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Showing 21051 - 21100Percentage of Cancers Linked to Viruses Potentially Overestimated
The results of a large-scale analysis of the association between DNA viruses and human malignancies suggest that many of the most common cancers are not associated with DNA viruses. The findings, published in the August issue of the Journal of Virology, challenge earlier studies suggesting that as...
Study Reveals Genes That Drive Glioblastoma
A team of researchers at the Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center has identified 18 new genes responsible for driving glioblastoma multiforme, the most common—and most aggressive—form of brain cancer in adults. The study was published online...
Long-Term Calcium-Channel Blocker Use for Hypertension Associated With Higher Breast Cancer Risk
Long-term use of a calcium-channel blocker to treat hypertension is associated with higher breast cancer risk, according to a report published by JAMA Internal Medicine. The study assessed the relationships between the major classes of hypertensive agents and risk of the two most common histologic...
Sanford-Burnham Researchers Map a New Metabolic Pathway Involved in Cell Growth
Deciphering the body's complex molecular pathways that lead to disease when they malfunction is highly challenging. Researchers at Sanford-Burnham Medical Research Institute now have a more complete picture of one particular pathway that can lead to cancer and diabetes. In a study published in...
Mechanism Offers Promising New Approach for Harnessing the Immune System to Fight Cancer
Scientists at St. Jude Children’s Research Hospital have discovered a way to target the immune system to shrink or eliminate tumors in mice without causing autoimmune problems. Researchers also found evidence that the same mechanism may operate in humans. The study was published online today...
Researchers Target ‘Cell Sleep’ to Lower Chances of Cancer Recurrence
An international research team led by scientists at the University of Pittsburgh Cancer Institute (UPCI) discovered that by preventing cancer cells from entering a state of cellular sleep, cancer drugs are more effective, and there is a lower chance of cancer recurrence. The findings, published...
Omega-3 Fatty Acids May Aid in Treatment and Prevention of Skin and Oral Cancers
Omega-3 fatty acids, contained in oily fish such as salmon and trout, selectively inhibit growth and induce cell death in early- and late-stage oral and skin squamous cell carcinomas, according to new research from scientists at Queen Mary, University of London. The findings were published online...
FDA Warns of Rare but Serious Skin Reactions with Acetaminophen
The U.S. Food and Drug Administration (FDA) is informing the public that acetaminophen has been associated with a risk of rare but serious skin reactions. These skin reactions, known as Stevens-Johnson Syndrome, toxic epidermal necrolysis, and acute generalized exanthematous pustulosis, can...
PET/CT Superior to Bone Marrow Biopsy for Diagnosis and Prognosis of Lymphoma Patients
A more precise method for determining bone marrow involvement in patients with diffuse large B-cell lymphoma—a key factor in tailoring patient management plans—has been identified by researchers in a study published in the August issue of The Journal of Nuclear Medicine. Imaging with...
Targeted Therapy Identified for Protein that Protects and Nourishes Cancer
Scientists at The University of Texas MD Anderson Cancer Center who identified a protein’s dual role in cancer promotion have discovered a way to shut it down, opening a potential new avenue for cancer treatment. Reporting their findings in the journal Cell, the researchers describe the first ...
Blocking Sugar Intake May Reduce Cancer Risk or Progression in Certain Malignant Tumors
Blocking dietary sugar and its activity in tumor cells may reduce cancer risk and progression, according to researchers from the Icahn School of Medicine at Mount Sinai in New York. The study, conducted in fruit flies and published in the August issue of Cell, provides insight as to why...
Researchers Uncover How a Potent Compound Kills Prostate Cancer Cells
A new study led by researchers at Sanford-Burnham Medical Research Institute reveals how a promising anticancer compound called SMIP004 specifically kills prostate cancer cells by compromising their ability to withstand environmental stress. The study, recently published in Oncotarget, uncovered...
Nonsentinel Lymph Node Positivity Appears to be Significant Prognostic Factor in Patients with Melanoma
Nonsentinel lymph node positivity appears to be a significant prognostic factor in patients with stage III melanoma, according to a study by Anna M. Leung, MD, of the John Wayne Cancer Institute at Saint John’s Health Center, Santa Monica, California, and colleagues. The study was published...
Acute Myeloid Leukemia Induces Bone Marrow Failure by Inhibiting Production of Hematopoietic Stem Cells
Scientists studying acute myeloid leukemia (AML) have discovered that rather than displacing hematopoietic stem cells in the bone marrow as previously believed, the cancer is in fact inhibiting production of downstream hematopoietic cells, effectively putting them to sleep. The findings were...
Digital Breast Tomosynthesis Reduces Breast Cancer Screening Recall Rate Compared to Mammography Alone
The addition of tomosynthesis to standard digital mammography resulted in a 30% reduction in overall recall rates among women being screened for breast cancer, according to a new study published online in Radiology. The results demonstrate that digital tomosynthesis is an effective tool in reducing ...
Some Women with Abnormal Breast Lesions May Avoid Surgery
Surgery is not always necessary for women with a type of breast tissue abnormality associated with a higher risk of cancer, according to a new study published online in Radiology. Researchers said that periodic imaging and clinical exam are effective in these patients when radiology and pathology...
Researchers Find Link Between Intestinal Bacteria and Lymphoma
Researchers from UCLA's Jonsson Comprehensive Cancer Center (JCCC) have discovered that specific types of bacteria that live in the gut are major contributors to lymphoma. The study, led by Robert H. Schiestl, PhD, Professor of Pathology and Laboratory Medicine, Environmental Health Sciences, and...
Decision Aids Reduce Men's Conflict about PSA Screening, but Don't Change Their Decisions
Men who decide to be screened for prostate cancer and those who forgo PSA screening stick with their decisions after receiving materials explaining the risks and benefits of the test, according to a study published in JAMA Internal Medicine. The study examined both Web-based and printed tools aimed ...
U.S. Preventive Services Task Force Recommends Screening for Lung Cancer in High-risk Individuals
The U.S. Preventive Services Task Force posted its final evidence report and draft recommendation statement on screening for lung cancer. The Task Force is providing an opportunity for public comment on this draft recommendation statement; comments can be submitted from July 30 to August ...
Higher Incidence of Non-Hodgkin Lymphoma Found in Regions with Close Proximity to Benzene Release Sites
The incidence of a non-Hodgkin lymphoma (NHL) is significantly higher in regions near facilities that release the chemical benzene into the environment, according to a new study published early online in Cancer. This and other studies like it will be critical to identifying and enacting public...
Gene Test Highly Accurate in Predicting Metastasis in Patients with Thymoma
Patients diagnosed with thymoma, a rare cancer of the thymus gland, may be able to avoid certain cancer treatments associated with severe adverse events if the results of a new test reveal they are at low risk of metastasis, according to a study published in PLOS ONE. The study, by researchers at...
Richard I. Fisher, MD, Named President and CEO of Fox Chase Cancer Center
Richard I. Fisher, MD, a leading cancer center administrator and nationally recognized hematology/oncology expert, has been appointed President and CEO of Fox Chase Cancer Center. Dr. Fisher will also hold the title of Cancer Center Director of Fox Chase, serving as the principal investigator on...
Intratumoral IL-12 Injections Shrink Melanoma and Merkel Cell Tumors
Intratumoral injections of plasmid DNA encoding interleukin-12 (IL-12), facilitated in its delivery by electroporation, results in tumor regression in patients with both metastatic melanoma and Merkel cell carcinoma, according to findings reported at the 2013 World Cutaneous Malignancies Congress...
FDA Limits Usage of Oral Ketoconazole Due to Potentially Fatal Liver Damage
The U.S. Food and Drug Administration (FDA) announced today that oral ketoconazole should not be used as first-line treatment for any fungal infection and should only be used for the treatment of endemic mycoses when alternative antifungal therapies are not available or tolerated. The use of...
Large Study Reveals Increased Cancer Risks Associated with Family History of the Disease
A family history of cancer increases the risk of other members of the family developing not only the same, or concordant, cancer but also a different, or discordant, cancer, according to a large study of 23,000 people in Italy and Switzerland. The study, published in Annals of Oncology, provides a...
New Biomarker for Colorectal Cancer Could Help Predict Whether Disease Will Spread
Scientists have identified a protein that could play a crucial role in recognizing whether patients with colorectal cancer are candidates for chemotherapy due to a high risk of their cancer spreading, according to a new study published in the British Journal of Cancer. Scientists at the University...
Digital PCR Technology Detects Brain Tumor–associated Mutation in Cerebrospinal Fluid
Researchers at Massachusetts General Hospital have used digital versions of a standard molecular biology tool to detect a common tumor-associated mutation in the cerebrospinal fluid of patients with brain tumors. In a report published in Molecular Therapy – Nucleic Acids, the...
AACR Warns That Diminished NIH Funding Jeopardizes Ability to Eradicate Cancer Health Disparities
This afternoon, the American Association for Cancer Research (AACR) hosted a congressional briefing to highlight the significance of federally funded biomedical research in improving our understanding of cancer health disparities and developing targeted interventions to eliminate them. The...
FDA Invites Public Input on Menthol in Cigarettes
The U.S. Food and Drug Administration (FDA) has issued an Advance Notice of Proposed Rulemaking (ANPRM) seeking additional information to help the agency make informed decisions about menthol in cigarettes. Despite decades of work to reduce tobacco use in the United States, it continues to be the...
Difference in Breast Cancer Survival Between Black and White Women Has Not Changed Substantially
In an analysis of 5-year survival rates among black and white women diagnosed with breast cancer between 1991 and 2005, black women continued to have a lower rate of survival, with most of the difference related to factors including poorer health of black patients at diagnosis and more advanced...
Oxygen Decelerates Many Tumors When Combined with Radiation Therapy
A multidisciplinary team at UT Southwestern Medical Center has found that measuring the oxygenation of tumors can be a valuable tool in guiding radiation therapy, opening the door for personalized therapies that keep tumors in check with oxygen enhancement. In a study examining tissue oxygenation...
Study Finds Boys More Likely to Receive HPV Vaccine When Their Mothers Receive Preventive Care
Boys are more likely to receive the quadrivalent human papillomavirus vaccine if their mothers receive flu shots or Pap screenings, according to a study from Kaiser Permanente published in the American Journal of Public Health. Study Details The study examined the electronic health records of...
Study Reveals Best of Three Schedules of Nab-paclitaxel/Bevacizumab in Metastatic Breast Cancer
In a phase II study evaluating three dosing regimens of nanoparticle albumin-bound (nab)-paclitaxel (Abraxane) given with bevacizumab (Avastin), weekly dosing of nab-paclitaxel resulted in the highest overall response rate and longest progression-free survival. The schedule of nab-paclitaxel given...
Integrative Medicine Interventions Found to Significantly Reduce Pain, Improve Quality of Life
An integrative approach to treating chronic pain significantly reduced pain severity and improved mood and quality of life, according to a new study from the Bravewell Practice-based Research Network (BraveNet) published in BMC Complementary and Alternative Medicine. Researchers found a reduction...
Protein Complex Linked to Cancer Growth May Act as Tumor Suppressor
Researchers at Moffitt Cancer Center in Tampa, Florida, and Tianjin Medical University Cancer Institute and Hospital in China have discovered a gene-expression signature that may lead to new immune therapies for patients with lung cancer. Their findings, published in The Journal of Clinical...
Cancer Survivors Have More Frequent and Severe Menopausal Hot Flashes
Women who survive cancer have more frequent, severe, and troubling hot flashes than other women with menopausal symptoms, according to a study published online in Menopause, the journal of The North American Menopause Society (NAMS). But surprisingly, the cancer survivors fare better...
Study Suggests Proteins Involved in Immunity May Be Responsible for Cancer-causing Mutations
A set of proteins involved in the body’s natural defenses produces a large number of mutations in human DNA, according to a study led by researchers at the National Institutes of Health. The findings, published in Nature Genetics, suggest that these naturally produced mutations are just as...
HPV Vaccine Reduces Prevalence of Oral HPV Infections in Costa Rican Study
A new study by the International Agency for Research on Cancer (IARC), in partnership with Costa Rican investigators and the National Cancer Institute (NCI), shows for the first time that the vaccine against human papillomavirus (HPV) types 16 and 18, which is used to prevent cervical cancer, also...
Molecular Relative of p53 Tumor-suppressor Protein also Helps Cancer Cells Thrive
The protein TAp73 shares extensive common gene sequences with the tumor-suppressor protein p53, and previous studies have suggested that it may function similarly to p53 to prevent tumor formation. However, unlike p53, the most commonly mutated gene in human tumors, TAp73 is rarely mutated and is...
Cancer Patients with Cardiovascular Risk Factors Who Receive Chest Radiation Should Have Cardiovascular Screening Every 5 to 10 Years
Cancer patients who receive chest radiation should be screened for heart disease every 5 to 10 years, according to the European Association of Cardiovascular Imaging (EACVI) of the European Society of Cardiology and the American Society of Echocardiography. Their recommendations are outlined in the ...
Cancer Organizations Provide Support for Required Cancer Center Distress Screening Programs
The American Psychosocial Oncology Society (APOS) has announced recommendations to support a new criterion for cancer center accreditation. In 2015, the American College of Surgeons (ACoS) Commission on Cancer (CoC) will require cancer centers to implement screening programs for...
Use of Androgen Deprivation Therapy for Treatment of Prostate Cancer Associated with Increased Risk of Acute Kidney Injury
In a study that included more than 10,000 men with nonmetastatic prostate cancer, use of androgen deprivation therapy was associated with a significantly increased risk of acute kidney injury, with variations observed with certain types of androgen deprivation therapies, according to a study in the ...
Most Commonly Used Ovarian Cancer Cell Lines Do Not Resemble Ovarian Cancer
Researchers from Memorial Sloan-Kettering Cancer Center recently discovered that the most frequently used cancer cell lines in ovarian cancer research are not suitable models of ovarian cancer. Their findings are the result of a detailed review of genomic data that recently became publicly...
Colorectal Cancer Survivors Face Increased Risk of Developing Subsequent Cancers of Different Types
According to a new study, colorectal cancer survivors face an increased risk of developing subsequent primary cancers, particularly second colorectal cancers and small intestinal cancers. These findings, published online in Cancer, may help in the development of screening guidelines for patients...
Nerves Play Key Role in Triggering Prostate Cancer and Promoting Metastases
Researchers at Albert Einstein College of Medicine of Yeshiva University have found that nerves play a critical role in both the development and spread of prostate tumors. Their findings, using both a mouse model and human prostate tissue, may lead to new ways to predict the aggressiveness of...
FDA Approves Afatinib for EGFR-mutant Late-stage Non–Small Cell Lung Cancer
The U.S. Food and Drug Administration (FDA) today approved the tyrosine kinase inhibitor afatinib (Gilotrif) for the first-line treatment of patients with metastatic non–small cell lung cancer (NSCLC) whose tumors express epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21...
Jamie H. Von Roenn, MD, Joins ASCO as Head of Education, Science, and Professional Development
Jamie H. Von Roenn, MD, Professor of Medicine at the Northwestern University Feinberg School of Medicine, has been named as the Senior Director of the Education, Science and Professional Development Department of the American Society of Clinical Oncology (ASCO). A long-time ASCO member and...
Protein Targeted for Cancer Drug Development Is Essential for Normal Heart Function
Scientists at St. Jude Children’s Research Hospital have discovered that a protein used by cancer cells to evade death also plays a vital role in heart health. This dual role complicates efforts to develop cancer drugs that target the protein, but may lead to new therapies for heart muscle...
Study Confirms Link Between High Blood Levels of Omega-3 Fatty Acids and Increased Risk of Aggressive Prostate Cancer
A second large, prospective study by scientists at Fred Hutchinson Cancer Research Center has confirmed the link between high blood concentrations of omega-3 fatty acids and an increased risk of prostate cancer. Study Details Published online in the Journal of the National Cancer Institute, the...
Critical Pathway in Cell Cycle May Lead to Cancer Development
A team of scientists at the Salk Institute for Biological Studies has identified why disruption of a vital pathway in cell cycle control leads to the proliferation of cancer cells. Their findings on telomeres, published today in Molecular Cell, suggest a potential target for preventive measures...
