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Showing 3601 - 3650FDA Approves Asciminib for Philadelphia Chromosome–Positive CML
On October 29, the U.S. Food and Drug Administration (FDA) granted accelerated approval to the kinase inhibitor asciminib (Scemblix) for patients with Philadelphia chromosome–positive chronic myeloid leukemia (Ph+ CML) in chronic phase who have been previously treated with two or more tyrosine...
FDA Authorizes Pfizer-BioNTech COVID-19 Vaccine for Emergency Use in Children Aged 5 Through 11 Years
On October 29, the U.S. Food and Drug Administration (FDA) authorized the emergency use of the Pfizer-BioNTech COVID-19 vaccine for the prevention of COVID-19 to include children aged 5 through 11 years. The authorization was based on the FDA’s thorough and transparent evaluation of the data that...
Morgan R.L. Lichtenstein, MD, on Insurance Plan, Prior Authorization, and Time to Receipt of Oral Anticancer Drugs
Morgan R.L. Lichtenstein, MD, of Columbia University Medical Center, discusses a single-center prospective study examining the complex relationship between time to oral oncolytic receipt and clinical or process-related factors, such as prior authorization, diagnosis, and insurance type.
Daniel J. Ma, MD, on HPV-Associated Oropharyngeal Squamous Cell Carcinoma: Comparing Longer and Shorter Courses of Radiotherapy
Daniel J. Ma, MD, of the Mayo Clinic Alix School of Medicine, discusses results from a phase III study of patients with HPV-associated oropharyngeal squamous cell carcinoma. Comparing a 2-week course of de-escalated adjuvant radiation therapy with the standard 6-week course, investigators found...
C. Jillian Tsai, MD, PhD, on Using Radiotherapy to Thwart Tumor Growth in Advanced Cancers
C. Jillian Tsai, MD, PhD, of Memorial Sloan Kettering Cancer Center, discusses results from the first randomized trial of stereotactic body radiation therapy (SBRT) to treat oligoprogressive, metastatic lung and breast cancers. The standard of care for patients with these types of tumors is to...
Do Diet-Related Molecules Play a Role in the Development of Aggressive Prostate Cancer?
Cleveland Clinic researchers have shown that diet-associated molecules in the gut may be associated with aggressive prostate cancer, suggesting dietary interventions may help reduce risk. These findings were published by Reichard et al in Cancer Epidemiology, Biomarkers & Prevention. While...
Study Finds Incidence of Pancreatic Cancer May Be Rising in Younger Women
The incidence of pancreatic cancer—which historically has been higher in men than in women—has increased among both men and women during the past decade, with a significantly greater relative increase observed in women younger than age 55 years, and especially among those aged 15 to 34 years. These ...
Aadel A. Chaudhuri, MD, PhD, on Personalizing Treatment for Oligometastatic Cancer
Aadel A. Chaudhuri, MD, PhD, of Washington University School of Medicine in St. Louis, discusses circulating tumor DNA, which has the potential to better personalize treatment for patients with oligometastatic cancer and help clinicians determine whether to offer systemic therapy alone or...
Patients With Multiple Myeloma May Lack T-Cell Responses to COVID-19 Vaccination
Patients with multiple myeloma lacking an antibody response to COVID-19 vaccine may also fail to mount a T-cell response, according to research from the Icahn School of Medicine at Mount Sinai. Concerningly, this scenario was most common among patients actively treated with anti-CD38 and...
Hypofractionated Postoperative Prostate Bed Radiotherapy Does Not Increase Patient-Reported Toxicity for Men With Prostate Cancer
A primary endpoint analysis of the NRG Oncology phase III NRG-GU003 clinical trial, which compared hypofractionated postoperative prostate bed radiotherapy (HYPORT) to conventional postprostatectomy radiotherapy (COPORT) for men with prostate cancer, determined that treatment with HYPORT yielded no ...
Study Finds Similar Survival Rates Among Patients With Metastatic Colorectal Cancer Younger and Older Than Age 50
Even though patients with metastatic colorectal cancer younger than age 50 tend to be more fit and receive more intensive treatment than older patients, survival for both groups is roughly the same, according to a study published by Lipsyc-Sharf et al in the Journal of the National Cancer...
Youssef Zeidan, MD, PhD, on HER2-Positive Breast Cancer: Treatment-Related Cardiotoxicity
Youssef Zeidan, MD, PhD, of Florida International University and the Lynn Cancer Institute, discusses the advances in radiotherapy planning and delivery that have reduced cardiac radiation exposure in patients with HER2-positive breast cancer who are treated with radiotherapy and trastuzumab...
David A. Palma, MD, PhD, on HPV-Associated Oropharyngeal Squamous Cell Carcinoma: Radiotherapy vs Surgery
David A. Palma, MD, PhD, of Ontario’s London Health Sciences Centre, discusses results of the ORATOR2 study, which compared two treatment options that could be de-escalated for patients with HPV-associated oropharyngeal squamous cell carcinoma: a lower-dose radiation approach (6 weeks instead of 7, ...
Study Examines Use of External-Beam Radiotherapy as a Bridging Therapy for Patients With HCC Awaiting Transplant
Patients with hepatocellular carcinoma (HCC) awaiting liver transplantation may benefit from noninvasive treatment with external-beam radiotherapy (EBRT) but are rarely given this therapy, according to a new analysis of U.S. national data. Findings were presented by Nima Nabavizadeh, MD, at the...
Annual Report to the Nation, Part 2: Focus on Patient Economic Burden Associated With Cancer Care
Part 2 of the latest Annual Report to the Nation on the Status of Cancer—provided by the American Cancer Society, National Cancer Institute, Centers for Disease Control and Prevention, and North American Association of Central Cancer Registries—has found that patients with cancer in the United...
Diana D. Shi, MD, on IDH-Mutant Gliomas: De Novo Pyrmidine Synthesis Inhibitor Under Study
Diana D. Shi, MD, of Dana-Farber Cancer Institute and Brigham and Women’s Cancer Center, discusses studies being planned and already underway to test BAY 2402234, a de novo pyrimidine synthesis inhibitor that possibly could be used clinically to target IDH-mutant gliomas and may act as a...
Robert A. Olson, MD, on Oligometastases: New Data on Stereotactic Ablative Radiotherapy
Robert A. Olson, MD, of the University of British Columbia, discusses phase II findings from the SABR-5 trial on stereotactic ablative radiotherapy for up to five oligometastases. Although toxicity of liver and adrenal metastases warrants caution, the trial seemed to show that this type of...
Study Finds Prior Authorization Costs Academic Radiation Oncology Clinics More Than $40 Million Every Year
The time required to secure prior authorization approvals for radiation therapy equates to a financial impact of more than $40 million annually for academic medical centers, according to a new study presented by Bingham et al at the 2021 American Society for Radiation Oncology (ASTRO) Annual...
Study Examines Relationship Between Risk of Cancer and Age of Smoking Initiation/Cessation
Data from a new study showed that those who started to smoke at earlier ages have an elevated likelihood of dying from cancer. Those who began at the youngest ages (before age 10 years) had four times the cancer mortality rates in adulthood than those who had never smoked. However, individuals who...
Melphalan Flufenamide Withdrawn From the U.S. Market
On October 22, Oncopeptides announced its decision to withdraw melphalan flufenamide (Pepaxto), a first-in-class peptide-drug conjugate, from the market in the United States, following results from the phase III OCEAN study in patients with relapsed or refractory multiple myeloma. The decision to...
Having Stage IV Lung Cancer Has Refocused My Life
The first indication I had stage IV lung cancer was a persistent cough during the beginning of the cold-and-flu season in the fall of 2013. I was 35 years old, never smoked, and in otherwise excellent health, so I ignored the cough for several months until I noticed my breathing had also become...
MD Anderson and Siemens Healthineers Collaborate to Enable Consistent Clinical Implementation of Quantitative MRI
The University of Texas MD Anderson Cancer Center and Siemens Healthineers recently announced the collaborative development of a global education program focused on enabling the implementation of consistent, high-quality magnetic resonance imaging (MRI) in radiation oncology. The program will...
MSK Launches New Center to Expand Commitment to Meeting the Unique Needs of Adolescents and Young Adults With Cancer
Although overall cancer cases are declining, they are on the rise in older adolescents and young adults (AYAs). Memorial Sloan Kettering Cancer Center (MSK) recently announced the establishment of the Lisa and Scott Stuart Center for Adolescent and Young Adult Cancers (the Stuart Center), expanding ...
FDA Expands Cetuximab Label for Encorafenib Combination in BRAF V600E Mutation–Positive Metastatic Colorectal Cancer
The U.S. Food and Drug Administration (FDA) has granted approval of a new indication for the EGFR inhibitor cetuximab (Erbitux) in combination with encorafenib (Braftovi) for the treatment of adults with metastatic colorectal cancer and a BRAF V600E mutation, as detected by an FDA-approved test,...
Cardio-oncology
The ASCO Post is pleased to reproduce installments of the Art of Oncology as published previously in the Journal of Clinical Oncology. These articles focus on the experience of suffering from cancer or of caring for people diagnosed with cancer, and they include narratives, topical essays,...
MD Anderson and BostonGene Announce Strategic Alliance to Advance Personalized Cancer Diagnostics and Treatments
The University of Texas MD Anderson Cancer Center and BostonGene Corporation recently announced a strategic alliance to advance the development and clinical integration of multiplatform biomarker signatures. Expands Upon Existing Collaborations The alliance brings together BostonGene’s innovative...
Urbanization in Bangladesh: The Prevalence of Breast Cancer Brings Unique Challenges
The number of deaths related to breast cancer are increasing at an alarming pace worldwide. According to a World Health Organization (WHO) 2020 report, approximately 2,088,849 new cases and 627,000 deaths related to breast cancer occurred in 2018.1 More than 55% of these deaths occurred in low- to ...
Memorial Sloan Kettering Cancer Center Announces New Early-Career Physician Research Program in Cancer Science
Memorial Sloan Kettering Cancer Center (MSK) recently announced a $25 million gift from Louis V. Gerstner, Jr, to create the Louis V. Gerstner, Jr Physician Scholars Program. Designed to support the innovative research of physician-scientists who are early in their career at MSK, the program will...
Cleveland Clinic Launches Center for Young-Onset Colorectal Cancer
According to the National Cancer Institute, cases of colorectal cancer in patients younger than age 50 have grown by more than 50% since the 1990s. Cleveland Clinic has addressed this trend with the establishment of a center focused on the diagnosis, care, and research of young-onset colorectal...
Caroline Chung, MD, Named MD Anderson’s First Chief Data Officer
The University of Texas MD Anderson Cancer Center recently appointed Caroline Chung, MD, Associate Professor of Radiation Oncology and Diagnostic Radiology, the new Vice President and Chief Data Officer (CDO). As the institution’s first-ever CDO, Dr. Chung will be responsible for shaping MD...
Financial Impact of Cardiovascular Disease and Cancer Care: Overlapping Toxicities
The leading causes of mortality in the United States are cardiovascular disease (23%) and cancer (21%), accounting for more than 40% of total deaths reported.1,2 The increasing rise in health-care expenditures over the past several decades has driven the need for metrics to further evaluate the...
MSK Announces Appointment of Deb Schrag, MD, FASCO, MPH, as Chair of the Department of Medicine
Deb Schrag, MD, FASCO, MPH, has been named the new Chair of the Department of Medicine at Memorial Sloan Kettering Cancer Center (MSK). Dr. Schrag has a deep familiarity with MSK, having previously spent 8 years at the institution as a physician and faculty member. She joins MSK from the...
IASLC Presents WCLC 2021 Lectureship Awards to International Array of Lung Cancer Researchers
The International association for the Study of Lung Cancer (IASLC), at its 2021 World Conference on Lung Cancer (WCLC), presented awards to clinicians and researchers who made significant contributions to the treatment of patients with lung cancer. The awards represent many major categories of lung ...
IASLC Names Kristin Richeimer, CAE, DES, Interim Chief Executive Officer
The Board of Directors of the International Association for the Study of Lung Cancer (IASLC) has announced the appointment of Kristin Richeimer, CAE, DES, to the position of Interim Chief Executive Officer (CEO). Ms. Richeimer joined the IASLC in 2010 as its first Director of Membership and brings ...
Michael Diaz, MD, Named President and Managing Physician at Florida Cancer Specialists & Research Institute
Florida Cancer Specialists & Research Institute (FCS) recently appointed Michael Diaz, MD, to the position of President and Managing Physician, effective January 1, 2022. Dr. Diaz succeeds Lucio Gordan, MD, who has served in that position since 2018. Dr. Gordan will continue to practice as a...
Katherine E. Reeder-Hayes, MD, MBA, on Geography, Breast Cancer Treatment, and Racial Disparities
Katherine E. Reeder-Hayes, MD, MBA, of the University of North Carolina at Chapel Hill, discusses the timeliness of breast cancer care for Black women compared with non-Black women in North Carolina. Her data showed that greater geographic variation exists in the timeliness of breast cancer care...
Aakash Desai, MPH, MD, on the Precision Oncology Promise: Can We Deliver?
Aakash Desai, MPH, MD, of the Mayo Clinic in Rochester, Minnesota, talks about the urgent need for drug pricing reform, given the average expenditure of Medicare part D, and the ultimate out-of-pocket costs for patients with cancer. The promise of precision oncology will fail, says Dr. Desai, if we ...
Jenny Jing Xiang, MD, on Improving Clinical Trial Recruitment With a Universal Prescreening Protocol
Jenny Jing Xiang, MD, of Yale University School of Medicine, discusses a universal, standardized clinical trial prescreening protocol, which streamlined research recruitment and was associated with yearly increases in patient enrollment at the Veterans Administration (VA) Connecticut Cancer Center. ...
Hope S. Rugo, MD, on Triple-Negative Breast Cancer: Treatment Findings From KEYNOTE-355 on Pembrolizumab and Chemotherapy
Hope S. Rugo, MD, of the University of California, San Francisco, discusses phase III results from the KEYNOTE-355 study of pembrolizumab plus chemotherapy, which improved overall survival vs chemotherapy alone in patients with previously untreated locally recurrent, inoperable, or metastatic...
Oncology Care in the Ongoing COVID-19 Pandemic: Expert Commentary
Recently, Govind Persad, JD, PhD, of the University of Denver Sturm College of Law, wrote an op-ed for The ASCO Post entitled “Oncology Care Remains Under Strain in the Ongoing COVID-19 Pandemic.” On this episode of the podcast, Dr. Persad further discusses the challenges that patients with cancer...
St. Jude Names Shannon Dean, MD, as Chief Medical Information Officer
Shannon Dean, MD, has joined St. Jude Children’s Research Hospital as Chief Medical Information Officer at a key time in the hospital’s efforts to enhance the patient experience. Dr. Dean will help oversee the launch of the hospital’s new electronic health record, which is scheduled to go live in...
Did Change in PSA-Based Screening Recommendation Hinder Prostate Cancer–Specific Survival?
Prostate-specific antigen (PSA) screening recommendations made by the U.S. Preventive Services Task Force (USPSTF) in 2012 may have led to worse outcomes for insured patients with prostate cancer, according to data presented at the 2021 ASCO Quality Care Symposium.1 Findings from the retrospective...
Study Assesses Benefit of Digital Health Tools for Cancer Survivors
New study results suggest that to maximize effects of digital support tools for cancer survivors, it is essential to personalize information and increase engagement efforts. The report, published by Leach et al in the journal Cancer, demonstrated significant improvement in the ability to manage...
Two Studies Examine the Efficacy of Immunotherapy for Leptomeningeal Carcinomatosis
Two new studies published in Nature Communications indicate that immunotherapy may benefit people with leptomeningeal carcinomatosis, a rare but serious complication of cancer that has spread to the brain and/or spinal cord. Approximately 5% to 8% of all patients with cancer develop leptomeningeal ...
National Cancer Act and Lung Cancer Screening: An Example of Intended Impact
The National Cancer Act of 1971 established a national priority to address the widely shared dread of a cancer diagnosis. The goal of the National Cancer Act was to strengthen the National Cancer Institute (NCI) to more effectively carry out the national effort against cancer. After the Act was...
BTK Inhibition in CLL: An Embarrassment of Riches
Chronic lymphocytic leukemia (CLL) is a B-cell lymphoproliferative disorder defined by a specific phenotype and the presence of more than 5,000 clonal B cells in the peripheral blood.1 In the absence of this number of circulating cells, its soft-tissue/bone-marrow counterpart is semantically...
Patients With Hematologic Malignancies: How Robust Is Their Immunity to SARS–CoV-2?
A large study from the United Kingdom has taken a deep dive into SARS–CoV-2 in the setting of cancer, yielding both concerning and encouraging findings about natural and vaccine-induced immunity. The study was presented at the Presidential Symposium during the European Society for Medical Oncology...
Do Patients Diagnosed With Cancer Living in Low-Income and Rural Areas Face an Increased Risk of Suicide?
Individuals diagnosed with cancer who live in low-income and rural areas may face an increased risk of suicide compared with patients living in high-income and urban areas, according to a study published by Suk et al in JAMA Network Open. The research focused on determining whether the risks and...
Study Examines Opinions on Telemedicine Among Patients Undergoing Radiotherapy
New research published by Shaverdian et al in JNCCN—Journal of the National Comprehensive Cancer Network assessed patient satisfaction and preferences associated with telemedicine. Researchers found 45% of people with cancer undergoing radiotherapy preferred telemedicine, whereas 34% preferred...
Susana N. Banerjee, MBBS, PhD, on Ovarian Cancer: Novel Combination Therapy Under Study
Susana N. Banerjee, MBBS, PhD, of The Royal Marsden NHS Foundation Trust, discusses phase I results that have generated interest in the combination of the RAF/MEK inhibitor VS-6766 and the FAK inhibitor defactinib for patients with recurrent low-grade serous ovarian cancer, a disease that typically ...
