patients undergoing neurosurgery, have provided evidence that place and grid cells exist also in humans. In patients with Alzheimer’s disease, the hippocampus and entorhinal cortex are frequently affected at an early stage, and these individuals often lose their way and cannot recognize the environment. Knowledge about the brain’s positioning system may, therefore, help us understand the mechanism underpinning the devastating spatial memory loss that affects people with this disease.

The discovery of the brain’s positioning system represents a paradigm shift in our understanding of how ensembles of specialized cells work together to execute higher cognitive functions. It has opened new avenues for understanding other cognitive processes, such as memory, thinking, and planning.

About the Nobel Laureates

John O’Keefe, PhD, was born in 1939 in New York City, USA, and holds both American and British citizenships. He received his doctoral degree in physiological psychology from McGill University, Canada in 1967. After that, he moved to England for postdoctoral training at University College London. He has remained at University College and was appointed Professor of Cognitive Neuroscience in 1987. Dr. O’Keefe is currently Director of the Sainsbury Wellcome Centre in Neural Circuits and Behaviour at University College ­London.

May-Britt Moser was born in Fosnavåg, Norway, in 1963 and is a Norwegian citizen. She studied psychology at the University of Oslo together with her future husband and co-Laureate Edvard Moser, PhD. She received her PhD in neurophysiology in 1995. She was a postdoctoral fellow at the University of Edinburgh and subsequently a visiting scientist at University College London before moving to the Norwegian University of Science and Technology in Trondheim in 1996. Dr. May-Britt Moser was appointed Professor of Neuroscience in 2000 and is currently Director of the Centre for Neural Computation in Trondheim.

Edvard I. Moser, PhD, was born in 1962 in Ålesund, Norway, and has Norwegian citizenship. He obtained his PhD in neurophysiology from the University of Oslo in 1995. He was a postdoctoral fellow together with his wife and coLaureate MayBritt Moser, PhD, first at the University of Edinburgh and later as a visiting scientist in Dr.  O’Keefe’s laboratory in London. In 1996, they moved to the Norwegian University of Science and Technology in Trondheim, where Dr. Edvard Moser became Professor in 1998. He is currently Director of the Kavli Institute for Systems Neuroscience in Trondheim. ■