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2025 ASCO Annual Meeting

Breast Cancer

Vepdegestrant Improves Progression-Free Survival in Select Patients With ESR1-Mutant Advanced Breast Cancer

Results from VERITAC-2 trial showed that the proteolysis-targeting chimera (PROTAC) vepdegestrant could extend progression-free survival for people with previously treated estrogen receptor (ER)-posit...

Colorectal Cancer

Encorafenib/Cetuximab Plus Chemotherapy Improves Survival in BRAF V600E–Mutant Metastatic Colorectal Cancer

Results from an international phase III study showed that the targeted therapy combination of encorafenib and cetuximab with mFOLFOX6 (leucovorin, fluorouracil, and oxaliplatin) chemotherapy may help ...

Issues in Oncology

ASCO 2025: Alcohol-Related Cancer Deaths Are on the Rise in the United States

A new study led by experts at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, is the first to look at trends over time in alcohol-linked cancer mortal...

Lung Cancer
Issues in Oncology

ASCO 2025: Impact of Wildfire-Related Pollution on Survival in NSCLC

Inhaling wildfire-related air pollution may reduce the likelihood of survival among patients with non–small cell lung cancer (NSCLC), according to new findings presented by Singhal et al at the 2025 A...

Prostate Cancer
Immunotherapy

Subset of Men With Rare Prostate Cancer May Benefit From Immunotherapy Added to Chemotherapy and Targeted Maintenance Therapy

Treatment options for aggressive-variant prostate cancer are limited, but a subset of patients have had promising long-term responses with a combination of carboplatin plus cabazitaxel chemotherapy, f...

Solid Tumors
Sarcoma

Spatial Transcriptomics Identifies Novel Subtypes Associated With Disease Prognosis in Leiomyosarcoma

Patients with leiomyosarcoma experience a high risk of recurrence and have limited treatment options. No biomarkers or targetable mutations currently improve diagnosis, prognosis, or treatment. Spatia...

Myelodysplastic Syndromes

Study Finds Novel Triplet Regimen Safe and Effective for Patients With Higher-Risk MDS and CMML

Patients with higher-risk myelodysplastic syndromes (MDS) and chronic myelomonocytic leukemia (CMML) often experience temporary responses to current treatments, such as hypomethylating agents, which l...

Kidney Cancer
Immunotherapy

CAR T-Cell Therapy Continues to Demonstrate Activity in Advanced Clear Cell Renal Cell Carcinoma

For patients with metastatic clear cell renal cell carcinoma who did not benefit from checkpoint and tyrosine kinase inhibitors, limited alternative treatment options are available. ALLO-316 is a nove...

Colorectal Cancer

Online Genetic Testing Platform Demonstrates Notable Engagement Among Patients With Young-Onset Colorectal Cancer

Universal germline testing is essential for identifying hereditary cancer risk, especially for patients with young-onset colorectal cancer who were diagnosed before the age of 50. However, the impleme...

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