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colorectal cancer
issues in oncology

Dietary Risk Factors for Early-Onset Colorectal Cancer

Researchers have found that diet-derived molecules known as metabolites may be the main drivers of early-onset colorectal cancer risk, especially those associated with red and processed meat, according to a recent study published by Jayakrishnan et al in npj Precision Oncology. Background Despite...

leukemia
genomics/genetics

Novel Insights May Transform Diagnosis and Treatment of Pediatric Patients With T-Lineage ALL

Researchers have uncovered that T-lineage acute lymphoblastic leukemia (ALL) may be frequently driven by genetic changes in noncoding portions of the DNA, according to a recent study published by Pölönen et al in Nature. The investigators believe these findings may lead to a paradigm shift in...

hematologic malignancies
supportive care

FDA Approves Axatilimab-csfr for Chronic GVHD

On August 14, the U.S. Food and Drug Administration (FDA) approved axatilimab-csfr (Niktimvo), a colony-stimulating factor–1 receptor–blocking antibody, for the treatment of chronic graft-vs-host disease (GVHD) after failure of at least two prior lines of systemic therapy in adult and pediatric...

gynecologic cancers

Efficacy of ‘Symptom-Triggered Testing’ for Detection of Ovarian Cancer

“Symptom-triggered testing”—prompted by symptoms such as pain, abdominal bloating/swelling, and feeling full soon after starting to eat—detected early-stage aggressive ovarian cancer in one of four individuals affected, according to an analysis from the ROCkeTS trial published by Kwong et al in the ...

skin cancer
immunotherapy

Combination Immunotherapies May Boost T-Cell Responses in Patients With Melanoma

Researchers may have uncovered how combination immunotherapies targeting the immune checkpoints PD-1 and LAG-3 may work together to activate immune responses in patients with melanoma, according to two recent studies published by Cillo et al and Andrews et al in Cell. The findings may shed light on ...

colorectal cancer
genomics/genetics

New Study May Unveil Prognostic Genetic Insights Into Colorectal Cancer

Researchers have reported novel genetic alterations and molecular classifiers of tumor variants in patients with colorectal cancer, according to a recent study published by Nunes et al in Nature. Background “Since 2018, Uppsala University and BGI [Genomics] have carried out in-depth cooperation on...

ARPA-H Awards to Develop Novel Technologies in Cancer Surgery

More than 2 years ago, President Joe Biden and First Lady Jill Biden reignited the Cancer Moonshot with the goals of reducing the cancer death rate in the United States by at least half (preventing more than 4 million cancer deaths) by 2047 and improving the experience of people who are touched by...

gynecologic cancers
issues in oncology

Salpingectomy vs Tubal Occlusion

Women whose fallopian tubes are removed during sterilization via laparoscopy may have only marginally more surgical complications compared with those whose tubes are cut during tubal occlusion, according to a recent study published by Strandell et al in The Lancet Regional Health–Europe. The...

solid tumors
issues in oncology

Cancer Cases and Mortality Among Men Predicted to Increase Globally

Investigators have uncovered disparities in the projected rates of future cancer incidence and mortality among men based on age and country’s socioeconomic status, according to a recent study published by Bizuayehu et al in Cancer. Background Prior research has shown that men may face higher rates...

breast cancer
cns cancers
issues in oncology

Sacituzumab Govitecan May Be Effective at Treating Breast Cancer–Related Brain Tumors

The antibody-drug conjugate sacituzumab govitecan-hziy may be effective in treating patients with breast cancer who have brain metastases or recurrent glioblastoma multiforme, according to a recent study published by Balinda et al in Nature Communications. Background About 50% of all female...

skin cancer
immunotherapy
issues in oncology

Pattern in Protein Production May Be Predictive of Side Effects From Immunotherapy in Patients With Melanoma

An activity pattern in certain genes responsible for building proteins known as spleen tyrosine kinases may predict the occurrence of severe side effects from immunotherapy in patients with melanoma, according to a recent study published by Monson et al in Clinical Cancer Research. Background...

breast cancer
issues in oncology

Gestational Diabetes and Risk for Breast Cancer

Women who develop gestational diabetes may not have a higher likelihood of being diagnosed with breast cancer, according to recent findings that will be presented by Christensen et al at the upcoming European Association for the Study of Diabetes Annual Meeting 2024 (Abstract 180). Background...

pancreatic cancer
issues in oncology

Metastasis-Directed Radiation Therapy Plus Chemotherapy in Oligometastatic Pancreatic Cancer

Researchers have demonstrated that adding metastasis-directed radiation therapy to standard-of-care chemotherapy may improve progression-free survival in patients with oligometastatic pancreatic cancer, according to a recent study published by Ludmir et al in the Journal of Clinical Oncology and...

lymphoma
skin cancer
immunotherapy

FDA Approves Immunotherapy for Relapsed or Refractory CTCL

On August 8, the U.S. Food and Drug Administration (FDA) approved denileukin diftitox-cxdl (Lymphir), a novel immunotherapy for the treatment of adult patients with relapsed or refractory cutaneous T-cell lymphoma (CTCL) who have received at least one prior systemic therapy. Denileukin diftitox is...

hematologic malignancies
issues in oncology

Efficacy of a JAK2/mTOR Inhibitor Combination in Controlling Acute Graft-vs-Host Disease

Adding a Janus kinase 2 (JAK2) inhibitor to standard immunosuppressive drugs may not improve prevention of acute graft-vs-host disease in patients with hematologic malignancies undergoing treatment with allogeneic hematopoietic cell transplantation, according to a recent study published by Pidala...

breast cancer
issues in oncology

Primary Ovarian Insufficiency, Early Menopause May Be Linked to Increased Risk of Breast Cancer

The risk of developing breast cancer may be increased among some women who undergo menopause prior to age 46, according to a recent study published by Allen-Brady et al in The Journal of Clinical Endocrinology & Metabolism. Background Early menopause occurs in women aged 40 to 45 years. Primary ...

cost of care
breast cancer
gynecologic cancers
colorectal cancer
lung cancer
prostate cancer

Cancer Screening Estimated to Cost $43 Billion Annually in United States

Cancer screening may cost more than $40 billion annually in the United States, according to a recent study published by Halpern et al in the Annals of Internal Medicine. Study Methods and Results In the recent modeling study, investigators used national health-care survey and cost resources data to ...

lung cancer
immunotherapy

Metastatic NSCLC Survival Rates in the Immunotherapy Era

The survival rates of patients with advanced non–small cell lung cancer (NSCLC) have improved since the introduction of the first immunotherapeutic in this population in the United States in 2015, according to a recent study published by Wang et al in Cancer. NSCLC accounts for up to 90% of all...

cns cancers

FDA Approves IDH1/2 Inhibitor for Certain Patients With Astrocytoma or Oligodendroglioma

The U.S. Food and Drug Administration (FDA) has approved vorasidenib (Voranigo), an isocitrate dehydrogenase-1 (IDH1) and -2 (IDH2) inhibitor, for adult and pediatric patients aged 12 years and older with grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation, following...

lung cancer

Should Low-Dose CT Screening Be Recommended for Those at Low Risk for Lung Cancer?

Lung cancer remains the leading cause of cancer-related deaths worldwide. Detecting this disease in its early stages significantly improves survival rates, making low-dose computed tomography (CT) screening an essential component in the fight against lung cancer. Recent studies, particularly from...

issues in oncology
solid tumors

Daily E-Cigarette Use May Be Linked to Higher Combustible Cigarette Cessation

U.S. adults who use e-cigarettes daily and smoke combustible cigarettes may be more likely to quit smoking traditional cigarettes compared with those who smoke but use e-cigarettes less frequently, according to a recent study published by Kasza et al in JAMA Network Open. The findings suggest that...

hematologic malignancies
issues in oncology

Investigating Fungal Bloodstream Infections in Bone Marrow Transplant Recipients

Researchers may have uncovered the mechanisms behind fungal bloodstream infections in patients who receive bone marrow transplants, according to a recent study published by Zhai et al in Nature Medicine. Background A phenomenon known as heteroresistance occurs when a tiny fraction of bacteria...

colorectal cancer
prostate cancer
pancreatic cancer
breast cancer
gynecologic cancers
issues in oncology
supportive care

Common Blood Tests May Improve Early Cancer Diagnosis

The results of routine blood tests could be used to speed up cancer diagnoses among patients with abdominal symptoms, according to a recent study published by Rafiq et al in PLOS Medicine. Background Most patients who report symptoms of abdominal pain or bloating to their physicians are referred...

sarcoma

FDA Grants Accelerated Approval to T-Cell Therapy for Unresectable or Metastatic Synovial Sarcoma

On August 2, the U.S. Food and Drug Administration (FDA) granted accelerated approval to afamitresgene autoleucel (Tecelra), a melanoma-associated antigen A4 (MAGE-A4)-directed genetically modified autologous T-cell immunotherapy, for adults with unresectable or metastatic synovial sarcoma who have ...

breast cancer
supportive care
issues in oncology

Novel AI Tool May Predict Risk of Chronic Pain in Patients With Breast Cancer

A novel artificial intelligence (AI) model may prove to be effective at predicting which patients with breast cancer are likely to develop chronic pain, according to a recent study published by Park et al in the Journal of Nursing Scholarship. The findings may help physicians to better understand...

gynecologic cancers

FDA Expands Endometrial Cancer Indication for Dostarlimab-gxly With Chemotherapy

On August 1, the U.S. Food and Drug Administration (FDA) approved dostarlimab-gxly (Jemperli) with carboplatin and paclitaxel, followed by single-agent dostarlimab, for adults with primary advanced or recurrent endometrial cancer. Dostarlimab was previously approved in July 2023 with carboplatin...

colorectal cancer
hepatobiliary cancer
issues in oncology

Liver Transplantation vs Standard Therapies in Patients With Colorectal Cancer Liver Metastasis

Certain patients with colorectal cancer that has metastasized to the liver may experience improved progression-free survival with liver transplantation compared with standard therapies, according to a recent study published by Byrne et al in JAMA Surgery. Background Colorectal cancer often...

issues in oncology

Education Level, Social Media Awareness May Be Linked to Cancer Fatalism

Investigators have found that patients with a lower level of education and social media awareness may hold more fatalistic beliefs about cancer compared with those who are more skilled at finding information through social media, according to a recent study published by Stimpson et al in Cancer...

lung cancer

New Report Shows Vaping and Smoking Together Increases Lung Cancer Risk Fourfold Compared to Smoking Alone

People who use e-cigarettes in conjunction with cigarette smoking are four times more likely to develop lung cancer than people who just smoke cigarettes, according to new study published by Harris et al the Journal of Oncology Research and Therapy. These findings were consistent across gender and...

bladder cancer
genomics/genetics

Can Mutations in DNA Damage Repair Genes Predict Cisplatin Response in Muscle-Invasive Urothelial Carcinoma?

The presence of a mutation in any one of three genes known to be involved in DNA damage repair may be associated with complete pathologic response to cisplatin-based neoadjuvant chemotherapy, as measured by pathologic downstaging at the time of cystectomy in patients with muscle-invasive urothelial ...

multiple myeloma

FDA Approves Daratumumab and Hyaluronidase-fihj With VRd for Multiple Myeloma

On July 30, the U.S. Food and Drug Administration (FDA) approved daratumumab and hyaluronidase-fihj (Darzalex Faspro) in combination with bortezomib, lenalidomide, and dexamethasone (VRd) for induction and consolidation in patients with newly diagnosed multiple myeloma who are eligible for...

hepatobiliary cancer
cardio-oncology

Do Nonstatin Cholesterol-Lowering Drugs Influence the Risk of Hepatic Cancer?

Investigators examined whether nonstatin cholesterol-lowering drugs may affect the risk of hepatic cancer, according to a recent study published by Zamani et al in Cancer. Background Hepatic cancer is the sixth most common cancer type across the world and the third leading cause of cancer-related...

skin cancer
immunotherapy

Key Immune Cells for Combating Aggressive Merkel Cell Carcinoma Uncovered

Researchers may have uncovered why some patients with Merkel cell carcinoma do not respond to immune checkpoint blockade therapy, according to a recent study published by Reinstein et al in Cancer Discovery. Background Merkel cell carcinoma—a rare but highly aggressive type of skin cancer—is known...

gastroesophageal cancer
hepatobiliary cancer
immunotherapy
issues in oncology

Fecal Microbiota Transplant May Help Patients With Gastrointestinal Cancers Overcome Immunotherapy Resistance

Fecal microbiota transplants may improve the effectiveness of immunotherapy in patients with gastrointestinal cancers, according to a recent study published by Kim et al in Cell Host & Microbe. Background Although immune checkpoint inhibitors have revolutionized cancer treatment, many patients...

breast cancer

Sara A. Hurvitz, MD, FACP, on New Therapeutic Strategies for HER2-Positive Metastatic Disease Including Brain Metastases

Sara A. Hurvitz, MD, FACP, of Fred Hutch Cancer Center, discusses her presentation on new therapeutic strategies for HER2-positive metastatic disease including brain metastases. Dr. Hurvitz is Senior Vice President and Director, Clinical Research Division, Fred Hutch Cancer Center, and Professor,...

colorectal cancer

Guardant Health’s Shield Blood Test Approved by the FDA as a Primary Screening Option for Colorectal Cancer

On July 29, the U.S. Food and Drug Administration (FDA) approved Guardant Health’s Shield blood test for colorectal cancer screening in adults aged 45 years and older who are at average risk for the disease. It is the first blood test to be approved by the FDA as a primary screening option for...

prostate cancer
issues in oncology

Is Lower-Dose Radiopharmaceutical Therapy Effective in Advanced Prostate Cancer?

Treatment with de-escalated actinium (Ac)-225–prostate-specific membrane antigen (PSMA)-617 or a combination of lutetium (Lu)-177/Ac-225–PSMA-617 resulted in similar median overall survival and prostate-specific antigen (PSA) response rates and better tolerance among patients with advanced-stage...

breast cancer
gynecologic cancers
issues in oncology

Risk of Breast Cancer May Be Lower Within First 10 Years Following Ovarian Cancer Diagnosis

Patients with BRCA1- or BRCA2-mutated ovarian cancer may have a lower risk of developing breast cancer following treatment, according to a recent study published by Evans et al in Genetics in Medicine. Background Previous research has estimated that the risk of developing breast cancer by the age...

cns cancers
issues in oncology

New Study Highlights Improvements in Treating Pediatric Patients With Retinoblastoma

The advancement of retinoblastoma treatment over the past 15 years may have resulted in a higher likelihood of vision preservation without compromising survival, according to a recent study presented by Kocharian et al at the Society of NeuroInterventional Surgery (SNIS) Annual Meeting 2024 and...

issues in oncology
hematologic malignancies
leukemia
lymphoma
bladder cancer

Cancer Risk From Exposure to Pesticides May Be Comparable to Risk From Smoking, Study Finds

Agricultural pesticides may carry a similar risk as smoking for some types of cancers, according to a recent study published by Gerken et al in Frontiers in Cancer Control and Society.   Background In modern agriculture practices, pesticides are essential to ensure high enough crop yields and food...

Introducing ‘Conexiant’

The publisher and editorial staff of The ASCO Post are happy to share an exciting announcement. While our company was formerly known as Harborside, powered by BroadcastMed, earlier this summer we announced a new name and platform for our business, Conexiant. Importantly, we continue our essential...

multiple myeloma
immunotherapy

Multiple Myeloma: Using Absolute Lymphocyte Count to Predict Outcomes After CAR T-Cell Therapy

A simple blood test that measures lymphocyte counts may predict whether patients with relapsed multiple myeloma are going to respond well to chimeric antigen receptor (CAR) T-cell immunotherapy, according to research published by Saldarriaga et al in Blood Advances. The study found that patients...

lymphoma
immunotherapy
issues in oncology

Shortening FDA-Mandated CAR T-Cell Therapy Monitoring Periods Could Improve Access to Treatment in Patients With DLBCL

Two hallmark toxicities of chimeric antigen receptor (CAR) T-cell therapy may be rare after 2 weeks following infusion in patients with diffuse large B-cell lymphoma (DLBCL), supporting a shorter, more flexible toxicity monitoring period., according to a recent study published by Ahmed et al in...

colorectal cancer
issues in oncology

Eliminating Racial Disparities in Colorectal Cancer Screening

Eliminating racial disparities in colorectal cancer testing may reduce the rate of colorectal cancer incidence and mortality among Black patients in the United States, according to a recent study published by Alagoz et al in the Journal of the National Cancer Institute. Background Although both the ...

breast cancer
supportive care

Kristin Rojas, MD, FACS, on Improving Sexual Health During Breast Cancer Treatment

Kristin Rojas, MD, FACS, of the University of Miami, shares key points from her discussion on improving sexual health during breast cancer treatment. Dr. Rojas is an Associate Professor of Surgery in the DeWitt Daughtry Family Department of Surgery, Division of Surgery, Miller School of Medicine at ...

breast cancer

Joseph A. Sparano, MD, FACP, on Premenopausal HR-positive Early Breast Cancer: What to Do Outside the OFSET Trial?

Joseph A. Sparano, MD, FACP, of Icahn School of Medicine at Mount Sinai, discusses his presentation on premenopausal patients with hormone receptor–positive early breast cancer. Dr. Sparano is the Ezra M. Greenspan, MD, Professor in Clinical Cancer Therapeutics, Chief of the Division of Hematology...

leukemia

Novel Target Identified for Treating HTLV-1–Associated Diseases

Blocking the tyrosine kinase KDR could lead to cell death caused by the degradation of the TAX viral protein, thereby treating diseases associated with human T-cell leukemia virus type 1 (HTLV-1), according to a recent study published by Mohanty et al in Nature Communications. Background HTLV-1 is...

solid tumors
issues in oncology

AACR, ASA, FDA Outline Considerations for Overall Survival Analyses in Clinical Trials

Experts from the American Association for Cancer Research (AACR), American Statistical Association (ASA), and U.S. Food and Drug Administration (FDA) have outlined considerations for clinical trial designs to enhance the collection and analysis of overall survival data in the context of modern-day...

breast cancer

Paolo Tarantino, MD, on the Current and Future Landscape of Antibody-Drug Conjugates

Paolo Tarantino, MD, of Dana-Farber Cancer Institute and Harvard Medical School, shares key points from his discussion on the current and future landscape of antibody-drug conjugates. Dr. Tarantino is an Advanced Research Fellow in the Breast Oncology Program at Dana-Farber Cancer Institute and...

breast cancer

Aditya Bardia, MD, MPH, FASCO, on Novel Therapies Targeting the Estrogen Receptor

Aditya Bardia, MD, MPH, FASCO, of UCLA Health/Jonsson Comprehensive Cancer Center, shares key points from his discussion on novel therapies targeting the estrogen receptor. Dr. Bardia is Professor, Department of Medicine, Division of Hematology/Oncology, and Director of Translational Research...

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