Surgeons Report Melanoma Recurs after 10 Years in More than 6% of Patients


Key Points

  • In an analysis of patients who received primary treatment at John Wayne Cancer Institute with 10 or more years follow-up, 6.9% showed late recurrence of melanoma. On an actuarial basis, late recurrence rates were 6.8% and 11.3% at 15 and 20 years, respectively, for those with no recurrence at 10 years.
  • Patients with a higher chance of late recurrence were typically a younger age at initial diagnosis and generally had more favorable tumor characteristics (thin, nonulcerated, node-negative).
  • Patients with a late recurrence were about 40% less likely to die of melanoma than were patients with an early recurrence.

Recurrence of melanoma skin cancer 10 or more years after initial treatment is more common than previously thought, occurring in more than 1 in 20 patients. However, according to a new study, these patients tend to live longer after their cancer returns than patients whose melanoma recurs in the first 3 years. The study results appear in the July issue of the Journal of the American College of Surgeons.

“For patients with melanoma, survival beyond 10 years without a recurrence has been considered nearly synonymous with a cure,” said principal investigator Mark Faries, MD, FACS, Professor of Surgery at the John Wayne Cancer Institute at Saint John’s Health Center, Santa Monica, California. “However, most studies do not follow-up patients longer than 10 years. Our study found that late melanoma recurrence is not rare and that it occurs more frequently in certain patient groups.”

Lifelong Follow-up Recommended

Dr. Faries said the study represents the largest reported group of melanoma patients with a first recurrence at least a decade later. Of 4,731 patients who were diagnosed with skin melanoma at their medical center and received long-term follow-up, 408 patients experienced a late melanoma recurrence after being disease-free for 10 or more years, the authors reported. 

Recurrence rates using actuarial analysis were reportedly 6.8% 15 years after initial treatment and 11.3% at 25 years.

When the investigators determined the melanoma recurrence rate by including only patients who received initial treatment at the John Wayne Cancer Institute, they found that 327 (6.9%) of the 4,731 patients showed a late recurrence.

“It appears the risk of melanoma recurrence is never completely gone,” Dr. Faries said. “One change that should result from our study is that people need to be followed up for life with a physician after a diagnosis of melanoma.”

Characteristics of Patients with Late Recurrence

The new study findings showed that late melanoma recurrence was less male-predominant than in patients whose cancer recurred within the first 3 years. Although 66% of 3,127 patients with an early melanoma recurrence were men, only 57% of the 408 patients with a late recurrence were male, the investigators reported. This difference may be because initially melanoma is more aggressive in men than in women, although the reasons for this are unclear, Dr. Faries said.

The researchers noted other differences existing between patient groups. Namely, patients whose melanoma did not recur until at least 10 years later were younger, on average, than those with an early recurrence: 41 vs 51 years of age. 

In addition, compared with the early-recurrence group, patients with a late recurrence tended to have had an original melanoma with characteristics indicating a more favorable disease outcome. Specifically, their original tumor was more likely to have been thin and nonulcerated, not have spread to the lymph nodes, and occurred at a site other than the head and neck.

Better Postrecurrence Survival Rate

Although the investigators found that late-recurring melanomas were more likely to develop in a site on the body distant from the original site, this group of patients had a better postrecurrence survival rate. Compared with patients whose cancer returned within 3 years, patients with a late recurrence were about 40% less likely to die of melanoma than were patients with an early recurrence, Dr. Faries said. Overall survival also was better in the late-recurrence group according to the researchers.

“Fortunately, the vast majority of melanoma patients who remain disease free longer than 10 years will not have a recurrence,” Dr. Faries said. “However, patients should be aware that persistent or unexplained symptoms anywhere in the body might indicate a recurrence of their melanoma, and they should return to their physician to make sure the symptoms are not related.”

Even when symptoms are absent, Dr. Faries recommended that patients get an annual clinical examination with their melanoma physician or primary care physician.

Study researchers received partial support from the National Cancer Institute, Melanoma Research Alliance, Dr. Miriam and Sheldon G. Adelson Medical Research Foundation, and Alan and Brenda Borstein.

The content in this post has not been reviewed by the American Society of Clinical Oncology, Inc. (ASCO®) and does not necessarily reflect the ideas and opinions of ASCO®.