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Eric Zhou, PhD, on Insomnia in Young Cancer Survivors: Online Program May Improve Quality of Life
Eric Zhou, PhD, of Dana-Farber Cancer Institute, discusses an existing online program called SHUTi (Sleep Healthy Using the Internet), that he and his team adapted to the needs of adolescent and young adult cancer survivors. After six online cognitive behavior therapy sessions delivered over 8...
SNMMI 2020: First Results of Total-Body Dynamic PET Scan in Patients With Cancer
Results from the first study using uEXPLORER to conduct total-body dynamic positron-emission tomography (PET) scans in patients with cancer suggested that it can be used to generate high-quality images of metastatic cancer. The research was presented at the Society of Nuclear Medicine and Molecular ...
SNMMI 2020: Role of PSMA PET/CT in the Management of Recurrent Prostate Cancer
New research outlines the role of prostate-specific membrane antigen (PSMA) positron-emission tomography/computed tomography (PET/CT) in the detection and management of recurrent disease in prostate cancer patients. In initial results from a multicenter trial assessing the impact of F-18 DCFPyL...
SNMMI 2020: Novel PET Radiotracer for Glioblastoma
A first-in-human study presented at the Society of Nuclear Medicine and Molecular Imaging (SNMMI) 2020 Annual Meeting and published by Zhang et al in the Journal of Nuclear Medicine has demonstrated the safety and favorable pharmacokinetic and dosimetry profile of Cu-64 EBRGD, a new, relatively...
Mark J. Ratain, MD, and Daniel Goldstein, MD, on Value in Cancer Care: How the Paradigm Is Shifting
Mark J. Ratain, MD, of the University of Chicago, and Daniel Goldstein, MD, of the Rabin Medical Center, discuss the challenges of achieving cancer care value, evolution of the “more-is-better” philosophy when it comes to oncology drugs, and highlights of the First International Summit on...
Study Links Mental Health Treatment to Possible Improved Cancer Survival
For people with cancer who have a mental health disorder, getting mental health treatment may help them live longer, a new study published by Berchuck et al in JAMA Oncology suggests. In the retrospective study, of more than 50,000 veterans treated for lung cancer within the Veterans Affairs (VA)...
Study Identifies Factors That May Predict Toxicities in Patients Treated With CAR T-Cell Therapy
Chimeric antigen receptor (CAR) T-cell therapy has proved to be a valuable treatment option for patients with lymphoma in whom other therapies have failed. In clinical trials, the cellular immunotherapy was shown to provide durable remissions for nearly 40% of patients with large B-cell lymphoma....
Deborah Schrag, MD, MPH, on Clinical Trial Design: Statistical Options and Challenges
Deborah Schrag, MD, MPH, of Dana-Farber Cancer Institute, offers her perspective on near-equivalence, Bayesian noninferiority, and the value of cancer drug optimization.
Deborah Schrag, MD, MPH, on Clinical Trial Design: Statistical Options and Challenges
Deborah Schrag, MD, MPH, of Dana-Farber Cancer Institute, offers her perspective on near-equivalence, Bayesian noninferiority, and the value of cancer drug optimization.
Two Studies Focus on Emerging Treatment Options for Patients With Neuroendocrine Tumors
Two new studies led by Renuka Iyer, MD, Section Chief for Gastrointestinal Oncology at Roswell Park Comprehensive Cancer Center, and published in Oncotarget and Cancer, respectively, highlight possible new treatment options for patients with neuroendocrine tumors. SurVaxM The first report,...
Lung Cancer in Nonsmoking Individuals: Differences in Genetics and Response to Treatment
Lung cancer in nonsmokers is a diverse and distinct disease from lung cancer in smokers and is likely to respond differently to targeted treatments, according to results from a new study published by Chen et al in the journal Cell. Scientists studied a patient population in Taiwan with high rates...
Experimental COVID-19 Vaccine Generates Immune Response, Deemed Safe in Phase I Trial
According to a press release from the National Institutes of Health, an investigational vaccine designed to protect against SARS-CoV-2, the virus that causes COVID-19—mRNA-1273—was generally well tolerated and prompted neutralizing antibody activity in healthy adults. These interim results were...
Mark J. Ratain, MD, on Chronic Lymphocytic Leukemia: Making a Case for Low-Dose Ibrutinib
Mark J. Ratain, MD, of the University of Chicago, talks about why ibrutinib—which can lead to cardiotoxicities—should be studied at a lower dose for patients with chronic lymphocytic leukemia. Data suggest a reduced dose may prevent dose interruption due to adverse events and may have a better...
Presence of ctDNA and CTCs and Prediction of Disease Recurrence in Patients With Triple-Negative Breast Cancer
In a preplanned secondary analysis of the BRE12-158 trial published in JAMA Oncology, Milan Radovich, PhD, and colleagues found that the presence of circulating tumor DNA (ctDNA) and circulating tumor cells (CTCs) in the plasma of women who have received neoadjuvant treatment for stage I, II, or...
Common Hypertension Medications May Also Reduce Risk of Colorectal Cancer
Medications commonly prescribed to treat high blood pressure may also reduce the risk of colorectal cancer, according to new research published by Cheung et al in the journal Hypertension. Angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARB) are often prescribed...
R. Donald Harvey, PharmD, BCOP, FCCP, FHOPA, on Cutting Cancer Care Costs With Alternative Pharmacologic Options
R. Donald Harvey, PharmD, BCOP, FCCP, FHOPA, of Emory University, discusses the ways in which clinical pharmacology can help yield cost savings without sacrificing efficacy by, for example, altering regimens to extend drug supplies, lowering doses, dosing less frequently, or shortening the duration ...
Blase N. Polite, MD, MPP, on Optimizing Cancer Policies in the United States
Blase N. Polite, MD, MPP, of the University of Chicago Medical Center, discusses his belief that, in the next few years, we can bend the cancer drug cost curve and tame health-care costs if physicians, pharmaceutical companies, payers, and government come together and agree on the value of...
Trends in Policy Coverage for ctDNA Testing
New research published by Douglas et al in JNCCN—Journal of the National Comprehensive Cancer Network examined coverage trends for circulating tumor DNA (ctDNA) testing, also known as liquid biopsy. In the first-ever study to analyze insurance coverage for ctDNA-based panel tests, researchers found ...
American Cancer Society Updates Guideline for HPV Vaccination
The American Cancer Society (ACS) has updated its guideline for human papillomavirus (HPV) vaccination, adapting a 2019 update from the Federal Advisory Committee on Immunization Practices (ACIP). The ACS first issued a guideline for routine use of the HPV vaccine in 2007, with an update issued in...
Patricia S. Steeg, PhD, Receives Women in Cancer Research Charlotte Friend Lectureship
The American Association for Cancer Research (AACR) has honored Patricia S. Steeg, PhD, with its 2020 Women in Cancer Research Charlotte Friend Memorial Lectureship. Dr. Steeg, Co-Director of the Office of Translational Resources and Associate Director of the Center for Cancer Research at the...
Christopher I. Amos, PhD, Receives Award for Research Excellence in Cancer Epidemiology and Prevention
The American Association for Cancer Research (AACR) is honoring Christopher I. Amos, PhD, with the 2020 AACR–American Cancer Society (ACS) Award for Research Excellence in Cancer Epidemiology and Prevention. Dr. Amos, the Selzman Endowed Professor, Director of the Institute for Clinical and...
Benjamin F. Cravatt, PhD, Receives Award for Outstanding Achievement in Chemistry in Cancer Research
The American Association for Cancer Research (AACR) is honoring Benjamin F. Cravatt, PhD, with the 2020 AACR Award for Outstanding Achievement in Chemistry in Cancer Research. Dr. Cravatt, Professor at the Skaggs Institute for Chemical Biology and the Gilula Chair of Chemical Biology for the...
Charles L. Sawyers, MD, FAACR, Voted AACR Academy President-Elect for 2020–2021
The Fellows of the American Association for Cancer Research (AACR) Academy have chosen Charles L. Sawyers, MD, FAACR, as President-Elect for 2020–2021. Dr. Sawyers will assume the presidency during the 2021 AACR Annual Meeting. Dr. Sawyers holds the Marie-Josée and Henry R. Kravis Chair in Human...
Neil Spector, MD, Physician-Scientist, Mentor, Author, Dies at 63
Neil Spector, MD, a physician-scientist, translational research leader, and oncology mentor died on June 14, 2020. He was 63. Dr. Spector was the Sandra Coates Associate Professor in the Department of Medicine, Associate Professor of Pharmacology and Cancer Biology, and a member of the Duke Cancer ...
Beth Levine, MD, Renowned Doctor and Researcher in the Field of Autophagy, Dies at 60
Beth Levine, MD, Professor of Internal Medicine and Microbiology, Director of the Center for Autophagy Research, and Charles Cameron Sprague Distinguished Chair in Biomedical Sciences at The University of Texas Southwestern Medical Center (UT Southwestern), and an investigator at the Howard Hughes ...
Oscar Colegio,MD, PhD, Expert on Skin Cancers Linked to Immunodeficiencies, Dies at 47
Oscar Colegio, MD, PhD, the Lawrence P. & Joan Castellani Family Endowed Chair in Dermatology at Roswell Park Comprehensive Cancer Center, Buffalo, New York, died unexpectedly on June 13, 2020, at a family residence in Connecticut. He was 47. Dr. Colegio had relocated to Buffalo when he was...
New James Cancer Diagnostic Center to Expedite Access to Diagnostic Testing
A recently opened center at The Ohio State University Comprehensive Cancer Center–Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC–James) gives patients direct, expedited access to diagnostic testing for cancer. The goal, said Chief Medical Officer David Cohn, MD,...
Cancer Genome Atlas Founding Members and Current Project Team Awarded 2020 AACR Team Science Awards
During its recent Virtual Annual Meeting II, the American Association for Cancer Research (AACR) presented its 2020 Team Science Awards to the founding members and the current project team associated with The Cancer Genome Atlas (TCGA). TCGA began in 2006 as a joint effort between the National...
Kunle Odunsi, MD, PhD, FRCOG, FACOG, Elected At-Large Director of SITC Board of Directors
Elected by a body of fellow immunotherapy researchers from across the globe, Roswell Park Comprehensive Cancer Center Deputy Director Kunle Odunsi, MD, PhD, FRCOG, FACOG, has been named At-Large Director of the Society for Immunotherapy of Cancer (SITC) Board of Directors. Dr. Odunsi will begin his ...
New Recommendations Offer Guidance for Clinicians and Patients on Genetic Testing for Prostate Cancer
An international panel of experts led by researchers and thought leaders at the Sidney Kimmel Cancer Center–Jefferson Health (SKCC) and the Department of Urology at Jefferson have published the first multidisciplinary, consensus-driven, prostate cancer genetic implementation framework for the...
FDA Collaborating on Use of Real-World Data to Inform COVID-19 Response Effort
On June 18, 2020, the U.S. Food and Drug Administration (FDA) took an additional step in harnessing real-world data to help inform the agency’s overall response to the COVID-19 public health emergency. The FDA announced its participation in the COVID-19 Diagnostics Evidence Accelerator, a...
AACR Recognizes Achievements of Three Cancer Researchers
The American Association for Cancer Research (AACR) is honoring three clinical cancer researchers for their outstanding achievements. Jedd D. Wolchok, MD, PhD, FASCO, will receive the 2020 AACR–Joseph H. Burchenal Award for Outstanding Achievement in Clinical Cancer Research. Lisa A. Newman, MD,...
A Long-Time Student of Leadership, Brian J. Bolwell, MD, FACP, Ultimately Takes the Reins at the Taussig Cancer Institute
In this edition of the Living a Full Life series, guest editor Jame Abraham, MD, FACP, interviewed his colleague Brian J. Bolwell, MD, FACP, Chairman of the Cleveland Clinic Taussig Cancer Institute and Professor of Medicine at the Cleveland Clinic. Among other things, Dr. Bolwell discussed his...
Jessica Karen Wong, MD, MEng, Joins Radiation Oncology Department at Fox Chase
Fox Chase Cancer Center announced that Jessica Karen Wong, MD, MEng, recently joined the Department of Radiation Oncology as Assistant Professor in the academic clinician track. Dr. Wong completed her radiation oncology residency program at Fox Chase, where she served as Chief Resident in 2019 and...
Geriatric Assessment: What Are You Waiting For?
The ASCO20 Virtual Scientific Program was the forum for an unusual but profoundly important event in oncology. Four studies that should be practice-changing were presented.1-4 These studies provided irrefutable evidence that we can improve the quality of life of older patients by reducing toxicity. ...
Expert Point of View: Philip McCarthy, MD
Philip McCarthy, MD, Professor of Oncology and Internal Medicine and Director of the Transplant and Cellular Therapy Center at Roswell Park Comprehensive Cancer Center, Buffalo, New York, found the results of the DREAMM-6 study to be “exciting and promising.” He commented: “The overall response...
AACR Recognizes New 2019–2020 Research Grantees
The American Association for Cancer Research (AACR) has announced its newest class of grant recipients. Fellowships The 2019 Anna D. Barker Fellowship in Basic Cancer Research was awarded to Chaoyun Pan, PhD, of Emory University, Atlanta, and Conghui Yao, PhD, of Harvard Medical School, Cambridge....
Lung Cancer Research Foundation Names Trudy Oliver, PhD, to Its Scientific Advisory Board
The Lung Cancer Research Foundation (LCRF) recently announced that Trudy Oliver, PhD, has joined its Scientific Advisory Board. Dr. Oliver is Associate Professor of Oncological Sciences at the University of Utah’s Huntsman Cancer Institute (HCI), where she has served since 2011, and is an HCI...
Phase II Study Evaluates Chemotherapy and Immunotherapy in Patients With Malignant Pleural Mesothelioma
Data from the phase II PrE0505 multicenter trial showed that adding durvalumab, an immune checkpoint antibody targeting programmed cell death ligand 1 (PD-L1), to the combination of cisplatin and pemetrexed chemotherapy improved outcomes in previously untreated patients with unresectable malignant...
A Visiting Resident Oncologist’s Training During the COVID-19 Pandemic
A visiting away elective is a resident’s designated time to visit another academic program to foster the growth of medical knowledge through patient care from the perspective of another health-care system and educational experience. The time dedicated to make this dream happen is grueling. First...
Guidance Available on Telemedicine Coverage During COVID-19 Pandemic
Effective for services starting March 1, 2020, and for the duration of the COVID-19 emergency, the Centers for Medicare & Medicaid Services (CMS) will reimburse for telehealth services for all beneficiaries. To help explain this and other changes to telehealth coverage related to the pandemic,...
Glenn D. Steele, Jr, MD, PhD, Named Chair of City of Hope Board of Directors
Health-care innovator and leader Glenn D. Steele Jr, MD, PhD, has been elected Board Chair at City of Hope. Dr. Steele joined the City of Hope Board of Directors in 2016 and was Chair of the Executive Compensation and Governance Committee from 2018 to 2020. “City of Hope has benefited from...
New NCCN Guidelines Offer Patients Help in Recognizing Side Effects From Immunotherapy
The National Comprehensive Cancer Network (NCCN) recently announced the publication of “NCCN Guidelines for Patients: Immunotherapy Side Effects—Immune Checkpoint Inhibitors.” These new guidelines are designed to educate patients and to help them recognize immune side effects so effective...
ASCO Opens Search for Chief Medical Officer: Express Interest by August 21, 2020
ASCO is conducting an open search for the position of Chief Medical Officer and Executive Vice President, as current Chief Medical Officer, Richard L. Schilsky, MD, FACP, FSCT, FASCO, prepares to retire in February 2021. ASCO’s Chief Medical Officer applies his/her medical and scientific knowledge ...
Insomnia in Adolescent and Young Adult Cancer Survivors
Adolescents and young adults (AYA) who have survived cancer may continue to suffer from insomnia long after treatment ends, interfering with a range of daily activities. In Pediatric Blood & Cancer, Eric S. Zhou, PhD, and Christopher J. Recklitis, PhD, MPH, of Dana-Farber Cancer Institute,...
Society for Immunotherapy of Cancer Names Recipients of Memorial Award and Lectureship
The Society for Immunotherapy of Cancer (SITC) has announced three recipients of the 2020 Richard V. Smalley, MD, Memorial Award and Lectureship, the society’s highest honor: they include Lieping Chen, MD, PhD, Gordon Freeman, PhD, and Arlene Sharpe, MD, PhD. The research conducted by Drs....
Addressing Discrimination and Bias in Medical Education
“As a medical student, I often felt marginalized from my medical community. I have been told that my name is ‘not American,’ fallen prey to being confused for support staff such as a janitor (even while wearing my white coat), and been asked questions like, ‘Where are you really from?’ or ‘How old...
Arnon P. Kater, MD, PhD, on CLL: Efficacy of Venetoclax in Relapsed or Refractory Disease
Arnon P. Kater, MD, PhD, of the University of Amsterdam, Cancer Center Amsterdam, discusses phase IIIb results from the VENICE I trial, which confirmed that venetoclax monotherapy can achieve deep responses and has a tolerable and manageable safety profile in patients with relapsed or refractory...
Jorge E. Cortes, MD, on Chronic Phase CML: Comparing Three Starting Doses of Ponatinib
Jorge E. Cortes, MD, of Georgia Cancer Center, discusses interim results from the OPTIC study, which showed a trend toward dose-dependent efficacy and safety, and may provide a refined understanding of the ponatinib benefit/risk profile and its relation to dose. Mature data from continued follow-up ...
Efstathios Kastritis, MD, on Amyloidosis: Daratumumab Plus Cyclophosphamide, Bortezomib, and Dexamethasone
Efstathios Kastritis, MD, of the University of Athens, discusses phase III findings of the Andromeda study. Adding daratumumab to cyclophosphamide, bortezomib, and dexamethasone resulted in deeper and more rapid hematologic responses and improved clinical outcomes in patients with newly diagnosed...
