Search Results
Your search for ,aGe matches 8736 pages
Showing 8301 - 8350Women With BRCA1 Mutations May Still Be at Risk for Rare Types of Uterine Cancer After Preventive Salpingo-Oophrectomy
Women with BRCA1 mutations may have an increased risk for developing rare types of aggressive uterine cancer despite having their ovaries and fallopian tubes removed, suggest preliminary findings presented at the Society of Gynecologic Oncology (SGO) Annual Meeting on Women’s Cancer held ...
Harms Outweigh Benefits for Women Aged 70 and Over in National Breast Cancer Screening Programs
Extending national breast cancer screening programs to women over the age of 70 does not result in a decrease in the number of cancers detected at advanced stages, according to new research from The Netherlands. Instead, researchers told attendees at the 9th European Breast Cancer Conference that...
Analysis of SWOG Trials Indicates No Survival Difference After 1 Year in Cancer Patients Treated In vs Out of Clinical Trials
In a study reported in the Journal of the National Cancer Institute, Unger et al evaluated whether cancer patients from SWOG clinical trials were similar to nontrial patients in baseline characteristics and survival. They found that, overall, trial participation in standard treatment arms did not...
Regular Physical Activity Reduces Breast Cancer Risk Irrespective of Age or Weight
Participating in athletic activities for more than an hour a day reduces the risk of breast cancer, and this applies to women of any age and any weight, regardless of geographic location, according to research presented at the 9th European Breast Cancer Conference in Glasgow. Compared with the...
Swedish Study Shows Lower Prostate Cancer Mortality in High-Incidence Areas
In a study reported in the Journal of the National Cancer Institute, Stattin et al found that rates of prostate cancer mortality, excess mortality in men with prostate cancer, and metastatic prostate cancer were lower in counties in Sweden with higher vs lower incidence of prostate cancer that...
High Circulating Tumor Cell Count at Baseline and Increases in Count During Treatment Linked to Reduced Survival in Metastatic Breast Cancer
In a pooled analysis of individual patient data reported in The Lancet Oncology, Bidard et al found that baseline circulating tumor cell counts and increases in counts during treatment were highly prognostic in patients with metastatic breast cancer beginning new treatment and that addition of...
Health Gap Between Adult Survivors of Childhood Cancer and Siblings Widens With Age
Adult survivors of childhood cancer face significant health problems as they age and are five times more likely than their siblings to develop new cancers, heart disease, and other serious health conditions beyond the age of 35, according to the latest findings from the Childhood Cancer Survivor...
Shortening of Leukocyte Telomeres Associated With Increased All-Cause and Breast Cancer–Specific Mortality in Breast Cancer Patients
Short telomeres are associated with increased risk of cancer, but data on telomere length and mortality in breast cancer survivors are inconsistent. In a study reported in the Journal of the National Cancer Institute, Duggan et al found that decreases in telomere length between baseline and 30...
Circulating Tumor Cell Count and Early Change in Count Are Prognostic for Survival in First-Line Docetaxel Treatment of Prostate Cancer
As reported in the Journal of Clinical Oncology, Goldkorn et al assessed the prognostic value of circulating tumor cell counts in patients with metastatic castration-resistant prostate cancer receiving standard first-line docetaxel plus prednisone with or without atrasentan in the SWOG S0421 trial. ...
No Overall Survival Benefit of First-Line Doxorubicin Plus Ifosfamide vs Doxorubicin Alone in Advanced Soft-Tissue Sarcoma
In the open-label, phase III EORTC 62012 trial reported in The Lancet Oncology, Judson et al found that doxorubicin plus ifosfamide was not associated with any overall survival advantage compared with doxorubicin alone in patients with advanced or metastatic soft-tissue sarcoma. Progression-free...
NCCN Advocates for Universal Lynch Syndrome Screening in Newly Diagnosed Colorectal Cancer
The National Comprehensive Cancer Network (NCCN) is recommending that newly diagnosed colorectal cancer patients be screened for Lynch syndrome, previously called hereditary nonpolyposis colorectal cancer. The NCCN’s proactive position should greatly help identify individuals and their...
Children With Cancer, Parents, and Providers Value Patient-Reported Outcomes Feedback
In a pilot trial (PediQUEST) reported in the Journal of Clinical Oncology, Wolfe et al assessed the effects of use of the PediQUEST electronic patient-reported feedback survey on health-related quality of life in children with advanced cancer. Although few significant improvements were observed,...
Satisfaction With Work-Life Balance Among U.S. Oncologists Lower Than Other Medical Specialties, Survey Says
The American Society of Clinical Oncology (ASCO) conducted a survey of U.S. oncologists between October 2012 and March 2013, evaluating satisfaction with work-life balance and career plans. The findings, reported in the Journal of Clinical Oncology by Shanafelt et al, indicate that most are...
Rituximab Maintenance Delays Need for Subsequent Treatment vs Watchful Waiting in Asymptomatic Nonbulky Follicular Lymphoma
In an open-label phase III trial reported by Ardeshna et al in The Lancet Oncology, rituximab (Rituxan) induction plus maintenance was found to delay the need for subsequent therapy and improve elements of quality of life vs watchful waiting in patients with advanced asymptomatic nonbulky...
First Comprehensive Report on U.S. Cancer Care Finds Patient Access Threatened by Growing Demand, Physician Shortages
The first-ever comprehensive assessment of challenges facing the U.S. cancer care system suggests that patient access to cancer care will be threatened as growing demand for care outstrips the supply of oncologists, and as cost pressures force the closure of small physician practices that form the...
Pilot Study Shows Decision Aid Helps in Decision-Making Regarding Mammography Screening in Women Aged ≥ 75 Years
Although it is recommended that women aged ≥ 75 years be informed of the benefits and risks of mammography before being screened, it appears that this is not common practice. As reported in JAMA Internal Medicine by Schonberg et al, a decision aid developed by the investigators helped improved...
No Apparent Increased Risk of Myelodysplastic Syndrome With Definitive Radiotherapy in Prostate Cancer
Exposure to ionizing radiation has been associated with increased risk of myelodysplastic syndrome, and it remains unclear whether radiation doses used in prostate cancer treatment result in increased risk. In a retrospective cohort study reported in the Journal of the National Cancer Institute,...
Higher Macrophage Inhibitory Cytokine-1 Levels Associated With Increased Risk of Colorectal Cancer
It is known that chronic inflammation plays a role in the development of colorectal cancer. In a study reported in the Journal of the National Cancer Institute, Mehta et al evaluated the association of the novel plasma inflammatory biomarker macrophage inhibitory cytokine-1 (MIC-1; growth...
IDH1-Mutant Malignant Astrocytomas May Be More Amenable to Surgical Resection and Linked to Better Prognosis
IDH1 mutation in patients with malignant astrocytomas may serve as a predictive molecular biomarker to guide aggressive surgical resection, according to the results of a study reported by Beiko et al in Neuro-Oncology. Maximal surgical resection may contribute a survival benefit in those who have...
Continued Survival Benefits With Radical Prostatectomy in Longer-Term Follow-up in Scandinavian Prostate Cancer Group-4 Trial
As reported in The New England Journal of Medicine by Bill-Axelson et al, additional long-term follow-up in the Scandinavian Prostate Cancer Group-4 trial (SPCG-4) continues to show significant benefits of radical prostatectomy vs watchful waiting in early prostate cancer, including reduced risk of ...
Fertility Concerns Affect Treatment Choices in Young Women With Breast Cancer, but Few Use Preservation Options
Little is known about how fertility concerns affect treatment decisions or fertility preservation strategies at the time of initial diagnosis of breast cancer. In an ongoing multicohort study reported in the Journal of Clinical Oncology, Ruddy et al found that most young women with breast cancer...
No Benefit of Early Zoledronic Acid in Reducing Skeletal-Related Events in Castration-Sensitive Prostate Cancer With Bone Metastases
As reported in the Journal of Clinical Oncology by Smith et al, the double-blind phase III Cancer and Leukemia Group B (CALGB) 9020/Alliance trial assessed the effect of early initiation of zoledronic acid in reducing risk of skeletal-related events in men with castration-sensitive prostate cancer. ...
Correlation of PIK3CA Mutation and Neoadjuvant Lapatinib/Letrozole Response in Hormone Receptor–Positive, HER2-Negative Breast Cancer
In a phase IIB study reported in the Journal of Clinical Oncology, Guarneri et al compared neoadjuvant letrozole plus lapatinib (Tykerb) or placebo in postmenopausal women with hormone receptor–positive, HER2-negative breast cancer. Response rates were similar in the two groups, but a...
Nonmelanoma Skin Cancer Linked to Other Cancers, Especially in Young Survivors
A study by Ong et al has found that people who had nonmelanoma skin cancer were at an increased risk for subsequently developing melanoma and a spectrum of 29 other cancer types. The risk was especially high among people who develop nonmelanoma skin cancer before the age of 25. The findings are...
Same Progression-Free Survival, Better Quality of Life With Lower-Dose Weekly vs Every-3-Week Carboplatin/Paclitaxel in Advanced Ovarian Cancer
In an open-label phase III trial (MITO-7) reported in The Lancet Oncology, Pignata et al found that while a lower-dose weekly carboplatin/paclitaxel regimen did not improve progression-free survival compared with standard every-3-week carboplatin/paclitaxel as first-line treatment of advanced...
Childhood Cancer Survivors at Very High Risk of Later Endocrine Disorders in Scandinavian Study
In a population-based cohort study (Adult Life after Childhood Cancer in Scandinavia, or ALiCCS) reported in The Lancet, Licht et al assessed the lifetime risk of endocrine disorders in Scandinavian long-term survivors of childhood cancer. They found a nearly fivefold increased risk of hospital...
Blood Test Could Improve Treatment for Children With Late-Stage Neuroblastoma
Research by Viprey et al has found that the detection of neuroblastoma mRNAs in peripheral blood and bone marrow aspirates from children diagnosed with stage IV neuroblastoma are independent predictors of event-free survival and overall survival. Their findings could help identify children with...
Screening With Visual Inspection of Cervix After 4% Acetic Acid Could Reduce Cervical Cancer Mortality by 22,000 per Year in India
Cervical cancer is the leading cause of cancer death in women in India, a nation where large-scale Pap smear screening is not feasible. As reported in the Journal of the National Cancer Institute, Shastri et al have performed a large cluster-randomized study of education and screening of Indian...
‘Real World’ Safety Study of Vemurafenib in BRAF V600–Mutated Metastatic Melanoma Shows Similar Safety Profile as Pivotal Trials
As reported in The Lancet Oncology by Larkin et al, interim results of a safety study designed to reflect the spectrum of patients encountered in routine practice suggest that vemurafenib (Zelboraf) has a safety profile in patients with BRAF V600–mutated metastatic melanoma similar to that...
BPA Exposure May Be Linked to Prostate Cancer, Study Shows
A new study suggests that levels of bisphenola A (BPA) in men’s urine may be a marker of prostate cancer and that low levels of BPA exposure can cause cellular changes in both nonmalignant and malignant prostate cells. The research, published in PLOS ONE, provides the first evidence that...
Meta-Analysis Shows Survival Benefit of Preoperative Chemotherapy in NSCLC
In a systematic review and individual patient meta-analysis reported in The Lancet, the NSCLC Meta-analysis Collaborative Group found that neoadjuvant therapy for non–small cell lung cancer (NSCLC) was associated with a significant 13% reduction in risk of death. Significant benefits in...
Early Palliative Care Benefits Patients With Advanced Cancer
In a study published in The Lancet, Zimmermann et al compared quality of life, symptom severity, and care satisfaction with early initiation of palliative care vs standard cancer care in patients with advanced cancer. Although early palliative care was not associated with improved quality of life...
African Americans Have Higher Prevalence of Multiple Myeloma Precursor Than Whites and Hispanics
A large population-based study by Landgren et al has found that African Americans are more likely to have a higher prevalence of monoclonal gammopathy of undetermined significance (MGUS), a precursor to the development of multiple myeloma, compared with whites or Hispanics. The study is published...
Standard 24 Gy More Effective Than 4 Gy in Radiotherapy for Indolent Lymphoma
Follicular lymphoma has been found to respond to radiotherapy doses as low as 4 Gy. In the phase III FORT trial reported in The Lancet Oncology, Hoskin et al compared radiotherapy with 4 Gy in two fractions vs 24 Gy in 12 fractions in patients with indolent lymphoma, finding that the 24-Gy regimen...
Anthropometric and Hormonal Factors Increase Risk for Male Breast Cancer
In a study reported in the Journal of the National Cancer Institute, Brinton et al assessed the role of anthropometric, medical history, and hormone-related factors in male breast cancer in the Male Breast Cancer Pooling Project. Factors found to be associated with risk included height,...
Event-Free Survival at 24 Months Can Serve as Endpoint for Disease-Related Outcome in Diffuse Large B-Cell Lymphoma Treated With Immunochemotherapy
In a study reported in the Journal of Clinical Oncology, Maurer et al found that patients with diffuse large B-cell lymphoma (DLBCL) treated with immunochemotherapy who achieve event-free survival at 24 months have overall survival that does not differ significantly from that in the general...
Adding Bevacizumab to Chemotherapy Improves Survival in Advanced Cervical Cancer
Retreatment with cisplatin has reduced effectiveness in patients with recurrent cervical cancer who have received cisplatin with radiation therapy. In a 2×2 factorial phase III trial reported in The New England Journal of Medicine, Tewari et al compared cisplatin/paclitaxel vs nonplatinum...
Selenium and Vitamin E Supplements May Increase Risk of Prostate Cancer in Some Men
A multicenter study led by Fred Hutchinson Cancer Research Center has found that high-dose supplementation with both the trace element selenium and vitamin E may increase the risk of high-grade prostate cancer. This risk is dependent upon a man’s selenium status prior to taking the...
Large Study Shows Preventive Ovarian Surgery in BRCA1 Mutation Carriers Should Be Performed Early for Greatest Benefit
The findings of a large international prospective study published in the Journal of Clinical Oncology by Finch et al suggest for the first time that women with BRCA1 mutations should have prophylactic oophorectomy by age 35, as waiting until a later age appears to increase the risk of ovarian...
Methotrexate-Induced Neurotoxicity Does Not Preclude Rechallenge in Children With ALL
In a study reported in the Journal of Clinical Oncology, Bhojwani et al from St. Jude Children’s Research Hospital assessed clinical, pharmacokinetic, and genetic risk factors for methotrexate-related clinical neurotoxicity and asymptomatic leukoencephalopathy in children with acute...
Rates of Breast Reconstruction After Mastectomy Increase, but Use Varies Widely According to Numerous Factors
In a study reported in the Journal of Clinical Oncology, Jagsi et al found that use of breast reconstruction in patients with breast cancer undergoing mastectomy has increased over time but varies according to a number of treatment and demographic characteristics. Study Details The study involved ...
Hormone Therapy Associated With Improved Survival in Women With Non–Small Cell Lung Cancer
Survival among people with lung cancer has been better for women than men, and the findings of a recent study indicate that female hormones may be a factor in this difference. The combination of estrogen plus progesterone and the use of long-term hormone therapy were associated with the most...
Minimal Pleural Effusion Predicts Poorer Survival in Non–Small Cell Lung Cancer
In a study reported in the Journal of Clinical Oncology, Ryu et al found that presence of minimal pleural effusion is associated with worsened survival in patients with non–small cell lung cancer (NSCLC) compared with no effusion, particularly among patients with early-stage disease. Study...
No Progression-Free Survival Difference for Dovitinib vs Sorafenib in Third-Line Targeted Treatment of Metastatic Renal Cell Carcinoma
Fibroblast growth factor (FGF) pathway activation may be a mechanism of escape from vascular endothelial growth factor (VEGF)-targeted therapies. In a phase III trial reported in The Lancet Oncology, Motzer et al compared the VEGF and FGF receptor tyrosine kinase inhibitor dovitinib vs sorafenib...
Oropharyngeal Cancer Patients Report Benefit in Salivary Function With Reduction of Radiation Dose to Bilateral Submandibular Lymph Nodes
For head and neck cancer patients undergoing radiation therapy, a reduction in the amount of radiation treatment volume to the submandibular (level IB) lymph nodes resulted in better patient-reported salivary function, according to research presented today at the 2014 Multidisciplinary Head and...
Unilateral Radiotherapy for Advanced Tonsil Cancer Yields Favorable Outcome
New research suggests that it is safe to limit radiation therapy to lymph nodes on only one side of the neck for lateralized tonsil cancer. In addition, the study findings show that primary tumor location, rather than the amount of lymph node involvement on the tumor side of the neck, drives the...
Avoiding Radiation to Major Salivary Glands in Head and Neck Cancer Is Safe and Improves Quality of Life
New research is showing that sparing the contralateral submandibular gland during radiation therapy in the treatment of locally advanced head and neck cancer is technically feasible and safe even in advanced-stage, node-positive disease and base-of-tongue lesions. Limiting radiation to these major...
Proteomic Mucin Profiling More Accurate Than Cytology and CEA in Identifying Cystic Precursors of Pancreatic Cancer
Pancreatic cystic lesions are frequently detected radiologic incidentalomas, a considerable proportion of which are pancreatic cancer precursors. In a study reported in the Journal of the National Cancer Institute, Jabbar et al found that proteomic mucin profiling of cyst fluid was more accurate...
CD49d-Positivity Is the Strongest Flow Cytometry–Based Predictor of Overall Survival in CLL
In a study reported in the Journal of Clinical Oncology, Bulian et al found that CD49d-positive chronic lymphocytic leukemia (CLL) patients have significantly poorer overall survival and treatment-free survival and that CD49d status is the strongest flow cytometry–based predictor of overall...
Nonsentinel Lymph Node Status Independently Predicts Melanoma-Specific Survival in Patients With Two or Three Positive Nodes
In a study reported in the Journal of Clinical Oncology, Pasquali et al assessed the prognostic utility of nonsentinel lymph node status in patients with cutaneous melanoma. They found that nonsentinel lymph node status was a significant independent predictor of melanoma-specific survival in...
