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Showing 17001 - 17050Novel Drug Combination Showed Antitumor Activity in Patients with Incurable BRCA-deficient Cancers
When given sequentially, two orally available experimental drugs—sapacitabine and seliciclib—worked together to elicit antitumor effects in patients with incurable BRCA-deficient cancers, according to phase I data presented at the AACR Annual Meeting 2013, held in Washington, DC, April...
Adding Cetuximab to Chemotherapy Enables Select Patients with Advanced Colorectal Cancer and Liver Metastasis to Undergo Surgery
New results from a clinical trial conducted in Shanghai, China, indicate that adding cetuximab (Erbitux) to standard chemotherapy enables some patients with otherwise inoperable liver metastases due to colorectal cancer have their metastases surgically removed. Such surgery can be curative, and is...
Alcohol Consumption Has No Impact on Breast Cancer Survival, According to New Research
Although previous research has linked alcohol consumption to an increased risk of developing breast cancer, a new study has found that drinking before and after diagnosis does not impact survival from the disease. In fact, a modest survival benefit was found in women who were moderate drinkers...
Statement by ASCO President Sandra M. Swain, MD, FACP, in Support of the Rally for Medical Research, April 8, 2013
A strong, stable federal investment in cancer research, prevention, and treatment is critical to continue the progress we are making for the more than 1.66 million Americans newly diagnosed with cancer every year. ASCO calls on Congress to renew its commitment to this life-sustaining research. As...
Ibrutinib Receives Third Breakthrough Therapy Designation from the FDA
Pharmacyclics, Inc, announced today that the FDA has granted an additional Breakthrough Therapy Designation for the investigational oral agent ibrutinib as monotherapy for the treatment of patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma with deletion of the short arm...
New Type of Experimental Drug Active in Platinum-resistant Ovarian Cancers
The antibody-drug conjugate DMUC5754A, a novel member of a relatively new class of drugs, showed activity in women with ovarian cancer, even those with hard-to-treat, platinum-resistant disease, in a phase I trial presented at the AACR Annual Meeting 2013, held in Washington, DC, April 6 to 10....
On-and-off Approach to Prostate Cancer Treatment May Compromise Survival
Taking a break from hormone-blocking prostate cancer treatments once the cancer seems to be stabilized is not equivalent to continuing therapy, a new large-scale international study finds. Previous smaller studies had indicated that intermittent androgen deprivation therapy might be just as good...
New Diagnostic Technology May Lead to Individualized Treatments for Prostate Cancer
A research team jointly led by scientists from Cedars-Sinai Medical Center and the University of California, Los Angeles, has enhanced a device they developed to identify and “grab” circulating tumor cells (CTCs) that break away from cancers and enter the blood, often leading to the...
Cisplatin-resistant Cancer Cells Sensitive to PARP Inhibitors
Poly (ADP-ribose) polymerase (PARP) inhibitors may be a novel treatment strategy for patients with cancer that has become resistant to the commonly used chemotherapy drug cisplatin, according to data from a preclinical study published in Cancer Research, a journal of the American Association for...
Roswell Park Scientists Advance Findings about Novel, Low-toxicity Anticancer Agent
Researchers at Roswell Park Cancer Institute (RPCI) have found that a new formulation of a promising anticancer agent, the small chemical molecule FL118, is even more effective in controlling two types of cancer than a version reported in PLOS ONE 6 months earlier proved to be. Additional evidence...
Prostate Cancer Risk Rises in Men with Lynch Syndrome
Men with Lynch syndrome face a higher lifetime risk of developing prostate cancer and appear to develop the disease at an earlier age, according to a new study led by researchers at the University of Michigan Comprehensive Cancer Center. Results of the study appear online in the Journal of Clinical ...
Mayo Clinic: New DNA Sequences Hone in on Breast, Ovarian Cancer Risk
Researchers at Mayo Clinic Cancer Center have identified new DNA sequences associated with breast cancer and ovarian cancer. The findings, which appear in three studies in the journals PLoS Genetics and Nature Genetics, will help reveal the underlying causes of these diseases and help researchers...
New Metabolite-based Diagnostic Test Could Help Detect Pancreatic Cancer Early
A new diagnostic test that uses a technique known as metabolomic analysis may be a safe and easy screening method that could improve the prognosis of patients with pancreatic cancer through earlier detection. Researchers examined the utility of metabolomic analysis as a diagnostic method for...
Many Doctors Do Not Provide Tobacco Cessation Assistance to Lung Cancer Patients
Physicians who care for lung cancer patients recognize the importance of tobacco cessation but often do not provide cessation assistance to their patients, according to a recent study published in the Journal of Thoracic Oncology. Survey Details An online survey was conducted in 2012 by the...
Moffitt Cancer Center Researchers Analyze HPV Vaccination Disparities among Girls from Low-income Families
Researchers at Moffitt Cancer Center and colleagues at the University of Florida studied health-care providers to determine the factors associated with disparities in human papillomavirus (HPV) vaccination among girls, ages 9 to 17, from low-income families. They found that physician vaccination...
Monoclonal Antibody Targets, Kills Leukemia Cells
Researchers at the University of California, San Diego Moores Cancer Center have identified a humanized monoclonal antibody that targets and directly kills chronic lymphocytic leukemia (CLL) cells. The findings, published in the online Early Edition of the Proceedings of the National Academy of...
Higher Soy Intake Prior to Lung Cancer Diagnosis Linked to Longer Survival in Chinese Women
New results from a large observational follow-up study conducted in Shanghai, China, indicate that women with lung cancer who consumed more soy food prior to their cancer diagnosis lived longer than those who consumed less soy. The study, published March 25 in the Journal of Clinical Oncology,...
Ganetespib Demonstrates Potency against ALK-positive Lung Cancer and Overcomes Crizotinib Resistance
A drug that indirectly impairs the function of several cancer-driving proteins, including anaplastic lymphoma kinase (ALK), may be an effective new treatment for patients with ALK-positive non–small cell lung cancer (NSCLC). The drug, ganetespib, may also be effective for treating patients...
Pathologists Identify Patterns of Mutations to Help Inform Design of Future Trials
Molecular driven therapeutic targets have resulted in a paradigm shift in the treatment of advanced lung adenocarcinoma. However, in early non–small cell lung cancer (NSCLC), surgical resection remains the treatment of choice with adjuvant chemotherapy. In a recent study published in the...
UC Davis Research Advances Efforts to Prevent Venous Thromboembolism
New research from the UC Davis Comprehensive Cancer Center, published in the Journal of Surgical Research, may help clinicians determine which patients are at highest risk for postsurgical blood clots in the legs or lungs. A team led by Robert J. Canter, MD, Associate Professor of Surgery at UC...
New Imaging Agent Enables Better Cancer Detection, More Accurate Staging
Researchers at the University of California, San Diego School of Medicine have shown that a new imaging dye, designed and developed at UC San Diego Moores Cancer Center, is an effective agent in detecting and mapping cancers that have reached the lymph nodes. The radioactive dye technetium Tc-99m...
Genetic Risk Strategies Needed for Young, Black, Female Breast Cancer Patients, Moffitt Cancer Center Study Shows
Researchers at Moffitt Cancer Center and colleagues in Canada have published study results focused on black women younger than 50, a population disproportionately afflicted with and dying from early-onset breast cancer compared to their white counterparts. The research published in The...
Moffitt Cancer Center Researchers Study Use of Dasatinib for Patients with High-risk MDS
Researchers at Moffitt Cancer Center have completed a phase II clinical trial to determine the safety and efficacy of dasatinib (Sprycel) for patients with higher-risk myelodysplastic syndromes (MDS), chronic myelomonocytic leukemia, or acute myeloid leukemia resulting from MDS and have failed ...
Gene Profile May Help Identify Risk for Hormone-sensitive, Hormone-insensitive Breast Cancer
The overexpression or underexpression of a newly identified set of genes related to lipid metabolism may help physicians identify whether or not a woman is at risk for hormone receptor–positive or hormone receptor–negative breast cancer and to subsequently tailor prevention strategies...
Study: Surgery Superior to Radiotherapy in Men with Localized Prostate Cancer
Surgery offers better survival benefit for men with localized prostate cancer, according to a large observational study, conducted by a group of researchers in Sweden and the Netherlands. The study, “Comparative oncologic effectiveness of radical prostatectomy and radiotherapy in prostate...
For Smokers, Low Levels of Vitamin D May Lead to Cancer
New research published online in Clinical Chemistry, the journal of the American Association for Clinical Chemistry, shows that decreased levels of vitamin D may predispose smokers to developing tobacco-related cancer. This study illustrates that simple vitamin D blood tests and supplements have...
More Than 60% of Ovarian Cancer Patients Do Not Receive Recommended Treatment, Study Shows
Women are 30% less likely to die of ovarian cancer if they have guideline-recommended treatment, yet nearly two-thirds of those with the disease do not receive it, often because they are cared for at hospitals that treat a small number of ovarian cancer patients. These are the findings of a study...
Cancer Researchers Discover New Type of Retinoblastoma in Very Young Children
A team of Canadian and international cancer researchers led by Brenda Gallie, MD,at the Princess Margaret Cancer Centre, University Health Network (UHN), has discovered a new type of retinoblastoma, a rapidly developing eye cancer that affects very young children—a finding that may...
Colon Cancer Patient Advocates and Physicians Urge Congress to Pass Bill Requiring Medicare Coverage of Virtual Colonoscopy
As Americans celebrate National Colorectal Cancer Awareness Month, the Colon Cancer Alliance, COLONTOWN—a survivor/patient support group for colorectal disease, including cancer—and the American College of Radiology call on Congress to pass the CT Colonography Screening...
Study Investigates Older Adults' Views on Cancer Screenings
A study from the Regenstrief Institute and the Indiana University Center for Aging Research has found that many older adults are hesitant to halt cancer screenings even when the screenings may no longer be beneficial or may even be potentially harmful. The study is among the first to explore older...
Tougher Criteria May Be Needed for African Americans Considering Prostate Cancer Surveillance
New research from The Cancer Institute of New Jersey suggests that more stringent criteria may be needed for African American men with prostate cancer when considering active surveillance of the disease. The findings, published in the latest online version of Urology found that the prevalence ...
Trio of Biomarkers May Help Identify Kidney Cancer in Early Stages
A new immunoassay that tests for the presence of three biomarkers appears to be a valid screening method for the early detection of malignant kidney cancer, according to data published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research....
Focal Therapy Offers Middle Ground for Some Prostate Cancer Patients
Men with low-risk prostate cancer who previously had to choose between aggressive treatment, with the potential for significant side effects, and active surveillance, with the risk of disease progression, may have a new option. Focal laser ablation uses precisely targeted heat, delivered through a...
Involving Other Providers in Palliative Care May Help Meet Growing Demand
As baby boomers age and the number of people with serious chronic illnesses continues to rise, the demand for experts in palliative medicine is sure to outstrip the supply, according Timothy E. Quill, MD, Professor of Medicine, Psychiatry and Medical Humanities in the Center for Ethics, Humanities...
Newly Identified Biomarkers May Help Predict Progression of Barrett’s Esophagus to Esophageal Adenocarcinoma
A series of microRNA expression signatures that may help to define progression of the precancerous condition Barrett’s esophagus into esophageal adenocarcinoma was reported recently in Cancer Prevention Research, a journal of the American Association for Cancer Research. “Once a rare...
Prospective Study Finds Many Children with Retinoblastoma Can Safely Forego Adjuvant Chemotherapy
New results from a prospective clinical trial conducted in France show that children with low-risk retinoblastoma do not need adjuvant chemotherapy to prevent disease recurrence or metastasis; the results also suggest that certain patients with intermediate-risk disease can receive less aggressive...
Nearly One in Four Women Newly Diagnosed with Breast Cancer Report PTSD Symptoms
A study by researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) at NewYork-Presbyterian/Columbia University Medical Center, has found that nearly one in four women (23%) newly diagnosed with breast cancer reported symptoms consistent with post-traumatic stress disorder (PTSD)...
Cancer Doesn’t Change Adolescent Girls’ Desire to Have Children, Study Shows
Researchers at Moffitt Cancer Center and colleagues have found that healthy adolescent females have predetermined expectations for becoming parents in the future, but have concerns about fertility and childbearing should they develop a life-threatening illness, such as cancer. The...
'Where You’re Treated Matters' in Terms of Cancer Survival
A study of older patients with advanced head and neck cancers has found that where they were treated significantly influenced their survival. The study, led by researchers at Fred Hutchinson Cancer Research Center and published in the March 1 online edition of Cancer, found that patients who...
FDA Approves Regorafenib for Advanced Gastrointestinal Stromal Tumors
The FDA has expanded the approved use of regorafenib (Stivarga) to treat patients with metastatic or unresectable gastrointestinal stromal tumors (GIST) that no longer respond to treatment with imatinib (Gleevec) or sunitinib (Sutent). Regorafenib, a multikinase inhibitor, blocks several enzymes...
FDA Approves New Treatment for HER2-positive, Metastatic Breast Cancer
The FDA approved ado-trastuzumab emtansine (Kadcyla), referred to as T-DM1 during clinical research, for patients with HER2-positive, metastatic breast cancer who were previously treated with trastuzumab (Herceptin) and taxane chemotherapy. “[Ado-trastuzumab emtansine] is trastuzumab...
Selumetinib Shown to Reverse Radioiodine Resistance in Some Advanced Thyroid Cancers
The experimental drug selumetinib may allow some patients with advanced thyroid cancer to overcome resistance to radioiodine, the most effective therapy for the disease, according to new research from Memorial Sloan-Kettering Cancer Center. Published in the February 14 issue of the New England...
Triple-negative Breast Cancer Subtypes Identified Using MicroRNA
A new, large-scale study of triple-negative breast cancer shows that small molecules called microRNA can be used to define four subtypes of this aggressive malignancy. The findings, by researchers at The Ohio State University Comprehensive Cancer Center – Arthur G. James Cancer Hospital and...
Experimental Drug Combination Selectively Destroys Lymphoma Cells
Laboratory experiments conducted by researchers at Virginia Commonwealth University Massey Cancer Center suggest that a novel combination of the investigational agent ibrutinib and bortezomib (Velcade) could potentially be an effective new therapy for several forms of blood cancer, including...
Researchers Discover Mutations Linked to Relapse Of Childhood Leukemia
After an intensive 3-year hunt through the genome, researchers have pinpointed mutations that lead to drug resistance and relapse in acute lymphoblastic leukemia (ALL) ,the most common type of childhood cancer—the first time anyone has linked the disease’s reemergence to specific...
NCI Researchers Identify Molecular Link between Metabolism and Breast Cancer
A protein associated with conditions of metabolic imbalance, such as diabetes and obesity, may play a role in the development of aggressive forms of breast cancer, according to new findings by researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their...
High-dose Vorinostat Effective at Treating Relapsed Lymphomas, Study Finds
Reporting the results of a phase I clinical trial to test the effectiveness of a new class of drugs to augment standard chemotherapy, a team led by Fred Hutchinson Cancer Research Center scientists found that giving patients high doses of vorinostat (Zolinza) in combination with another round...
Less Invasive Treatment Is Associated with Improved Survival in Early-stage Breast Cancer
Patients with early-stage breast cancer who were treated with lumpectomy plus radiation may have a better chance of survival compared with those who underwent mastectomy, according to Duke Medicine research. The study, which appeared online January 28, 2013, in the journal Cancer, raises new...
MD Anderson Study Finds Qigong Improves Quality of Life for Breast Cancer Patients Undergoing Radiation Therapy
Researchers from The University of Texas MD Anderson Cancer Center have found qigong, an ancient mind-body practice, reduces depressive symptoms, and improves quality of life in women undergoing radiotherapy for breast cancer. The study, published in the journal Cancer, is the first to examine...
Researchers Discover Promising Prognostic Marker for Aggressive Breast Cancer
A team of researchers led by Goutham Narla, MD, PhD, at Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, and collaborators at the Mount Sinai School of Medicine and Erasmus Medical Center, have discovered a gene variant that drives the spread of...
