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David B. Roth, MD, PhD, Named Director of New Penn Center for Precision Medicine

David B. Roth, MD, PhD, has been appointed Director of the new Penn Center for Precision Medicine. In his new role, he will lead efforts to accelerate the implementation of precision medicine into clinical care. Dr. Roth is an expert in DNA repair and mechanisms of programmed gene rearrangements...

AACR CEO Margaret Foti, PhD, MD (hc), Honored With James Ewing Layperson’s Award From SSO

Margaret Foti, PhD, MD (hc), CEO of the American Association for Cancer Research (AACR), was recognized during the plenary session at the 69th Society of Surgical Oncology (SSO) Annual Cancer Symposium with the James Ewing Layperson’s Award for her dedication to the prevention and cure of cancer;...

Sadik Esener, PhD, Selected to Lead OHSU’s Large-Scale Early Cancer Detection Initiative

Sadik Esener, PhD, has been recruited to the Oregon Health & Science University (OHSU) Knight Cancer Institute to lead the first large-scale early cancer detection program of its kind. Dr. Esener will be the Director of the Institute’s Center for Early Detection Research and has been awarded...

A Political Activist Challenges the Drug Approval Process and the U.S. Government

The U.S. Food and Drug Administration’s (FDA’s) primary concern in the drug approval process is to ensure that the drug is safe and effective. For the past several decades, the advocacy groups have vociferously painted the agency as a stodgy bureaucracy that prevents desperate patients access to...

Things May Not Be What They Seem: Are Old Cancer Treatment Theories New Again?

The adage “you can’t judge a book by its cover,” is true, but authors still need to be aware of the importance of first impressions. The title of science writer Travis Christofferson’s book Tripping Over the Truth: The Return of the Metabolic Theory of Cancer Illuminates a New and Hopeful Path to ...

2016 Oncology Meetings

APRIL European Lung Cancer ConferenceApril 13-16 • Geneva, SwitzerlandFor more information:www.esmo.org/Conferences/ELCC-2016-Lung-Cancer American Society for Colposcopy and Cervical Pathology (ASCCP) Annual MeetingApril 13-16 • New Orleans, LouisianaFor more...

Michael J. Birrer, MD, PhD, Named Recipient of the 2016 Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher

The Claudia Cohen Research Foundation and the Foundation for Women’s Cancer announced ­Michael J. Birrer, MD, PhD, as the 2016 recipient of the Claudia Cohen Research Foundation Prize for Outstanding Gynecologic Cancer Researcher. The $50,000 prize was presented at the Society of Gynecologic...

Lili Yang, PhD, Receives CIRM Funding to Investigate iNKT Modification and Transplantation

With new funding awarded by the California Institute for Regenerative Medicine (CIRM), Lili Yang, PhD, Assistant Professor in the Department of Microbiology, Immunology & Molecular Genetics and the Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research (BSCRC) at the...

Joan Massagué, PhD, to Receive 2016 Pezcoller Foundation–AACR International Award for Cancer Research

The 2016 Pezcoller Foundation-American Association for Cancer Research (AACR) International Award for Cancer Research will be presented to Joan Massagué, PhD, Director of the Sloan Kettering Institute and Alfred P. Sloan Chair at Memorial Sloan Kettering Cancer Center in New York, at the AACR...

global cancer care

Cancer on the Global Stage: Incidence and Cancer-Related Mortality in Israel

The ASCO Post is pleased to continue this special feature on the worldwide cancer burden. In this issue, we feature a close look at the cancer incidence and mortality rates in Israel. The aim of this special feature is to highlight the global cancer burden for various countries of the world. For...

pancreatic cancer

Phase Ib/II Study Reports High Response Rates Seen With Addition of Cisplatin to Regimen for Advanced Pancreatic Cancer

The oncology research team at HonorHealth Research Institute in Scottsdale, Arizona, is spearheading a phase Ib/II trial that is demonstrating promising results with a novel regimen in patients with advanced pancreatic cancer. “The patients we are treating have advanced adenocarcinoma of the...

Itai Yanai, PhD, to Lead Institute for Computational Medicine at NYU Langone Medical Center

Itai Yanai, PhD, whose in-depth study of how embryos develop has led to breakthroughs in the analysis of gene composition and expression, has been named the inaugural Director of the newly created Institute for Computational Medicine at NYU Langone Medical Center. He officially takes his new...

Susan Block, MD, Honored With AAHPM Palliative Care Lifetime Achievement Award

Susan Block, MD, an institute physician in the Department of Psychosocial Oncology and Palliative Care at Dana-Farber Cancer Institute, a Harvard Medical School Professor, and Director of the Serious Illness Care Program at Ariadne Labs, received the Lifetime Achievement Award at the American...

Samuel Waxman Cancer Research Foundation Appoints Robert Hromas, MD, to Its Scientific Advisory Board

The Samuel Waxman Cancer Research Foundation (SWCRF) announced the addition of cancer researcher Robert Hromas, MD, Chair of Medicine at University of Florida Health, to its scientific advisory board (SAB). Dr. Hromas, who continues his position at the University of Florida Health, will join his...

Peter Paul Yu, MD, FASCO, Named Physician-in-Chief of Hartford HealthCare Cancer Institute

Hartford HealthCare has named Past ASCO President Peter Paul Yu, MD, FASCO, the first Physician-in-Chief of Hartford HealthCare Cancer Institute. As Physician-in-Chief, Dr. Yu will be responsible for working closely and collaboratively with physicians and nurses who practice within the Hartford...

gastroesophageal cancer

Survival Period for Esophageal Cancer Is Tied to Race and Income

African American patients with esophageal cancer survive fewer months after diagnosis than white patients, but only if they also have low incomes, according to a study presented by Loretta ­Erhunmwunsee, MD, at the Annual Meeting of the Society of Thoracic Surgeons. Dr. ­Erhunmwunsee led the study...

lymphoma
leukemia

Selected Abstracts From 2015 ASH Annual Meeting: Part 4

Here is the final installment of selected abstracts from the proceedings of the 2015 American Society of Hematology (ASH) Annual Meeting and Exposition, focusing on Hodgkin lymphoma, follicular lymphoma, diffuse large B-cell lymphoma, and chronic lymphocytic leukemia. For other selected abstracts...

FDA Approves Defibrotide for Complication of Stem Cell Transplant

On March 30, 2016, the U.S. Food and Drug Administration (FDA) approved defibrotide sodium (Defitelio) for the treatment of adult and pediatric patients with hepatic veno-occlusive disease, also known as sinusoidal obstructive syndrome, with renal or pulmonary dysfunction following hematopoietic...

Patrick Moore, MD, MPH, Named NCI Outstanding Investigator, Awarded $6.4 Million for Discovering Cancer Viruses

Patrick Moore, MD, MPH, has received the National Cancer Institute (NCI) Outstanding Investigator Award, and was awarded $6.4 million to further his work into the link between viruses and cancer. This NCI grant provides 7 years of secured support, giving the investigator freedom from the pressure...

Jennie R. Crews, MD, FACP, Named President of the Association of Community Cancer Centers

Jennie R. Crews, MD, FACP, became the new President of the Association of Community Cancer Centers (ACCC) during the recent ACCC 42nd Annual Meeting in Washington, DC. Dr. Crews brings more than 18 years of experience in advancing quality oncology care, currently as the Medical Director for Cancer ...

breast cancer

Sarah L. Blair, MD, on Early-Stage Breast Cancer in Older Women: Surgical Management

Sarah L. Blair, MD, of UC San Diego Moores Cancer Center, discusses surgical resection of breast cancer, which has the best chance of cure and is better than hormonal treatment alone, even in patients over age 80.

lymphoma

MicroRNA miR-181a Reduces NFκB Signaling in Diffuse Large B-Cell Lymphomas

A recent study by researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine showed that a microRNA called miR-181a dampens signals from the cancer-driving NFκB protein pathway in diffuse large B-cell lymphoma (DLBCL). By reducing NFκB...

health-care policy

NCI Announces Blue Ribbon Panel to Help Guide Vice President Biden’s National Cancer Moonshot Initiative

On April 4, 2016, The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), announced a Blue Ribbon Panel of scientific experts, cancer leaders, and patient advocates that will inform the scientific direction and goals at NCI of Vice President Joe Biden’s National...

Jeffrey Fowler, MD, Begins Presidency of Society of Gynecologic Oncology

Jeffrey Fowler, MD, John G. Boutselis Chair in Gynecologic Oncology and Professor and Vice-Chair of Obstetrics and Gynecology at The Ohio State University Wexner Medical Center, started his 1-year term as the 48th President of the Society of Gynecologic Oncology (SGO) at the conclusion of the...

Clifford A. Hudis, MD, FACP, Named ASCO’s Next CEO

Clifford A. Hudis, MD, FACP, Chief of the Breast Medicine Service, Vice President for Government Relations, and Chief Advocacy Officer at Memorial Sloan Kettering Cancer Center (MSKCC), and Professor of Medicine at Weill Cornell Medical College, has been named the next Chief Executive Officer...

cns cancers

Louis Burt Nabors, MD, on Primary and Recurrent Gliomas: Notable Developments in Management

Louis Burt Nabors, MD, of the University of Alabama at Birmingham Comprehensive Cancer Center, discusses improvements in the 2016 NCCN Guidelines for glioma, anaplastic oligodendroglioma, and glioblastoma.

multiple myeloma

Kenneth Anderson, MD, on Multiple Myeloma Guideline Updates

Kenneth Anderson, MD, of Dana-Farber Cancer Institute, discusses how the many advances in the treatment of multiple myeloma affect current and future clinical practice.

pain management

Judith Paice, PhD, RN, on Managing Cancer Pain: Strategies for Prescribing Opioids

Judith Paice, PhD, RN, of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University, discusses strategies for safe opioid prescribing: making a comprehensive assessment, stratifying risk, using universal precautions, and educating practitioners on safe storage and disposal.

lung cancer

Douglas E. Wood, MD, on Lung Cancer: Workup and Staging

Douglas E. Wood, MD, of the University of Washington, discusses best practices, which enable a complete workup in 1 to 2 weeks in almost all patients, saving unnecessary testing. 

lung cancer

Douglas E. Wood, MD, on Lung Cancer Screening: Status and Patient Selection

Douglas E. Wood, MD, of the University of Washington, discusses important new developments in early detection, the need to educate primary care physicians and patients, and the potential to save up to 15,000 lives each year.

prostate cancer

Throwing Out the Baby With the Bathwater: A Critical Appraisal of the USPSTF Recommendation Against Screening for Prostate Cancer

In 2012, the U.S. Preventive Services Task Force (USPSTF) issued a recommendation against routine screening for prostate cancer.1,2 The grade D recommendation was considered controversial at the time, and remains so now, because many stakeholders have weighed the same body of evidence and come to...

leukemia

Jeffrey Jones, MD, MPH, on Chronic Lymphocytic Leukemia: Optimizing Treatment With New Agents

Jeffrey Jones, MD, MPH, of the Ohio State University Comprehensive Cancer Center, discusses the use of small molecule inhibitors in developing an individualized treatment plan for patients with CLL.

pancreatic cancer

Mahmoud Al-Hawary, MD, on Pancreatic Cancer: The Role of Imaging

Mahmoud Al-Hawary, MD, of the University of Michigan Comprehensive Cancer Center, discusses the role of radiology in diagnosing and staging pancreatic tumors, optimizing imaging techniques, and the value of structured reporting.

lung cancer

The POPLAR Trial: PD-L1 Blockade With Atezolizumab in Second- or Third-Line Non–Small Cell Lung Cancer

The randomized phase II ­POPLAR trial—reported by Fehrenbacher and colleagues and reviewed in this issue of The ASCO Post—is another key piece of information for the medical community regarding the value of immune checkpoint blockers in second/third-line treatment of patients with non–small cell...

colorectal cancer

Christopher Willett, MD, on Localized Rectal Cancer: Emerging Treatment Paradigms

Christopher Willett, MD, of Duke Cancer Center, discusses short and long courses of treatment, neoadjuvant chemotherapy with or without radiation, and organ preservation without surgery.

breast cancer

Kevin C. Oeffinger, MD, on Controversies in Breast Cancer Screening Strategies

Kevin C. Oeffinger, MD, of Memorial Sloan Kettering Cancer Center, discusses American Cancer Society recommendations, including the advice that women with an average risk of breast cancer should undergo regular screening mammography starting at age 45, and that women 55 and older should have...

leukemia

Jerald Radich, MD, on Chronic Myeloid Leukemia: Managing Advanced-Phase Disease

Jerald P. Radich, MD, of the Fred Hutchinson Cancer Research Center, discusses ways to prevent advanced-phase chronic myeloid leukemia through adherence to prescribed treatment and routine monitoring of disease burden.

lung cancer

Rogerio Lilenbaum, MD, on Metastatic NSCLC: Managing EGFR-Mutation–Positive Disease

Rogerio Lilenbaum, MD, of Yale Cancer Center/Smilow Cancer Hospital, discusses the importance of tumor profiling for non–small cell lung cancer and strategies for treating EGFR-positive disease in the first-line setting.

symptom management
survivorship

Joseph B. Narus, DNP, GNP-BC, ANP, on Sexual Function in Survivors: Guideline Update

Joseph B. Narus, DNP, GNP-BC, ANP, of Memorial Sloan Kettering Cancer Center, discusses the impact of cancer treatment on men’s sexual health, and treatment options to improve erectile function.

gastroesophageal cancer

Jaffer Ajani, MD, on Metastatic Gastroesophageal Cancers: Expert Perspective

Jaffer Ajani, MD, of The University of Texas MD Anderson Cancer Center, discusses the importance of HER2/neu testing and other aspects of treating patients with advanced gastroesophageal adenocarcinoma.

breast cancer

William Gradishar, MD, on Breast Cancer Guideline Updates

William Gradishar, MD, of the Robert H. Lurie Comprehensive Cancer Center at Northwestern University, discusses updates including preoperative HER2-directed therapy, optimal adjuvant endocrine treatment in premenopausal women, and an approach for managing ER+ metastatic disease.

survivorship

ENDO 2016: Engineered Ovary Implant Restores Fertility in Mice

Northwestern University scientists used a three-dimensional (3D) printer to create a prosthetic ovary—an implant that allowed mice that had their ovaries surgically removed to bear live young. The results were presented by Laronda et al on Saturday, April 2, at the Endocrine Society's Annual...

breast cancer

ENDO 2016: BPA Changes Fetal Development of the Mammary Gland, Can Raise Breast Cancer Risk

A new culture system that tests the role of chemical exposure on the developing mammary gland has found that bisphenol A (BPA) directly affects the mammary gland of mouse embryos. The study results, presented by Speroni et al Friday, April 1, at the Endocrine Society's Annual Meeting in Boston...

health-care policy
palliative care

Joseph Simone, MD: Highlights of the 21st Annual NCCN Conference

Joseph V. Simone, MD, of the Simone Consulting Company, gives his expert perspective on the important messages of this year’s meeting.

gynecologic cancers

Wui-Jin Koh, MD, on Vulvar Cancer: Guidelines Update

Wui-Jin Koh, MD, of the Fred Hutchinson Cancer Research Center, discusses the multiple services required to best treat this rare cancer.

hepatobiliary cancer

Anne Covey, MD, on Hepatocellular Carcinoma: Guideline Updates for Locoregional Treatment

Anne Covey, MD, of Memorial Sloan Kettering Cancer Center, discusses the role of ablation and arterial-directed therapy in the treatment of hepatocellular carcinoma.

hepatobiliary cancer

Daniel T. Chang, MD, on Hepatocellular Carcinoma: Guideline Updates for Locoregional Treatment

Daniel T. Chang, MD, of the Stanford Cancer Institute, discusses the role of radiation therapy in the treatment of hepatocellular carcinoma.

issues in oncology

TP53 Gene Variant S47 May Contribute to Increased Cancer Risk in People of African Descent

For years, clinical data have shown that African Americans have a higher death rate and shorter period of survival among patients with commonly diagnosed cancers. While studies have focused on whether socioeconomic factors contribute to these statistics, researchers have been diligently trying to...

prostate cancer

Widely Cited Prostate-Specific Antigen Screening Publications Influence Biopsy Rates and Associated Complications

While absolute rates of biopsy and postbiopsy complications have decreased following several benchmark prostate-specific antigen (PSA) screening publications, the relative risk for each patient continues to increase, according to a new study by Mayo Clinic researchers. The study is the largest to...

palliative care

Toby C. Campbell, MD, on Palliative Care: Patient and Provider Perspectives

Toby C. Campbell, MD, of the University of Wisconsin Carbone Cancer Center, discusses palliative care, hospice care, and best supportive care practices, as well as the challenges of symptom management and end-of-life issues.

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