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NCI Awards $2 Million Grant to University of Pittsburgh School of Dental Medicine to Study How Cancer Spreads to Bone

With a $2 million, 5-year grant from the National Cancer Institute (NCI), researchers at the University of Pittsburgh School of Dental Medicine will examine the molecular mechanisms that allow certain cancers, particularly multiple myeloma, to spread to the bone. The project could lead to new...

In Memoriam: Kelly Traw

Regretfully, The ASCO Post has learned that Kelly Traw, 49, passed away on September 2, 2014, at Johns Hopkins Hospital in Baltimore. While her obituary did not mention a cause of death, it said that, “She will be greatly missed by her extended family and by the many friends who supported her...

AACR Honors Zhu Chen, MD, PhD, for Distinguished Public Service and Global Impact in Cancer Research

The American Association for Cancer Research (AACR) honored Zhu Chen, MD, PhD, with the 2014 AACR Award for Distinguished Public Service and Global Impact in Cancer Research in Biomedical Science at the AACR’s inaugural meeting in China, called New Horizons in Cancer Research: Harnessing...

A History of Medical Oncology

BOOKMARK Title: Therapeutic Revolution: The History of Medical Oncology From Early Days to the Creation of the SubspecialtyAuthor: Pierre R. BandPublisher: Bentham SciencePublication date: 2014Price: $39.00 (eBook); $78.00 (print on demand); 213 pagesAvailable at: eurekaselect.com   According to...

2014 Oncology Meetings

NOVEMBER Chemotherapy Foundation SymposiumNovember 4 - 8 • New York, New YorkFor more information:www.chemotherapyfoundationsymp-osium.org Diagnostic Error in Medicine 5th International ConferenceNovember 11-14 • Baltimore, MarylandFor more information:www.hopkinscme.edu/CourseDetail.aspx/80028747...

issues in oncology

Professional Associations Collaborate to Launch Stereotactic Radiosurgery Patient Registry

The American Association of Neurological Surgeons (AANS) and the American Society for Radiation Oncology (ASTRO) are partnering to launch and support a national registry for stereotactic radiosurgery (SRS) treatments. The partnership was announced recently at the ASTRO Annual Meeting. The SRS...

solid tumors

Nearly 800 New Cancer Medicines and Vaccines in Development, PhRMA Reports

America’s biopharmaceutical research companies are currently developing nearly 800 new medicines and vaccines for cancer, according to a report released recently by the Pharmaceutical Research and Manufacturers of America (PhRMA).1 Perseverance Needed “In recent decades, we have seen great progress ...

$1 Million Raised in Honor of 40th Anniversary of Milestone

Gifts totaling $1 million in honor of the 40th anniversary of the cure for testicular cancer were recently announced at a celebration for the physician scientist who developed the treatment. Family, friends, colleagues, and men grateful for their lives gathered at the Indianapolis Museum of Art to...

solid tumors

Treating Testicular Cancer in 2014

Testicular cancer is one of oncology’s true success stories. It is a highly treatable disease, usually curable, that most often develops in young and middle-aged men. Despite the success in testicular cancer, there are still clinical challenges ranging from staging to optimum therapeutic...

head and neck cancer

Adding Cetuximab to Chemoradiation Did Not Benefit Patients With Advanced Head and Neck Cancer: What Were the Reasons?

Two landmark randomized studies demonstrated improved survival of patients with head and neck cancer receiving the epidermal growth factor receptor (EGFR) antibody cetuximab (Erbitux) concurrent with radiotherapy compared with radiotherapy alone,1 and similar improvement in patients with...

cns cancers

MD Anderson Receives $5 Million Grant for Research in Glioblastoma

The Broach Foundation for Brain Cancer Research has made a $5 million commitment to support glioblastoma multiforme research at The University of Texas MD Anderson Cancer Center in Houston. James and Jamie Broach established the Broach Foundation in 2011, just months after Mr. Broach was diagnosed...

gynecologic cancers

NIH 2014 New Innovator Award Recipient Pamela Kreeger, PhD, to Study Metastasis in Ovarian Cancer

Pamela Kreeger, PhD, Assistant Professor of Biomedical Engineering at the University of Wisconsin-Madison, is among a group of researchers to receive a 2014 New Innovator Award from the National Institutes of Health. Dr. Kreeger will receive funding of nearly $2.3 million. She has chosen to study...

breast cancer

Variety of Adjuvant Strategies Explored in HER2‑Positive and Other Breast Cancer Types

Adjuvant trastuzumab (Herceptin) was shown to be effective in patients with breast cancers ≤ 2 cm, regardless of estrogen receptor status, in a meta-analysis1 of five chemotherapy trials, but a “pressing question” remaining is whether T1a/b, N0 tumors warrant the use of adjuvant trastuzumab, Andrew ...

breast cancer

For Triple-Negative Breast Cancer, Adding Carboplatin to Anthracycline/Taxane Produces Benefit, but How Much?

Combination chemotherapy for triple-negative breast cancer is anthracycline- and taxane-based and has not really changed much in the past 10 years, but “we are starting to see emerging data with selective activity of platinum agents,” Priyanka ­Sharma, MD, told participants at the Best of ASCO...

thyroid cancer

Lenvatinib Receives Priority Review Designation for Advanced Thyroid Cancer

The U.S. Food and Drug Administration (FDA) has given Priority Review designation to the New Drug Application for lenvatinib mesylate as a treatment for progressive radioactive iodine–refractory differentiated thyroid cancer. Lenvatinib is an oral multiple receptor tyrosine kinase inhibitor with a...

issues in oncology

E-Cigarettes Unhelpful in Smoking Cessation Among Patients With Cancer

In a new study of patients with cancer who smoke, those using e-cigarettes in addition to traditional cigarettes were more nicotine-dependent and equally or less likely to have quit smoking traditional cigarettes than nonusers.1 The rising use of e-cigarettes has raised many questions among...

prostate cancer

Peter Carroll, MD, MPH, Receives Grant for Early Detection of Prostate Cancer

The ZERO Cancer Research Fund has awarded the Jim Lafferty Memorial Research Grant in the amount of $45,000 to Peter Carroll, MD, MPH, of the University of California San Francisco, for the purpose of researching new and improved methods for early detection of prostate cancer. The grant is part of...

leukemia

Blinatumomab Receives FDA Priority Review Designation in Acute Lymphoblastic Leukemia

The U.S. Food and Drug Administration (FDA) has accepted for review Amgen’s Biologics License Application for blinatumomab for the treatment of adults with Philadelphia chromosome–negative relapsed/refractory B-precursor acute lymphoblastic leukemia (ALL). As part of the acceptance, the FDA granted ...

supportive care

FDA Approves Netupitant and Palonosetron Combination Capsule for Chemotherapy-Induced Nausea and Vomiting

The U.S. Food and Drug Administration (FDA) has approved a combination of netupitant and palonosetron (Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy. The new drug, also known as NEPA, is a fixed-combination capsule comprised of two agents: oral palonosetron, which ...

lymphoma

FDA Approves Bortezomib Injection for Previously Untreated Patients With Mantle Cell Lymphoma

The U.S. Food and Drug Administration (FDA) has approved bortezomib (Velcade) injection for previously untreated patients with mantle cell lymphoma. This is the first treatment in the United States to be approved for use in previously untreated patients with mantle cell lymphoma. Bortezomib was...

lung cancer
palliative care

Novel Oral Agent Treats Cachexia in Patients With Non–Small Cell Lung Cancer

For the first time, studies show that a drug is effective in treating several domains of cancer-related cachexia. Oral anamorelin increased lean body mass, achieved weight gain, and improved quality of life in patients with cancer-related cachexia in two pivotal phase III studies presented together ...

global cancer care

Women Underrepresented in Oncology Leadership Positions, Greek Survey Shows

A growing number of oncologists in Greece are female, but women continue to be underrepresented in leadership positions, according to a survey reported at the ESMO 2014 Congress. “In Greece, and across Europe, women oncologists still find it hard to access leadership or academic positions,” said...

issues in oncology

Practice-Changing Results at ESMO 2014

A record number of 19,859 attendees at the European Society for Medical Oncology (ESMO) 2014 Congress discussed changes to oncology that will soon have a positive impact on the care of patients around the world. “We are particularly pleased to see participants from 131 countries at the congress...

UCSF Study Finds $18 Billion Tobacco Toll in California, 2009

Smoking took an $18.1 billion toll in California in 2009—$487 for each resident—and was responsible for more than one in seven deaths in the state, more than from AIDS, influenza, diabetes, or many other causes, according to the first comprehensive analysis in more than a decade on the financial...

breast cancer

BRCA Mutations Found in Many Breast Tumors Called ‘ER-Positive’

BRCA mutations may occur in nearly one-third of breast cancer patients who would have been described as having triple-negative cancer except that their tumors express low levels of estrogen receptor, so the tumors are described as ER–low positive, according to researchers from The University of...

issues in oncology

Partnering With Community Centers to Advance Oncology Care

Last fall, Richard R. Barakat, MD, FACS, the Ronald O. Perelman Chair in Gynecologic Surgery at Memorial Sloan Kettering Cancer Center, was named to the new position of Deputy Physician-in-Chief for the Memorial Sloan Kettering Regional Care Network and Cancer Alliance, a new initiative meant to...

leukemia

Recent Reports and Perspectives on Chronic Lymphocytic Leukemia

Recent articles on developments and controversies in the treatment of chronic lymphocytic leukemia include the following features from The ASCO Post, which are also available at www.ascopost.com: “Recent FDA Approvals Foster Growing Treatment Armamentarium for Chronic Lymphocytic Leukemia and Rare ...

leukemia

Linking Biology and Therapy in Chronic Lymphocytic Leukemia

Recent discoveries in biology, therapy, and (most importantly) the interplay between these two have led to groundbreaking advances in chronic lymphocytic leukemia (CLL). These advances underline the impact of the “translational” approach to cancer management in general. Standard of Care...

More on Chemotherapy Costs

I took exception to a number of the comments made by Rena Conti, PhD, in The ASCO Post (“Health-Care Reform Is Changing the Oncology Landscape,” October 15, 2014, page 1). I realize that The ASCO Post is not a peer-reviewed and indexed publication, but as an ASCO member, I also recognize that the...

The 2014 Nobel Prize in Physiology or Medicine Awarded to John O’Keefe, PhD, and Jointly to May-Britt Moser, PhD, and Edvard I. Moser, PhD

The 2014 Nobel Prize in Physiology or Medicine has been awarded with one half to John O’Keefe, PhD, of University College London, and the second half jointly awarded to May-Britt Moser, PhD, and Edvard I. Moser, PhD, of the Norwegian University of Science and Technology in Trondheim, for their...

breast cancer

Impressive Survival Data for Women With HER2-Positive Breast Cancer Increase First-Line Use of Pertuzumab/Trastuzumab

"Impressive,” “outstanding,” and “unprecedented” are among the terms used to describe the 56.5-month overall survival for women with HER2-positive metastatic breast cancer receiving first-line treatment with pertuzumab (Perjeta) in combination with trastuzumab (Herceptin) and docetaxel in the...

Printed NCCN Guidelines for Patients Now Available Through Amazon.com

The National Comprehensive Cancer Network (NCCN), with the support of the NCCN Foundation, recently announced the availability of printed versions of the NCCN Guidelines for Patients for order on Amazon.com for the following cancer types: Breast (Stages 0–IV), Colon, and Pancreatic Cancers;...

issues in oncology
lymphoma

The Power of Laughter

The following essay by Julie Vose, MD, MBA, FASCO, is adapted from The Big Casino: America’s Best Cancer Doctors Share Their Most Powerful Stories (May 2014), coedited by Stan Winokur, MD, and Vincent Coppola. The book is available on Amazon.com and thebigcasino.org.   When I met Cindy, she was...

New James Cancer Hospital in Columbus, Ohio, Opening in December 2014

In December 2014, The Ohio State University Comprehensive Cancer Center, the James Cancer Hospital and Solove Research Institute will open the doors of a new 1.1 million square foot, 21-floor freestanding cancer hospital—making Columbus, Ohio, home to the third largest cancer hospital in the United ...

2014 Oncology Meetings

NOVEMBER EORTC-NCI-AACR International Symposium on Molecular Targets and Cancer TherapeuticsNovember 18-21 • Barcelona, SpainFor more information: www.aacr.org ESMO Symposium on Immuno-OncologyNovember 21-22 • Geneva, Switzerland For more information: www.esmo.org/Conferences/Immuno-Oncology-2014...

cns cancers

A Candidly Humorous Approach to the Cancer Journey

BOOKMARK Title: Shrinkage: Manhood, Marriage, and the Tumor That Tried to Kill MeAuthor: Bryan BishopPublisher: Thomas Dunne BooksPublication date: April 29, 2014Price: $25.99; hardcover, 336 pages   At 30 years old, Bryan Bishop was having the time of his life. Known to millions of radio fans as...

issues in oncology

A Father and Son’s Journey Through Medicine

BOOKMARK Title: The Good Doctor: A Father, a Son, and the Evolution of Medical EthicsAuthor: Barron H. Lerner, MDPublisher: Beacon PressPublication date: May 13, 2014Price: $25.95; hardcover, 240 pages   One morning in 1996, an infectious disease specialist was making rounds when he and his team...

Martine Extermann, MD, PhD, Honored at the International Society of Geriatric Oncology’s Annual Meeting in Portugal

Martine Extermann, MD, PhD, Senior Member of the Senior Adult Oncology and Health Outcomes & Behavior Programs at Moffitt Cancer Center, was the recipient of the 2014 Paul Calabresi Award. Named after the first president of the International Society of Geriatric Oncology (SIOG), the award...

Breast Cancer Researcher to Lead Radiation Oncology at IU School of Medicine

Richard C. Zellars, MD, from the Johns Hopkins University School of Medicine has been named Professor and Chair of Radiation Oncology at the Indiana University School of Medicine, pending approval by the Indiana Univerity trustees. He will begin his new duties in January. A breast cancer...

Institute of Medicine Elects 70 New Members, 10 Foreign Associates

The  Institute of Medicine (IOM) has announced the names of 70 new members and 10 foreign associates during its 44th Annual Meeting held in October.  Election to the IOM is considered one of the highest honors in the fields of health and medicine and recognizes individuals who have demonstrated...

Tina Lundgren Elected Chairman of the Ronald McDonald House New York Board of Directors

Ronald McDonald House® New York announced that Tina Lundgren has been elected to serve as Chairman of its Board of Directors. Mrs. Lundgren will succeed Stanley B. Shopkorn, Managing Director of Hilltop Park Associates LLC, who has served as chairman since 2006. Mrs. Lundgren will serve a 3-year...

2014 Ellen Stovall Award Presented to Giuliana Rancic, E! News Co-Anchor and Co-Host of The Fashion Police

As part of the Lilly Oncology On Canvas Art Competition, Lilly Oncology and the National Coalition for Cancer Survivorship created the Ellen Stovall Award in honor of Ellen Stovall, a tireless advocate for cancer survivors and former president and CEO of NCCS. The award recognizes those who use...

survivorship

Lilly Oncology On Canvas Art Competition Names 2014 Winners

The 10th anniversary of the Lilly Oncology On Canvas Art Competition was celebrated with the presentation of awards and display of winning entries on October 23 in New York’s Grand Central Terminal. The competition, which is presented by Lilly Oncology and National Coalition for Cancer Survivorship ...

lung cancer

ASCO Endorses CAP/IASLC/AMP Guidelines for Molecular Testing of Patients With Non–Small Cell Lung Cancer

Personalized medicine is an established treatment concept for patients with advanced non–small cell lung cancer (NSCLC), and molecular characterization of tumors is crucial for choice of (first-line) therapy. As of right now, we have U.S. Food and Drug Administration (FDA)-approved drugs for two...

Three Initiatives Together Form the Diversity Program Consortium

Building Infrastructure Leading to Diversity (BUILD)—BUILD is a set of experimental training awards designed to learn how to attract students from diverse backgrounds into the biomedical research workforce and encourage them to become future contributors to the NIH-funded research enterprise. The...

NIH Awards More Than $30 Million to Enhance Diversity in the Biomedical Research Workforce

The National Institutes of Health (NIH) announced the award of more than $30 million in fiscal year 2014 funds to develop new approaches that engage researchers, including those from backgrounds underrepresented in biomedical sciences, and prepare them to thrive in the NIH-funded workforce. These...

leukemia

From the Genome to the Bedside: New Treatment Options for Children and Young Adults With Philadelphia Chromosome–Like ALL

The outcome for adolescents and young adults with acute lymphoblastic leukemia (ALL) is inferior to that in children, and the outcome for children with ALL who experience relapse is dismal. Therefore, new therapeutic options are urgently needed to improve survival rates for this high-risk ALL...

issues in oncology
colorectal cancer

Half of Premature Colorectal Cancer Deaths Due to Socioeconomic Inequality

Half of all premature deaths from colorectal cancer (described as deaths in people ages 25 to 64) in the United States are linked to ethnic, socioeconomic, and geographic inequalities, and therefore could be prevented according to a new study by American Cancer Society researchers. The report,...

gastrointestinal cancer

The RAINBOW Trial: Dawn of a New Era in Upper Gastrointestinal Malignancies

As reviewed in this issue of The ASCO Post (page 155), the RAINBOW trial is an international phase III study demonstrating improved overall survival with ramucirumab (Cyramza) plus paclitaxel as second-line therapy for patients with advanced gastric/gastroesophageal junction adenocarcinoma over...

integrative oncology
pain management

Study Shows Integrative Medicine Can Relieve Pain and Anxiety for Cancer Inpatients

Researchers at The Penny George Institute for Health and Healing in Minneapolis have found that integrative medicine therapies can decrease pain and anxiety for hospitalized cancer patients. Their findings were published recently in the Journal of the National Cancer Institute Monographs.1...

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