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colorectal cancer

Increased Travel Burden Decreases Likelihood of Receiving Radiation Therapy for Rectal Cancer Treatment

Increased travel distance to a cancer treatment facility negatively impacts the likelihood that patients with stage II/III rectal cancer will receive radiation therapy to treat their disease, according to a study analyzing 26,845 patient records from the National Cancer Data Base (NCDB) published...

solid tumors

Modified CAR T Cells Overcome Immune Suppression, Effective Against Solid Tumors in Preclinical Models

Adding a genetically engineered “switch receptor” to second-generation CAR T cells blocked PD-1–mediated immune suppression, and made the immunotherapy effective against solid tumors in preclinical models, according to a study published by Liu et al in Cancer Research....

issues in oncology

Closing the Clinical Trial Gap for Adolescents and Young Adults With Cancer

Although overall survival rates for patients with cancer continue to soar—with 14.5 million cancer survivors today1—most of that gain is among pediatric and older adult patients. For adolescents and young adults with cancer—defined by the National Cancer Institute (NCI) as those in the 15- to...

Lauren Streicher, MD, Announced as Medical Director for Northwestern Medicine’s Upcoming Center for Sexual Health

Northwestern Medical Group recently announced that ­Lauren Streicher, MD, will be joining Northwestern Medicine in Chicago. Dr. Streicher is a clinical leader in gynecology, a published author, and a trusted medical contributor for many local and national media outlets. In her new role, Dr....

ASTRO Expands Its Advocacy and Government Relations Team With New Assistant Director

The American Society for Radiation Oncology (ASTRO) recently welcomed Stephanie Quinn as its Assistant Director of Congressional Relations, a key position on the Society’s government relations and advocacy team. As ASTRO’s chief liaison to Capitol Hill, Ms. Quinn will lead efforts to educate...

hematologic malignancies

2016 ASH-AMFDP Scholars to Study Malaria, Immunotherapy for Hematologic Malignancies

The American Society of Hematology (ASH) is pleased to announce that Natasha Archer, MD, MPH, of Dana-Farber/Boston Children’s Cancer and Blood Disorders Center, and Rayne Rouce, MD, of Baylor College of Medicine, have been selected to participate in the American Society of Hematology-Harold Amos...

issues in oncology

Is This the Dawn of Cancer Biosimilars?

The Patient Protection and Affordable Care Act, signed into law in 2010, did more than make it possible for millions of Americans to afford health care; it also established an abbreviated approval pathway for biologic products that are “biosimilar” to, or shown to be “interchangeable” with, a U.S....

Study Finds Correlation Between Number of Drug Suppliers and Drug Shortages

Astudy published in the Journal of Oncology Practice1 found that individual drugs with fewer suppliers were associated with an increased likelihood of shortages compared to drugs with a large number of suppliers. The article titled, “Association between the Number of Suppliers for Critical...

Conquering Cancer With Dr. Kim

There are many different ways to treat cancer: surgery, radiation therapy, chemotherapy, and more, sometimes used alone and sometimes in combination. But, in certain circumstances, the best treatment option for a patient may not look much like treatment at all. Instead of attempting to eliminate...

ASCO University® Launches New Certificate Programs for Advanced Practitioners

The role of advanced practitioners in oncology is growing as the demand for team-based care increases—and with that growth comes a need for training materials specifically tailored to this group. ASCO University®, ASCO’s home for lifelong learning, has collaborated with the Association of Physician ...

Direct Your Patients to Cancer.Net for Patient-Friendly Videos

Check out some of the newest Cancer.Net patient-friendly videos produced by ASCO. New topics include an introduction to sarcoma, brain tumors, and managing the side effects of chemotherapy. These videos give people with cancer and their families and friends an additional option for receiving...

2016 Pre–Annual Meeting Educational Programs Feature Important Topics for Modern Cancer Care Providers

For oncology professionals looking to maximize their learning and networking opportunities, ASCO will be offering two types of Pre–Annual Meeting Educational Programs ahead of its 2016 Annual Meeting in Chicago this summer. Offered since 2012, Pre–Annual Meeting Seminars are a series of in-depth...

survivorship

Cancer Survivorship Research: Learning From the Past to Improve Future Outcomes

Soon after effective therapies for some childhood malignancies were first identified, early leaders in our field had concerns about what would happen to surviving patients as they aged. In 1975, Giulio D’Angio, MD, one of the founders of modern pediatric radiation oncology, presciently called for...

Two Fellows Selected for ASCO’s Inaugural Health Policy Fellowship Program

ASCO has announced the two physicians selected for its new Health Policy Fellowship, which kicked off this past October. Robert M. Daly, MD, and Steve Y. Lee, MD, will be the fellows for the inaugural class, which runs from July 1, 2016, to July 1, 2017. The program, aimed at oncologists in the...

Douglas A. Levine, MD, FACOG, FACS, Appointed Director of Gynecologic Oncology at NYU Langone

Douglas A. Levine, MD, FACOG, FACS, will join the faculty of NYU Langone Medical Center as Director of the Division of Gynecologic Oncology at its Laura and Isaac Perlmutter Cancer Center and the Department of Obstetrics and Gynecology, effective May 15, 2016. Dr. Levine brings an exceptional...

Robert Seeger, MD, Awarded Lifetime Achievement Award From Pediatric Blood and Marrow Transplant Consortium

Robert Seeger, MD, Division Head for Basic and Translational Research of the Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles (CHLA), has been selected for the 2016 Lifetime Achievement Award from the Pediatric Blood and Marrow Transplant Consortium (PBMTC). As the eighth...

Laurie H. Glimcher, MD, Named President of Dana-Farber Cancer Institute

Laurie H. Glimcher, MD, an internationally recognized immunologist, has been named the next president and CEO of the Dana-Farber Cancer Institute. Dr. Glimcher is currently the Stephen and Suzanne Weiss Dean of the Medical College at Weill Cornell Medicine in New York, where she is also Professor...

Expert Point of View: David Raben, MD

“As radiation oncologists, we have pushed some important envelopes to try to mitigate long-term toxicity,” said David Raben, MD, Professor of Radiation Oncology at the University of Colorado Cancer Center, Aurora, Colorado. “We’ve been able to utilize intensity-modulated radiation techniques to...

head and neck cancer

Late Toxicity Improved With Response-Adapted Volume De-escalation in Locally Advanced Head and Neck Cancer

Efforts to reduce the late toxicity associated with chemoradiotherapy for locally advanced head and neck squamous cell cancer have focused on radiation therapy dose de-escalation in select populations, according to James Melotek, MD, a radiation oncologist at the University of Chicago. “Patients...

hepatobiliary cancer

Annual Report Cites Continued Decline in Most Cancer Mortality but Trends Toward Increased Liver Cancer Incidence, Mortality

Earlier this month, experts from four major institutions issued the annual Report to the Nation on the Status of Cancer (1975–2012). This year’s report showed that death rates continued to decline for all cancers combined, as well as for most cancer sites for men and women of all major racial and...

lymphoma

FDA Approves Obinutuzumab in Follicular Lymphoma

The U.S. Food and Drug Administration (FDA) has approved obinutuzumab (Gazyva), an anti-CD-20 monoclonal antibody, for use in combination with bendamustine (Bendeka, Treanda) followed by obinutuzumab monotherapy for the treatment of patients with follicular lymphoma who relapsed after, or are...

solid tumors

FDA Approves Everolimus for Neuroendocrine Tumors of GI or Lung Origin

The U.S. Food and Drug Administration (FDA) has approved everolimus (Afinitor), an mTOR inhibitor, for the treatment of adult patients with progressive, well-differentiated nonfunctional neuroendocrine tumors of gastrointestinal (GI) or lung origin with unresectable, locally advanced, or metastatic ...

lung cancer

FDA Approves Crizotinib for ROS1-Positive Metastatic Non–Small Cell Lung Cancer

The U.S. Food and Drug Administration has approved the tyrosine kinase inhibitor crizotinib (Xalkori) for the treatment of patients with metastatic non–small cell lung cancer (NSCLC) whose tumors are ROS1-positive. Crizotinib was first approved in 2011 for the treatment of patients whose tumors are ...

SSO 2016: Largest Surgical Oncology Conference Yet

The Society of Surgical Oncology (SSO) Annual Cancer Symposium is not only the largest surgical oncology conference in the world, but the 69th meeting, recently held in Boston, is the group’s largest ever, according to SSO Past President Jeffrey A. Drebin, MD, PhD, the John Rhea Barton Professor...

symptom management

Phone Triage System Offers Potential to Reduce Patient Visits to the Emergency Department for Cancer Treatment–Related Symptoms

A quality improvement initiative to reduce the reliance of patients on visits to the emergency department for treatment of side effects related to cancer treatment was reported to be highly effective, according to early findings from a new study. 1 The strategy, involving a telephone triage...

issues in oncology

Update on CancerLinQ: A Rapid Health-Care Learning System

On March 26, 2013, ASCO announced that it had completed a prototype of CancerLinQ™, the Society’s groundbreaking health information–technology initiative to achieve higher quality, higher value cancer care with better outcomes for patients. At this year’s 2016 ASCO Quality Care Symposium, Robert S. ...

symptom management

Anticoagulation in Patients With Cancer: Understanding the Complexities of Prophylaxis and Management

Venous thromboembolic events are more prevalent in patients with cancer than in persons without it. Cancer is associated with a high rate of venous thromboembolism recurrence, bleeding, requirement for long-term anticoagulation, and reduced quality of life. Moreover, thrombosis is the second most...

leukemia

Chronic Lymphocytic Leukemia: The Golden Drug Only for Golden Agers?

As reviewed in this issue of The ASCO Post, Burger and colleagues recently reported findings of the RESONATE-2 trial of ibrutinib (Imbruvica) vs chlorambucil (Leukeran) as initial therapy for elderly patients with chronic lymphocytic leukemia (CLL).1 The study met its primary endpoint of...

symptom management

Neurofeedback Reduces Pain, Increases Quality of Life for Cancer Patients Suffering From Chemotherapy-Induced Neuropathy

A new study from The University of Texas MD Anderson Cancer Center evaluating the use of neurofeedback found a decrease in the experience of chronic pain and an increase in quality of life among patients with neuropathic pain. The study was presented at the annual meeting of the American...

gynecologic cancers

SGO 2016: Advanced Ovarian Cancer Caused by Genetic Mutations Linked to Better PFS and OS Following Treatment Including Bevacizumab

Women with advanced ovarian cancer caused by genetic mutations—including in BRCA1 and BRCA2—lived significantly longer than those who did not have a mutation following treatment with a chemotherapy regimen that included bevacizumab (Avastin). According to a study, those with BRCA1 and a ...

issues in oncology

Global Perspectives on the Integration of Biosimilars Into Oncology Practice

Dr. Robert Rifkin, Medical Director of Biosimilars at US Oncology Research, moderates a roundtable discussion on Global Perspectives on the Integration of Biosimilars into Oncology Practice, held in conjunction with the 2015 American Society of Hematology Annual Meeting in Orlando, Florida....

breast cancer
leukemia
lung cancer

Specific Form of CYP3A7 Gene Associated With Poor Outcomes for Patients With Several Cancer Types

Among patients with breast cancer, lung cancer, or chronic lymphocytic leukemia (CLL), those who had a specific form of the CYP3A7 gene (CYP3A7*1C) had worse outcomes compared with those who did not have CYP3A7*1C. This may be related to how the patients metabolize the therapeutics used to treat...

breast cancer

Processed Meat Consumption May Increase Risk of Breast Cancer for Latinas

Latinas who eat processed meats such as bacon and sausage may have an increased risk for breast cancer, according to a new study that did not find the same association among white women. The study, published by Kim et al in Cancer Causes & Control, suggests that race, ethnicity, genetics,...

lung cancer

Dietary Glycemic Index Linked to Lung Cancer Risk in Non-Hispanic White Populations

Consuming a diet with a high glycemic index was independently associated with an increased risk of developing lung cancer in non-Hispanic whites, according to a new epidemiologic study from The University of Texas MD Anderson Cancer Center. This research, published by Melkonian et al in Cancer...

colorectal cancer

Laboratory Study Explores How High-Fat Diet Influences the Development of Intestinal Tumors

A study published by Beyaz et al in Nature reveals how a high-fat diet makes the cells of the intestinal lining more likely to become cancerous. It joins a growing body of research that finds obesity and eating a high-fat, high-calorie diet are significant risk factors for many types of cancer....

breast cancer
supportive care

Study Finds Many Patients With Breast Cancer Develop Symptoms of Post-Traumatic Stress Disorder; Symptoms Diminished Over 1 Year

According to a study led by Ludwig-Maximilians-Universitaet (LMU) researchers, a majority of patients diagnosed with breast cancer go on to develop symptoms of post-traumatic stress disorder, and in most of these cases, symptoms persist for at least a year. These findings were published by Voigt et ...

issues in oncology

Study Evaluates Patient/Oncologist Perceptions of Whole-Exome Sequencing in Advanced Cancer

A majority of people with advanced cancer want to hear findings from DNA sequencing and to learn how those results may affect their health and treatment options, Dana-Farber Cancer Institute scientists report. Their findings were reported by Gray et al in Genetics in Medicine. The discovery...

issues in oncology

ASCO Report Finds U.S. Cancer Care System Ill-Equipped to Deliver New Advances to Patients

As the nation embarks on an ambitious “moonshot” to accelerate progress against cancer, our system for delivering today's cancer treatments must be better prepared to bring advances to all patients, warns a new report from ASCO. The State of Cancer Care in America: 2016, published...

breast cancer
lymphoma

Early MRI Screening Reduces Risk of Breast Cancer Death for Survivors of Childhood Hodgkin Lymphoma

Researchers at Princess Margaret Cancer Centre have confirmed in a screening effectiveness study that early screening with magnetic resonance imaging (MRI) can reduce breast cancer mortality for female survivors of childhood Hodgkin lymphoma who received chest radiation. The findings published by...

breast cancer

Single Dose of Trastuzumab Kickstarts Immune Response in Certain Breast Cancers

A tumor’s immune response to a single dose of the HER2 inhibitor trastuzumab (Herceptin) predicted which patients with HER2-positive breast cancer would respond to the drug on a more long-term basis, according to the results of a study published by Varadan et al in Clinical Cancer Research....

lung cancer

FDA Approves Crizotinib for ROS1-Positive Metastatic NSCLC

The U.S. Food and Drug Administration today approved the tyrosine kinase inhibitor crizotinib (Xalkori) for the treatment of patients with metastatic non–small cell lung cancer (NSCLC) whose tumors are ROS1-positive. Crizotinib was first approved in 2011 for the treatment of patients...

cns cancers

Combination Therapy May Be Better Than Radiotherapy Alone to Treat Aggressive Brain Cancer, According to Early Study

Radiotherapy effectively damages brain tumors, but the cancer cells can repair themselves in order to live on. Now, researchers at Sidney Kimmel Cancer Center at Thomas Jefferson University have tested a strategy that combines radiotherapy with a drug that shuts down the ability of tumor to mend...

head and neck cancer
gastroesophageal cancer

Researchers Find Possible Association Between Oral Bacteria and Esophageal Cancer

University of Louisville School of Dentistry researchers have found that a bacterial species responsible for gum disease, Porphyromonas gingivalis, is present in 61% of patients with esophageal squamous cell carcinoma. The findings, published by Gao et al in Infectious Agents and Cancer, only...

U.S. Senate Confirms Robert M. Califf, MD, as FDA Commissioner

On February 24, 2016, Stephen Ostroff, MD, Acting Director of the U.S. Food and Drug Administration (FDA) issued a statement to announce that the U.S. Senate voted in support of the confirmation of Robert M. Califf, MD, to be Commissioner FDA. In the statement, Dr. ­Ostroff said, “Dr. Califf has...

breast cancer

A TV Host’s Breast Cancer Survival Story

Bookmark Title: Had I Known: A Memoir of SurvivalAuthor: Joan Lunden with Laura MortonPublisher: Harper CollinsPublication date: September 2015Price: $26.99; hardcover, 336 pages In 1974, several weeks after Betty Ford became the nation’s First Lady, she underwent a mastectomy for breast cancer....

Questions From Younger Patients About Colorectal Cancer Should Be Addressed Promptly

A study in Cancer1 finding an increasing rate of colorectal cancer among patients under the age of 50 should serve to raise awareness about the need for testing among those with “red-flag” symptoms and earlier screening for those at high risk, the study’s corresponding author, Samantha Hendren, MD, ...

gastrointestinal cancer

‘Red-Flag’ Symptoms That Could Signal Colorectal Cancer in Patients Under 50 Years Old Should Be Taken Seriously

In clinical practice, Samantha Hendren, MD, MPH, has been “shocked by what a large proportion of patients we are seeing who are under 50 and presenting with colorectal cancer,” often with advanced disease due to delayed diagnosis. “And that is because patients and physicians don’t even think of...

Cancer MoonShot 2020 Announces the Formation of a National Pediatrics Consortium

Cancer MoonShot 2020 has announced the formation of the Pediatrics Consortium focused on bringing the promise of combined immunotherapy as the next-generation standard of cancer care to children diagnosed with the disease. With leadership at Phoenix Children’s Hospital helping to initiate this...

symptom management

Selected Abstracts From 2015 ASH Annual Meeting: Part 3

Here are several more abstracts selected from the proceedings of the 2015 American Society of Hematology (ASH) Annual Meeting and Exposition, focusing on the topic of anticoagulation and the cancer patient. For other selected abstracts from this conference, see the December 25, 2015, and the...

Keith Hanson McGregor, PhD, Appointed New ESMO CEO

The European Society for Medical Oncology (ESMO) has announced the appointment of Keith Hanson McGregor, PhD, as its new CEO. Dr. McGregor is currently ­ESMO’s Chief Operating Officer. Dr. McGregor joined ESMO in 2009 as Senior Director of a newly formed Business Division, in charge of developing...

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