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Cancer Cured My Life

The following essay by Richard M. Levine, MD, is adapted from The Big Casino: America’s Best Cancer Doctors Share Their Most Powerful Stories, which is coedited by Stan Winokur, MD, and Vincent Coppola and published in May 2014. The book is available on Amazon.com and the bigcasino.org. I’m a...

solid tumors

Engaging Clinicians in the Collection of Cancer Registry Data to Improve Clinical Research

In June, the Commission on Cancer of the American College of Surgeons published a revision of its Facility Oncology Registry Data Standards (FORDS) manual, which contains all the data items, codes, and rules to abstract data into cancer registries at the more than 1,500 Commission on...

issues in oncology

The Importance of Supporting the Role of Women Leaders in Oncology

I am honored to be the 52nd President of ASCO and thrilled to have followed in the steps of six remarkable women to hold this important leadership position in a professional Society that represents nearly 40,000 oncologists around the world caring for people with cancer. My six female predecessors...

cns cancers

Pilot Study: Research Team Used Focused Ultrasound to Open Blood-Brain Barrier in Patient With Malignant Brain Tumor

A team at Sunnybrook Health Sciences Centre in Toronto has used focused ultrasound to enable temporary and targeted opening of the blood-brain barrier, allowing the more effective delivery of chemotherapy into a patient’s malignant brain tumor. This is the first known report of the noninvasive...

issues in oncology

ASCO Launches TAPUR to Assess the Off-Label Use of Targeted Therapies for Patients With Advanced Cancers

Two years ago, Richard L. ­Schilsky, MD, FACP, FASCO, Chief Medical Officer of ASCO, proposed a unique clinical trial concept during an educational session on the challenges of delivering precision medicine services in a community setting at ASCO’s Annual Meeting. The idea was to design a clinical...

sarcoma

Trabectedin in Unresectable or Metastatic Liposarcoma or Leiomyosarcoma

In the Clinic provides overviews of novel oncology agents, addressing indications, mechanisms, administration recommendations, safety profiles, and other essential information needed for the appropriate clinical use of these drugs. On October 23, 2015, trabectedin (Yondelis) was approved for the...

head and neck cancer

The Role of Botulinum Toxin in Head and Neck Cancer

Head and neck cancer and its treatment can result in a variety of neuromuscular and musculoskeletal pain and functional sequelae. Commonly seen conditions in patients with the disease include neck pain and spasm, hemifacial spasm, trismus, dysphonia, dysarthria, neuropathic pain, and salivary...

American Board of Internal Medicine Names Richard G. Battaglia, MD, FACP, Chief Medical Officer

The American Board of Internal Medicine (ABIM) announced that Richard G. Battaglia, MD, FACP, has joined the senior leadership team of the organization and will serve as Chief Medical Officer, leading ABIM’s effort to incorporate feedback from practicing physicians and key stakeholders into...

lung cancer

Checkmate 057: Nivolumab Improves Survival vs Docetaxel  in Advanced Nonsquamous Non–Small Cell Lung Cancer

In the phase III CheckMate 057 trial, reported in The New England Journal of Medicine by Hossein Borghaei, DO, of Fox Chase Cancer Center, and colleagues, the programmed cell death protein 1 (PD-1) inhibitor nivolumab (Opdivo) improved overall survival vs docetaxel in patients with advanced...

integrative oncology

Graviola

The use of dietary supplements by patients with cancer has increased significantly over the past 25 years despite insufficient evidence of safety and effectiveness. Finding reliable sources of information about dietary supplements can be daunting. Patients typically rely on family, friends, and the ...

A Shrink Tells the Inside Story of Psychiatry

Bookmark Title: Shrinks: The Untold Story of PsychiatryAuthor:   Jeffrey A. Lieberman, MD, with Ogi OgasPublisher: Little, Brown and CompanyPublication date: March 10, 2015Price: $28.00, hardcover; 352 pages Jeffrey A. Lieberman, MD, is the Lawrence C. Kolb Professor and Chairman of Psychiatry at...

solid tumors
kidney cancer

Changing Landscape in the Treatment of Metastatic Renal Cell Carcinoma: Findings With Nivolumab and Cabozantinib

In the October 25 issue of The ASCO Post, we presented two important studies in previously treated advanced renal cell carcinoma, including the paper by Motzer et al “Nivolumab versus everolimus in advanced renal-cell carcinoma” (CheckMate 025), published in The New England Journal of Medicine,...

lung cancer

Updated Guidelines for Treating Stage IV NSCLC: Trying to Keep Up

In late August 2015, Gregory A. Masters, MD, and colleagues published an update to the ASCO guidelines for systemic therapy for stage IV non–small cell lung cancer (NSCLC), summarized in this issue of The ASCO Post.1 This builds on the full guidelines published in 20092 and the additional switch...

issues in oncology

ACS Breast Cancer Screening Guidelines: Balancing the Benefits and Harms of Mammography

For the past 30 years, mammography screening has been one of the most contentious issues in medicine. Controversy has generally centered on the age at which to begin mammography screening (40 vs 50 years) and also, to a lesser extent, on the age at which it should stop. The recent American Cancer...

breast cancer
issues in oncology

Getting the Content and the Message Right in Breast Cancer Screening Guidelines

According to recent national headlines, the American Cancer Society (ACS) now recommends that women at average risk of breast cancer should “screen later and less often.”1 While the new ACS recommendations (summarized in this issue of The ASCO Post) might initially be taken as casting doubt on the...

breast cancer
issues in oncology

ACS Guideline Update on Breast Cancer Screening for Women at Average Risk

As reported in JAMA by Kevin C. Oeffinger, MD, of Memorial Sloan Kettering Cancer Center, New York, and colleagues, the American Cancer Society (ACS) has issued an update to its 2003 guideline on breast cancer screening for women at average risk of breast cancer.1 Robert A. Smith, PhD, of the...

How QOPI® Is Improving Oncology Care

Launched in 2002 as a pilot program to promote excellence in oncology care, the origins of ASCO’s Quality Oncology Practice Initiative (QOPI®) date as far back as 1997, when the Institute of Medicine (IOM) created a National Cancer Policy Board to assess the state of cancer care in the United...

New ASCO Answers Guide to Caregiving

This new ASCO Answers guide helps family caregivers better understand their role in the cancer care team. While there is no one way to be a caregiver, ASCO Answers: Caregiving is designed to help caregivers provide ongoing support as the person with cancer’s needs change. In addition to providing...

Applications Open for ASCO’s New Policy Fellowship Program

On October 15, ASCO launched a new fellowship program aimed at providing physicians with the necessary skills to shape cancer policy. ASCO is actively recruiting oncologists in the early phase of their careers that have leadership, civic, policy, or advocacy experience, and a keen interest in...

The Bridge Project Receives $20 Million Gift From the Commonwealth Foundation for Cancer Research

The Commonwealth Foundation for Cancer Research has pledged $20 million to the Bridge Project, a collaborative research program of the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology (MIT) and Dana-Farber/Harvard Cancer Center (DF/HCC), to accelerate the...

City of Hope Announces New Appointments

City of Hope in Duarte, California, recently announced the following new appointments. Susanne G. Warner, MD Dr. Warner has been appointed Assistant Clinical Professor in the Department of Surgery. She received her medical degree from Texas A&M Health Science Center College of Medicine, where...

skin cancer

Talimogene Laherparepvec for Treatment of Unresectable Cutaneous, Subcutaneous, and Nodal Melanoma Lesions

In the Clinic provides overviews of novel oncology agents, addressing indications, mechanisms, administration recommendations, safety profiles, and other essential information needed for the appropriate clinical use of these drugs. On October 27, 2015, talimogene laherparepvec (Imlygic) was...

skin cancer

Ipilimumab in Adjuvant Treatment of Cutaneous Melanoma With Nodal Involvement

In the Clinic provides overviews of novel oncology agents, addressing indications, mechanisms, administration recommendations, safety profiles, and other essential information needed for the appropriate clinical use of these drugs. On October 28, 2015, ipilimumab (Yervoy) was approved for adjuvant ...

ASH Honors Nancy Speck, PhD, and Karl Welte, MD, With 2015 Henry M. Stratton Medal

The American Society of Hematology (ASH) will recognize Nancy Speck, PhD, of the University of Pennsylvania Perelman School of Medicine, and Karl Welte, MD, of Hannover Medical School, with the 2015 Henry M. Stratton Medal for their seminal contributions in the areas of basic and...

issues in oncology

Alfred Goldberg, PhD, and Paul Richardson, MD, to Present 2015 ASH Ernest Beutler Lecture

The American Society of Hematology (ASH) will honor Alfred Goldberg, PhD, of Harvard Medical School, and Paul Richardson, MD, of Dana-Farber Cancer Institute, with the 2015 Ernest Beutler Lecture and Prize for their significant research advances in the area of proteasome inhibitors and their...

hematologic malignancies

The State of Progress in Hematologic Malignancies

The number of targeted therapies approved by the U.S. Food and Drug Administration (FDA) in the treatment of a variety of cancers, especially hematologic malignancies, continues to rise. In 2014 alone, 4 of the 10 new agents directed at discrete molecular targets approved by the FDA were for blood...

solid tumors
colorectal cancer

Oncologists Encouraged to Learn More About Lesser-Known Heritable Gastrointestinal Cancers

The genetic basis for inherited colorectal cancer is proving to be a much bigger and more complicated “pie” than was appreciated just a few years ago, according to Michael Hall, MD, Director of Gastrointestinal Risk Assessment at Fox Chase Cancer Center, Philadelphia. “With next-generation...

issues in oncology
cost of care

Centers for Medicare & Medicaid Services Releases 2016 Medicare Physician Fee Schedule: Impact on Radiation Oncology

The final 2016 Medicare Physician Fee Schedule released October 30, 2015, by the Centers for Medicare & Medicaid Services (CMS) included cuts to radiation oncology clinics that were slightly less severe than anticipated, according to a news release issued by the American Society for Radiation...

ASH Announces Stephen S. Chung, MD, as Inaugural Jake Wetchler Foundation ASH Scholar for Pediatric Innovation Recipient

The American Society of Hematology (ASH) recently announced that Stephen S. Chung, MD, will receive the inaugural Jake Wetchler Foundation ASH Scholar Award for Pediatric Innovation for his research on the mechanisms of bone marrow failure syndromes. This work could ultimately lead to an improved...

cns cancers

Actionable Targets Identified in Brain Metastases

New research shows that paired primary tumor and brain metastases share a common ancestor, but as the metastases develop in the brain, they exhibit novel genetic alterations that can activate a number of signaling pathways. More than half of the mutations represent potential therapeutic targets....

breast cancer
kidney cancer
prostate cancer
skin cancer

Quick Takes From ECC 2015 Include New Data in Melanoma, Prostate and Breast Cancers, and Renal Cell Carcinoma

The 2015 European Cancer Congress (ECC), held recently in Vienna, represented the combined efforts of the European Cancer Organisation (ECCO), the European Society for Medical Oncology (ESMO), and other partner organisations, constituting the largest European platform for oncology education. At...

gastroesophageal cancer

Evidence Mounts for Less-Intense Chemoradiation Therapy for Low-Risk Oropharyngeal Cancer

A new study shows that deintensification of chemoradiation therapy translates to excellent pathologic complete response rates in low-risk human papillomavirus (HPV)-associated oropharyngeal cancer.1 Patient-reported outcomes showed that side effects declined after 8 weeks. The hope is that these...

Howard Hochster, MD, Named President-Elect of ISGIO

The International Society of Gastrointestinal Oncology (ISGIO) has named Howard Hochster, MD, as President-Elect. Dr. Hochster, Professor of Medical Oncology; Associate Director for Clinical Sciences at Yale Cancer Center; and Director of the Gastrointestinal Cancers Program at Smilow Cancer...

Kara Kelly, MD, Will Head Joint Pediatric Hematology/Oncology Program at Roswell Park and Three Other Buffalo Institutions

Kara Kelly, MD, has been appointed as the new leader of the joint program in pediatric hematology/oncology, a partnership of Women & Children’s Hospital of Buffalo (WCHOB), Roswell Park Cancer Institute (RPCI), UBMD Pediatrics, and the University at Buffalo (UB). WCHOB, RPCI, and UB have...

cns cancers

Study Lowers the Age Bar for Radiation in Children With Ependymoma

The good news is that children as young as 1 year old with the aggressive brain tumor ependymoma can be treated safely and effectively with immediate postoperative radiation therapy, according to the results of a trial presented at the 2015 ASTRO Annual Meeting.1 “Ependymoma is the third most...

Expert Point of View: David Beyer, MD

In an interview with The ASCO Post, incoming ASTRO President David Beyer, MD, provided his perspective on the use of hypofractionation in prostate cancer. Dr. Beyer is Medical Director of the Cancer Centers of Northern Arizona in Sedona. “Fractionation has been an important topic over the past few...

Preston Robert Tisch Brain Tumor Center at Duke Receives $7 Million Outstanding Investigator Award

The Preston Robert Tisch Brain Tumor Center at Duke has received nearly $7 million in funding under the National Cancer Institute’s (NCI) Outstanding Investigator Award program for work on two novel immunotherapy approaches to treat brain tumors. The award recognizes the work of principal...

prostate cancer

Genomic Test Identifies Patients With Prostate Cancer in Need of Intensified Salvage Therapy

Prostate cancer has been slow to catch up with breast cancer in terms of using biomarkers, but a new study represents progress in this regard. A genomic classifier called Decipher® provides important information that can be used to make treatment decisions for men with prostate cancer and a rising...

leukemia

Changing the Outlook for Chronic Lymphocytic Leukemia

Small-molecule inhibitors, especially ibrutinib (Imbruvica) and idelalisib (Zydelig), have greatly changed the outlook for patients with chronic lymphocytic leukemia. William G. Wierda, MD, PhD, Professor and Center Medical Director in the Department of Leukemia at The University of Texas MD...

Antoni Ribas, MD, PhD, Receives NCI Outstanding Investigator Award

UCLA Jonsson Comprehensive Cancer Center member ­Antoni Ribas, MD, PhD, has received a National Cancer Institute (NCI) Outstanding Investigator Award of $4.2 million in recognition of his research conducted in the development of new immunotherapies that utilize the human body’s own natural defenses ...

hematologic malignancies

Genomics Now Driving Treatment of Waldenström’s Macroglobulinemia

The treatment of Waldenström’s macroglobulinemia has been greatly impacted by an understanding of its genomics, according to Steven P. Treon, MD, PhD, of Dana-Farber/Brigham and Women’s Cancer Center and Massachusetts General Hospital Cancer Center, Boston. Dr. Treon brought listeners up to date on ...

Expert Point of View: Clifford Hudis, MD

Discussant Clifford Hudis, MD, Chief, Breast Medicine Service at Memorial Sloan Kettering Cancer Center, New York, highlighted the obvious clinical advantages of APF530 over the current standard of care. “If this drug were simply the same in price and availability, why wouldn’t you use it? It’s...

breast cancer
supportive care

APF530 Superior to Ondansetron in Preventing Chemotherapy-Induced Nausea or Vomiting

As part of a three-drug regimen, APF530 (extended-release formulation of granisetron) has become the first 5-HT3 (5-hydroxytryptamine) receptor antagonist to demonstrate superiority over the standard of care for delayed nausea and vomiting after highly emetogenic chemotherapy. According to the...

Expert Point of View: Clifford Hudis, MD, Shanu Modi, MD, and Richard Gelber, PhD

Discussant Clifford Hudis, MD, Chief of Breast Medicine Service at Memorial Sloan Kettering Cancer Center, New York, highlighted neratinib’s benefits while also advocating caution in interpreting the results due to incomplete data, the serious side effect of diarrhea, and the potentially...

AACC Elects Michael J. Bennett, PhD, 2017 President, Names New Treasurer and Board Members

The American Association for Clinical Chemistry (AACC) has announced that Michael J. Bennett, PhD, has been elected to serve on the AACC Board as President-Elect beginning in January 2016, followed by successive terms as the Association’s 68th President in 2017 and Past President in 2018. The AACC...

Nationally Regarded Oncology Nurse Practitioner, Mary Pazdur, RN, MSN, Remembered by Friends and Colleagues

Oncology nurse practitioner Mary Pazdur, RN, MSN, spent her professional life bettering the clinical care and outcomes of cancer patients, culminating in her career at the National Cancer Institute (NCI), in the Laboratory of Tumor Immunology and Biology, working with patients on cancer vaccine...

One Long Shift With a Nurse on a Cancer Ward

Bookmark Title: The Shift: One Nurse, Twelve Hours, Four Patients’ Lives Author: Theresa Brown, RN Publisher: Algonquin Books Publication date: September 22, 2015 Price: $15.59; hardcover, 272 pages If health care were looked at through an architect’s eyes, nurses would be the girders holding the...

survivorship

Starting Over

My diagnosis of pleural mesothelioma early in 2015 couldn’t have been more surprising. In one day, I went from being a healthy, vibrant woman with a busy career and the excitement of launching a promising new business venture to a woman facing the greatest challenge of her life. The fact that my...

Mayo Clinic Names Bobbie Gostout, MD, Vice President

The Mayo Clinic Board of Trustees named Bobbie Gostout, MD, Vice President of the Mayo Clinic. Dr. Gostout will be the physician leader for Mayo’s community practice in the Midwest, including Mayo Clinic Health System in Iowa, Minnesota, and Wisconsin, and Mayo Clinic’s Minnesota-based community...

Elizabeth Blackburn, PhD, Named President of the Salk Institute

Elizabeth Blackburn, PhD, has been named President of the Salk Institute for Biological Studies. Dr. Blackburn will join the Salk Institute from the University of California, San Francisco (UCSF), where she is Professor in the Department of Biochemistry and Biophysics. She will assume her new role...

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