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Showing 8351 - 8400Age and Comorbidity Affect Completion of Adjuvant Trastuzumab Therapy in Older Patients With Early-Stage Breast Cancer
In a population-based study reported in the Journal of Clinical Oncology, Vaz-Luis et al assessed duration and toxicity of adjuvant trastuzumab (Herceptin) in older patients with early-stage breast cancer. They found that age and comorbidity affected treatment completion rates and that significant...
Rituximab Active in Nodular Lymphocyte–Predominant Hodgkin Lymphoma
Mature results of a phase II study reported in the Journal of Clinical Oncology by Advani et al indicate that rituximab (Rituxan) is active in nodular lymphocyte–predominant Hodgkin lymphoma, which is characterized by expression of CD20 by malignant cells. Most patients relapsed, but durable...
Blacks, Hispanics, Older Americans Not Benefiting Equally From Improvements in Colon Cancer Treatment
While new and better treatments have improved the odds of survival for patients diagnosed with late-stage colorectal cancer, that progress has been largely confined to non-Hispanic whites and Asians and those under age 65, according to a new study published in Cancer Causes and Control. Sineshaw et ...
Lenalidomide, Particularly When Combined With Oral Melphalan, Increases Risk of Second Primary Hematologic Malignancy in Myeloma Therapy
Lenalidomide (Revlimid) has been associated with risk for second primary malignancies in patients with myeloma. In a meta-analysis of individual patient data reported in The Lancet Oncology, Palumbo et al found that lenalidomide was associated with a significantly increased risk of second primary...
Aspirin and NSAID Use Reduce Risk of Invasive Epithelial Ovarian Cancer
In a study reported in Journal of the National Cancer Institute, Trabert et al in the Ovarian Cancer Association Consortium found that aspirin use and high-dose nonsteroidal anti-inflammatory drug (NSAID) use were associated with significant reductions in risk for ovarian cancer, with the greatest...
SSO-ASTRO Consensus Guideline: Margins Wider Than 'No Ink on Tumor' Do Not Further Reduce Risk of Ipsilateral Breast Tumor Recurrence
The Society of Surgical Oncology (SSO) and American Society for Radiation Oncology (ASTRO) formed a multidisciplinary expert panel in 2013 to examine the relationship between surgical margin width and ipsilateral breast tumor recurrence and develop guidelines on margins for breast-conserving...
Antifungal Itraconazole Shows Activity in Basal Cell Carcinoma
In an open-label exploratory phase II trial reported in the Journal of Clinical Oncology, Kim et al found that the antifungal agent itraconazole, which inhibits the Hedgehog signaling pathway, reduced tumor cell proliferation, Hedgehog pathway activity, and tumor area in patients with basal cell...
Radiotherapy for Bulky Disease Added to R-CHOP Improves Outcome in Elderly Patients With Aggressive B-Cell Lymphoma
In an analysis reported in the Journal of Clinical Oncology, Held et al studied elderly patients with aggressive B-cell non-Hodgkin lymphoma and bulky disease in the most effective treatment arm of the RICOVER-60 trial, which included radiotherapy. The investigators compared outcomes ...
Coordination of Care Improves Patient-Reported Quality of Supportive Care Among Patients With Colorectal Cancer
In a study reported in the Journal of Clinical Oncology, van Ryn et al assessed patient-reported quality of care among patients with colorectal cancer in the Veterans Affairs health-care system. The investigators found significant gaps in patient-centered quality of supportive care, but also found...
Crizotinib Produces Durable Responses in Small Study of Patients With Advanced, Chemoresistant ALK-Positive Lymphoma
In a brief communication in the Journal of the National Cancer Institute, Passerini et al described compassionate use experience with the ALK inhibitor crizotinib (Xalkori) in a group of patients with chemoresistant advanced ALK-positive lymphoma. Response was observed in 10 of 11 patients, and...
PTX3 Haplotype in Donors Increases Risk of Invasive Aspergillosis in Stem Cell Transplantation
In a study reported in The New England Journal of Medicine, Cunha et al found that receipt of a stem cell transplant from donors with a homozygous haplotype (h2/h2, G-A/G-A) in PTX3, the gene encoding the soluble pattern-recognition receptor pentraxin 3 (PTX3), is associated with significantly...
Newly Created Risk Stratification Database Aids in Predicting Outcomes in Prostate Cancer
The pan-Canadian Prostate Cancer Risk Stratification database was created to report on the patient, tumor, and treatment factors that were predictive of biochemical and clinical outcomes in patients who underwent radiotherapy for prostate cancer. Risk stratification in the management of those with...
High Incidence of Complications Other Than Urinary Incontinence or Erectile Dysfunction After Prostatectomy or Radiotherapy for Prostate Cancer
Studies of complications of surgery or radiotherapy for prostate cancer generally focus on incontinence and erectile dysfunction. In a population-based cohort study reported in The Lancet Oncology, Nam et al assessed the frequency of other complications associated with such treatment and found high ...
Hyaluronan Synthase 3 Variant Associated With Increased Risk of Anthracycline-Related Cardiomyopathy
In a study reported in the Journal of Clinical Oncology, Wang et al in the Children’s Oncology Group identified a common single nucleotide polymorphism, rs2232228, in the hyaluronan synthase 3 (HAS3) gene that is associated with anthracycline dose–related risk of cardiomyopathy in...
Expressive Writing Improves Symptoms and Physical Function in Patients With Renal Cell Carcinoma
In a trial reported in the Journal of Clinical Oncology, Milbury et al compared cancer symptoms, physical and mental function, depressive symptoms, fatigue, and sleep outcomes after sessions of expressive writing about cancer vs writing about neutral topics in patients with renal cell carcinoma....
Unfavorable Prognosis in Advanced Serous Ovarian Cancer May Be Linked to Estrogen Receptor Beta Isoform
Anomalies in the cytoplasmic expression of estrogen receptor beta 2 appear to be associated with poorer outcomes in patients with advanced serous ovarian cancer, according to the results of a study reported by Ciucci et al in Gynecologic Oncology. This isoform may represent an independent...
Adjuvant Chemotherapy for Isolated Locoregional Recurrence of Breast Cancer Associated With Significantly Better Disease-Free and Overall Survival
Isolated locoregional recurrence of breast cancer is associated with high risk of distant metastasis and death. In the CALOR trial reported in The Lancet Oncology, Aebi et al found that adjuvant chemotherapy after complete resection improves disease-free survival in patients with isolated...
Potential Therapeutic Role for Aspirin in the Management of Sporadic Vestibular Schwannoma
In patients with sporadic vestibular schwannoma, aspirin may be of benefit in minimizing tumor growth, according to the results of a retrospective study presented by Kandathil et al in Otology and Neurotology. This finding may eliminate the need for invasive therapy and may complement existing...
Yoga Improves Inflammation, Fatigue, and Vitality in Breast Cancer Survivors
In a study reported in the Journal of Clinical Oncology, Kiecolt-Glaser et al found that yoga reduced levels of inflammatory cytokines and fatigue and increased vitality in breast cancer survivors. Study Details In the study, 200 women with stage 0 to IIIA breast cancer who had completed...
Higher Dietary Lycopene Intake Associated With Reduced Risk of Lethal Prostate Cancer and Reduced Tumor Angiogenesis
In a study reported in the Journal of the National Cancer Institute, Zu et al found that higher dietary lycopene intake was associated with reduced risk of lethal prostate cancer and reduced tumor angiogenesis. Lycopene-rich foods include tomatoes and tomato-based products. Study Details The...
ASCO Issues New Recommendations for Family History-Taking in Oncology Setting
When oncologists see a new patient, they should emphasize careful documentation of first- and second-degree cancer family history, according to new recommendations published by the American Society of Clinical Oncology. The recommendations are the first to focus on family history-taking...
Patients With Near-Complete Response After Induction Therapy May Be Candidates for Bladder-Sparing Therapy
Bladder-sparing approaches are typically reserved for patients with bladder cancer who have a complete response to combined modality induction therapy (radiation plus chemotherapy). A new phase II study suggests that patients with near-complete response should also be considered for bladder-sparing ...
Prolonged Hormone Therapy Exposure Increases Risk of Diabetes and Cardiovascular Disease in Older Patients With Prostate Cancer
Although androgen deprivation therapy extends survival in men with prostate cancer, its use is associated with unwanted side effects. In addition to the well-known side effects of impaired sexual function and hot flashes, prolonged exposure to androgen deprivation therapy can also lead to diabetes...
Study Examines Immunotherapy in Metastatic Castration-Resistant Prostate Cancer
In the randomized, phase III CA184-043 trial, ipilimumab (Yervoy) improved progression-free survival and prostate-specific antigen (PSA) response compared with placebo, but failed to improve overall survival significantly in postdocetaxel metastatic castration-resistant prostate cancer....
Following USPSTF Mammography Screening Guidelines Could Save Billions of Dollars and Result in More Women Screened
Although controversial, reducing mammography screening frequency from annually to biennially for women aged 50 to 74 could save the health-care system billions of dollars annually and screen 15% more women compared with the current practice, according to a cost analysis by O’Donoghue et al....
Improved Survival With Four-Drug Induction Regimen Followed by Maintenance in Initial Treatment of Transplant-Ineligible Multiple Myeloma
In an updated analysis of an Italian phase III trial reported in the Journal of Clinical Oncology, Palumbo et al found that induction with bortezomib (Velcade), melphalan, prednisone, and thalidomide (Thalomid) followed by bortezomib plus thalidomide maintenance (VMPT-VT) significantly improved...
Is the Traumatic Impact of Cancer Overestimated in Children With Cancer?
In a study reported in the Journal of Clinical Oncology, Phipps et al found no evidence of increased post-traumatic stress disorder (PTSD) or post-traumatic stress symptoms (PTSS) in children with cancer and observed a heightened sense of perceived growth related to cancer events in these children. ...
Good Results With Telephone Genetic Counseling for Breast and Ovarian Cancer
As genomic testing becomes more common, genetic counseling is increasingly performed via telephone. BRCA1/2 mutation carries increased risk for breast and ovarian cancer. In a noninferiority study reported in the Journal of Clinical Oncology, Schwartz et al compared genetic counseling for BRCA1/2...
Telephone-Based Intervention Improves Colorectal Cancer Screening in At-Risk Relatives of Patients With Colorectal Cancer
Individuals at increased familial risk of colorectal cancer have poor adherence to colonoscopy screening recommendations, especially those in rural and other geographically underserved populations. In a study (Family CARE trial) reported in the Journal of Clinical Oncology, Kinney et al found that...
PI3K-Delta Inhibitor Idelalisib Produces High Response Rates in Relapsed Indolent Lymphoma
Phosphatidylinositol 3-kinase (PI3K)-delta mediates B-cell receptor signaling and microenvironment support signals that promote the growth and survival of malignant B lymphocytes. In a phase II study reported in The New England Journal of Medicine, Gopal et al found that the PI3K-delta inhibitor...
ASCO Survey of Oncologists Finds High Overall Career Satisfaction, but Nearly Half Report Burnout
A survey of oncologists by Shanafelt et al has found that approximately 45% had at least one symptom of burnout, with risk being greatest among younger oncologists and those spending more hours per week devoted to direct patient care. However, overall career satisfaction remains high, especially...
Adding Idelalisib to Rituximab Improves Progression-Free and Overall Survival in Patients With Difficult-to-Treat, Relapsed CLL
Use of standard chemotherapy is difficult in patients with relapsed chronic lymphocytic leukemia (CLL) who have significant coexisting medical conditions. In a phase III trial reported in The New England Journal of Medicine, Furman et al found that the combination of idelalisib, an oral inhibitor...
Intensive Follow-up Increases Surgical Treatment of Recurrence With Curative Intent in Colorectal Cancer
In a study (FACS trial) reported in JAMA, Primrose et al compared outcomes with intensive follow-up with carcinoembryonic antigen measurement (CEA), computed tomography (CT), both, or minimum follow-up after curative surgery for primary colorectal cancer. Intensive strategies resulted in a...
Dermoscopy Shows Characteristics of Cutaneous Metastases of Visceral Cancers
In a case series reported in JAMA Dermatology, Chernoff et al found that dermoscopic identification of vascular structures in cutaneous nodules in patients with known cancer diagnosis should raise suspicion for cutaneous metastasis. Study Details In the study, high-quality dermoscopic images of...
Cognitive-Behavioral Therapy Plus Hypnosis Controls Fatigue in Breast Cancer Patients Receiving Radiotherapy
In a study reported in the Journal of Clinical Oncology, Montgomery et al found that an intervention consisting of cognitive-behavioral therapy plus hypnosis produced better control of fatigue than supportive meetings with trained interventionists for women undergoing radiotherapy for breast...
Study Shows 20% of Women With Ovarian Cancer Have Inherited Genetic Mutations That Increase Risk of Disease
A large-scale genetic analysis of women with ovarian cancer with no known family histories of breast or ovarian cancer has found that one-fifth of them had inherited alterations in genes known to be associated with these cancers. The findings could lead to the development of better screening...
Intensity-Modulated Radiation Therapy Improves Survival in Patients With Head and Neck Cancer
Patients with cancers of the head and neck who received intensity-modulated radiation therapy experienced improved outcomes, as well as reduced toxicities, compared to patients receiving conventional radiation therapy, according to findings published online in Cancer by Beadle et al. The study is...
Model of Individualized Estimates Shows Risk of Overdiagnosis in Screening-Detected Prostate Cancers Varies Widely by Age, PSA, and Gleason Score
It is estimated that overdiagnosis occurs in approximately 20% to 40% of prostate cancers detected at screening in U.S. men aged 50 to 84 years, with the likelihood of overdiagnosis varying widely according to patient age and tumor characteristics. In a study reported in the Journal of the...
11-Protein Signature Distinguishes Good and Poor Outcome in Node-Negative, Adjuvant Therapy–Naive, Triple-Negative Breast Cancer
In a study reported in the Journal of the National Cancer Institute, Liu et al performed global proteomic profiling in samples from patients with triple-negative breast cancer in an attempt to identify a risk signature. They identified a novel 11-protein signature that independently predicts...
One-Fifth of Hospitalizations for Patients With Gastrointestinal Cancer Considered Avoidable
In a study reported in the Journal of Clinical Oncology, Brooks et al found that oncology clinicians considered 19% of hospitalizations for patients with gastrointestinal cancers to be avoidable. Study Details In the study, 201 sequential hospital admissions in 154 patients with gastrointestinal...
Afatinib Improves Progression-Free Survival vs Cisplatin/Gemcitabine in First-Line Treatment of Asian Patients With Advanced EGFR-Mutant NSCLC
Afatinib (Gilotrif) improves progression-free survival compared with pemetrexed (Alimta)/cisplatin in first-line treatment of patients with EGFR mutation–positive advanced non–small cell lung cancer (NSCLC). In the phase III LUX-Lung 6 trial reported in The Lancet Oncology, Wu ...
Long-Term/High-Dose Use of ACE Inhibitors Associated With Reduced Colorectal Cancer Risk in Hypertensive Subjects
Preclinical data suggest a role of angiotensin II in colorectal cancer. In a study reported in the Journal of the National Cancer Institute, Makar et al assessed whether use of angiotensin converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) treatment for hypertension was...
Addition of Nintedanib to Docetaxel Improves Progression-Free Survival as Second-Line Treatment in NSCLC
In a phase III trial (LUME-Lung 1) reported in The Lancet Oncology, Reck et al assessed the addition of nintedanib to docetaxel in second-line treatment of non–small cell lung cancer (NSCLC). The combination significantly improved progression-free survival in all patients and improved overall ...
High Prevalence of Platinum-Related Hearing Loss in Children With High-Risk Neuroblastoma, With Differences According to Audiometry Scales
The reported prevalence of platinum-associated ototoxicity in children with high-risk neuroblastoma varies widely due to small patient samples and use of disparate grading scales. In a study reported in the Journal of Clinical Oncology, Landier et al in the Children’s Oncology Group assessed...
Breast-Conservation Therapy Associated With Better Cancer-Specific Survival Than Mastectomy in Patients With Early-Stage Invasive Ductal Carcinoma
In a study reported in JAMA Surgery, Agarwal et al compared breast cancer–specific survival rates of patients with early-stage invasive ductal carcinoma undergoing breast-conservation therapy (lumpectomy followed by radiation), mastectomy alone, or mastectomy with radiation using the SEER...
Surgeon Experience Affects Likelihood of Sentinel Lymph Node Biopsy in Older Women With Breast Cancer
Sentinel lymph node biopsy is standard of care for axillary staging in clinically node-negative breast cancer, and underuse of sentinel lymph node biopsy could be associated with unnecessary axillary lymph node dissection and lymphedema. In a study reported in JAMA Surgery, Yen et al assessed the...
Both Mindfulness-Based Stress Reduction and, More So, Cognitive Behavioral Therapy Improve Insomnia in Cancer Patients
In a noninferiority trial reported in the Journal of Clinical Oncology, Garland et al compared the effects of mindfulness-based stress reduction vs cognitive-behavioral therapy for treatment of insomnia in patients with cancer. They found that both techniques improved insomnia, with...
High Presurgical Levels of Angiogenic and Growth Factors Are Associated With Poorer Survival After Gastric Resection
In patients undergoing gastric resection for gastric/gastroesophageal junction cancers, high levels of angiogenic and growth factors are associated with poorer overall survival, according to the results of a retrospective study presented by Park et al in the Annals of Surgical Oncology. Thus, these ...
No Increased Risk of Local Recurrence After Breast-Conserving Surgery in Triple-Negative Breast Cancer in Single-Center Study
Triple-negative breast cancer may be considered a relative contraindication to breast-conserving surgery. In a study reported in JAMA Surgery, Gangi et al from Cedars-Sinai Medical Center in Los Angeles assessed outcomes in a large cohort of women undergoing breast-conserving surgery at their...
Superior Progression-Free Survival With Obinutuzumab/Chlorambucil vs Rituximab/Chlorambucil in Previously Untreated CLL With Coexisting Conditions
Obinutuzumab (Gazyva) is a glycoengineered type 2 anti-CD20 antibody that appears to exhibit increased activity against chronic lymphocytic leukemia cells (CLL), with increased antibody-dependent cellular cytotoxicity and reduced complement-dependent cytotoxicity, compared with rituximab (Rituxan). ...
