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Showing 13051 - 13100Precision Medicine Clinical Trial for Metastatic Pancreatic Cancer Now Open at Multiple Sites
The first clinical trial to compare standard-of-care chemotherapy with molecularly tailored therapy (also known as precision medicine) for metastatic pancreatic cancer is now enrolling patients at multiple sites around the country. Patients who have been treated with one round of chemotherapy for...
AMA Announces Board of Trustees for 2016–2017
The American Medical Association (AMA) has introduced the 21 members of its Board of Trustees for the coming year, following elections held during the Annual Meeting of the AMA House of Delegates. Andrew W. Gurman, MD, an orthopedic hand surgeon, was sworn in as the 171st President of the AMA. In...
Use Questions From Patients to Help Them Make Informed Treatment Decisions
Recent reports about treatment options for patients with ductal carcinoma in situ, and the ensuing debate and comments played out in the media, may prompt increased questions from patients. A review summarizing data about these treatment options concluded that surgery and radiation therapy “remain...
Surgery and Radiation Therapy Remain Standard of Care for Managing Ductal Carcinoma in Situ
A review of more than 50 studies (many randomized controlled trials) concluded that surgery and radiation therapy “remain standard-of-care treatment options” in the management of ductal carcinoma in situ.1 The review continues the widely reported discussion on managing ductal carcinoma in situ,...
Taubman Prize Jointly Awarded to Suzanne L. Topalian, MD, and Jedd D. Wolchok, MD, PhD, for Groundbreaking Work in Cancer Immunotherapy
Two clinician-scientists whose groundbreaking work has shown how the human body’s own immune system can fend off cancer will share the 2016 $100,000 Taubman Prize for Excellence in Translational Medical Science, the University of Michigan’s A. Alfred Taubman Medical Research Institute announced....
Ohio State Names Timothy Pawlik, MD, MPH, PhD, Chair of Surgery and Chair for Cancer Research
The Ohio State University Wexner Medical Center has appointed a nationally recognized surgeon and liver cancer expert to lead its surgical and surgical oncology programs. Timothy Pawlik, MD, MPH, PhD, will be the Chair of the Medical Center’s Department of Surgery, as well as The Urban Meyer III...
Inside Knowledge From a Cancer Survivor
Curtis Pesmen is a well-regarded writer who has authored six books of nonfiction as well as numerous articles for publications such as Esquire and The New York Times. He also has served as founding editor of LIVESTRONG Quarterly and often speaks and writes on patient advocacy. Shortly after...
A Journalist’s Cancer Saga
Readers of the recently published memoir A Series of Catastrophes & Miracles: A True Story of Love, Science, and Cancer find out that the book has a happy ending on the cover page of chapter 1. Spoiler: I lived, writes the author, Mary Elizabeth Williams, an acclaimed journalist with a list...
An Exotic Journey Into Immunotherapy
In his new book, Sharks Get Cancer, Mole Rats Don’t: How Animals Could Hold the Key to Unlocking Cancer Immunity in Humans, James S. Welsh, MD, examines a wide array of animal and human biologic phenomena, searching for clues that might help us unlock the full power of the human immune system....
Newly Launched Genomic Data Commons to Facilitate Data and Clinical Information Sharing
The Genomic Data Commons (GDC), a unified data system that promotes sharing of genomic and clinical data among researchers, was launched on June 6 with a visit from Vice President Joe Biden to the operations center at the University of Chicago. An initiative of the National Cancer Institute (NCI),...
St. Jude Is First U.S. Children’s Hospital to Earn CAP ISO15189 Accreditation
The St. Jude Department of Pathology has received accreditation to the ISO15189 standard under the College of American Pathologists (CAP) 15189SM Accreditation Program. St. Jude is the first children’s hospital in the nation to be accredited under this program. The accreditation is based on the...
St. Jude Children’s Research Hospital Names Michael Dyer, PhD, Chair of Developmental Neurobiology
St. Jude Children’s Research Hospital has named Michael Dyer, PhD, Chair of the Department of Developmental Neurobiology. “A true visionary in his field, Dr. Dyer is a remarkable scientist who has worked tirelessly to unravel some of the long-held mysteries of childhood cancer,” said James R....
2016 Oncology Meetings
JULY The 5th International Inflammatory Breast Cancer ConferenceJuly 9-10 • Boston, MassachusettsFor more information:www.hmscmeregistration.org/events/breast-cancer-new-horizons-current-controversies/custom-21-857304c388f143b7840614d1bb151442.aspx 24th Biennial Congress of the European Association ...
Peter S. Conti, MD, PhD, Receives SNMMI 2016 Paul C. Aebersold Award for Outstanding Achievement in Basic Nuclear Medicine Science
Peter S. Conti, MD, PhD, Professor of Radiology, Pharmaceutical Sciences, and Biomedical Engineering, and Director of the Molecular Imaging Center at the Keck School of Medicine at the University of Southern California, has been named the 2016 recipient of the prestigious Paul C. Aebersold Award....
Clinical Trials Actively Recruiting Patients With Ocular Cancer
Phase 0 Study Title: Use of Definity® Contrast Agent for Ultrasound of Intraocular Tumors Study Type: Interventional/single-group assignment Study Sponsor and Collaborators: Emory University Purpose: To determine if microbubbles may be used as a contrast agent to help image tumors in the eye. In...
VUMC Designated as a Lung Cancer Screening Center
Vanderbilt University Medical Center (VUMC) has been designated a Lung Cancer Screening Center by the American College of Radiology (ACR). The ACR Lung Cancer Screening Center designation is a voluntary program that recognizes facilities that have committed to practice safe, effective diagnostic...
Katherine L. Nathanson, MD, Receives AACR’s Frohlich Visiting Professorship
Katherine L. Nathanson, MD, Professor of Medicine in the Division of Translational Medicine and Human Genetics at the Perelman School of Medicine of the University of Pennsylvania, has received the 2015 Frohlich Visiting Professorship through the American Association for Cancer Research (AACR)....
Erratum
In the June 10 issue of The ASCO Post, the article "Anti–PD-1 Inhibitor Gains Foothold in Merkel Cell Carcinoma," a photo labeled Paul Nghiem, MD, PhD, is incorrect. The photo that was printed is Paul Nguyen, MD, of the Dana-Farber Cancer Institute. A photo of Dr. Nghiem is shown here. Dr. Nghiem ...
Geriatric Patients With Cancer and the Problem of Polypharmacy
Older patients with cancer generally have multiple comorbidities, with each often requiring separate medications. Studies have shown that polypharmacy and inappropriate drug use are prevalent among older cancer patients, leading to an enormous amount of preventable adverse events, many requiring...
Pembrolizumab in Triple-Negative Breast Cancer: Emerging New Treatment Modality
Lajos Pusztai, MD, DPhil, Professor of Medicine, Chief of Breast Medical Oncology and Co-Director of Cancer Genetics Research Program at Yale Cancer Center, New Haven, Connecticut, commented on KEYNOTE-012. He remarked that the overall response rate of 18.5% to the single agent is similar to...
Anti–PD-1 Treatment With Pembrolizumab in Gastric/Gastroesophageal Junction Cancers: Who Is Likely to Respond?
Immune checkpoint inhibitors have emerged as one of the most promising new areas of drug development in oncology. Broad activity has been observed for these agents across a spectrum of hematologic malignancies and solid tumors. As reviewed in this issue of The ASCO Post, Muro and colleagues now...
Nivolumab or Ipilimumab Treatment May Increase Risk of Developing Autoimmune Joint and Tissue Disease
Case reports on 13 patients with cancer suggest that patients taking the immunotherapeutics ipilimumab (Yervoy) and nivolumab (Opdivo) may be at higher-than-normal risk of developing autoimmune joint and tissue diseases, including inflammatory arthritis, according to a preliminary study by Johns...
Hypofractionated Radiation Found Equivalent to Conventionally Fractionated Regimen in Early-Stage Breast Cancer
Early-stage breast cancer patients receiving a shorter course of whole-breast irradiation with higher radiation doses per fraction reported equivalent cosmetic, functional, and pain outcomes over time as those receiving a longer, lower-dose per fraction course of treatment, according to researchers ...
Three Leaders in Radiation Oncology Awarded the ASTRO Gold Medal
Three leaders in radiation oncology have been named recipients of the American Society for Radiation Oncology (ASTRO) Gold Medal. Benedick A. Fraass, PhD, FASTRO; Christopher G. Willett, MD, FASTRO; and Anthony L. Zietman, MD, FASTRO; will be recognized at an awards ceremony during ASTRO’s 58th...
Five Early-Career Cancer Researchers Selected as Pew-Stewart Scholars
The Pew Charitable Trusts and the Alexander and Margaret Stewart Trust have announced the 2016 class of Pew-Stewart scholars for cancer research. Five scientists from top research institutions in the United States were selected for their dedication to pursuing innovative leads aimed at finding a...
Tackling the Symptoms of Long-Term Fatigue and Insomnia in Cancer Survivors
Fatigue and sleep disruption are common occurrences for most patients diagnosed with cancer. Simply having a serious physical illness like cancer along with its associated pain, hospitalization, and treatment, as well as the attendant psychological impact, all contribute to the onset of fatigue...
Cancer Treatment Centers of America Names Rajesh K. Garg, MD, JD, as President and CEO
Cancer Treatment Centers of America Global, Inc. (CTCA) has announced that Rajesh Garg, MD, JD, a highly regarded health-care industry leader with more than 25 years of experience across the health-care spectrum, will become its President and CEO. His appointment was effective June 20, 2016. He...
Global Oncology Appoints Donna Barry as First Executive Director
Nonprofit Global Oncology, Inc (GO) has announced that Donna Barry has been appointed to be its first Executive Director, effective immediately. U.S. and global investments in improving cancer outcomes are minimal—in 2011, only 1.2% of total development assistance for global health was focused on...
European Demand for Radiotherapy Expected to Rise Approximately 16% Over Next Decade
The demand for radiotherapy across all European countries will increase by an average of 16% between 2012 and 2025, with the highest expected increase being for prostate cancer cases (24%), according to a new study published by Borras et al in Radiotherapy and Oncology.1 These projections came...
Cervical Cancer Prevention Badly Needed in India
With the advent of the Papanicolaou (Pap) test and population-based screening, along with the development of the human papillomavirus (HPV) vaccine, cervical cancer has become a largely preventable disease for many. However, in India, cervical cancer is a leading cause of cancer mortality. To...
Ixazomib: A Relevant Addition to Myeloma Therapy
In 2015, four new drugs were approved for the treatment of multiple myeloma by the U.S. Food and Drug Administration: panobinostat (Farydak), daratumumab (Darzalex), elotuzumab (Empliciti), and ixazomib (Ninlaro). Of them, the first three are drugs with unique new targets, whereas ixazomib is the...
NCCN Awards Research Grants to Support Studies of Mirvetuximab Soravtansine in Various Cancers
The National Comprehensive Cancer Network® (NCCN) Oncology Research Program (ORP) has awarded eight grants to investigators to support clinical and preclinical studies of mirvetuximab soravtansine (IMGN853) and advance scientific knowledge of its uses in ovarian and other folate receptor alpha...
Medical Decision-Making: At the Heart of Care for Older Patients With Cancer
Although oncology has moved toward a personalized approach to care, medical decision-making within the context of multidisciplinary care has broad public health implications. To shed light on this and other relevant issues, The ASCO Post recently spoke with William Dale, MD, PhD, of the University ...
David Spigel, MD, Appointed as Sarah Cannon Chief Scientific Officer
Sarah Cannon announced the promotion of David Spigel, MD, as Chief Scientific Officer. The new appointment supports the continuous expansion of clinical research and drug development programs, which provides patients with access to novel therapies at the earliest stages. As Chief Scientific...
Expert Point of View: Samir Gupta, MD
Samir Gupta, MD, Associate Professor of Medicine at the University of California San Diego, who has led trials of colorectal cancer screening, commented on this study for The ASCO Post. Although there are approximately 138,000 new colorectal cancer diagnoses a year in the United States, only...
Expert Point of View: Peter C. Enzinger, MD
Not so FAST? The study discussant Peter C. Enzinger, MD, Director of the Center for Esophageal and Gastric Cancer at Dana-Farber/Brigham and Women’s Cancer Center, Boston, viewed the findings of the FAST trial as promising but voiced several considerations, as did Gulam A. Manji, MD, PhD,...
Vast Differences Globally in Cancer Drug Retail Prices
A pilot study revealed large differences in median retail prices for 23 cancer drugs in 7 different countries, with the highest retail prices identified in the United States and the lowest, in India and South Africa. Notably, after the monthly drug price is expressed as a percentage of domestic...
CAR T-Cell Therapy Using Double Target Aimed at Solid Tumors in Preclinical Models
Chimeric antigen receptors (CARs), engineered from a patient's own immune cells, have been successful for treating blood cancers, but using CARs for solid tumors has been limited by side effects to normal tissues containing the protein targeted by the engineered cells. Now, in a report published...
Influence of Age and Comorbidities on Rates of Colorectal Cancer Screening in the Elderly
Colorectal cancer (CRC) is a common and costly disease, largely of the elderly, with nearly 25% of cases diagnosed among patients aged 75–84 years. However, but the guidelines for CRC screening of Americans aged 75 or older vary according to the source. In a study published by Klabunde et al...
ASCO Announces New Award Honoring Visionary Leader Allen S. Lichter, MD, FASCO
During the 2016 Annual Meeting, ASCO announced the creation of the Allen S. Lichter Visionary Leader Award to recognize ASCO members who have transformed the oncology field or significantly advanced the mission of ASCO, the Conquer Cancer Foundation, or CancerLinQ, LLC, through their leadership,...
Expert Point of View: Tiffany A. Traina, MD, and Larry Norton, MD
Study discussant Tiffany A. Traina, MD, Clinical Director of the Breast Medicine Service and Associate Attending at Memorial Sloan Kettering Cancer Center and Assistant Professor of Medicine at Weill Cornell Medicine, commented, “The overall trial results demonstrate that not only is docetaxel...
ASCO Releases the Updated Version of Its Value Framework
Last June, ASCO published its initial concept for a value framework in the Journal of Clinical Oncology (JCO).1 The framework, developed by ASCO’s Value in Cancer Care Task Force, is designed to provide a standardized approach to assist physicians and patients in assessing the “value” of a new...
For High-Risk Neuroblastoma, Two Transplants May Be Better Than One
In children with high-risk neuroblastoma, tandem autologous stem cell transplant (ASCT) improved event-free survival rates in the ANBL0532 trial from the Children’s Oncology Group. The study was presented at the plenary session of the 2016 ASCO Annual Meeting by Julie R. Park, MD, of Seattle...
Autologous Stem Cell Transplantation Offers Safe, Effective Option for Patients With HIV-Associated Lymphoma
A phase II, multicenter trial published by Alvarnas et al in Blood challenges the generally held belief that individuals with human immunodeficiency virus (HIV) and aggressive lymphoma are not candidates for standard treatment. According to the researchers, people with HIV-associated lymphoma who...
Patient Navigators Improve Comprehensive Cancer Center Screening Rates
A clinical trial conducted by Massachusetts General Hospital (MGH) investigators has found that the use of patient navigators—individuals who assist patients in receiving health care services—may improve comprehensive cancer screening rates among patient populations not likely to...
Report Finds Families of Cancer Survivors Challenged by Intense, Episodic Caregiving Experiences
A new report shows that people caring for a loved one with cancer often have more intense, episodic caregiver responsibilities than those caring for someone with other health needs. The report, from the National Alliance for Caregiving in partnership with the National Cancer Institute and the...
SNMMI 2016: VASH Collimator Allows Three-Dimensional Imaging of the Breast With Less Radiation
Preliminary tests have demonstrated that a new device may enable existing breast cancer imagers to provide up to six times better contrast of tumors in the breast, while maintaining the same or better image quality and halving the radiation dose to patients. The advance is made possible by a new...
Protein Could Help Identify Chronic Graft-vs-Host Disease
A new study published by Kariminia et al in the journal Blood has identified a protein that could diagnose chronic graft-vs-host disease in patients undergoing blood and bone marrow transplantation. The work was led by researchers in the Michael Cuccione Childhood Cancer Research Program at BC...
SNMMI 2016: Pretargeted Radioimmunotherapy Eliminates Colorectal Cancer in Preclinical Studies
Presenters at the 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI) unveiled a novel radioimmunotherapy that combines a cancer-seeking antibody with potent radionuclide agents, resulting in complete remission of colorectal cancer in mouse models (Scientific Paper...
SNMMI 2016: PET/CT Imaging of Prostate Cancer With Specific Agent May Be an Accurate Prebiopsy/Preoperative Guide
With surgical removal at the frontline of defense against prostate cancer, oncologists are considering prostate-specific molecular imaging at the point of initial biopsy and preoperative planning to root out the full extent of disease, researchers showed at the 2016 Annual Meeting of the Society of ...
