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Showing 3201 - 3250Disparities in Colorectal Cancer Death Rates Take a Large Economic Toll
Disparities in colorectal cancer death rates take a large toll on the national economy, with poorer, less-educated communities bearing the greatest burden, according to data presented at the Eighth American Association for Cancer Research (AACR) Conference on the Science of Cancer Health...
Researchers Call for Hospitals to Establish Bereavement Programs for Families of Deceased Patients
Backed by a growing body of research, investigators at Dana-Farber Cancer Institute are calling for all hospitals to establish bereavement programs for families of deceased patients. In a report published by Morris and Block in the Journal of Palliative Medicine, researchers say such...
Liquid Biopsy Promotes Precision Medicine by Tracking Patient's Cancer
A team of researchers, including scientists from the Translational Genomics Research Institute (TGen), has reported that analyzing circulating tumor DNA (ctDNA) can track how a patient's cancer evolves and responds to treatment. In a study published in Nature Communications, Muhammed Murtaza, PhD, ...
ABC3: Higher Insulin Is an Independent Prognostic Factor in Advanced Breast Cancer
Patients with metastatic breast cancer who have higher insulin levels than normal, but are not diabetic, have a significantly worse prognosis compared with those who have normal insulin levels, according to data being presented (Abstract BP129) at the Advanced Breast Cancer Third International...
Researchers Discover SEC23B, Gene Associated With Cowden Syndrome, Contributes to Thyroid Cancer Risk
Cleveland Clinic researchers have discovered a gene associated with Cowden syndrome, an inherited condition that carries high risks of thyroid, breast, and other cancers, and a subset of noninherited thyroid cancers. These findings were published by Yehia et al in the American Journal of Human...
Exercise Could Provide a Margin of Safety for Women Who Want to Delay Preventive Mastectomy
Regular physical activity could play a role in helping women at high-risk of breast cancer delay the need for drastic preventive measures such as prophylactic mastectomy, according to new research led by the Perelman School of Medicine at the University of Pennsylvania. Results of the WISER Sister...
Newly Discovered Tumor-Suppressor Gene Affects Melanoma Survival
Of the hundreds of genes that can be mutated in a single case of melanoma, only a handful may be true drivers of cancer. A new study published by Arafeh et al in Nature Genetics, a Weizmann Institute of Science team has revealed one of the drivers of a particularly deadly subset of melanomas that...
A Cancer Diagnosis Can Lead to Significant Loss of Working Hours, Income
A new analysis indicates that when American adults are diagnosed with cancer, they experience significant decreases in the probability of working, in the number of hours they work, and correspondingly, in their incomes. Such negative impacts of a cancer diagnosis are particularly pronounced among...
Researchers Link Immunosuppressive Mycophenolate Mofetil to Increased Risk of Central Nervous System Lymphoma
A study led by Johns Hopkins researchers has linked the immunosuppressive drug mycophenolate mofetil to an increased risk of central nervous system lymphoma in solid organ transplant patients. But the same study also found that another class of immunosuppressive drugs, calcineurin inhibitors, given ...
ECC 2015: Treatment of Elderly Patients With Breast Cancer Varies Throughout Europe
First results from the largest international comparison of the treatment of elderly patients with breast cancer have shown substantial differences in the use of surgery, hormone therapy, and chemotherapy among European countries. The European Registration of Cancer Care (EURECCA) study compared the ...
ECC 2015: Discovery of Differences Between Tumors of Younger and Older Patients With Colorectal Cancer May Lead to Better Treatments
Colorectal cancer is on the rise among younger patients. Although some of the younger-onset cases can be explained by hereditary factors, the majority arise spontaneously. Researchers have now found that tumors in younger patients with colorectal cancer may be molecularly distinct from those of...
ECC 2015: Genetic Screening of Brain Metastases Could Reveal New Targets for Treatment
Unraveling the genetic sequences of cancer that has spread to the brain could offer unexpected targets for effective treatment, according to new research (Abstract 2905) presented at the 2015 European Cancer Congress in Vienna, Austria, and published simultaneously by Brastianos et al in...
ECC 2015: Use of Aspirin Linked to Improved Survival in Gastrointestinal Cancers
Aspirin improved survival in patients with tumors situated throughout the gastrointestinal tract, results from a large study in the Netherlands showed. This is the first time that survival data from patients with tumors in different gastrointestinal locations have been analyzed at the same time;...
ECC 2015: Study Finds Significant Genetic Differences Between Breast Cancers That Relapse and Those That Do Not
Although most patients with breast cancer are cured after treatment, in about one in five patients, the cancer will recur, returning either to the same place as the original tumor or metastasizing to other parts of the body. Now, researchers have taken an important step toward understanding why...
Breast Cancer Symposium: Adjuvant Radiation After Lumpectomy May Benefit Some Elderly Women With Triple-Negative Breast Cancer
Adjuvant radiation therapy may be omitted for elderly women with estrogen receptor–positive, early-stage breast cancer who receive hormone therapy. Limited data exist to guide treatment decision-making for elderly women with triple-negative breast cancer. As some findings thus far have shown...
Pancreatic Cancer Action Network and AACR Invite Applications for 2016 Research Grants
The American Association for Cancer Research (AACR) and the Pancreatic Cancer Action Network announced the opening of the 2016 Research Grants Program to support early-career investigators to focus on pancreatic cancer. Two grant mechanisms, the Pathway to Leadership Grant and the Career...
Internationally Acclaimed Cancer Researcher, Gianni Bonadonna, MD, Dies at 81
Gianni Bonadonna, MD, was considered the “Father of Italian Oncology,” but his scientific contributions to the field and his generous collegial spirit extended far beyond the shores of his native land. Dr. Bonadonna was at the forefront in the battle to convince the surgical...
Call for APOS 2016 Award Nominations
The American Psychosocial Oncology Society (APOS) will be celebrating 30 years of psychosocial oncology at the 13th Annual APOS Conference, to be held March 3 to 5, 2016, in San Diego. Colleagues, mentors, students, and others who have made an impact on psychosocial oncology can be nominated for an ...
Patients With Fewer Than 50 Moles May Be at Risk for More Aggressive Melanoma
People with more than 50 moles have an increased risk of developing melanoma, but those with fewer than 50 moles should still be alert for this disease. In fact, according to new research presented at the American Academy of Dermatology’s 2015 Summer Academy Meeting in New York, those with...
Organ Transplant Recipients May Be More Likely to Develop Aggressive Melanoma
Organ transplant recipients are twice as likely to develop melanoma as people who do not undergo a transplant and three times more likely to die of the skin cancer, suggested new research by a multi-institutional team. The findings, reported by Robbins et al in the Journal of Investigative...
Long-Term Survival in Ovarian Cancer May Be Better Than Expected in Some Patients
Combing data collected on thousands of California patients with ovarian cancer, University of California Davis researchers have determined that almost one-third of patients survived at least 10 years after diagnosis. The findings upend the notion that women diagnosed with cancer of the ovaries...
Birinapant in Combination With Carboplatin May Be Effective Against Serous Ovarian Cancer
High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but it frequently recurs after the first line of treatment. A team of University of California, Los Angeles, researchers has discovered that a subset of tumor cells that don’t produce the protein CA125, ...
Study Finds Underinvestment in Long-Term Cancer Research
Pharmaceutical firms underinvest in long-term research to develop new cancer-fighting drugs due to the greater time and cost required to conduct such research, according to a newly published study authored by Massachusetts Institute of Technology (MIT) economists. These findings were published by...
Many Young Cancer Patients May Have Limited Awareness of Fertility Preservation Options
A new study points to the need for increased awareness of fertility preservation options for young patients with cancer. Published by Shnorhavorian et al in Cancer, the study found that factors such as gender, education, and insurance status impact whether patients and their physicians have...
New Analysis Points the Way to Earlier Diagnosis of Pediatric Chest Tumors
Researchers led by St. Jude Children’s Research Hospital scientists have developed new diagnostic criteria to enable clinicians to distinguish malignant cancerous chest cavity masses from those caused by fungal histoplasmosis infection. Their findings were published by Naeem et al in the...
New Biomarkers Might Help Personalize Metastatic Colorectal Cancer Treatment
Metastatic colorectal cancer patients have improved survival rates when they respond to the first line of chemotherapy their doctors recommend. To better predict how patients will respond to chemotherapeutic agents before they begin treatment, researchers at University of California (UC) San Diego...
Lymph Nodes Signal More Aggressive Thyroid Cancer, Even in Young Patients
Patients older than age 45 with thyroid cancer that has spread to neck lymph nodes have long been considered at higher risk of dying, but the same has not been true for younger patients. Now researchers at the Duke Cancer Institute and the Duke Clinical Research Institute have found that...
Latina Patients With Breast Cancer Need More Culturally Relevant, Language-Specific Stress Management Tools
It is estimated that one of every three Latina women will be diagnosed with cancer during her lifetime. Moffitt Cancer Center researchers, along with collaborators at the University of South Florida, recently published a study about the attitudes and cultural perspectives of Latinas undergoing...
ASCO 2015: Glioblastoma Poliovirus Therapy Works Best at a Low Dosage
A modified poliovirus therapy that is showing activity in patients with glioblastoma works best at a low dosage, according to the research team at Duke’s Preston Robert Tisch Brain Tumor Center. The dosage findings for the first 20 patients in the phase 1 trial were presented June 1 at the...
ASCO 2015: Biomarker Analysis Reveals Several Potential Treatment Targets in Subtype of Anal Cancer
Squamous cell anal carcinomas are rare, representing only about 2% of gastrointestinal cancer diagnoses. These cancers, which are associated with the human papillomavirus (HPV), sometimes prove very difficult to treat, recurring or developing metastases following standard treatment. Seeking to...
ASCO 2015: Anastrozole Offers Higher Breast Cancer–Free Interval Rates Than Tamoxifen Following Lumpectomy and Radiation for DCIS
A phase III trial comparing 5 years of tamoxifen vs 5 years of the aromatase inhibitor anastrozole for postmenopausal women treated for ductal carcinoma in situ (DCIS) found 10-year breast cancer–free interval rates were higher in the anastrozole group than in the tamoxifen group (93.5% vs...
ASCO 2015: ASCO Announces First-Ever Clinical Trial
ASCO announced its first-ever clinical trial, which will offer patients with advanced cancer access to molecularly targeted cancer drugs and collect “real-world” data on clinical outcomes, to help learn the best uses of these drugs outside of indications approved by the U.S. Food and...
Good Prognosis for Parenthood for Women Treated for Hodgkin Lymphoma During Childhood or Adolescence
In a German study reported in The Lancet Oncology, Brämswig et al found that women treated for Hodgkin lymphoma during childhood or adolescence had a good prognosis for achieving parenthood. Study Details This prospective longitudinal study included 467 female patients aged < 18 years at...
Preclinical Study Points to Possible Treatment for Lethal Pediatric Brain Cancer
Using brain tumor samples collected from children in the United States and Europe, an international team of scientists found that the drug panobinostat (Farydak) and similar gene-regulating drugs may be effective at treating diffuse intrinsic pontine glioma (DIPG), an aggressive and lethal form of...
Bilateral Prophylactic Mastectomy Rarely More Cost-Effective Than Screening Mammography for High-Risk Women
Annual screening mammography is significantly more cost-effective than bilateral prophylactic mastectomy in managing the care of most women at high risk for breast cancer. Women with a known BRCA gene mutation, which carries an exceptionally high risk, are a notable exception. These were the...
Fallopian Tube Removal May Protect Premenopausal Women at High Risk for Ovarian Cancer From Some Surgical Side Effects
A new surgical approach that removes the fallopian tubes—while sparing the ovaries—may provide premenopausal women at high risk for ovarian cancer, particularly those with BRCA1/2 mutations, with a surgical option that minimizes cancer risk while also reducing some of the negative...
Identifying Processes That Lead to Discontinuation of Chemotherapy for Patients With NSCLC at End of Life
According to a recent study by Perl et al published in the Journal of Oncology Practice, the administration of chemotherapy near death is recognized by patients, their families, and oncologists as “aggressive and poor-quality care.” Despite this, rates of end-of-life chemotherapy have...
New Study Reveals Effective Treatment Program for Breast Cancer Survivors With ‘Chemobrain’
In a new study, UCLA researchers have developed a cognitive rehabilitation program to address post-treatment cognitive changes, sometimes known as “chemobrain,” which can affect up to 35% of post-treatment breast cancer patients. Their findings were reported by Erocli et al in...
Overweight Girls Face Increased Risk of Colorectal Cancer Later in Life
Girls who are overweight as young children and teens may face an increased risk for colorectal cancer decades later, regardless of what they weigh as adults, suggests a new study published by Zhang et al in Cancer Epidemiology, Biomarkers & Prevention. “Our study supports the growing...
BRAF Wild-Type Melanomas During Dabrafenib Treatment for Metastatic BRAF V600E Melanoma
In a case report in JAMA Dermatology, Carrera et al described development of multiple wild-type BRAF melanomas and a metastasis with a different BRAF mutation in a patient receiving dabrafenib (Tafinlar) for BRAF V600E–mutant metastatic melanoma. Development of Melanomas As described...
AACR Names Nancy E. Davidson, MD, President-Elect for 2015-2016
The American Association for Cancer Research (AACR) today announced the election of Nancy E. Davidson, MD, Director of the University of Pittsburgh Cancer Institute and UPMC CancerCenter in Pittsburgh, as its President-Elect for 2015–2016. Dr. Davidson will officially become President-Elect...
Women Who Undergo Delayed Breast Reconstruction May Experience More Cancer‑Related Distress Than Women Who Undergo Mastectomy Alone
In women who have undergone mastectomy, those who underwent delayed breast reconstruction experienced greater cancer-related distress over the long term compared with women who underwent mastectomy alone, according to a prospective study by Metcalfe et al in the Journal of Surgical Oncology. For...
California Primary Care Physicians Struggle to Adapt to Breast Density Law, Study Shows
Ten months after California legislators enacted a controversial law mandating that radiologists notify women if they have dense breast tissue, University of California (UC), Davis researchers have found that half of primary care physicians are still unfamiliar with the law, and many don't feel...
Study Finds Many Women Lack Understanding of Their Breast Cancer, Especially Minority Patients
A population-based study of women who had undergone surgery for breast cancer has found that many lacked understanding of the basic characteristics of their disease, including stage, grade, and tumor characteristics. Minority patients were less likely than white patients to have the correct...
Breast Cancer Diagnoses and Survival Outcomes Vary by Race/Ethnicity
Among nearly 375,000 U.S. women diagnosed with invasive breast cancer, the likelihood of diagnosis at an early stage, and survival after stage I diagnosis, varied by race and ethnicity, with much of the difference accounted for by biologic differences, according to a study reported by Iqbal et al...
Many Cancer Survivors Have Unmet Physical and Mental Needs Related to Their Disease and Its Treatment
Even decades after being cured, many cancer survivors face physical and mental challenges resulting from their disease and its treatment, according to a new study reported by Burg et al in Cancer. The findings could help clinicians and other experts develop interventions that are tailored to the...
American Psychosocial Oncology Society Issues Call for 2015 Award Nominations
The American Pyschosocial Oncology Society (APOS) announced today that it is accepting nominations for its 2015 awards. The deadline for submitting nominations is December 31, 2014. These awards will be presented at the World Congress of Psycho-Oncology, to be held July 30 to August 1, 2015. For...
SABCS 2014: Ovarian Suppression Added to Hormonal Therapy Reduces Risk of Recurrence in Some Premenopausal Women
Results of the large international SOFT trial present a convincing argument for the addition of ovarian function suppression to adjuvant hormonal therapy to reduce the risk of recurrence in premenopausal women with hormone receptor–positive breast cancer at high enough risk to be treated with ...
SABCS 2014: Breast Cancer in Men and Women Has Different Biologic Characteristics and Outcomes
Results from the largest series of male breast cancer cases ever studied showed that there was significant improvement in overall survival for male breast cancer patients over the duration of the study, but the improvement was not as good as has been seen for female breast cancer patients,...
SABCS 2014: High Tumor Immune Cell Levels May Identify HER2-Positive Breast Cancer Patients Who Might Benefit From Chemotherapy Alone
Women with HER2-positive breast cancer who had high levels of immune cells in their tumors had a decreased risk of cancer recurrence after treatment with chemotherapy alone compared with their counterparts who had low levels of tumor-infiltrating immune cells, according to data presented at the...
