Search Results
Your search for s matches 6886 pages
Showing 6201 - 6250RNA Sequencing Could Help Doctors Tailor Unique Prostate Cancer Treatment Programs
Sequencing RNA, not just DNA, could help doctors predict how prostate cancer tumors will respond to treatment, according to research published in the journal Genome Biology. Because a tumor’s RNA shows the real-time changes a treatment is causing, the authors believe that this could be a...
Study Shows Curcumin Blocks the Metastasis of Colon Cancer by a Novel Mechanism
A team of researchers led by the University of Arizona Steele Children’s Research Center discovered that curcumin—the bioactive molecule derived from the spice turmeric—blocks the protein cortactin in colon cancer. Cortactin, a protein essential for cell movement, is frequently...
Inclusion of Endogenous Hormone Levels Improves Risk Prediction for Postmenopausal Breast Cancer
In a study reported in the Journal of Clinical Oncology, Tworoger et al found that inclusion of endogenous hormone levels in the Gail and Rosner-Colditz risk scores improved prediction of postmenopausal invasive breast cancer. Study Details The study involved 437 patients with breast cancer and...
Early Study Identifies Tumor-Suppressor Gene, Potential Therapy for Medulloblastoma
An international, multi-institutional research group led by scientists at the Cancer and Blood Diseases Institute (CBDI) at Cincinnati Children’s Hospital Medical Center has identified a novel molecular pathway that causes an aggressive form of medulloblastoma, The study, reported by He et al ...
Active Surveillance for Clinical Stage I Testicular Cancer Associated With ‘Excellent’ Outcomes
In a retrospective study reported in the Journal of Clinical Oncology, Kollmannsberger et al found that active surveillance for patients with clinical stage I testicular cancer is associated with very good outcomes. Most relapses occurred within 2 years of orchiectomy in patients with nonseminoma...
Accuracy of Edinburgh Ovarian Tissue Cryopreservation Criteria in Girls and Young Women With Cancer
A study reported in The Lancet Oncology by Wallace et al evaluated the accuracy of criteria used for predicting ovarian insufficiency and offering ovarian tissue cryopreservation in young women with cancer at the Edinburgh Children’s Cancer Centre. Ovarian tissue cryopreservation with later...
Increasing Incidence of Merkel Cell Carcinoma in Queensland, Australia
In a study reported in JAMA Dermatology, Youlden et al found that the incidence of Merkel cell carcinoma in Queensland, Australia, a known high-risk area, increased by 2.6% annually between 1993 and 2010. Five-year relative survival was 41%, with significantly better survival found in patients aged ...
Genomic Sequencing Reveals Unique Genetic Alterations in Chromophobe Renal Cell Carcinoma
An international scientific collaboration led by Baylor College of Medicine as part of The Cancer Genome Atlas initiative has revealed clues about genetic alterations that may contribute to a rare form of kidney cancer. The study, which describes the landscape of somatic genomic alterations of...
Swedish Study Reports Increasing Rates of Severe Infection Requiring Hospitalization After Prostate Biopsy
Transrectal ultrasound guided biopsy is the standard for detecting prostate cancer, but international reports have suggested that the risks associated with the procedure are increasing. In a new nationwide population-based study reported in The Journal of Urology, Swedish researchers found that 6%...
Poorer Psychosexual Functioning in Adult Female Survivors of Childhood Cancer
In an analysis in the Childhood Cancer Survivor Study population reported in the Journal of Clinical Oncology, Ford et al found that adult woman survivors of childhood cancer have poorer psychosexual function than their siblings without childhood cancer. Risk factors for poorer function included...
Jesse L. Steinfeld, MD, Past Surgeon General, ASCO President, and Valiant Foe of Big Tobacco, Dies at 87
The 1964 Surgeon General’s Report on Smoking and Health started a culture change in the way Americans viewed tobacco and their health, and has saved countless million of lives. But the 1964 Report remained scientifically ambiguous on certain vital issues, such as the effect smoking had on the ...
Oncologists Respond Rapidly to Clinical Trial Evidence on Use of EGFR Inhibitors
Use of panitumumab (Vectibix) and cetuximab (Erbitux) in patients with metastatic colorectal cancer decreased significantly after the publication of clinical trial evidence that anti-EGFR antibodies should be restricted to wild-type KRAS tumors, subsequent ASCO guidelines recommending testing for...
Study Detects New ALK Mutations at Neuroblastoma Relapse
In a study reported in the Journal of Clinical Oncology, Schleiermacher et al found ALK mutations at relapse of neuroblastoma that were not present at diagnosis. They also found that subclonal mutations may be present at diagnosis with clonal expansion observed at relapse. The study involved...
FDA Approves Bevacizumab for Aggressive and Late-Stage Cervical Cancer
The U.S. Food and Drug Administration (FDA) has approved the antiangiogenic agent bevacizumab (Avastin) for the treatment of persistent, recurrent, or metastatic cervical cancer. The new indication is approved for use in combination with paclitaxel and cisplatin or paclitaxel and topotecan. The FDA ...
Scientists Pinpoint Gene Likely to Promote Childhood Cancers
Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified a gene that contributes to the development of several childhood cancers, in a study conducted in mouse models. If the findings prove to be applicable to humans, the research could...
Prostate Cancer Prevention Trial Identifies Men Most Likely to Undergo Challenging Study Procedures
Healthy men participating in the Prostate Cancer Prevention Trial who actively participate in all steps of the clinical trial are most likely to undergo a biopsy, according to a study by Gritz et al published in Cancer Epidemiology, Biomarkers & Prevention. The Prostate Cancer Prevention Trial, ...
Successful Vemurafenib Treatment of Progressive BRAF V600E–Mutated Anaplastic Pleomorphic Xanthoastrocytoma
The BRAF inhibitor vemurafenib (Zelboraf) is approved for treatment of BRAF-mutated metastatic melanoma. There are reports indicating that vemurafenib may be active in the treatment of intracranial neoplasms with BRAF mutations. As reported in the Journal of Clinical Oncology, Lee et al from...
U.S. Lung Cancer Rates Vary by Subtype, Sex, Race/Ethnicity, and Age
A new analysis confirms that U.S. lung cancer rates are declining overall, but it also uncovers previously unrecognized trends related to cancer subtype, sex, race/ethnicity, and age. Published early online in Cancer, the findings provide a more accurate picture of the state of lung cancer in the...
FDA Approves First Noninvasive DNA Screening Test for Colorectal Cancer
The U.S. Food and Drug Administration (FDA) today approved Cologuard, the first stool-based colorectal screening test that detects the presence of red blood cells and DNA mutations that may indicate the presence of certain kinds of abnormal growths that may be cancers such as colon cancer or...
TP53, TET2, and DNMT3A Mutations Predict Poorer Survival After Hematopoietic Stem Cell Transplant in Patients With Myelodysplastic Syndrome
It is unclear whether somatic mutations that are strongly associated with phenotype and prognosis in myelodysplastic syndrome are also predictive of outcome after allogeneic hematopoietic stem cell transplantation. In a study reported in the Journal of Clinical Oncology, Bejar et al found that...
Regular, Moderate Physical Activity Decreases Breast Cancer Risk in Postmenopausal Women
Postmenopausal women who in the previous 4 years had undertaken the equivalent of at least 4 hours of walking per week had a 10% decreased risk of invasive breast cancer compared with women who were less active, according to a new study. The findings suggest that regular physical activity, even of...
Adding Gemtuzumab Ozogamicin to Chemotherapy Improves Event-Free Survival but Not Overall Survival in Children and Adolescents With De Novo AML
In a Children’s Oncology Group phase III trial reported in the Journal of Clinical Oncology, Gamis et al found that the addition of gemtuzumab ozogamicin (Mylotarg), an immunoconjugate targeting CD33, resulted in significantly prolonged event-free survival but not overall survival when added...
Genome-Wide Association Study Finds New Genetic Risk Markers in Pancreatic Cancer
A large DNA analysis of people with and without pancreatic cancer has identified several new genetic markers that signal increased risk of developing the highly lethal disease, reported scientists from Dana-Farber Cancer Institute. The study by Wolpin et al was published in Nature Genetics. The...
Study Identifies New Gene Fusion in Aggressive Estrogen Receptor–Positive Breast Cancer
Researchers from the Lester and Sue Smith Breast Center at Baylor College of Medicine have reported new information about the genetic alterations that may contribute to the development of a breast cancer subtype typically associated with more aggressive forms of the disease and higher recurrence...
Largest Cancer Genetic Analysis Reveals New Way of Classifying Cancer
Researchers with The Cancer Genome Atlas (TCGA) Research Network have completed the largest, most diverse tumor genetic analysis ever conducted, revealing a new approach to classifying cancers. The work, published in Cell, not only revamps traditional ideas of how cancers are diagnosed and treated, ...
College of American Pathologists Publishes Recommendations for Prostate Cancer Active Surveillance
Prostate cancer is the second leading cause of cancer death in men in the United States. Active surveillance offers low-risk prostate cancer patients a means to avoid the potentially harmful side effects from treatment. In a recent article in the Archives of Pathology & Laboratory Medicine, a...
Improved Prognosis Seen in Older Women With Mammography-Detected Breast Cancer
Mammography-detected breast cancer is associated with a shift to earlier stage diagnosis in older women, subsequently reducing the rate of more advanced, difficult-to-treat cases, according to a new study by Malmgren et al published in the journal Radiology. The findings lend support to regular...
Renowned Pathologist Emmanuel Farber, MD, PhD, Dies
Cancer research lost a pioneer on August 3, 2014, with the passing of Emmanuel Farber, MD, PhD, a renowned pathologist who made fundamental contributions to our understanding of chemical carcinogenesis. Dr. Farber’s studies in experimental pathology demonstrated that chemical carcinogens are...
Significant Variation in Use of Single-Fraction Radiation Therapy for Palliation of Bone Metastases
Standardizing prescribing practices for single-fraction radiation therapy for palliation of bone metastases could lead to cost savings and improvement in patients’ quality of life, according to a study published in the August issue of the International Journal of Radiation Oncology •...
Taiwanese Study Shows Increased Risk of Head and Neck Cancer in Patients With Diabetes
In a Taiwanese retrospective cohort study reported in JAMA Otolaryngology–Head & Neck Surgery, Tseng et al found that diabetes was associated with increased risk of head and neck cancer, including increased risk of oral cavity, oropharyngeal, and nasopharyngeal cancers. Study Details...
Blood and Saliva Tests Help Predict Recurrence of HPV-Related Oral Cancer
Physicians at Johns Hopkins have developed blood and saliva tests that help accurately predict recurrences of HPV-linked oral cancers in a substantial number of patients. The tests screen for DNA fragments of the human papillomavirus (HPV) shed from cancer cells lingering in the mouth or other...
Investigational Compound ABT-414 Receives Orphan Drug Designation for Glioblastoma Multiforme
The U.S. Food and Drug Administration has granted orphan drug designation to AbbVie’s investigational compound ABT-414, which is being evaluated for safety and efficacy in patients with glioblastoma multiforme. ABT-414 is an investigational anti-EGFR (epidermal growth factor receptor)...
Study Suggests Recent Use of Some Birth Control Pills May Be Associated With Increased Breast Cancer Risk
Women who recently used birth control pills containing high-dose estrogen and a few other formulations had an increased risk for breast cancer, whereas women using some other formulations did not, according to data published in Cancer Research. “Our results suggest that use of contemporary...
Growth-Driving Cancer Cells May Be Better Targets for Therapy Than Cells That Proliferate the Fastest, Study Suggests
Of the many subgroups of cells vying for control within a cancerous tumor, the most dangerous may not be those that can proliferate the fastest, researchers at Dana-Farber Cancer Institute reported in a study published in Nature. The findings have important implications for the treatment of cancer...
Minimal Residual Disease–Based Risk-Directed Therapy Is Effective in Children With BCR-ABL1–Like B-Cell ALL
BCR-ABL1–like acute lymphoblastic leukemia (ALL), a recently identified B-cell ALL subtype associated with poor outcome, has a gene-expression profile similar to BCR-ABL1–positive disease without the presence of the BCR-ABL1 fusion protein. In a retrospective analysis reported in the...
Anti–IL-6 Antibody Siltuximab Produces Durable Responses in Multicentric Castleman's Disease
Multicentric Castleman’s disease is characterized by overproduction of interleukin-6 (IL-6). In a trial reported in The Lancet Oncology, van Rhee et al found that the anti–IL-6 antibody siltuximab (Sylvant) produced a significantly better response rate vs placebo in patients with the...
Researchers Identify Genetic Mutations Linked to Salivary Gland Tumors
Research conducted at the Florida campus of The Scripps Research Institute (TSRI) has discovered links between a set of genes known to promote tumor growth and mucoepidermoid carcinoma, an oral cancer that affects the salivary glands. The discovery could help physicians develop new treatments that...
Acupuncture Provides Significant Quality-of-Life Improvements Among Breast Cancer Patients With Aromatase Inhibitor–Related Joint Pain
Use of electroacupuncture—a form of acupuncture where a small electric current is passed between pairs of acupuncture needles—produces significant improvements in fatigue, anxiety, and depression in as little as 8 weeks for early-stage breast cancer patients experiencing joint pain...
Improved Overall Survival With Primary Over Consolidation Intraperitoneal Chemotherapy After Optimal Cytoreduction for Advanced Ovarian Cancer
Compared with intravenous (IV) followed by consolidation intraperitoneal (IP) chemotherapy, primary IV/IP chemotherapy was associated with a statistically significant improvement in overall survival—but not progression-free survival—in patients with advanced epithelial ovarian cancer...
Study Helps Compare Risks of Endoscopic vs Surgical Resection for Early Esophageal Cancer
A new study published in the Journal of the National Cancer Institute by researchers at Northwestern Medicine shed new light on the risks associated with the growing popularity of endoscopic resection in the treatment of localized, early-stage esophageal cancer. Merkow et al found that the...
Researchers Identify Irreversible Inhibitor for KRAS Gene Mutation
Cancer researchers at UT Southwestern Medical Center have discovered a molecule that selectively and irreversibly interferes with the activity of a mutated cancer gene common in 30% of tumors. The molecule, SML-8-73-1 (SML), interferes with the KRAS gene, whose proteins influence when cells...
Failure to Adopt a Healthy Lifestyle More Than Doubles Risk of Metabolic Syndrome in Childhood Cancer Survivors
A St. Jude Children’s Research Hospital study found that 73% of adult survivors of childhood cancer more than doubled their risk of developing metabolic syndrome and related health problems by failing to follow a heart-healthy lifestyle. The results were published online in the journal...
First Surveillance Imaging at 6 Months May Be Adequate for Most Patients After Treatment for Early-Stage Non‒Small Cell Lung Cancer
Early surveillance imaging (< 6 months) after stereotactic body radiation therapy for early-stage non–small cell lung cancer (NSCLC) seems to be of limited benefit, resulting in definitive intervention in only 3% of patients, according to the findings of a study in Practical Radiation...
FDA Expands Approved Use of Ibrutinib for Chronic Lymphocytic Leukemia
The U.S. Food and Drug Administration (FDA) today expanded the approved use of ibrutinib (Imbruvica) to treat patients with chronic lymphocytic leukemia (CLL) who carry deletions of the short arm of chromosome 17, which are associated with poor responses to standard treatment for CLL. Ibrutinib...
Statin Use Associated With Decreased Risk of Barrett's Esophagus
Statin use was associated with a significantly reduced risk of developing Barrett’s esophagus, according to a new study by Nguyen et al in Gastroenterology. Obese patients experienced the greatest level of risk reduction with statin use. While statins have been associated with a reduced risk...
FDA Approves Idelalisib for Three Types of Blood Cancers
The U.S. Food and Drug Administration (FDA) has approved idelalisib (Zydelig) for the treatment of patients with three types of blood cancers. Idelalisib is being granted traditional approval to treat patients with relapsed chronic lymphocytic leukemia (CLL). Used in combination with rituximab...
Metabolic Enzyme Stops Growth of Most Common Type of Kidney Cancer
In an analysis of metabolites in human kidney tissue, a research team from the Perelman School of Medicine at the University of Pennsylvania identified an enzyme key to applying the brakes on tumor growth. The new study, published in Nature by Simon et al, demonstrated that an enzyme called FBP1,...
FDA Grants Bevacizumab Priority Review for Recurrent Platinum-Resistant Ovarian Cancer
The U.S. Food and Drug Administration (FDA) has accepted Genentech’s supplemental Biologics License Application and granted Priority Review for bevacizumab (Avastin) plus chemotherapy for the treatment of women with recurrent platinum-resistant ovarian cancer. “The majority of women...
Noninvasive Image Texture Analysis May Provide Tumor Heterogeneity Information With Prognostic Potential in NSCLC
Noninvasive quantitative computed tomography–based texture analysis can accurately differentiate the presence of a KRAS mutation from pan–wild-type non–small cell lung cancer (NSCLC), based on the results of a study in PLOS ONE. Weiss et al reported that this tumor heterogeneity...
Negative HPV Screening Test Result Is a Better Predictor of Cervical Cancer Risk Than a Negative Pap Test Result
A study by investigators at the National Cancer Institute of more than 1 million women has found that a negative test for human papillomavirus (HPV) infection is a more reliable predictor of the risk of developing cervical cancer than a negative Pap test. The findings suggest that primary HPV...
